Der Stand der Totalsynthese zu Beginn des 21. Jahrhunderts

Ein neues Jahrtausend hat begonnen – Grund genug, sich die Frage zu stellen, welchen Stand die Totalsynthese von Naturstoffen erreicht hat. Dieser Aufsatz mochte eine Antwort geben, indem er die Entwicklung dieser chemischen Disziplin, die Aspekte von exakter Wissenschaft und schoner Kunst in sich vereint, von Anbeginn bis in die heutige Zeit beschreibt; es wird geschildert, wie viel wir in der Wissenschaft der Totalsynthese schon erreicht haben, aber auch, dass dieses Forschungsgebiet den Kinderschuhen gerade erst entschlupft.

[1]  G. Quinkert,et al.  Asymmetrische Totalsynthese von (+)‐Östron , 1980 .

[2]  J. Goodman,et al.  Enantio- and diastereoselective aldol reactions of achiral ethyl and methyl ketones with aldehydes: the use of enol diisopinocampheylborinates , 1990 .

[3]  A. Bélanger,et al.  The total synthesis of (+)-ryanodol. Part II. Model studies for rings B and C of (+)-anhydroryanodol. Preparation of a key pentacyclic intermediate , 1990 .

[4]  D. Barton,et al.  A New Photochemical Reaction1 , 1960 .

[5]  K. Nicolaou,et al.  Chemical Biology of Epothilones. , 1998, Angewandte Chemie.

[6]  H. Mitchell,et al.  Totalsynthese von Everninomicin 13,384‐1 – Teil 2: Synthese des FGHA2‐Fragments , 1999 .

[7]  D. E. Wright.  The orthosomycins, a new family of antibiotics , 1979 .

[8]  C. Sih,et al.  Synthesis of the C10-C34 segment of the immunosuppressant FK506 , 1990 .

[9]  R. Terrell,et al.  The Enamine Alkylation and Acylation of Carbonyl Compounds , 1963 .

[10]  E. Corey,et al.  Stereospecific total synthesis of gibberellic acid , 1978 .

[11]  D. Schinzer,et al.  Totalsynthese von (−)-Epothilon A† , 1997 .

[12]  E. Corey,et al.  A simple and enantioselective synthesis of (+)-biotin , 1988 .

[13]  Dale L. Boger,et al.  Bleomycin: Untersuchungen zu Synthese und Wirkungsmechanismus , 1999 .

[14]  R. A. Daines.  The total synthesis of amphotericin B , 1987 .

[15]  T. Jamison,et al.  Combinatorial libraries of transition-metal complexes, catalysts and materials. , 1998, Current opinion in chemical biology.

[16]  Y. Kita,et al.  Asymmetrische Totalsynthese von Fredericamycin A , 1999 .

[17]  T. Kametani,et al.  Letter: A formal regio- and stereoselective total synthesis of estrone. A convenient synthesis of D-homoestrone. , 1976, Journal of the American Chemical Society.

[18]  E. Corey,et al.  Total synthesis of (+-)-.alpha.- and (+-)-.beta.-copaenes and ylangenes , 1973 .

[19]  T. J. Katz,et al.  Metathesis of a cyclic trisubstituted alkene. Preparation of polyisoprene from 1-methylcyclobutene , 1976 .

[20]  A. Bélanger,et al.  The total synthesis of (+)-ryanodol. Part III. Preparation of (+)-anhydroryanodol from a key pentacyclic intermediate , 1990 .

[21]  K. Nicolaou,et al.  An Approach to Epothilones Based on Olefin Metathesis , 1996 .

[22]  A. Scott.  The discovery of nature's pathway to vitamin B12. A 25 year odyssey , 1994 .

[23]  J. Clardy,et al.  Total Synthesis of the Macrolide Antibiotic Cytovaricin. , 1990 .

[24]  S. Blechert,et al.  Die Olefinmetathese in der organischen Synthese , 1997 .

[25]  H. Nagasawa,et al.  Expeditious enantioselective syntheses of indole alkaloids of Aspidosperma- and Hunteria-type , 1987 .

[26]  K. Nicolaou,et al.  The endiandric acid cascade. Electrocyclizations in organic synthesis. 3. "Biomimetic" approach to endiandric acids A-G. Synthesis of precursors , 1982 .

[27]  S. Ikegami,et al.  A total synthesis of d1-coriolin , 1980 .

[28]  E. and,et al.  A Short Enantioselective Total Synthesis of Dammarenediol II , 1996 .

[29]  G. Stork,et al.  Anions of protected cyanohydrins as acyl carbanion equivalents and their use in a new synthesis of ketones , 1971 .

[30]  R. Hughes,et al.  Total Synthesis of Vancomycin , 1999 .

[31]  E. Corey,et al.  A simple and efficient synthesis of (7E, 9E, 11Z, 13E)-(5S, 6R, 15S)-trihydroxyeicosatetraenoic acid (6R-lipoxin A) , 1989 .

[32]  B. McCarry,et al.  Acetylenic bond participation in biogenetic-like olefinic cyclizations. II. Synthesis of dl-progesterone. , 1971, Journal of the American Chemical Society.

[33]  D. Ginsburg,et al.  THE SYNTHESIS OF MORPHINE , 1954 .

[34]  K. Nicolaou,et al.  Total Synthesis of Brevetoxin-B .1. Cdefg Framework , 1995 .

[35]  E. Corey,et al.  Total synthesis of venustatriol , 1988 .

[36]  K. Nicolaou.  The Battle of Calicheamicin γ , 1993 .

[37]  A. Eschenmoser,et al.  Natural product synthesis and vitamin B12. , 1977, Science.

[38]  C. Beevers,et al.  The crystal structure of strychnine hydrogen bromide , 1951 .

[39]  A. Tebbe,et al.  The First Synthesis of a Daphnane Diterpene: The Enantiocontrolled Total Synthesis of (+)-Resiniferatoxin , 1997 .

[40]  S. Danishefsky,et al.  Totalsynthese von Eleutherobin: zum Schluß eine Überraschung , 1998 .

[41]  B. Stoltz,et al.  Design and Implementation of an Efficient Synthetic Approach to Pyranosylated Indolocarbazoles: Total Synthesis of (+)-RK286c, (+)-MLR-52, (+)-Staurosporine, and (−)-TAN-1030a , 1997 .

[42]  R. Rzasa,et al.  Total Synthesis of the Novel, Immunosuppressive Agent (−)-Pateamine A from Mycale sp. Employing a β-Lactam-Based Macrocyclization , 1998 .

[43]  A. Armstrong,et al.  Total Synthesis of Avermectin B1a: Planning of the Synthesis and Preparation of the C1-C10 "Southern" Hydrobenzofuran Fragment , 1990 .

[44]  Craig J. Forsyth,et al.  Total synthesis of halichondrin B and norhalichondrin B , 1992 .

[45]  K. Nicolaou,et al.  Total synthesis of elfamycins: aurodox and efrotomycin. 2. Coupling of key intermediates and completion of the synthesis , 1985 .

[46]  N. Koumura,et al.  Total synthesis of Hemibrevetoxin B , 1995 .

[47]  M. Braun.  Regioselektive synthese von daunomycinon und γ-rhodomycinon , 1980 .

[48]  P. Parsons,et al.  Tandem Reactions in Organic Synthesis: Novel Strategies for Natural Product Elaboration and the Development of New Synthetic Methodology. , 1996, Chemical reviews.

[49]  S. Danishefsky,et al.  Total synthesis of dl-quadrone , 1980 .

[50]  W. D. Ollis,et al.  The total synthesis of strychnine. , 1954, Experientia.

[51]  E. Corey,et al.  Synthesis of Vane's prostaglandin X, 6,9alpha-oxido9alpha,15alpha-dihydroxyprosta-(Z)5,(E)13-dienoic acid. , 1977, Journal of the American Chemical Society.

[52]  Motomasa Kobayashi,et al.  Structure of swinholide A, a potent cytotoxic macrolide from the Okinawan marine sponge , 1989 .

[53]  R. Willstätter.  Ueber ψ-Tropin , 1896 .

[54]  S. Schreiber,et al.  Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[55]  M. Demuth,et al.  Total synthesis of (−)-coriolin , 1986 .

[56]  G. Schmid,et al.  A total synthesis of lasalocid A , 1978 .

[57]  C. Harris,et al.  Structure of the glycopeptide antibiotic vancomycin. Evidence for an asparagine residue in the peptide , 1982 .

[58]  K. Nicolaou,et al.  The endiandric acid cascade. Electrocyclizations in organic synthesis. 4. Biomimetic approach to endiandric acids A-G. Total synthesis and thermal studies , 1982 .

[59]  K. Nicolaou,et al.  Chemistry and Biology of Taxol , 1994 .

[60]  R. Gregg,et al.  BIOMIMETIC AND SYNTHETIC APPROACHES TO MARINE SPONGE ALKALOIDS DERIVED FROM BIS-PYRIDINE MACROCYCLES. A REVIEW , 1998 .

[61]  Y. Kita,et al.  Total synthesis of discorhabdin C : a general aza spiro dienone formation from O-silylated phenol derivatives using a hypervalent iodine reagent , 1992 .

[62]  E. E. Tamelen,et al.  Biogenetic-type total synthesis. dl-Tetrahymanol , 1972 .

[63]  K. Nicolaou,et al.  Stereocontrolled construction of key building blocks for the total synthesis of amphoteronolide B and amphotericin B , 1987 .

[64]  N. Vicker,et al.  Synthesis of strychnine via the Wieland-Gumlich aldehyde , 1992 .

[65]  E. Corey,et al.  Total synthesis of lactacystin , 1992 .

[66]  P. Andersson,et al.  Total synthesis of balanol, part 2. Completion of the synthesis and investigation of the structure and reactivity of two key heterocyclic intermediates , 1997 .

[67]  J. Winkler,et al.  The First Total Syntheses of Ircinol A, Ircinal A, and Manzamines A and D. , 1998, Journal of the American Chemical Society.

[68]  D. R. Parrish,et al.  Asymmetric synthesis of bicyclic intermediates of natural product chemistry , 1974 .

[69]  D. Boger,et al.  Thermal reactions of cyclopropenone ketals: application of the cycloaddition reactions of delocalized singlet vinylcarbenes: three-carbon 1,1-/1,3-dipoles: an alternative synthesis of deacetamidocolchiceine: formal total synthesis of colchicine , 1986 .

[70]  S. Schreiber,et al.  Total synthesis of the immunosuppressive agent (-)-discodermolide , 1993 .

[71]  E. Corey,et al.  Enantioselective Total Synthesis of Ecteinascidin 743 , 1996 .

[72]  R. Hughes,et al.  Total Synthesis of Vancomycin Aglycon-Part 2: Synthesis of Amino Acids 1-3 and Construction of the AB-COD-DOE Ring Skeleton. , 1998, Angewandte Chemie.

[73]  P. Wender,et al.  GENERAL METHODOLOGY FOR CIS‐HYDROISOQUINOLINE SYNTHESIS: SYNTHESIS OF RESERPINE , 2002 .

[74]  Norihiko Tanimoto,et al.  Synthese von natürlich vorkommendem (−)‐Calyculin A , 1994 .

[75]  K. Nicolaou,et al.  Totalsynthese des Vancomycin‐Aglycons – Teil 3: letzte Schritte , 1998 .

[76]  D. Boger,et al.  Total Synthesis of Bleomycin A2 and Related Agents. 3. Synthesis and Comparative Evaluation of Deglycobleomycin A2,Epideglycobleomycin A2, Deglycobleomycin A1, and Desacetamido-, Descarboxamido-, Desmethyl-, and Desimidazolyldeglycobleomycin A2 , 1994 .

[77]  H. Maruyama,et al.  A stereocontrolled synthesis of thienamycin from 6-aminopenicillanic acid , 1986 .

[78]  R. Woodward,et al.  A SIMPLIFIED ROUTE TO A KEY INTERMEDIATE IN THE TOTAL SYNTHESIS OF RESERPINE , 1956 .

[79]  R. Woodward,et al.  Total Synthesis of (±)-Reserpine , 2022, Synfacts.

[80]  N. Keen,et al.  Concise Syntheses of (−)- and (+)-Syringolide 1 and (−)-Δ7-Syringolide 1 , 1997 .

[81]  G. Sauer,et al.  New Type of Asymmetric Cyclization to Optically Active Steroid CD Partial Structures , 1971 .

[82]  Robert Robinson,et al.  LXIII.—A synthesis of tropinone , 1917 .

[83]  John C. Sheehan,et al.  The Enchanted Ring: The Untold Story of Penicillin , 1986 .

[84]  R. Hungate,et al.  The total synthesis of the aglycon of avermectin A1a , 1987 .

[85]  K. Nicolaou,et al.  Total synthesis of amphoteronolide B and amphotericin B. 1. Strategy and stereocontrolled construction of key building blocks , 1988 .

[86]  Ashutosh Kumar Singh,et al.  Synthesis of (.+-.)-Fredericamycin A (I). , 1993 .

[87]  W. S. Johnson,et al.  Biomimetic polyene cyclizations. , 1976, Angewandte Chemie.

[88]  M. Dobler.  Ionophores and Their Structures , 1981 .

[89]  T. Weller,et al.  Simple preparation of a useful c/d-ring fragment for the construction of 11-keto steroids , 1984 .

[90]  J. Bonjoch,et al.  Total Synthesis of (-)-Strychnine via the Wieland-Gumlich Aldehyde. , 1999, Angewandte Chemie.

[91]  R. S. Coleman,et al.  ATROPDIASTEREOSELECTIVE TOTAL SYNTHESIS OF PHLEICHROME AND THE PROTEIN KINASE C INHIBITOR CALPHOSTIN A , 1994 .

[92]  K. Nicolaou,et al.  Total Synthesis of Sarcodictyins A and B , 1998 .

[93]  K. Nicolaou,et al.  Total synthesis of everninomicin 13,384-1--Part 3: synthesis of the DE fragment and completion of the total synthesis. , 1999, Chemistry.

[94]  C. Switzer,et al.  Total synthesis of natural estrone and estradiol methyl ethers in extremely high enantiomeric purity via an asymmetric Michael addition to an unsaturated sulfoxide , 1986 .

[95]  Sue-Lein Wang,et al.  Total Synthesis of (−)-Dendrobine via α-Carbonyl Radical Cyclization , 1997 .

[96]  A. Hoveyda.  Catalyst discovery through combinatorial chemistry. , 1998, Chemistry & biology.

[97]  K. Tomioka,et al.  A Biogenetic-type Asymmetric Synthesis of Optically Active Amaryllidaceae Alkaloids: (+)- and (-)-Galanthamine from L-Tyrosine , 1977 .

[98]  K. Nicolaou,et al.  Totalsynthese von Vancomycin , 1999 .

[99]  E. Corey,et al.  Total Synthesis ofd,l-Caryophyllene andd,l-Isocaryophyllene , 1963 .

[100]  T. Bryson,et al.  Boron annulation: total synthesis of (±)-estrone methyl ether , 1980 .

[101]  H. Muxfeldt,et al.  TETRACYCLINES. V. A TOTAL SYNTHESIS OF 6-DEOXY-6-DEMETHYLTETRACYCLINE. , 1965, Journal of the American Chemical Society.

[102]  R. Terrell,et al.  A NEW SYNTHESIS OF 2-ALKYL AND 2-ACYL KETONES , 1954 .

[103]  R. Volante,et al.  Total synthesis of immunosuppressant (-)-FK-506 , 1989 .

[104]  R. Sakai,et al.  Biologically active natural products , 1990 .

[105]  D. R. Parrish,et al.  The stereocontrolled synthesis of trans-hydrindan steroidal intermediates. , 1973, The Journal of organic chemistry.

[106]  Leonard Katz,et al.  Manipulation of Modular Polyketide Synthases. , 1997, Chemical reviews.

[107]  G. Stork,et al.  Allylic radicals in cyclization reactions , 1988 .

[108]  Ulrich Rosentreter,et al.  Reaktionen an Indolderivaten, XXXIX. Stereoselektive Totalsynthese von Eburnamonin, Eburnamin und Eburnamenin , 1979 .

[109]  Y. Hayakawa,et al.  Total synthesis of dl-dendrobine. , 1972, Journal of the American Chemical Society.

[110]  Guncheol Kim,et al.  The temporary silicon connection method in the control of regio- and stereochemistry. Applications to radical-mediated reactions. The stereospecific synthesis of C-glycosides , 1991 .

[111]  Susan Band Horwitz,et al.  Total Synthesis of (–)‐Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones , 1997 .

[112]  E. Corey,et al.  An enantioselective synthesis of (6R)-lactacystin , 1993 .

[113]  Isamu Shiina,et al.  Total Asymmetric Synthesis of Taxol by Dehydration Condensation between 7-TES Baccatin III and Protected N-Benzoylphenylisoserines Prepared by Enantioselective Aldol Reaction , 1998 .

[114]  S. Danishefsky,et al.  Stereocontrolled Total Synthesis of Hispidospermidin , 1997 .

[115]  W. Roush,et al.  Enantioselective Total Synthesis of (-)-Chlorothricolide , 1994 .

[116]  M. Jung,et al.  Stereoselectivity in intramolecular Diels-Alder reactions. A short total synthesis of (±)-estrone , 1984 .

[117]  D. M. Bailey,et al.  Cationic Cyclizations Involving Olefinic Bonds. II.1 Solvolysis of 5-Hexenyl and trans-5,9-Decadienyl p-Nitrobenzenesulfonates , 1964 .

[118]  R. Woodward,et al.  The Penems, a New Class of β‐Lactam Antibiotics. 6. Synthesis of 2‐alkylthiopenem carboxylic acids , 1980 .

[119]  G. Stork.  The stereospecific synthesis of reserpine , 1989 .

[120]  C. Walling.  Some aspects of the chemistry of alkoxy radicals , 1967 .

[121]  M. Schwartz,et al.  Letter: A biogenetically patterned synthesis of the morphine alkaloids. , 1975, Journal of the American Chemical Society.

[122]  B. Fitzgerald,et al.  Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo. , 1992, The Journal of biological chemistry.

[123]  D. Hua,et al.  Asymmetric synthesis via chiral sulfinylallyl anion. Total synthesis of (+)-hirsutene: facile ring closure involving enol thioether and enol acetate moieties , 1985 .

[124]  C. Mitch,et al.  Studies directed towards the total synthesis of morphine alkaloids , 1982 .

[125]  H. Irngartinger,et al.  Radikalische Cyclisierung von Dienen, VI. Totalsynthese von (−)‐Coriolin und (−)‐Epicoriolin aus (S)‐(+)‐Carvon , 1993 .

[126]  Robert G. Bergman,et al.  Reactive 1,4-dehydroaromatics , 1973 .

[127]  E. Taylor,et al.  A facile synthesis of quinine and related cinchona alkaloids. , 1972, Journal of the American Chemical Society.

[128]  R. Moore.  Structure of palytoxin. , 1981, Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles.

[129]  J. Bindra,et al.  2 – Isolation and Structure , 1977 .

[130]  Ulhas S. Warrier,et al.  Total Synthesis of the Antiparasitic Agent Avermectin B1a , 1995 .

[131]  W. Ayer,et al.  The synthesis of dl-lycopodine. , 1968, Journal of the American Chemical Society.

[132]  I. Paterson,et al.  Enantioselective aldol condensations: The use of ketone boron enolates with chiral ligands attached to boron. , 1987 .

[133]  D. Hart,et al.  An enantioselective approach to carbapenem antibiotics: formal synthesis of (+)-thienamycin , 1985 .

[134]  G. Fallon,et al.  Constituents of Endiandra species. I. Endiandric acid, a novel carboxylic acid from Endiandra introrsa (Lauraceae), and a derived lactone , 1981 .

[135]  E. Corey,et al.  The Logic of Chemical Synthesis , 1989 .

[136]  H. Reichenbach,et al.  Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution† , 1996 .

[137]  K. Nicolaou,et al.  Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics. , 1999, Angewandte Chemie.

[138]  E. Corey,et al.  Phenylthiomethyllithium and Bis(phenylthio)methyllithium , 1966 .

[139]  G. Stork,et al.  Temporary Magnesium and Aluminum Connections in [4 + 2] Cycloadditions , 1995 .

[140]  A. Lupi,et al.  A Total Synthesis of Aphidicolin: Stereospecific Synthesis of (±)‐3α, 18‐Dihydoxy‐17‐Noraphidicolan‐16‐one , 1983 .

[141]  P. Verhoest,et al.  Total synthesis of (+)-phorboxazole A. , 1998, Journal of the American Chemical Society.

[142]  K. Nicolaou,et al.  Total synthesis of amphoteronolide B , 1987 .

[143]  S. Bräse,et al.  Palladium in action: domino coupling and allylic substitution reactions for the efficient construction of complex organic molecules , 1999 .

[144]  K. Trueblood,et al.  The structure of vitamin B12. I. An outline of the crystallographic investigation of vitamin B12 , 1957, Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences.

[145]  Stuart L. Schreiber,et al.  Stereoselective Synthesis of over Two Million Compounds Having Structural Features Both Reminiscent of Natural Products and Compatible with Miniaturized Cell-Based Assays , 1998 .

[146]  Y. Kashman,et al.  Structure of swinholide-a, a new macrolide from the marine sponge theonella swinhoei , 1985 .

[147]  M. Shibasaki,et al.  Stereocontrolled synthesis of (+)-thienamycin from 3(R)-hydroxybutyric acid , 1985 .

[148]  B. Lohray,et al.  One pot synthesis of homochiral aziridines and aminoalcohols from homochiral 1,2-cyclic sulfates , 1989 .

[149]  R. J. Anderson,et al.  Biogenetic-type synthesis of the isoeuphenol system , 1970 .

[150]  B. Arison,et al.  The structure of efrotomycin. , 1985, The Journal of antibiotics.

[151]  A. Eschenomoser.  [Organic natural-product synthesis today. vitamin b 12 as an example]. , 1974, Die Naturwissenschaften.

[152]  R. Woodward,et al.  Synthesis and revised structure of isolongistrobine , 1973 .

[153]  S. Ahn,et al.  An asymmetric total synthesis of (−)-fumagillol , 1997 .

[154]  T. Katsuki,et al.  A rapid esterification by means of mixed anhydride and its application to large-ring lactonization. , 1979 .

[155]  A. Szabo,et al.  Haplophytine. Novel type of indole alkaloid , 1973 .

[156]  K. Nicolaou,et al.  Total synthesis of calicheamicin .gamma.1I. 3. The final stages , 1993 .

[157]  S. Hanessian,et al.  Synthesis of (+)-avermectin B1a , 1986 .

[158]  J. Falck,et al.  Synthesis of the Polycyclopropane Antibiotic FR-900848 via the Horeau Gambit , 1996 .

[159]  Won Hyung Yoon,et al.  New synthetic technology for the synthesis of hindered alpha-diazoketones via acyl mesylates. , 1999, Organic letters.

[160]  C. Forsyth,et al.  Efficient Synthesis of Okadaic Acid. 2. Synthesis of the C1−C14 Domain and Completion of the Total Synthesis , 1998 .

[161]  B. A. Pearlman.  A method for effecting the equivalent of a de Mayo reaction with formyl acetic ester , 1979 .

[162]  T. Oki,et al.  Dynemicins, new antibiotics with the 1,5-diyn-3-ene and anthraquinone subunit. II. Antitumor activity of dynemicin A and its triacetyl derivative. , 1991, The Journal of antibiotics.

[163]  R. Woodward.  The total synthesis of a tetracycline , 1963 .

[164]  L. Overman,et al.  Synthesis applications of cationic aza-Cope rearrangements. 26. Enantioselective total synthesis of (-)-strychnine , 1993 .

[165]  G. Stork,et al.  CONCERTED INTRAMOLECULAR DISPLACEMENT WITH REARRANGEMENT IN ALLYLIC SYSTEMS. DISPLACEMENT OF AN ALLYLIC ESTER WITH A CARBANION , 1979 .

[166]  M. Crimmins,et al.  Double Diastereoselection in Intramolecular Photocycloadditions: A Radical Rearrangement Approach to the Total Synthesis of the Spirovetivane Phytoalexin (±)-Lubiminol , 1998 .

[167]  J. J. Clair,et al.  Stereocontrolled Synthesis of (±)-12a-Deoxytetracycline , 1996 .

[168]  Michael Rosen,et al.  Naturstoffe als Sonden zum Studium zellulärer Funktionen-Untersuchungen von Immunophilinen , 1992 .

[169]  E. Corey,et al.  Enantioselective Total Synthesis of .beta.-Elemene and Fuscol Based on Enantiocontrolled Ireland-Claisen Rearrangement , 1995 .

[170]  B. W. Erickson,et al.  3 – Solid-Phase Peptide Synthesis , 1976 .

[171]  S. Martin,et al.  General strategies for the synthesis of indole alkaloids. Total synthesis of (.+-.)-reserpine and (.+-.)-.alpha.-yohimbine , 1987 .

[172]  C. Illig,et al.  Stereoselective synthesis of (.+-.)-cyanocycline. , 1986, Journal of the American Chemical Society.

[173]  M. Franck-Neumann,et al.  Synthese cyclopropenique totale d'un triquinane naturel lineaire, le (±)-hirsutene , 1989 .

[174]  L. Overman,et al.  Total Synthesis of (±)-Scopadulcic Acid B , 1997 .

[175]  K. Nicolaou,et al.  Chemie und Biologie der Epothilone , 1998 .

[176]  D. Barton.  Reason and imagination : reflections on research in organic chemistry : selected papers of Derek H.R. Barton , 1996 .

[177]  J. Howbert,et al.  Synthetic studies on areneolefin cycloadditions -VI- two syntheses of (±)-coriolin. , 1983 .

[178]  B. D. Vineyard,et al.  Asymmetric hydrogenation with a complex of rhodium and a chiral bisphosphine , 1975 .

[179]  E. Corey,et al.  Total synthesis of (±)-tricyclohexaprenol, a possible forerunner of sterols in the evolution of biomembranes , 1987 .

[180]  P. Coleman,et al.  Enantioselective Synthesis of Altohyrtin C (Spongistatin 2): Synthesis of the EF‐Bis(pyran) Subunit , 1997 .

[181]  R. Woodward,et al.  Imidazole alkaloids of Macrorungia longistrobus: Revised structures and total syntheses , 1976 .

[182]  E. Abraham,et al.  Cephalosporin C, a New Antibiotic containing Sulphur and D-α-Aminoadipic Acid , 1955, Nature.

[183]  K. Tomer,et al.  Structure of brevetoxin A as constructed from NMR and mass spectral data , 1987 .

[184]  R. Woodward,et al.  Novel synthesis of prostaglandin F2.alpha. , 1973 .

[185]  R. Mah,et al.  Introduction of angular methyl groups via radical cyclization , 1989 .

[186]  E. Corey,et al.  A route for the enantioselective total synthesis of antheridic acid, the antheridium-inducing factor from anemia phyllitidis , 1991 .

[187]  Masakatsu Shibasaki,et al.  Asymmetrische Katalyse mit Hetero‐Dimetall‐Verbindungen , 1997 .

[188]  James D White,et al.  Total synthesis of (+)-aplasmomycin , 1986 .

[189]  N. J. Tom,et al.  Synthesis of (+)-dynemicin A and analogs of wide structural variability: establishment of the absolute configuration of natural dynemicin A. , 1995, Chemistry & biology.

[190]  E. Corey,et al.  A New Magnesium-Catalyzed Doubly Diastereoselective anti-Aldol Reaction Leads to a Highly Efficient Process for the Total Synthesis of Lactacystin in Quantity , 1998 .

[191]  K. Nicolaou,et al.  Total Synthesis of Brevetoxin B. 2. Completion , 1995 .

[192]  K. Nicolaou,et al.  Totalsynthese der CP-Verbindungen CP-263,114 und CP 225,917 – Teil 1: Synthese von Schlüsselintermediaten und neue präparative Erkenntnisse , 1999 .

[193]  K. Zhao,et al.  Total syntheses of (-)-histrionicotoxin and (-)-histrionicotoxin 235A , 1990 .

[194]  T. Kaneko,et al.  CP-225,917 and CP-263,114, novel Ras farnesylation inhibitors from an unidentified fungus. I. Taxonomy, fermentation, isolation, and biochemical properties. , 1997, The Journal of antibiotics.

[195]  I. Kuwajima,et al.  Total synthesis of (±)-cortisone. Double hydroxylation reaction for the construction of corticoid side chain , 1986 .

[196]  G. Gross,et al.  Synthesen auf dem Vitamin‐B12‐Gebiet. 4. Mitteilung Partialsynthese von Vitamin B12 , 1960 .

[197]  S. D. Kimball,et al.  Anthracyclines and related substances. 4. A novel regio- and stereoselective total synthesis of 7-epidaunomycinone and daunomycinone. , 1982 .

[198]  J. Mcmurry,et al.  Stereospecific total synthesis of steroids via isoxazole annelation. dl-D-Homotestosterone and dl-progesterone , 1967 .

[199]  T. Fukuyama,et al.  Total synthesis of (.+-.)-FR-900482 , 1992 .

[200]  A. Robichaud,et al.  Asymmetric Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C , 1994 .

[201]  S. Tanis,et al.  A formal total synthesis of (±)-aphidicolin , 1985 .

[202]  E. Corey,et al.  Total synthesis of dl-cedrene and dl-cedrol , 1969 .

[203]  S. Danishefsky,et al.  Total synthesis of rapamycin via a novel titanium-mediated aldol macrocyclization reaction , 1993 .

[204]  K. Nicolaou,et al.  The Wittig and Related Reactions in Natural Product Synthesis , 1997 .

[205]  R. Lerner,et al.  The First Decade of Antibody Catalysis: Perspective and Prospects , 1996 .

[206]  K. Nicolaou,et al.  Palladium-Catalyzed Functionalization of Lactones via Their Cyclic Ketene Acetal Phosphates. Efficient New Synthetic Technology for the Construction of Medium and Large Cyclic Ethers , 1997 .

[207]  S. Sehgal,et al.  Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.:II. FERMENTATION, ISOLATION AND CHARACTERIZATION , 1975 .

[208]  David R. Williams,et al.  Synthesis strategies for marine diterpenes. Total synthesis of the clavularanes , 1993 .

[209]  K. Nicolaou,et al.  Chemistry and Biology of the Enediyne Anticancer Antibiotics , 1991 .

[210]  M. Lanotte,et al.  The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. , 1991, Experimental cell research.

[211]  Xiao-tao Chen,et al.  The Total Synthesis of Eleutherobin: A Surprise Ending. , 1998, Angewandte Chemie.

[212]  Roald Hoffmann,et al.  Die Erhaltung der Orbitalsymmetrie , 1969 .

[213]  D. J. Berrisford,et al.  Ligand‐Accelerated Catalysis , 1995 .

[214]  E. Corey,et al.  First application of attractive intramolecular interactions to the design of chiral catalysts for highly enantioselective Diels-Alder reactions , 1991 .

[215]  A. Kende,et al.  A simple total synthesis of (plus or minus)-dendrobine. , 1974, Journal of the American Chemical Society.

[216]  E. Corey,et al.  Highly enantioselective borane reduction of ketones catalyzed by chiral oxazaborolidines. Mechanism and synthetic implications , 1987 .

[217]  R. Mook,et al.  Free-radical cyclization of bromo acetals. Use in the construction of bicyclic acetals and lactones , 1983 .

[218]  I. Kuwajima,et al.  Enantioselective Total Synthesis of (−)-Taxol , 1998 .

[219]  Stuart L. Schreiber,et al.  Natural Products as Probes of Cellular Function: Studies of Immunophilins , 1992 .

[220]  Paul D. Johnson,et al.  Coupling of cyclopropapyrroloindole (CPI) derivatives. The preparation of CC-1065, ent-CC-1065, and analogs , 1987 .

[221]  A. Kozikowski,et al.  A practical synthesis of the Chinese "nootropic" agent huperzine A: a possible lead in the treatment of Alzheimer's disease , 1989 .

[222]  N. Ohashi,et al.  Synthesis of (±)-fredericamycin A , 1986 .

[223]  E. Francotte,et al.  Total Synthesis of (±)‐Lysergic Acid by an Intramolecular Imino‐Diels‐Alder Reaction. Preliminary communication , 1981 .

[224]  D. Barton,et al.  Invention of new reactions useful in the chemistry of natural products , 1986 .

[225]  S. Ley,et al.  Total Synthesis of Avermectin B1a: Synthesis of the C11-C25 Spiroacetal Fragment , 1990 .

[226]  E. Corey,et al.  A new enantiospecific route to the pseudopterosins , 1990 .

[227]  Toshihiro Nishimura,et al.  Asymmetric Total Synthesis of Taxol\R , 1999 .

[228]  R. Ryhage,et al.  Prostaglandins and Related Factors 15. THE STRUCTURES OF PROSTAGLANDIN E1, F1α, AND F1β , 1963 .

[229]  A. Eschenmoser,et al.  Synthese des Colchicins , 1959 .

[230]  R. Keenan,et al.  Studies on tumor promoters: the first synthesis of the phorbol skeleton , 1987 .

[231]  R. Willstätter.  Synthese des Tropidins , 2022 .

[232]  R. Lerner,et al.  Antibody catalysis of difficult chemical transformations , 1993 .

[233]  M. Uskoković,et al.  Total synthesis of quinine and quinidine. I. , 1970, Journal of the American Chemical Society.

[234]  B. Trost,et al.  A total synthesis of aphidicolin , 1979 .

[235]  K. Sharpless,et al.  Vicinal diol cyclic sulfates. Like epoxides only more reactive , 1988 .

[236]  S. Schreiber,et al.  Tandem Use of Cobalt-Mediated Reactions to Synthesize (+)-Epoxydictymene, a Diterpene Containing a Trans-Fused 5−5 Ring System , 1997 .

[237]  Y. Kishi,et al.  Total synthesis of rifamycins. 2. Total synthesis of racemic rifamycin S , 1980 .

[238]  Joseph P. Adams,et al.  Synthesis of (−)-Histrionicotoxin by a Tandem Process , 1999 .

[239]  K. Nicolaou,et al.  Zaragozic Acid A/Squalestatin S1: Synthetic and Retrosynthetic Studies , 1994 .

[240]  S. Danishefsky,et al.  Eine konvergente Totalsynthese von Calicheamicin γI1 , 1994 .

[241]  E. Corey,et al.  Constitution of Antheridium-Inducing Factor of Anemia Phyllitidis , 1986 .

[242]  A. W. Burgstahler,et al.  The Stereochemistry of Polyene Cyclization , 1955 .

[243]  P. A. Wallace,et al.  TOTAL SYNTHESIS OF BREVETOXIN A : PART 2 : SECOND GENERATION STRATEGY AND CONSTRUCTION OF EFGH MODEL SYSTEM , 1999 .

[244]  R. Mook,et al.  Vinyl radical cyclization. 2. Dicyclization via selective formation of unsaturated vinyl radicals by intramolecular addition to triple bonds. Applications to the synthesis of butenolides and furans , 1983 .

[245]  Mark A. Johnson,et al.  Stereospecific total synthesis of aphidicolin , 1979 .

[246]  W. Oppolzer,et al.  Synthesis of (±)-hirsutene by a catalytic allylpalladium-alkyne cyclization/carbonylation cascade , 1994 .

[247]  R. Kennedy,et al.  Enantioselective total synthesis of aphidicolin , 1987 .

[248]  K. Nicolaou,et al.  Totalsynthese der CP‐Verbindungen CP‐263,114 und CP 225,917 – Teil 2: Entwicklung der Schlußstrategie , 1999 .

[249]  T. Nakata,et al.  Synthetic studies on (+)-aplasmomycin. 2. Stereoselective synthesis of Corey's key intermediate, a formal total synthesis , 1986 .

[250]  R. Newton,et al.  Steric control in prostaglandin synthesis involving bicyclic and tricyclic intermediates , 1980 .

[251]  P. Wender,et al.  General methodology for cis-hydroisoquinoline synthesis. III: A sixteen step synthesis of reserpine , 1987 .

[252]  R. K. Boeckman,et al.  An enantioselective and highly convergent synthesis of (+)-ikarugamycin , 1989 .

[253]  S. Ley,et al.  Synthesis of the β-lactam antibiotic (+)- thienamycin via an intermediate π-allyltricarbonyliron lactone complex , 1985 .

[254]  J. L. Wood,et al.  Total Syntheses of (+)- and (-)-Syringolides , 1995 .

[255]  O. B. Wallace,et al.  The Total Synthesis of (.+-.)-Scopadulcic Acids A and B and (.+-.)-Scopadulciol , 1995 .

[256]  H. Matsumoto,et al.  A stereoselective total synthesis of estrone by an intramolecular cycloaddition reaction of olefinic o-quinodimethane. , 1977, Journal of the American Chemical Society.

[257]  Won Hyung Yoon,et al.  A Novel Route to the Fused Maleic Anhydride Moiety of CP Molecules. , 1999, Angewandte Chemie.

[258]  D. Boger,et al.  Singlet oxygen oxidation of bipyrroles: total synthesis of d,l- and meso-isochrysohermidin , 1993 .

[259]  M. Isobe,et al.  Synthesis of a marine polyether toxin, okadaic acid [4]p1 -- total synthesis , 1987 .

[260]  S. Caron,et al.  Total Synthesis of Zaragozic Acid A (Squalestatin S1). Degradation to a Relay Compound and Reassembly of the Natural Product , 1996 .

[261]  S. Nguyen,et al.  Syntheses and activities of new single-component, ruthenium-based olefin metathesis catalysts , 1993 .

[262]  T. Fukuyama,et al.  Synthetic studies on tetrodotoxin and related compounds. IV. Stereospecific total syntheses of DL-tetrodotoxin. , 1972, Journal of the American Chemical Society.

[263]  C. Khosla.  Harnessing the Biosynthetic Potential of Modular Polyketide Synthases. , 1997, Chemical reviews.

[264]  D. Johnston,et al.  Total synthesis of (.+-.)-thienamycin , 1978 .

[265]  H. Fischer,et al.  Synthese des Hämatoporphyrins, Protoporphyrins und Hämins , 1929 .

[266]  B. Pressman,et al.  Biological applications of ionophores. , 1976, Annual review of biochemistry.

[267]  Demosthenes Fokas,et al.  Convergent Synthesis of (+/-)-Dihydroisocodeine in 11 Steps by the Tandem Radical Cyclization Strategy - a Formal Total Synthesis of (+/-)-Morphine , 1992 .

[268]  E. Magnier,et al.  Manzamine alkaloids, syntheses and synthetic approaches , 1998 .

[269]  E. Corey,et al.  Synthesis of racemic .alpha.-trans- and .beta.-trans-bergamotene , 1971 .

[270]  J. L. Gleason,et al.  A Total Synthesis of FK-506(1). , 1996, The Journal of organic chemistry.

[271]  David A. Evans,et al.  Enantioselektive Synthese von Altohyrtin C (Spongistatin 2): Synthese der AB- und CD-Spiroketale†‡ , 1997 .

[272]  T. Yasumoto,et al.  Isolation and structural elucidation of the causative toxin of the diarrhetic shellfish poisoning. , 1982 .

[273]  S. Schreiber,et al.  Cobalt-Mediated Total Synthesis of (+)-Epoxydictymene , 1994 .

[274]  B. E. Rossiter.  7 – Synthetic Aspects and Applications of Asymmetric Epoxidation , 1985 .

[275]  T. Saegusa,et al.  New stereoselective synthesis of steroids , 1981 .

[276]  I. Paterson,et al.  Tetrahedron report number 190 , 1985 .

[277]  George M. Whitesides,et al.  Enzymes in Synthetic Organic Chemistry , 1994 .

[278]  E. Corey,et al.  Letter: Preparation of an optically active prostaglandin intermediate via asymmetric induction. , 1975, Journal of the American Chemical Society.

[279]  S. Schreiber,et al.  Chemistry and biology of the immunophilins and their immunosuppressive ligands. , 1991, Science.

[280]  J. Gage,et al.  Asymmetric Synthesis of Calyculin A. 3. Assemblage of the Calyculin Skeleton and the Introduction of a New Phosphate Monoester Synthesis , 1992 .

[281]  Jonathan P. Wright,et al.  A triply convergent enantioselective total synthesis of (+)-ikarugamycin , 1989 .

[282]  B. Ganem,et al.  .alpha.-Silylated vinyl ketones. New class of reagents for the annelation of ketones , 1973 .

[283]  G. Stork,et al.  Vinyl radical cyclization in the synthesis of natural products: seychellene , 1985 .

[284]  L. Overman,et al.  ASYMMETRIC TOTAL SYNTHESES OF (-)- AND (+)-STRYCHNINE AND THE WIELAND-GUMLICH ALDEHYDE , 1995 .

[285]  E. Corey,et al.  Total synthesis of (.+-.)-retigeranic acid , 1985 .

[286]  N. Langlois,et al.  Application of a modification of the Polonovski reaction to the synthesis of vinblastine-type alkaloids. , 1976, Journal of the American Chemical Society.

[287]  R. L. Funk,et al.  Synthesis of bridged bicycloalkanes via the alicyclic Claisen rearrangement. A new approach to quadrone , 1986 .

[288]  K. Nicolaou,et al.  DIE TOTALSYNTHESE VON EPOTHILON A : DER ZUGANG DURCH OLEFINMETATHESE , 1997 .

[289]  J. Banfield,et al.  Constituents of Endiandra species. IV. Isolation of 2-(8'-[(E,E)-5'-phenylpenta-2',4''-dien-1''-yl]bicyclo[4,2,0]octa-2',4'-dien-7'-yl)acetic acid, a biogenetically predicted metabolite of Endiandra introrsa (Lauraceae) and its structure determination by means of 1D and 2D N.M.R. spectroscopy , 1982 .

[290]  G. Stork.  Progress in the synthesis of polycyclic natural products: The total synthesis of lycopodine , 1968 .

[291]  A. Barrett,et al.  Total Synthesis of the Pentacyclopropane Antifungal Agent FR-900848 , 1996 .

[292]  T. A. Spencer,et al.  The synthesis of colchicine , 1961 .

[293]  R. Lerner,et al.  From molecular diversity to catalysis: lessons from the immune system. , 1995, Science.

[294]  B. Kim,et al.  Cyclic sulfates containing acid-sensitive groups and chemoselective hydrolysis of sulfate esters , 1989 .

[295]  M. Hirama,et al.  A chiral total synthesis of compactin , 1982 .

[296]  Ashutosh Kumar Singh,et al.  Stereospecific total synthesis of (.+-.)-cafestol , 1987 .

[297]  A. Maureen Rouhi,et al.  VANILLOIDS: HOT RELIEF FOR PAIN , 1998 .

[298]  W. Oppolzer.  Camphor as a natural source of chirality in asymmetric synthesis , 1990 .

[299]  D. Spring,et al.  Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis. , 1998, Angewandte Chemie.

[300]  B. M. Trost.  Atomökonomische Synthesen – eine Herausforderung in der Organischen Chemie: die Homogenkatalyse als wegweisende Methode , 1995 .

[301]  P. Grieco,et al.  Complete transfer of chirality in the [3,3]-sigmatropic rearrangement of allylic acetates catalyzed by palladium(II). Application to stereocontrolled syntheses of prostaglandins possessing either the C-15(S) or C-15(R) configuration , 1980 .

[302]  T. Ho,et al.  The Total Synthesis of Daunomycinone , 1973 .

[303]  C. NicolaouK,et al.  エンジアンドル酸の流れ(cascade) 有機合成における電子環化反応 II エンジアンドル酸C―Gの段階的,立体制御全合成 , 1982 .

[304]  K. Nicolaou,et al.  Total Synthesis of Eleutherobin and Eleuthosides A and B , 1998 .

[305]  W. Christ,et al.  Total Synthesis of Palytoxin Carboxylic Acid and Palytoxin Amide , 1989 .

[306]  R. Mooney,et al.  The Insecticidal Principles of Haplophyton cimicidum. III. The Nature of the Acidic Function of Haplophytine1 , 1958 .

[307]  M. Toyota,et al.  Enantioselective total synthetic route to (+)-aphidicolin , 1995 .

[308]  Daniel Solé,et al.  Totalsynthese von (−)‐Strychnin über den Wieland‐Gumlich‐Aldehyd , 1999 .

[309]  H. Nemoto,et al.  A highly stereoselective total synthesis of (±)-estrone and (±)-adrenosterone , 1988 .

[310]  D. Barton.  The use of photochemical reactions in organic synthesis , 1968 .

[311]  R. Borzilleri,et al.  Total Synthesis of the Unusual Marine Alkaloid (-)-Papuamine Utilizing a Novel Imino Ene Reaction , 1995 .

[312]  E. Corey,et al.  Total synthesis of (.+-.)-antheridium-inducing factor (AAn) of the Fern Anemia phyllitidis. Clarification of stereochemistry , 1985 .

[313]  W. Knowles.  Application of organometallic catalysis to the commercial production of L-DOPA , 1986 .

[314]  E. J. Sorensen,et al.  A Concise Synthesis of Fumagillol. , 1999, Angewandte Chemie.

[315]  R. L. Funk,et al.  Intramolecular cycloaddition reactions of exocyclic nitrones: Application in the total synthesis of terpenes , 1985 .

[316]  A. Guerriero,et al.  Isolation from the Mediterranean Stolonifern Coral Sarcodictyon roseum of Sarcodictyin C, D, E, and F, novel diterpenodic alcohols esterified by (E)‐ or (Z)‐N(1)‐methylurocanic acid. Failure of the carbon‐skeleton type as a classification criterion , 1988 .

[317]  K. McNamara,et al.  Use of dilithiomethane equivalent in a novel one-flask [2 + 1 + 2] cyclopentannulation reaction: a highly efficient total synthesis of (.+-.)-hirsutene. , 1992 .

[318]  P. Gauvreau,et al.  Synthesis of (.+-.)-Fredericamycin A , 1994 .

[319]  A. P. Doerschuk,et al.  REVERSIBLE ISOMERIZATIONS IN THE TETRACYCLINE FAMILY , 1955 .

[320]  D. Barton,et al.  New and selective reactions and reagents in carbohydrate chemistry , 1981 .

[321]  R. Woodward,et al.  THE SYNTHESIS OF PATULIN , 1950 .

[322]  E. Corey,et al.  Total synthesis of (.+-.)-paeoniflorigenin and paeoniflorin , 1993 .

[323]  B. Trost,et al.  Synthesis of dl-coriolin , 1981 .

[324]  W. Roush,et al.  Enantioselective Total Synthesis of (−)-Chlorothricolide via the Tandem Inter- and Intramolecular Diels−Alder Reaction of a Hexaenoate Intermediate , 1998 .

[325]  A. Bélanger,et al.  The total synthesis of (+)-ryanodol. Part IV. Preparation of (+)-ryanodol from (+)-anhydroryanodol , 1990 .

[326]  E. Corey,et al.  Exceptionally Simple Enantioselective Syntheses of Chiral Hexa- and Tetracyclic Polyprenoids of Sedimentary Origin. , 1998, Angewandte Chemie.

[327]  R. Woodward,et al.  THE CYCLIZATION OF SQUALENE IN CHOLESTEROL SYNTHESIS , 1953 .

[328]  H. Waldmann,et al.  Organic Synthesis Highlights , 1990 .

[329]  R. Mook,et al.  Vinyl radical cyclizations mediated by the addition of stannyl radicals to triple bonds , 1987 .

[330]  S. Ghosh,et al.  Cyclopentanoid allylsilanes in synthesis : A stereoselective synthesis of (+)-hirsutene , 1990 .

[331]  E. Corey,et al.  Simple, stereospecific syntheses of C17- and C18- Cecropia juvenile hormones (racemic) from a common intermediate , 1970 .

[332]  W. Perkin.  LXVI.—Experiments on the synthesis of the terpenes. Part I. Synthesis of terpin, inactive terpineol, and dipentene , 1904 .

[333]  T. R. Kelly,et al.  Efficient, regiospecific synthesis of (.+-.)-daunomycinone , 1980 .

[334]  R. Sakai,et al.  Additional antitumor ecteinascidins from a Caribbean tunicate: crystal structures and activities in vivo. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[335]  P. Bartlett,et al.  A stereospecific total synthesis of estrone via a cationic olefinic cyclization. , 1973, Journal of the American Chemical Society.

[336]  K. Tomooka,et al.  The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor , 1997 .

[337]  S. Meyer,et al.  Total Synthesis of (-)-Rapamycin Using an Evans-Tishchenko Fragment Coupling , 1993 .

[338]  K. Isono,et al.  Structure of cytovaricin–acetonitrile (1:1), C47H80O16.C2H3N , 1983 .

[339]  T. Kaneko,et al.  CP-225,917 and CP-263,114: Novel Ras Farnesylation Inhibitors from an Unidentified Fungus. 2. Structure Elucidation , 1997 .

[340]  Davidr . Evans,et al.  Total synthesis of (+)-A83543A [(+)-lepicidin A] , 1993 .

[341]  T. Fukuyama,et al.  SYNTHETIC STUDIES ON POLYETHER ANTIBIOTICS. 6. TOTAL SYNTHESIS OF MONENSIN. 3. STEREOCONTROLLED TOTAL SYNTHESIS OF MONENSIN , 2002 .

[342]  Nicolaou,et al.  Total Synthesis of Everninomicin 13,384-1-Part 2: Synthesis of the FGHA(2) Fragment. , 1999, Angewandte Chemie.

[343]  Emil Fischer,et al.  Synthese des Traubenzuckers , 1890 .

[344]  E. Corey,et al.  Chirally directed synthesis of (-)-methyl 5(S), 6(S)-oxido-7-hydroxyheptanoate, a key intermediate for the total synthesis of leukotrienes A, C, D and E , 1981 .

[345]  D. Boger,et al.  Total Synthesis of Bleomycin A2 and Related Agents. 2. Synthesis of (-)-Pyrimidoblamic Acid, epi-(+)-Pyrimidoblamic Acid, (+)-Desacetamidopyrimidoblamic Acid, and (-)-Descarboxamidopyrimidoblamic Acid , 1994 .

[346]  Robert H. Grubbs,et al.  Ring-Closing Metathesis and Related Processes in Organic Synthesis , 1995 .

[347]  D. Curran,et al.  A samarium(II) iodide promoted tandem radical cyclization. The total synthesis of (.+-.)-hypnophilin and the formal synthesis of (.+-.)-coriolin , 1988 .

[348]  A. Balog,et al.  Totalsynthese von ( ‐ )‐Epothilon B: eine Erweiterung der Suzuki‐Kupplung und Erkenntnisse über Struktur‐Wirkungs‐Beziehungen der Epothilone , 1997 .

[349]  S. Rychnovsky,et al.  Concise total synthesis of (+)-(9S)-dihydroerythronolide A , 1987 .

[350]  E. Corey,et al.  Synthesis of brefeldin A, carpaine, vertaline, and erythronolide B from nonmacrocyclic precursors , 1975 .

[351]  M. Siegel,et al.  Calichemicins, a novel family of antitumor antibiotics. 1. Chemistry and partial structure of calichemicin .gamma.1I , 1987 .

[352]  E. Corey,et al.  A stereoselective and practical synthesis of 5,6(S,S)-epoxy-15(S)-hydroxy-7(E),9(E),11(Z),13(E)-eicosatetraenoic acid (4), possible precursor of the lipoxins , 1986 .

[353]  K. Nicolaou,et al.  Total synthesis of brevetoxin A , 1998, Nature.

[354]  E. Corey,et al.  Total synthesis of (+-)-porantherine , 1974 .

[355]  T. Fukuyama,et al.  Practical total synthesis of (.+-.)-mitomycin C , 1989 .

[356]  A. Greene,et al.  Asymmetric approach to Pauson-Khand bicyclization. Enantioselective formal synthesis of hirsutene , 1990 .

[357]  G. Stork,et al.  CHIRAL SYNTHESIS OF PROSTAGLANDINS FROM CARBOHYDRATES. SYNTHESIS OF (+)-15-(S)-PROSTAGLANDIN A2 , 1976 .

[358]  K. Nakatani,et al.  Synthetic studies on duocarmycin. 1. Total synthesis of dl-duocarmycin A and its 2-epimer , 1994 .

[359]  J. Ziller,et al.  Synthesis and Applications of RuCl2(CHR‘)(PR3)2: The Influence of the Alkylidene Moiety on Metathesis Activity , 1996 .

[360]  Yoshito Kishi,et al.  Synthesis of Palytoxin from Palytoxin Carboxylic Acid , 1994 .

[361]  M. Majewski,et al.  Total synthesis of both (+)-compactin and (+)-mevinolin. A general strategy based on the use of a special TiCl3/C8K mixture for dicarbonyl coupling , 1988 .

[362]  R. Woodward.  Recent advances in the chemistry of natural products , 1968, Pure and applied chemistry. Chimie pure et appliquee.

[363]  H. Kolbe.  Beiträge zur Kenntniss der gepaarten Verbindungen , 1845 .

[364]  K. Nicolaou,et al.  Totalsynthese des Vancomycin‐Aglycons – Teil 1: Synthese der Aminosäuren 4–7 und Aufbau des AB‐COD‐Ringgerüsts , 1998 .

[365]  C. Heathcock,et al.  Total Synthesis of Petrosin , 1994 .

[366]  R. Noyori,et al.  Asymmetric catalysis in organic synthesis , 1994 .

[367]  K. Nicolaou,et al.  Total synthesis of calicheamicin .gamma.1I , 1992 .

[368]  A. Balog,et al.  Totalsynthese von (—)‐Epothilon A , 1996 .

[369]  David A. Evans,et al.  Chiral enolate design , 1981 .

[370]  E. J. Corey,et al.  Außergewöhnlich einfache enantioselektive Synthesen von chiralen hexa‐ und tetracyclischen Polyprenoiden sedimentären Ursprungs , 1998 .

[371]  H. Nemoto,et al.  First enantioselective total synthesis of (+)-cortisone , 1990 .

[372]  K. Nicolaou,et al.  Synthesis of Zaragozic Acid A/Squalestatin S1 , 1995 .

[373]  Ashutosh Kumar Singh,et al.  Total synthesis of (.+-.)-atractyligenin , 1987 .

[374]  C. Forsyth,et al.  An Efficient Total Synthesis of Okadaic Acid , 1997 .

[375]  K. Nicolaou,et al.  Totalsynthese von Everninomicin 13,384‐1 – Teil 3: Synthese des DE‐Fragments und Abschluß der Totalsynthese , 1999 .

[376]  J. Gage,et al.  Total synthesis of (+)-calyculin A , 1992 .

[377]  J. Clardy,et al.  Isolation and structure of brevetoxin B from the "red tide" dinoflagellate Ptychodiscus brevis (Gymnodinium breve) , 1981 .

[378]  G. Kraus,et al.  The total synthesis of lycopodine using bridgehead intermediates , 1987 .

[379]  G. Stork,et al.  Epoxynitrile cyclization. General method of ring formation , 1974 .

[380]  S. Takano,et al.  A concise stereocontrolled total synthesis of (+)-estrone , 1992 .

[381]  W. Oppolzer,et al.  Enantioselective synthesis of (+)-3-isorauniticine via a catalytic tandem palladium-ene/carbonylation reaction , 1991 .

[382]  H. Reichenbach,et al.  Epothilon A und B – neuartige, 16gliedrige Makrolide mit cytotoxischer Wirkung: Isolierung, Struktur im Kristall und Konformation in Lösung† , 1996 .

[383]  A. H. Cook.  The chemistry of the penicillins , 1948 .

[384]  Y. Umezawa,et al.  Total synthesis of bleomycin A21) , 1982 .

[385]  Frank Koehn,et al.  Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata , 1990 .

[386]  C. Huynh,et al.  A New Synthesis of Desacetamidocolchiceine*,1 , 1965 .

[387]  R. Bonnett.  The Chemistry of the Vitamin B12 Group. , 1963 .

[388]  E. Corey,et al.  A new synthetic route to (+/-)-perhydrohistrionicotoxin. , 1977, Helvetica chimica acta.

[389]  J. Baldwin,et al.  On the Biosynthesis of Manzamines , 1992 .

[390]  Y. Kita,et al.  Asymmetric Total Synthesis of Fredericamycin A. , 1999, Angewandte Chemie.

[391]  G. Stork,et al.  A construction of the angularly hydroxylated cis 1,8-naphthalenedione system typical of the tetracyclines , 1984 .

[392]  P. Jacobi.  Total Synthesis of (±)-Saxitoxin , 1984, Synfacts.

[393]  Y. Qiu.  The total synthesis of (-)-discodermolide , 1995 .

[394]  Y. Kishi,et al.  A total synthesis of d,1-histrionicotoxin , 1985 .

[395]  E. Corey,et al.  A stable and easily prepared catalyst for the enantioselective reduction of ketones. Applications to multistep syntheses , 1987 .

[396]  S. Danishefsky,et al.  Total Synthesis of (.+-.)-FR-900482 , 1995 .

[397]  W. S. Johnson.  Biomimetische Cyclisierungen von Polyenen , 1976 .

[398]  R. B. Clayton.  Biosynthesis of sterols, steroids, and terpenoids. Part I. Biogenesis of cholesterol and the fundamental steps in terpenoid biosynthesis , 1965 .

[399]  W. Oppolzer.  Intramolecular Cycloaddition Reactions of ortho-Quinodimethanes in Organic Synthesis , 1978 .

[400]  G. Jung,et al.  Organische Chemie an fester Phase , 1996 .

[401]  W. Oppolzer.  Intermolecular Diels–Alder Reactions , 1991 .

[402]  H. Miyabe,et al.  Total Synthesis of (-)-Balanol , 1994 .

[403]  D. Boger,et al.  Total Synthesis of Bleomycin A2 and Related Agents. 1. Synthesis and DNA Binding Properties of the Extended C-Terminus: Tripeptide S, Tetrapeptide S, Pentapeptide S, and Related Agents , 1994 .

[404]  A. Bélanger,et al.  The total synthesis of (+)-ryanodol. Part I. General strategy and search for a convenient diene for the construction of a key tricyclic intermediate , 1990 .

[405]  M. Isobe,et al.  Synthetic studies toward marine toxic polyethers (2) synthesis of the B-segment of okadaic acid and coupling with the C-segment , 1984 .

[406]  Won Hyung Yoon,et al.  Novel strategies to construct the gamma-hydroxy lactone moiety of the CP molecules. Synthesis of the CP-225,917 core skeleton. , 1999, Organic letters.

[407]  R. Sachleben,et al.  Total synthesis of (.+-.)-saframycin A , 1990 .

[408]  W. Roush.  Total synthesis of (.+-.)-dendrobine , 1978 .

[409]  K. Nicolaou,et al.  New synthetic technology for the stereocontrolled construction of 1,1'-disaccharides and 1,1':1'',2-trisaccharides. Synthesis of the FG ring system of everninomicin 13,384-1 , 1997 .

[410]  I. Paterson,et al.  Total Synthesis of (-)-Ebelactone A and B , 1995 .

[411]  K. Nicolaou.  The Total Synthesis of Brevetoxin B: A Twelve‐Year Odyssey in Organic Synthesis , 1996 .

[412]  R. Woodward,et al.  The penems, a new class of .beta.-lactam antibiotics: 6-acylaminopenem-3-carboxylic acids , 1978 .

[413]  David A. Evans,et al.  Enantioselektive Synthese von Altohyrtin C (Spongistatin 2): Verknüpfung der Fragmente und Korrektur der Strukturzuordnung†‡ , 1997 .

[414]  K. Shimizu,et al.  High‐Throughput Strategies for the Discovery of Catalysts , 1998 .

[415]  R. Wiechert,et al.  Neuartige asymmetrische Cyclisierung zu optisch aktiven Steroid‐CD‐Teilstücken , 1971 .

[416]  Robert G. Bergman,et al.  p-Benzyne. Generation as an intermediate in a thermal isomerization reaction and trapping evidence for the 1,4-benzenediyl structure , 1972 .

[417]  S. Masamune,et al.  Macrolides. Recent progress in chemistry and biochemistry. , 1977, Angewandte Chemie.

[418]  E. Corey,et al.  Letter: A total synthesis of natural 20(S)-camptothecin. , 1975, The Journal of organic chemistry.

[419]  G. Schulte,et al.  The total synthesis of indolizomycin , 1993 .

[420]  K. Nicolaou,et al.  Total Synthesis of Brevetoxin-B .2. 2nd Generation Strategies and Construction of the Dioxepane Region [Defg] , 1995 .

[421]  M. Jung,et al.  Vinylsilanes as carbonyl precursors. Use in annelation reactions , 1974 .

[422]  K. Nicolaou,et al.  Durch Olefinmetathese zum Epothilongerüst , 1996 .

[423]  E. Corey,et al.  Stereospecific total synthesis of the dl-C18 Cecropia juvenile hormone , 1968 .

[424]  P. A. Wallace,et al.  Total Synthesis of Brevetoxin A: Part 3: Construction of GHIJ and BCDE Ring Systems , 1999 .

[425]  P. Magnus,et al.  Stereoselectivity of intramolecular dicobalt octacarbonyl alkene-alkyne cyclizations: short synthesis of dl-coriolin , 1983 .

[426]  K. Akimoto,et al.  The total synthesis of (+/-)-coriolin. , 1980, The Journal of antibiotics.

[427]  M. Toyota,et al.  Pd2+-Promoted cyclization in linear triquinane synthesis total synthesis of (±)-hirsutene , 1993 .

[428]  E. Corey,et al.  Total synthesis of maytansine , 1980 .

[429]  K. Nicolaou,et al.  Total synthesis of amphotericin B. 3. The final stages , 1988 .

[430]  P. Magnus,et al.  Total synthesis of (+)-koumine, (+)-taberpsychine, and (+)-koumidine , 1989 .

[431]  R. Hirschmann.  Medicinal Chemistry in the Golden Age of Biology: Lessons from Steroid and Peptide Research , 1991 .

[432]  A. Meyers.  Chiral oxazolines ‐ their legacy as key players in the renaissance of asymmetric synthesis , 1998 .

[433]  M. Shiozaki,et al.  Stereo-controlled synthesis of intermediates of (±)-thienamycin , 1980 .

[434]  M. Kurosu,et al.  Total Synthesis of (±)-Batrachotoxinin A , 1998 .

[435]  K. Nicolaou,et al.  TOTAL SYNTHESIS OF ZARAGOZIC ACID A/SQUALESTATIN S1 , 1994 .

[436]  J. Westley.  Polyether antibiotics: versatile carboxylic acid ionophores produced by Streptomyces. , 1977, Advances in applied microbiology.

[437]  E. Corey,et al.  Enantioselective route to a key intermediate in the total synthesis of forskolin , 1988 .

[438]  M. Natchus,et al.  The Pinene Path to Taxanes. 6. A Concise Stereocontrolled Synthesis of Taxol , 1997 .

[439]  E. Corey,et al.  The total synthesis of helminthosporal. , 1965, Journal of the American Chemical Society.

[440]  J. Carretero,et al.  A practical route towards α,β-unsaturated δ-lactones based on a [3+3] strategy. Synthesis of (−)-argentilactone , 1988 .

[441]  Tetsuaki Tanaka,et al.  Synthetic studies on aphidicolane and stemodane diterpenes. V. A facile formal total synthesis of (±)-aphidicolin via a Lewis acid-mediated stereoselective spiroannelation , 1995 .

[442]  R. Woodward,et al.  The penems, a new class of .beta.-lactam antibiotics. 2. Total synthesis of racemic 6-unsubstituted representatives , 1979 .

[443]  A. C. Day,et al.  Total synthesis of colchicine modelled on a biogenetic theory. , 1965, Tetrahedron.

[444]  P. Wipf,et al.  Total Synthesis of the Spiroketal Naphthoquinone (±)-Diepoxin σ , 1999 .

[445]  E. Corey,et al.  Total synthesis of picrotoxinin , 1979 .

[446]  K. Trueblood,et al.  Structure of Vitamin B12 , 1956, Nature.

[447]  David R. Spring,et al.  Untersuchungen zur Hypothese der Manzaminalkaloid‐Biosynthese , 1998 .

[448]  Ronald J. Biediger,et al.  First total synthesis of taxol. 2. Completion of the C and D rings , 1994 .

[449]  E. Corey,et al.  An Efficient and Concise Enantioselective Total Synthesis of Lactacystin. , 1998, Angewandte Chemie.

[450]  C. Sehon,et al.  Total Synthesis of the Enantiomer of the Furanocembrane Rubifolide. , 1997, The Journal of organic chemistry.

[451]  Barry M. Trost,et al.  Atom Economy—A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way , 1995 .

[452]  D. Zacharias.  The crystal structure and absolute configuration of the dihydrobromide of (+)‐haplophytine , 1970 .

[453]  K. Nicolaou,et al.  Total Synthesis of Eleutherobin , 1997 .

[454]  G. Stork,et al.  Alkylation and Michael additions of glycine ethyl ester. Use in alpha-amino acid synthesis and as acyl carbanion equivalent. , 1976, The Journal of organic chemistry.

[455]  G. Mehta,et al.  A general approach to linearly fused triquinane natural products: total syntheses of (±)-hirsutene, (±)-coriolin, and (±)-capnellene , 1986 .

[456]  D. Sternbach,et al.  Synthesis of polyquinanes. 3. The total synthesis of (.+-.)-hirsutene: the intramolecular Diels-Alder approach , 1990 .

[457]  A. Limberg,et al.  Total Synthesis of (−)‐Epothilone A , 1997 .

[458]  K. Nicolaou,et al.  Total Synthesis of Taxol. 4. The Final Stages and Completion of the Synthesis , 1995 .

[459]  L. Paquette,et al.  Rapid Three-Component Assembly of (±)-Hirsutene , 1990 .

[460]  P. Beaulieu,et al.  Progress in natural product chemistry by the chiron and related approaches - synthesis of avermectin B1a , 1987 .

[461]  J. Clardy,et al.  Structure of brevetoxin A (GB-1 toxin), the most potent toxin in the Florida red tide organism Gymnodinium breve (Ptychodiscus brevis). , 1986, Journal of the American Chemical Society.

[462]  D. Boger,et al.  Diastereoselective Total Synthesis of the Vancomycin Aglycon with Ordered Atropisomer Equilibrations , 1999 .

[463]  W. Roush,et al.  Total Synthesis of Olivomycin A , 1999 .

[464]  W. C. Still,et al.  Synthesis of the polyether antibiotic monensin. 3. Coupling of precursors and transformation to monensin , 1980 .

[465]  E. Corey,et al.  Total Synthesis of α-Caryophyllene Alcohol , 1964 .

[466]  G. Breault,et al.  The temporary silicon connection in the control of the regiochemistry of 4 + 2 cycloadditions , 1992 .

[467]  D. Boger,et al.  Bleomycin: Synthetic and Mechanistic Studies. , 1999, Angewandte Chemie.

[468]  R. Woodward,et al.  The Total Synthesis of Cephalosporin C1 , 1966 .

[469]  Roald Hoffmann,et al.  Conservation of orbital symmetry , 1968 .

[470]  M. Bunnage,et al.  Total Synthesis of Balanol , 1994 .

[471]  P. Schultz,et al.  Combinatorial approaches to materials science , 1998 .

[472]  T. Livinghouse,et al.  Acylnitrilium ion-initiated heteroannulations in alkaloid synthesis. An efficient, stereocontrolled, total synthesis of the Orchidaceae alkaloid (.+-.)-dendrobine , 1992 .

[473]  O. Wintersteiner,et al.  ON THE STEREOCHEMISTRY OF RESERPINE , 1955 .

[474]  J. Hook,et al.  Total synthesis of gibberellic acid. The hydrofluorene route , 1980 .

[475]  Yusheng Wu,et al.  TOTAL SYNTHESIS OF (+)-NEOCARZINOSTATIN CHROMOPHORE , 1998 .

[476]  H. Snyder,et al.  Plant Insecticides. II.1 The Alkaloids of Haplophyton Cimicidum , 1952 .

[477]  M. Rowley,et al.  Total synthesis of (+)-ophiobolin C , 1989 .

[478]  G. Schmid,et al.  Synthetic studies on polyether antibiotics. 5. Total synthesis of monensin. 2. Stereocontrolled synthesis of the right half of monensin , 1979 .

[479]  S. Thaisrivongs,et al.  Efficient, stereoselective total synthesis of (.+-.)-aphidicolin , 1981 .

[480]  S. Hitchcock,et al.  A Convergent Total Synthesis of Calicheamicin γ , 1994 .

[481]  J. Bijvoet,et al.  The Fourier synthesis of the crystal structure of strychnine sulphate pentahydrate , 1951 .

[482]  K. Nicolaou,et al.  Synthesen und biologische Eigenschaften von Prostaglandinendoperoxiden, Thromboxanen und Prostacyclinen , 1978 .

[483]  E. Gibbons.  Total synthesis of (.+-.)-pleuromutilin , 1982 .

[484]  R. Dolle,et al.  Comprehensive survey of combinatorial library synthesis: 1998. , 1999, Journal of combinatorial chemistry.

[485]  W. Greenlee,et al.  Marasmic acid—I : Total synthesis of (±)-isomarasmic acid , 1980 .

[486]  K. Nicolaou,et al.  Additions and Corrections - Total Synthesis of Elfamycins: Aurodox and Efrotomycin. 1. Strategy and Construction of Key Intermediates , 1985 .

[487]  O. Jeger,et al.  Zur Kenntnis der Triterpene. 190. Mitteilung. Eine stereochemische Interpretation der biogenetischen Isoprenregel bei den Triterpenen , 1955 .

[488]  R T Major,et al.  The Ginkgo, the Most Ancient Living Tree , 1967, Science.

[489]  R. Woodward,et al.  The total synthesis of vitamin B12 , 1973, Pure and applied chemistry. Chimie pure et appliquee.

[490]  H. Nemoto,et al.  A formal regio- and stereoselective total synthesis of estrone. A convenient synthesis of D-homoestrone , 1976 .

[491]  K. Fujimoto,et al.  Total synthesis of natural (-)-echinosporin. Determination of the absolute configuration , 1989 .

[492]  R. Kania,et al.  First Enantioselective Total Synthesis of a Naturally Occurring Dolabellane. Revision of Absolute Configuration , 1996 .

[493]  C. Graebe,et al.  Ueber Fabrikation von künstlichem Alizarin , 1870 .

[494]  P. Bartlett.  5 – Olefin Cyclization Processes That Form Carbon–Carbon Bonds , 1984 .

[495]  K. Nicolaou,et al.  Saragossasäure A/Squalestatin S1: synthetische und retrosynthetische Untersuchungen , 1994 .

[496]  G. Wittig,et al.  Zur Reaktionsweise des Pentaphenyl-phosphors und einiger Derivate , 1953 .

[497]  K. Nicolaou,et al.  The Art and Science of Organic and Natural Products Synthesis , 1998 .

[498]  K. Nicolaou,et al.  Total Synthesis of Taxol. 2. Construction of A and C Ring Intermediates and Initial Attempts To Construct the ABC Ring System , 1995 .

[499]  K. Krohn,et al.  Synthetische Anthracyclinone, VIII1) Totalsynthese des Daunomycinons , 1979 .

[500]  Robert H. Grubbs,et al.  Recent advances in olefin metathesis and its application in organic synthesis , 1998 .

[501]  E. Corey,et al.  Efficient and mild lactonization method for the synthesis of macrolides , 1974 .

[502]  J. O. Gardner,et al.  Haloketal cyclization. General method for the synthesis of functionalized cis bicyclic ketones , 1973 .

[503]  E. Corey,et al.  Enantioselective Total Synthesis of the Potent Anti-HIV Agent Neotripterifordin. Reassignment of Stereochemistry at C(16) , 1997 .

[504]  R. Hirschmann.  Die Medizinische Chemie im Goldenen Zeitalter der Biologie: Lehren aus der Steroid‐ und Peptidforschung , 1991 .

[505]  E. Corey,et al.  An experimental demonstration of the stereochemistry of enzymic cyclization of 2,3-oxidosqualene to the protosterol system, forerunner of lanosterol and cholesterol , 1991 .

[506]  Jae Chol Lee,et al.  Total Synthesis of Colchicine. α-Methoxy-Substituted Oxyallyl [4 + 3] Cycloaddition Approach , 1998 .

[507]  K. Seppelt,et al.  Xenon-tetrakis(pentafluoroorthotellurat), Xe(OTeF5)4† , 1978 .

[508]  K. Nicolaou,et al.  Synthese des ersten vollstndig funktionalisierten Gerstes der Saragossasuren/Squalestatine , 1994 .

[509]  M. Sofia,et al.  Stereospecific reductive methylation via a radical cyclization-desilylation process , 1986 .

[510]  M. Slater,et al.  Stereospecific dicobalt octacarbonyl mediated enyne cyclization for the synthesis of the cytotoxic sesquiterpene (.+-.)-quadrone , 1987 .

[511]  K. Tatsuta,et al.  Total synthesis of carbomycin B and josamycin (leucomycin A3) , 1980 .

[512]  S. Hecht,et al.  Total synthesis of bleomycin , 1982 .

[513]  C. Heathcock,et al.  Synthetic and biological studies of compactin and related compounds. 4. Total synthesis of (+)-compactin , 1985 .

[514]  P. Wender,et al.  Total synthesis of quadrone and terrecyclic acid A , 1985 .

[515]  S. Ley,et al.  Total Synthesis of Avermectin B1a: Synthesis of the Carbohydrate Bis-Oleandrose Fragment and Coupling to the Avermectin B1a Aglycone , 1990 .

[516]  P. Balaram,et al.  Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system , 1981 .

[517]  T. I. Richardson,et al.  Nonconventional Stereochemical Issues in the Design of the Synthesis of the Vancomycin Antibiotics: Challenges Imposed by Axial and Nonplanar Chiral Elements in the Heptapeptide Aglycons. , 1998, Angewandte Chemie.

[518]  E. Corey,et al.  Demonstration of the Synthetic Power of Oxazaborolidine-Catalyzed Enantioselective Diels-Alder Reactions by Very Efficient Routes to Cassiol and Gibberellic Acid , 1994 .

[519]  M. Malacria,et al.  BIOMIMETIC DIASTEREOSELECTIVE TOTAL SYNTHESIS OF EPI-ILLUDOL VIA A TRANSANNULAR RADICAL CYCLIZATIONS STRATEGY , 1997 .

[520]  J. Finn,et al.  TOTAL SYNTHESIS OF THE HYPOCHOLESTEROLEMIC AGENT (+)‐COMPACTIN , 1983 .

[521]  J. Findlay,et al.  On the chemistry and high field nuclear magnetic resonance spectroscopy of rapamycin , 1980 .

[522]  E. Corey,et al.  TOTAL SYNTHESIS OF (+-)-VERMICULINE , 1975 .

[523]  I. Guzei,et al.  Synthesis of (−)-Fumagillin , 1999 .

[524]  A. Bélanger,et al.  Total synthesis of ryanodol , 1979 .

[525]  K. Isono,et al.  The absolute configuration of cytovaricin: isolation of methyl beta-D-cymaroside by methanolysis. , 1983, The Journal of antibiotics.

[526]  B. Salvatore,et al.  Total Synthesis of (+)-Calyculin A and (−)-Calyculin B , 1998 .

[527]  E. Corey,et al.  ENANTIOSELECTIVE TOTAL SYNTHESIS OF GRACILINS B AND C USING CATALYTIC ASYMMETRIC DIELS-ALDER METHODOLOGY , 1995 .

[528]  James P. Dittami,et al.  Total synthesis of (.+-.)-ovalicin , 1985 .

[529]  David A. Evans,et al.  TOTALSYNTHESE DES VANCOMYCIN- UND DES EREMOMYCIN-AGLYCONS , 1998 .

[530]  A. Kende,et al.  Letter: Total synthesis of (+/-)-daunomycinone and (+/-)-carminomycinone. , 1976, Journal of the American Chemical Society.

[531]  T. P. Lockhart,et al.  Evidence for the reactive spin state of 1,4-dehydrobenzenes , 1981 .

[532]  P. Grieco,et al.  Bicyclo[2.2.1]heptanes as intermediates in the synthesis of steroids. Total synthesis of estrone , 1980 .

[533]  D. Curran,et al.  Tandem radical approach to linear condensed cyclopentanoids. Total synthesis of (.+-.)-hirsutene , 1985 .

[534]  A. Eschenmoser.  Centenary Lecture. (Delivered november 1969). Roads to corrins , 1970 .

[535]  E. Corey,et al.  Catalytic enantioselective synthesis of a key intermediate for the synthesis of prostanoids , 1991 .

[536]  C. Heathcock,et al.  Daphniphyllum alkaloids. Part 5. Total synthesis of (.+-.)-daphnilactone A: a novel fragmentation reaction , 1989 .

[537]  S. Åsbrink,et al.  The Isolation of Prostaglandin. , 1957 .

[538]  J. Crosby.  Synthesis of optically active compounds: A large scale perspective , 1991 .

[539]  K. Nicolaou,et al.  Radiofrequenz‐verschlüsselte kombinatorische Chemie , 1995 .

[540]  E. Corey,et al.  The Synthesis of Dihydroconessine1 , 1959 .

[541]  D. Julius,et al.  The capsaicin receptor: a heat-activated ion channel in the pain pathway , 1997, Nature.

[542]  O. Nuyken,et al.  Allylruthenium(IV)‐Komplexe als hocheffiziente ROMP‐Katalysatoren , 1996 .

[543]  E. Corey,et al.  An efficient and simple method for the conversion of 15-HPETE to 14,15-EPETE (lipotriene A) and 5-HPETE to leukotriene a as the methyl esters , 1984 .

[544]  Toshikazu Oki,et al.  Crystal and molecular structure of dynemicin A: a novel 1,5-diyn-3-ene antitumor antibiotic , 1990 .

[545]  E. Corey,et al.  Total synthesis of prostaglandins F1-alpha, E1, F2-alpha, and E2 (natural forms) from a common synthetic intermediate. , 1970, Journal of the American Chemical Society.

[546]  G. Sauer,et al.  Synthesis of D-norgestrel. , 1975, Angewandte Chemie.

[547]  M. Isobe,et al.  Synthetic studies toward marine toxic polyethers (1) a stereocontrolled synthesis of the C-segnent of okadaic acid , 1984 .

[548]  J. Winkler,et al.  Stereochemical control in the construction of vicinally substituted cyclopentanes and cyclohexanes. Intramolecular conjugate addition of β-ketoester anions. , 1983 .

[549]  C. Heathcock,et al.  Total syntheses of (+/-)-preussomerins G and I. , 1999, Organic letters.

[550]  R. Ryhage,et al.  The structure of prostaglandin E F1 and F2. , 1962 .

[551]  G. Jung,et al.  Organic Chemistry on Solid Supports , 1996 .

[552]  E. Corey,et al.  Total Synthesis of Erythromycins. 4. Total Synthesis of Erythronolide B1 , 1978 .

[553]  E. Corey,et al.  The origin of greater than 200:1 enantioselectivity in a catalytic Diels-Alder reaction as revealed by physical and chemical studies , 1992 .

[554]  M. Hayward,et al.  Total Synthesis of Altohyrtin A (Spongistatin 1): Part 1 , 1998 .

[555]  G. E. Keck,et al.  A highly convergent total synthesis of (+)-compactin , 1986 .

[556]  R. Mook,et al.  Five vs six membered ring formation in the vinyl radical cyclization , 1986 .

[557]  P. Wipf,et al.  Asymmetric Total Synthesis of the Stemona Alkaloid (-)-Stenine , 1995 .

[558]  G. Georg,et al.  Asymmetric synthesis of (1′R,3R,4R)-4-acetoxy-3-(1′-((tert-butyldimethylsilyl)oxy)ethyl)-2- azetidinone and other 3-(1′-Hydroxyethyl)-2-azetidinones from (S)-(+)-Ethyl 3-hydroxybutanoate: Formal total synthesis of (+)-thienamycin , 1987 .

[559]  E. Corey,et al.  New mechanistic and stereochemical insights on the biosynthesis of sterols from 2,3-oxidosqualene , 1991 .

[560]  K. Yeung,et al.  The total synthesis of swinholide A. Part 4: Synthesis of swinholide A and isoswinholide A from the protected monomeric seco acid, pre-swinholide A , 1995 .

[561]  K. Nicolaou.  DIE TOTALSYNTHESE VON BREVETOXIN B : EINE ZWOLF JAHRE WAHRENDE ODYSSEE IN DER ORGANISCHEN SYNTHESE , 1996 .

[562]  D. Hart,et al.  Convergent total synthesis of (.+-.)-colchicine and (.+-.)-desacetamidoisocolchicine , 1981 .

[563]  A. Kubo,et al.  Synthesis of saframycins. I. Total synthesis (+/-)-saframycin B and its congeners. , 1987, Chemical & pharmaceutical bulletin.

[564]  G. Stork,et al.  Control of ring junction stereochemistry via radical cyclization , 1985 .

[565]  E. Logusch,et al.  Reductive alkylation of enediones. 2. Synthesis of corticosteroids , 1980 .

[566]  Taeyoung Yoon,et al.  The Total Synthesis of Dynemicin A Leading to Development of a Fully Contained Bioreductively Activated Enediyne Prodrug , 1996 .

[567]  E. Corey,et al.  THE SYNTHESIS OF DIHYDROCONESSINE. A METHOD FOR FUNCTIONALIZING STEROIDS AT C18 , 1958 .

[568]  Motomasa Kobayashi,et al.  Absolute stereostructure of swinholide A, a potent cytotoxic macrolide from the Okinawan marine sponge Theonella swinhoei , 1990 .

[569]  N. Rosen,et al.  A concise total synthesis of dysidiolide through application of a dioxolenium-mediated Diels-Alder reaction , 1998 .

[570]  E. Corey,et al.  An Enantioselective Synthetic Route to Atractyligenin Using the Oxazaborolidine-Catalyzed Reduction of β-Silyl- or β-Stannyl-Substituted α,β-Enones as a Key Step , 1997 .

[571]  C. Szántay,et al.  Die Totalsynthese des (+)-Yohimbins und (−)-β-Yohimbins , 1969 .

[572]  L. Overman,et al.  First total synthesis of Lycopodium alkaloids of the magellanane group. Enantioselective total syntheses of (-)-magellanine and (+)-magellaninone , 1993 .

[573]  L. Overman,et al.  Enantioselective Total Synthesis of (-)-7-Deacetoxyalcyonin Acetate. First Synthesis of a Eunicellin Diterpene , 1995 .

[574]  Won Hyung Yoon,et al.  Total Synthesis of the CP Molecules CP-225,917 and CP-263,114- Part 2: Evolution of the Final Strategy. , 1999, Angewandte Chemie.

[575]  G. Stork,et al.  A general method for the stereocontrolled synthesis of polypropionate-derived sequences , 1986 .

[576]  E. Corey,et al.  Enantiospecific total synthesis of pseudopterosins A and E , 1989 .

[577]  E. Carreira,et al.  (+)-ZARAGOZIC ACID C : SYNTHESIS AND RELATED STUDIES , 1995 .

[578]  R. Daniel Little,et al.  Electroreductive cyclization reactions. Stereoselection, creation of quaternary centers in bicyclic frameworks, and a formal total synthesis of quadrone. , 1990 .

[579]  R. Zamboni,et al.  Total synthesis of dl-coriolin , 1980 .

[580]  David Taub,et al.  The Total Synthesis of Steroids1 , 1952 .

[581]  J. Kallen,et al.  Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. II. Structure elucidation, stereochemistry and physico-chemical properties. , 1999, The Journal of antibiotics.

[582]  M. Isobe,et al.  Synthetic studies toward marine toxic polyethers (4) synthesis of segment -A of okadaic acid via -selectivity by heteroconjugate addition , 1985 .

[583]  E. Abraham,et al.  Isolation of cephalosporin C, a penicillin-like antibiotic containing d-α-aminoadipic acid , 1956 .

[584]  T. Mak,et al.  An improved synthesis of (−)-syringolides and X-ray structural characterization of synthetic (−)-syringolide 1 , 1998 .

[585]  W. Catterall,et al.  Identification of peptide components of the brevetoxin receptor site of rat brain sodium channels. , 1994, The Journal of biological chemistry.

[586]  R. Little,et al.  Intramolecular 1,3-diyl trapping reactions. A formal total synthesis of (.+-.)-coriolin , 1985 .

[587]  C. Beevers,et al.  Crystal Structure of Strychnine Hydrobromide , 1950, Nature.

[588]  Bengt Samuelsson,et al.  Stereospecific total synthesis of a "slow reacting substance" of anaphylaxis, leukotriene C-1 , 1980 .

[589]  T. Fukuyama,et al.  Synthetic studies on tetrodotoxin and related compounds. 3. A stereospecific synthesis of an equivalent of acetylated tetrodamine. , 1972, Journal of the American Chemical Society.

[590]  Masaaki Suzuki,et al.  Prostaglandin Syntheses by Three‐Component Coupling. New Synthetic Methods (49) , 1984 .

[591]  Bryan E. Roberts,et al.  TOTAL SYNTHESIS OF DYSIDIOLIDE , 1997 .

[592]  E. S. Binkley,et al.  A highly efficient total synthesis of (.+-.)-lycopodine , 1978 .

[593]  M. Isobe,et al.  Synthesis of maytansinoid. A general approach via heteroconjugate addition strategy and the total synthesis of (.+-.)-maysine and (.+-.)-N-methylmaysenine , 1984 .

[594]  L. Overman,et al.  Enantioselective Total Synthesis of Hispidospermidin , 1998 .

[595]  K. Sharpless,et al.  Addition Reactions with Formation of Carbon–Oxygen Bonds: (ii) Asymmetric Methods of Epoxidation , 1991 .

[596]  M. Finn,et al.  8 – On the Mechanism of Asymmetric Epoxidation with Titanium—Tartrate Catalysts , 1985 .

[597]  E. Corey,et al.  Enantioselective total synthesis of miroestrol , 1993 .

[598]  Recent advances in the use of tandem reactions for organic synthesis , 1995 .

[599]  Davidr . Evans,et al.  The asymmetric synthesis of β-lactam antibiotics - IV. A formal synthesis of thienamycin. , 1986 .

[600]  R. Heck.  Palladium reagents in organic syntheses , 1985 .

[601]  E. Corey,et al.  Total synthesis of dl-sirenin , 1969 .

[602]  S. Nguyen,et al.  Ring-opening metathesis polymerization (ROMP) of norbornene by a Group VIII carbene complex in protic media , 1992 .

[603]  P. Magnus,et al.  SILICON IN SYNTHESIS. 20. SYNTHESIS OF (.+-.)-HIRSUTENE USING ORGANOSILICON-MEDIATED TRANSFORMATIONS , 1982 .

[604]  E. Corey,et al.  The first enantioselective synthesis of the chemotactic factor sirenin by an intramolecular [2 + 1] cyclization using a new chiral catalyst , 1995 .

[605]  J. Tamariz,et al.  A doubly-convergent and regioselective synthesis of (±)-daunomycinone , 1984 .

[606]  S. Rundqvist,et al.  The isolation of prostaglandin F from sheep prostate glands. , 1960 .

[607]  S. Hanessian,et al.  The total, stereocontrolled synthesis of a chemical precursor to (+)-thienamycin. A formal synthesis of the antibiotic , 1982 .

[608]  Samuel J. Danishefsky,et al.  EINE TOTALSYNTHESE VON TAXOL , 1995 .

[609]  A. Ganguly,et al.  DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY AT THE C16 ORTHOESTER OF EVERNINOMICIN ANTIBIOTICS; A NOVEL ACID-CATALYZED ISOMERIZATION OF ORTHOESTERS , 1997 .

[610]  K. Nicolaou,et al.  Total Synthesis of Vancomycin Aglycon-Part 3: Final Stages. , 1998, Angewandte Chemie.

[611]  K. Nicolaou,et al.  Synthesis of epothilones A and B in solid and solution phase , 1997, Nature.

[612]  S. Schreiber,et al.  Immunophilin-ligand complexes as probes of intracellular signaling pathways. , 1991, Transplantation proceedings.

[613]  T. Nakata,et al.  A stereospecific total synthesis of d,l-saxitoxin. , 1977, Journal of the American Chemical Society.

[614]  E. Corey.  Simple synthesis of ()--trans-bergamotene , 1985 .

[615]  J. Mccauley.  Kishi's group achieved the total synthesis of pinnatoxin A (3) and ent-3. They reported that only natural pinnatoxin A was toxic , 1998 .

[616]  Wei,et al.  Total Synthesis of Sanglifehrin A. , 1999, Angewandte Chemie.

[617]  S. Schreiber,et al.  Total synthesis of FK506 and an FKBP probe reagent, [C(8),C(9)-13C2]-FK506 , 1990 .

[618]  Ronald J. Biediger,et al.  First total synthesis of taxol. 1. Functionalization of the B ring , 1994 .

[619]  S. Danishefsky,et al.  Optically specific synthesis of estrone and 19-norsteroids from 2,6-lutidine. , 1976, Journal of the American Chemical Society.

[620]  H. Nagaoka,et al.  Total synthesis of (±)-gibberellic acid , 1989 .

[621]  Fourcroy.  Bemerkungen zu dem Aufsatze der Amsterdammer Chemiker über das vorgebliche kohligsaure Gas , 1803 .

[622]  B. Rudd,et al.  The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. III. Biosynthesis. , 1992, The Journal of antibiotics.

[623]  E. Corey,et al.  A new system for catalytic enantioselective reduction of achiral ketones to chiral alcohols. Synthesis of chiral α-hydroxy acids , 1990 .

[624]  P. Tavecchia,et al.  Syntheses of trisaccharide C-D-E and tetrasaccharide B-C-D-E fragments found in orthosomycins. , 1990, Carbohydrate research.

[625]  E. Corey,et al.  ENANTIOSELECTIVE TOTAL SYNTHESIS OF ASPIDOPHYTINE , 1999 .

[626]  K. Nicolaou,et al.  Total synthesis of taxol , 1994, Nature.

[627]  A. Eschenmoser.  Vitamin B12: Experimente zur Frage nach dem Ursprung seiner molekularen Struktur† , 1988 .

[628]  Nicolas Winssinger,et al.  SOLID AND SOLUTION PHASE SYNTHESIS AND BIOLOGICAL EVALUATION OF COMBINATORIAL SARCODICTYIN LIBRARIES , 1998 .

[629]  H. Brown,et al.  A NEW TECHNIQUE FOR THE CONVERSION OF OLEFINS INTO ORGANOBORANES AND RELATED ALCOHOLS , 1956 .

[630]  R. Woodward,et al.  The total synthesis of chlorophyll , 1960 .

[631]  A. D. Buss,et al.  The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity. , 1992, The Journal of antibiotics.

[632]  B. Simoneau,et al.  Total syntheses of ML-236A and compactin by combining the lactonic (silyl) enolate rearrangement and aldehyde-diene cyclocondensation technologies , 1989 .

[633]  E. E. Tamelen.  Bioorganic chemistry. Total synthesis of tetra- and pentacyclic triterpenoids , 1975 .

[634]  R. Noyori,et al.  Prostaglandin-Synthesen durch Dreikomponenten-Kupplung , 1984 .

[635]  A. Pfenninger.  Asymmetric Epoxidation of Allylic Alcohols: The Sharpless Epoxidation , 1986 .

[636]  Amos B. Smith,et al.  Total syntheses of (+)-paspalicine and (+)-paspalinine , 1990 .

[637]  P. Leadlay,et al.  Combinatorial approaches to polyketide biosynthesis. , 1997, Current opinion in chemical biology.

[638]  S. Masamune,et al.  Makrolide. Neuere Fortschritte ihrer Chemie und Biochemie , 1977 .

[639]  R. J. Anderson,et al.  Biogenetic-type total synthesis. 24,25-Dihydrolanosterol, 24,25-dihydro- 13(17) -protosterol, isoeuphenol, (-)-isotirucallol, and parkeol. , 1972, Journal of the American Chemical Society.

[640]  R. Hughes,et al.  TOTAL SYNTHESIS OF VANCOMYCIN. PART 3 : SYNTHESIS OF THE AGLYCON , 1999 .

[641]  R. Woodward.  Biogenesis of the Strychnos Alkaloids , 1948, Nature.

[642]  Daisuke Uemura,et al.  Further studies on palytoxin. II. structure of palytoxin , 1981 .

[643]  D. R. Parrish,et al.  Novel total syntheses of (+)-estrone-3-methyl ether, (+)-13beta-ethyl-3-methoxygona-1,3,5(10)-trien-17-one, and (+)-equilenin 3-methyl ether. , 1975, The Journal of organic chemistry.

[644]  Yan-Hui Liu,et al.  The structure of new oligosaccharide antibiotics, 13-384 components 1 and 5 , 1989 .

[645]  G. Stork,et al.  Cyclization of vinyl radicals: a versatile method for the construction of five- and six-membered rings , 1982 .

[646]  J. Westley.  Chapter 25. The Polyether Antibiotics: Monocarboxylic acid ionophores , 1975 .

[647]  J. Barrow,et al.  Total Syntheses of Vancomycin and Eremomycin Aglycons. , 1998, Angewandte Chemie.

[648]  D. Barton,et al.  A Synthesis of Aldosterone Acetate1 , 1960 .

[649]  H. Rapoport,et al.  Synthesis of (-)-vindoline , 1987 .

[650]  K. Nicolaou.  Synthesis of macrolides , 1977 .

[651]  A. Schultz,et al.  First Asymmetric Synthesis of a Hasubanan Alkaloid. Total Synthesis of (+)-Cepharamine , 1998 .

[652]  J. Mulzer,et al.  Formal Total Synthesis of (—)-Morphine by Cuprate Conjugate Addition† , 1996 .

[653]  G. I. Poos,et al.  STEREOSPECIFIC TOTAL SYNTHESIS OF CORTISONE , 1952 .

[654]  K. Nicolaou,et al.  Total Synthesis of Brevetoxin B. 3. Final Strategy and Completion , 1995 .

[655]  G. Gasic,et al.  Synthesis and biological properties of prostaglandin endoperoxides, thromboxanes and prostacyclins. , 1978, Angewandte Chemie.

[656]  K. Nicolaou,et al.  New Synthetic Technology for the Synthesis of Aryl Ethers: Construction of C-O-D and D-O-E Ring Model Systems of Vancomycin , 1997 .

[657]  R. Woodward,et al.  The total synthesis of dl-6-demethyl-6-deoxytetracycline , 1968 .

[658]  G. Stork,et al.  Total synthesis of lupeol , 1971 .

[659]  Yun He,et al.  Total Synthesis of the CP Molecules CP-263,114 and CP-225,917- Part 1: Synthesis of Key Intermediates and Intelligence Gathering. , 1999, Angewandte Chemie.

[660]  J. Winkler,et al.  STEREOCHEMICAL CONTROL OF THE INTERNAL MICHAEL REACTION. A NEW CONSTRUCTION OF TRANS-HYDRINDAN SYSTEMS , 1982 .

[661]  R. L. Funk,et al.  THE COBALT WAY TO DL‐ESTRONE, A HIGHLY REGIOSPECIFIC FUNCTIONALIZATION OF 2,3‐BIS(TRIMETHYLSILYL)ESTRATRIEN‐17‐ONE , 1979 .

[662]  J. J. Clair,et al.  Stereoselective Synthesis of β-Mannopyranosides via the Temporary Silicon Connection Method , 1996 .

[663]  L. Tietze.  Domino Reactions in Organic Synthesis. , 1996, Chemical reviews.

[664]  M. Schnute,et al.  The First Formal Asymmetric Synthesis of Phorbol , 1997 .

[665]  E. Corey,et al.  Stereospecific total synthesis of gibberellic acid. A key tricyclic intermediate , 1978 .

[666]  David A. Evans,et al.  Enantioselektive Synthese von Altohyrtin C (Spongistatin 2): Synthese des EF‐Bis‐(tetrahydropyran)‐Fragments , 1997 .

[667]  G. Stork,et al.  Regiospecific trapping of radicals from cyclization reactions. Cyclic nitriles via isocyanide trapping , 1983 .

[668]  K. Koga,et al.  SYNTHETIC STUDIES ON OPTICALLY ACTIVE β-LACTAMS. STEREOCONTROLLED SYNTHESIS OF CHIRAL THIENAMYCIN INTERMEDIATE FROM D-GLUCOSE , 1982 .

[669]  M. Ohno,et al.  An enantioselective synthesis of a key intermediate to thienamycin by chemicoenzymatic approach , 1988 .

[670]  P. Bertinato,et al.  Total synthesis of rapamycin , 1995 .

[671]  M. Beier,et al.  Chemical etiology of nucleic acid structure: comparing pentopyranosyl-(2'-->4') oligonucleotides with RNA. , 1999, Science.

[672]  R. Rodrigo,et al.  A convergent synthesis of (±)daunomycinoni , 1984 .

[673]  J. Boukouvalas,et al.  Total Synthesis of (+)-Dysidiolide , 1998 .

[674]  K. Nicolaou.  Der Kampf um Calicheamicin γ 1I , 1993 .

[675]  P. Schuda,et al.  The synthesis of dl-coriolin , 1985 .

[676]  Motomasa Kobayashi,et al.  Molecular conformation of swinholide A, a potent cytotoxic dimeric macrolide from the Okinawan marine sponge Theonella swinhoei: x-ray crystal structure of its diketone derivative , 1991 .

[677]  E. Corey,et al.  Total synthesis of humulene , 1967 .

[678]  J. M. Scott.  Enantioselective Synthesis of Non‐Racemic Chiral Molecules on an Industrial Scale , 2007 .

[679]  M. Ward,et al.  Hexaazaoctadecahydrocoronene. Structural and physical properties of [HOC]n (n=0, 1+, 2+, 3+, 4+) , 1990 .

[680]  M. Ihara,et al.  STUDIES ON THE SYNTHESES OF HETEROCYCLIC COMPOUNDS. 800. A FORMAL TOTAL SYNTHESIS OF (.+‐.)‐THIENAMYCIN AND A (.+‐.)‐DECYSTEAMINYLTHIENAMYCIN DERIVATIVE , 1980 .

[681]  R. Woodward,et al.  The penems, a new class of .beta.-lactam antibiotics. 5. Total synthesis of racemic 6-.alpha.-hydroxyethylpenemcarboxylic acids , 1980 .

[682]  F. Pietra,et al.  Sarcodictyin A and Sarcodictyin B, Novel Diterpenoidic Alcohols Esterified by (E)-N(1)-Methylurocanic Acid. Isolation from the Mediterranean Stolonifer Sarcodictyon roseum , 1987 .

[683]  Feng Xu,et al.  Total synthesis of strychnan and aspidospermatan alkaloids. 3. The total synthesis of (.+-.)-strychnine , 1993 .

[684]  K. Nicolaou,et al.  Synthesis of the First Fully Functionalized Core of the Zaragozic Acids/Squalestatins , 1994 .

[685]  M. Toyota,et al.  An expeditious and efficient formal synthesis of (±)-aphidicolin , 1994 .

[686]  P. Coleman,et al.  ENANTIOSELECTIVE SYNTHESIS OF ALTOHYRTIN C (SPONGISTATIN 2) : FRAGMENT ASSEMBLY AND REVISION OF THE SPONGISTATIN 2 STEREOCHEMICAL ASSIGNMENT , 1997 .

[687]  C. Schaffner,et al.  Polyene macrolide antibiotic amphotericin B. Crystal structure of the N-iodoacetyl derivative. , 1971, Journal of the American Chemical Society.

[688]  R. Little,et al.  CONSEQUENCES OF INTRAMOLECULAR DIYL TRAPPING REACTIONS USING UNACTIVATED DIYLOPHILES. A SHORT, CONVERGENT SYNTHESIS OF HIRSUTENE , 1983 .

[689]  G. Stork,et al.  Conjugate addition of acyl carbanion equivalents via the protected cyanohydrin method , 1974 .

[690]  S. Danishefsky,et al.  First Total Synthesis of Staurosporine and ent-Staurosporine , 1995 .

[691]  Y. Kishi,et al.  Total synthesis of rifamycins. 1. Stereocontrolled synthesis of the aliphatic building block , 1980 .

[692]  Tein-Fu Wang,et al.  A formal, stereocontrolled synthesis of (±) estrone employing the trimethylsilylcyanohydrin cope rearrangement , 1981 .

[693]  E. Corey,et al.  Total synthesis of (.+-.)-5,6-oxido-7,9-trans,11,14-cis-eicosapentaenoic acid, a possible precursor of SRSA , 1979 .

[694]  K. Nicolaou,et al.  Total synthesis of rapamycin , 1993 .

[695]  P. Coleman,et al.  Enantioselective Synthesis of Altohyrtin C (Spongistatin 2): Synthesis of the AB- and CD-Spiroketal Subunits†‡ , 1997 .

[696]  A. Eschenmoser,et al.  Untersuchungen über den sterischen Verlauf säurekatalysierter Cyclisationen bei terpenoiden Polyenverbindungen. 3. Mitteilung. Zur Stereochemie der Bicyclofarnesylsäuren , 1957 .

[697]  Ge Yang,et al.  Total Synthesis of (−)-Discodermolide: An Application of a Chelation-Controlled Alkylation Reaction , 1997 .

[698]  L. Overman,et al.  Asymmetric synthesis of either enantiomer of opium alkaloids and morphinans. Total synthesis of (-)- and (+)-dihydrocodeinone and (-)- and (+)-morphine , 1993 .

[699]  R. Rivero,et al.  Total synthesis of (.+-.)-breynolide: an aglycon derivative of a potent, orally active hypocholesterolemic agent , 1991 .

[700]  E. Corey.  STUDIES ON THE TOTAL SYNTHESIS OF PROSTAGLANDINS , 1971, Annals of the New York Academy of Sciences.

[701]  P. Hickmott.  Enamines: recent advances in synthetic, spectroscopic, mechanistic, and stereochemical aspects—I , 1982 .

[702]  P. Fuchs,et al.  Synthesis of the South Unit of Cephalostatin. 7. Total Syntheses of (+)-Cephalostatin 7, (+)-Cephalostatin 12, and (+)-Ritterazine K1 , 1999 .

[703]  J. Banfield,et al.  Constituents of Endiandra species. II. (E)-4-(6'-Phenyltetracyclo[5,4,2,03,13,010,12]-trideca-4',8'-dien-11'-yl)but-2-enoic acid from Endiandra introrsa (Lauraceae) , 1982 .

[704]  J. Cossy,et al.  Photoreductive cyclization: Application to the total synthesis of (±) Hirsutene , 1987 .

[705]  P. Jadhav,et al.  Chiral synthesis via organoboranes. 13. A highly diastereoselective and enantioselective addition of [(Z)-.gamma.-alkoxyallyl]diisopinocampheylboranes to aldehydes , 1988 .

[706]  D. Boger,et al.  Total Synthesis of Bleomycin A2 and Related Agents. 4. Synthesis of the Disaccharide Subunit 2-O-(3-O-Carbamoyl-.alpha.-D-mannopyranosyl)-L-gulopyranose and Completion of the Total Synthesis of Bleomycin A2 , 1994 .

[707]  P. Aldrich,et al.  THE TOTAL SYNTHESIS OF YOHIMBINE , 1958 .

[708]  K. Nicolaou,et al.  Total Synthesis of Swinholide A, Preswinholide A, and Hemiswinholide A , 1996 .

[709]  K. Nicolaou,et al.  Total Synthesis of Brevetoxin B. 1. First Generation Strategies and New Approaches to Oxepane Systems , 1996 .

[710]  R. Woodward,et al.  The Total Synthesis of 6-Demethyl-6-Deoxytetracycline , 1962 .

[711]  Kenji Ito,et al.  Synthesis of (−)-terrecyclic acid A. Absolute configuration of terrecyclic acid A and quadrone , 1984 .

[712]  S. Sehgal,et al.  Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. , 1975, The Journal of antibiotics.

[713]  S. Danishefsky,et al.  The total synthesis of avermectin A1a. New protocols for the synthesis of novel 2-deoxypyranose systems and their axial glycosides , 1987 .

[714]  F. West,et al.  The Total Synthesis of a Natural Cardenolide: (+)-Digitoxigenin , 1996 .

[715]  R. Sachleben,et al.  Stereocontrolled total synthesis of (.+-.)-saframycin B , 1982 .

[716]  D. Boger,et al.  Enantioselective Total Synthesis of (+)-Duocarmycin A, epi-(+)-Duocarmycin A, and Their Unnatural Enantiomers , 1996 .

[717]  G. Stork,et al.  A NEW ALKYLATION OF CARBONYL COMPOUNDS. II1 , 1956 .

[718]  F. Evans,et al.  a new aromatic ester diterpene from Euphorbia poisonii , 1976 .

[719]  S. Ghosh,et al.  Symmetry-Driven Synthesis of Indole Alkaloids: Asymmetric Total Syntheses of (+)-Yohimbine, (-)-Yohimbone, (-)-Yohimbane, and (+)-Alloyohimbane , 1994 .

[720]  J. D. Karkas,et al.  Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[721]  E. S. Binkley,et al.  Total synthesis of lycopodium alkaloids: (.+-.)-lycopodine, (.+-.)-lycodine, and (.+-.)-lycodoline , 1982 .

[722]  H. Furukawa,et al.  Oxiranyl Anions in Organic Synthesis: Application to the Synthesis of Hemibrevetoxin B , 1997 .

[723]  E. Corey,et al.  A short and efficient enantioselective route to a key intermediate for the total synthesis of forskolin , 1989 .

[724]  J. R. Hanson,et al.  Protecting Groups in Organic Synthesis , 1999 .

[725]  K. Nicolaou,et al.  Letter: Synthesis of novel macrocyclic lactones in the prostaglandin and polyether antibiotic series. , 1975, Journal of the American Chemical Society.

[726]  R. Woodward,et al.  THE TOTAL SYNTHESIS OF LYSERGIC ACID AND ENGROVINE , 1954 .

[727]  Q. Jiang,et al.  Total Synthesis of (+)-Quassin from (+)-Carvone , 1998 .

[728]  N. Saccomano,et al.  Enantioselective synthesis of an intermediate for the intramolecular Diels-Alder construction of 11-ketosteroids , 1987 .

[729]  Y. Fujise,et al.  Total synthesis of indole and dihydroindole alkaloids. 14. A total synthesis of vindoline , 1978 .

[730]  C. Fairchild,et al.  Eleutherobin, a New Cytotoxin that Mimics Paclitaxel (Taxol) by Stabilizing Microtubules , 1997 .

[731]  J. Winkler.  Tandem Diels−Alder Cycloadditions in Organic Synthesis , 1996 .

[732]  B. Max.  This and that: survival and certainty , 1987 .

[733]  M. Chu-Moyer,et al.  The total synthesis of dl-indolizomycin , 1990 .

[734]  P. Williard,et al.  Five- and six-membered-ring formation from olefinic .alpha.,.beta.-epoxy ketones and hydrazine , 1977 .

[735]  D. Friedrich,et al.  BRIDGEHEAD OXIRANYL SESQUITERPENOIDS. ASYMMETRIC TOTAL SYNTHESIS OF (-)-SALSOLENE OXIDE , 1997 .

[736]  K. Nicolaou,et al.  Total Synthesis of Taxol. 1. Retrosynthesis, Degradation, and Reconstitution , 1995 .

[737]  J. F. Walker,et al.  The Insecticidal Principles of Haplophyton cimicidum. I. Haplophytine1 , 1954 .

[738]  M. Crimmins,et al.  REARRANGEMENT OF CYCLOBUTYL CARBINYL RADICALS : TOTAL SYNTHESIS OF THE SPIROVETIVANE PHYTOALEXIN ()-LUBIMINOL , 1996 .

[739]  K. Isono,et al.  Cytovaricin, a novel antibiotic. , 1981, The Journal of antibiotics.

[740]  K. Nicolaou,et al.  Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells† , 1997 .

[741]  E. Corey,et al.  Stereo-controlled synthesis of dl-prostaglandins F2.alpha. and E2 , 1969 .

[742]  G. Stork.  Radical Cyclization in the Control of Regio- and Stereochemistry , 1988 .

[743]  G. Stork,et al.  The stereospecific total synthesis of dl-lycopodine. , 1968, Journal of the American Chemical Society.

[744]  K. Yeung,et al.  The total synthesis of swinholide A. Part 3: A stereocontrolled synthesis of (−)-pre-swinholide A. , 1995 .

[745]  J. Howbert,et al.  Synthetic studies on arene-olefin cycloadditions -III- total synthesis of (±)-hirsutene☆ , 1982 .

[746]  F. Zutterman,et al.  Sesquiterpene lactones: A total synthesis of (±) quadrone , 1983 .

[747]  M. Hatanaka,et al.  A stereocontrolled synthesis of the key intermediate of (+)-thienamycin from (R)-(−)-3-hydroxybutyric acid esters , 1987 .

[748]  J. C. Sheehan,et al.  THE TOTAL SYNTHESIS OF PENICILLIN V , 1957 .

[749]  K. Nicolaou,et al.  Synthesis of 16-membered-ring macrolide antibiotics. 4. Carbomycin B and leucomycin A3: total synthesis of cyclic key intermediate , 1981 .

[750]  W. C. Still,et al.  Synthesis of the polyether antibiotic monensin. 2. Preparation of intermediates , 1980 .

[751]  I. Kawamoto,et al.  Total synthesis of prostaglandin F2.alpha. by chirality transfer from D-glucose , 1978 .

[752]  M. Wu,et al.  Synthetic Study of Colchicine , 1974 .

[753]  R. Woodward,et al.  The penems, a new class of .beta.-lactam antibiotics. 4. Syntheses of racemic and enantiomeric penem carboxylic acids , 1979 .

[754]  The X-ray crystal structure of rapamycin, C51H79NO13 , 1978 .

[755]  R. W. Armstrong,et al.  Total Synthesis of Calyculin C , 1998 .

[756]  S. Martin,et al.  Applications of intramolecular Diels-Alder reactions to alkaloid synthesis. A formal total synthesis of (.+-.)-dendrobine , 1991 .

[757]  K. Nicolaou,et al.  TOTALSYNTHESE VON SANGLIFEHRIN A , 1999 .

[758]  K. Nicolaou,et al.  Ein außergewöhnlicher Zugang zur anellierten Maleinsäureanhydrid‐Einheit der CP‐Moleküle , 1999 .

[759]  N. Moss,et al.  Thermal rearrangement of divinylcyclopropane systems. A new formal total synthesis of (±)-quadrone , 1985 .

[760]  B. Sugavanam,et al.  Syntheses in the cinchona alkaloid series. , 1970, Journal of the American Chemical Society.

[761]  J. Toth,et al.  Synthesis via vinyl sulfones. 21. Total synthesis of dl-morphine , 1987 .

[762]  J. Rebek,et al.  Synthesis of ergot alkaloids from tryptophan , 1984 .

[763]  T. Hudlický,et al.  Total synthesis of (.+-.)-hirsutene , 1980 .

[764]  E. Corey,et al.  An efficient and catalytically enantioselective route to (S)-(−)-phenyloxirane , 1988 .

[765]  M. Chu-Moyer,et al.  A remarkable cyclopropanation: the total synthesis of myrocin C , 1992 .

[766]  K. Nambiar,et al.  Asymmetric total synthesis of erythromycin. 3. Total synthesis of erythromycin , 1981 .

[767]  R. Neier,et al.  TANDEM REACTIONS COMBINING DIELS-ALDER REACTIONS WITH SIGMATROPIC REARRANGEMENT PROCESSES AND THEIR USE IN SYNTHESIS , 1998 .

[768]  Amjad Ali,et al.  ENANTIOSELECTIVE TOTAL SYNTHESES OF IRCINAL A AND RELATED MANZAMINE ALKALOIDS , 1999 .

[769]  M. Desai.  Chapter 3 – Total Synthesis of ( ± )-Ginkgolide B , 1991 .

[770]  K. Nambiar,et al.  Asymmetric Total Synthesis of Erythromycin. 1. Synthesis of an Erythronolide A Seco Acid Derivative via Asymmetric Induction , 1981 .

[771]  P. Guiry,et al.  Total synthesis of isorobustin , 1990 .

[772]  M. VanNieuwenhze,et al.  Catalytic Asymmetric Dihydroxylation , 1994 .

[773]  E. Corey,et al.  2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene. , 1966, Journal of the American Chemical Society.

[774]  E. Corey,et al.  TOTAL SYNTHESIS OF d,l-LONGIFOLENE , 1961 .

[775]  E. Corey,et al.  Total synthesis of (±)-forskolin , 1988 .

[776]  R. Sagdeev,et al.  Did Bohr Share Nuclear Secrets , 1995 .

[777]  S. Schreiber,et al.  Total synthesis of the anthelmintic agent hikizimycin , 1990 .

[778]  I. Kuwajima,et al.  Highly efficient method for coriolin synthesis , 1997 .

[779]  L. Overman,et al.  First total synthesis of scopadulcic acid B , 1993 .

[780]  K. B. Sharpless.  d,1-Malabaricanediol. First cyclic natural product derived from squalene in a nonenzymic process , 1970 .

[781]  A. Kozikowski,et al.  The isoxazoline route to the hypocholesterolemic agent compactin: use of the isoxazoline as a 1,3-diene equivalent , 1987 .

[782]  K. Nicolaou,et al.  Total Synthesis of Brevetoxin A: Part 4: Final Stages and Completion , 1999 .

[783]  L. Overman,et al.  Enantioselective Total Synthesis of (-)-Ptilomycalin A , 1995 .

[784]  K. Nicolaou,et al.  Chemistry and biology of natural and designed enediynes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[785]  E. Corey,et al.  Practical enantioselective Diels-Alder and aldol reactions using a new chiral controller system , 1989 .

[786]  A. Balog,et al.  Total Synthesis of Epothilone A. , 1996 .

[787]  K. Wiesner.  Total synthesis of delphinine-type alkaloids by simple, fourth generation methods , 1979 .

[788]  J. V. Nelson,et al.  Stereoselective aldol condensations via boron enolates , 1979 .

[789]  J. Collins,et al.  Synthetic studies on quassinoids: total synthesis of (.+-.)-chaparrinone , 1990 .

[790]  David R. Liu,et al.  The Methyl Group at C(10) of 2,3-Oxidosqualene is Crucial to the Correct Folding of This Substrate in the Cyclization-Rearrangement Step of Sterol Biosynthesis , 1992 .

[791]  J. B. White,et al.  Total synthesis of a fully protected palytoxin carboxylic acid , 1989 .

[792]  E. Corey,et al.  Total synthesis and absolute configuration of 7,20-diisocyanoadociane , 1987 .

[793]  D. Curran.  Cascade Radical Reactions in Organic Synthesis: An Overview , 1998 .

[794]  A. McPhail,et al.  Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. , 1971, Journal of the American Chemical Society.

[795]  R. L. Funk,et al.  Transition-metal-catalyzed alkyne cyclizations. A cobalt-mediated total synthesis of dl-estrone , 1980 .

[796]  O. Kodama,et al.  Synthesis of (−)-syringolides 1 and 2 , 1995 .

[797]  K. Folkers,et al.  Structure of Vitamin B6. II , 1939 .

[798]  R. Reamer,et al.  The synthesis of 3-(1′-hydroxyethyl)-2-azetidinone-4-yl acetic acid via dianion chemistry - an important intermediate in thienamycin total synthesis , 1982 .

[799]  K. Nicolaou,et al.  The endiandric acid cascade. Electrocyclizations in organic synthesis. I. Stepwise, stereocontrolled total synthesis of endiandric acids A and B , 1982 .

[800]  K. Nicolaou,et al.  Practical synthesis of oligosaccharides. Partial synthesis of avermectin B1a , 1984 .

[801]  T. Ho.  Tandem Organic Reactions , 1992 .

[802]  E. Corey,et al.  Total synthesis of (.+-.)-aphidicolin , 1980 .

[803]  H. Clarke.  The chemistry of penicillin , 1949 .

[804]  E. Abraham,et al.  The structure of cephalosporin C , 1961 .

[805]  S. Caron,et al.  Total synthesis of zaragozic acid A (squalestatin S1). Synthesis of the relay compound , 1996 .

[806]  Stefan Bräse,et al.  Total Synthesis of Vancomycin—Part 2: Retrosynthetic Analysis, Synthesis of Amino Acid Building Blocks and Strategy Evaluations , 1999 .

[807]  D. Watt,et al.  An enantioselective synthesis of (+)-picrasin B, (+)-.DELTA.2-picrasin B, and (+)-quassin from the R-(-) enantiomer of the Wieland-Miescher ketone , 1990 .

[808]  R. K. Boeckman,et al.  Synthetic studies directed toward naturally occurring cyclooctanoids. 2. A stereocontrolled assembly of (.+-.)-pleuromutilin via a remarkable sterically demanding oxy-Cope rearrangement , 1989 .

[809]  A. Eschenmoser.  Studies on the synthesis of corrins , 1963 .

[810]  R. Woodward,et al.  The Total Synthesis of Quinine , 1945 .

[811]  T. Imanishi,et al.  1, 6-DIHYDRO-3 (2H)-PYRIDINONES AS SYNTHETIC INTERMEDIATES. STEREOSELECTIVE SYNTHESIS OF (±)-CORYNANTHEIDOL AND (±)-QUININE , 1982 .

[812]  K. Nicolaou,et al.  Chemie und Biologie von Endiin‐Cytostatica/Antibiotica , 1991 .

[813]  R. Woodward,et al.  THE TOTAL SYNTHESIS OF QUININE1 , 1944 .

[814]  M. Isobe,et al.  Synthetic studies toward marine toxic polyethers (3) stereocontrol for segment-A1 of okadaic acid by means of oxymercuration and epoxydation , 1985 .

[815]  P. Jacobi,et al.  Formal Total Syntheses of the β-Lactam Antibiotics Thienamycin and PS-5 , 1996 .

[816]  W. Bornmann,et al.  Biomimetic alkaloid syntheses. 15. Enantioselective syntheses with epichlorohydrin: total syntheses of (+)-, (-)- and (.+-.)-vindoline and a synthesis of (-)-vindorosine , 1987 .

[817]  M. Tius,et al.  A novel approach to the synthesis of morphine alkaloids: the synthesis of (d,l)-thebainone-A , 1992 .

[818]  E. E. Tamelen.  BIOORGANIC CHARACTERIZATION AND MECHANISM OF THE 2,3-OXIDOSQUALENE → LANOSTEROL CONVERSION , 1983 .

[819]  K. Nicolaou,et al.  Total synthesis of calicheamicin .gamma.1I. 2. Development of an enantioselective route to (-)-calicheamicinone , 1993 .

[820]  K. Nicolaou,et al.  Total Synthesis of Taxol. 3. Formation of Taxol's ABC Ring Skeleton , 1995 .

[821]  E. Corey,et al.  Total synthesis of the quinonoid alcohol dehydrogenase coenzyme (1) of methylotrophic bacteria , 1981 .

[822]  K. Nicolaou,et al.  Gezielt entworfene Epothilone: kombinatorische Synthese, Induktion der Tubulin‐Polymerisation und cytotoxische Wirkung gegen taxolresistente Tumorzellen , 1997 .

[823]  L. Steinrauf,et al.  The structure of monensic acid, a new biologically active compound. , 1967, Journal of the American Chemical Society.

[824]  F. Hauser,et al.  Total syntheses of (.+-.)-duanomycinone. Regiospecific preparations of (.+-.)-7,9-dideoxydaunomycinone and 6,11-dihydroxy-4-methoxy-7,8,9,10-tetrahydronaphthacene-5,9,12-trione , 2002 .

[825]  P. A. Wallace,et al.  Total Synthesis of Brevetoxin A: Part 1: First Generation Strategy and Construction of BCD Ring System , 1999 .

[826]  C. R. Correia,et al.  Intramolecular photoinduced diene-diene cyaloadditions: a selective method for the synthesis of complex eight-membered rings and polyquinanes , 1987 .

[827]  P. D. Clercq.  Biotin: A Timeless Challenge for Total Synthesis , 1997 .

[828]  E. Corey,et al.  Short Enantioselective Synthesis of (-)-Ovalicin, a Potent Inhibitor of Angiogenesis, Using Substrate-Enhanced Catalytic Asymmetric Dihydroxylation , 1994 .

[829]  E. Corey,et al.  Enantioselective total synthesis of oleanolic acid, erythrodiol, .beta.-amyrin, and other pentacyclic triterpenes from a common intermediate , 1993 .

[830]  Yujia Dai,et al.  CARBOCYCLIC RING CONSTRUCTION VIA AN INTRAMOLECULAR DIELS-ALDER REACTION OF AN IN SITU-GENERATED, HETEROATOM-STABILIZED ALLYL CATION : TOTAL SYNTHESIS OF ()-LYCOPODINE , 1998 .

[831]  D. Hart,et al.  A Diels-Alder approach to Stemona alkaloids: total synthesis of stenine , 1993 .

[832]  J. Mendoza,et al.  Total synthesis of natural ambruticin , 1990 .

[833]  A. F. Peerdeman.  The absolute configuration of natural strychnine , 1956 .

[834]  E. Carreira,et al.  Synthesis of (+)-Zaragozic Acid C , 1994 .

[835]  M. Shibasaki,et al.  Formal Total Synthesis of (-)-Dendrobine Using Zirconium-Promoted Reductive Cyclization , 1994 .

[836]  Peter I. Dalko,et al.  Totalsynthese von Altohyrtin A (Spongistatin 1): Teil 1 , 1998 .

[837]  S. Schreiber,et al.  Total syntheses of Di- and tri-O-methyl dynemicin A methyl esters , 1993 .

[838]  D. Boger,et al.  Total Synthesis of Luzopeptins A−C , 1999 .

[839]  K. Nicolaou,et al.  Total Synthesis of Epothilone A: The Olefin Metathesis Approach , 1997 .

[840]  W. Greenlee,et al.  Marasmic acid—II : Total synthesis of (±)-marasmic acid , 1980 .

[841]  A. Armstrong,et al.  Total Synthesis of Avermectin B1a: Final Coupling Reactions and the Total Synthesis of Avermectin B1a Aglycone , 1990 .

[842]  Takeshi Matsumoto,et al.  A new synthesis of d1-coriolin A. Application of a new SN2 reaction at a neopentylic position , 1982 .

[843]  C. Bunn,et al.  XI. The X-Ray Crystallographic Investigation of the Structure of Penicillin , 1949 .

[844]  G. Stork,et al.  Letter: Chiral synthesis of prostaglandins from carbohydrates. Synthesis of (+)-15-(S)-prostaglandin A2. , 1976, Journal of the American Chemical Society.

[845]  G. Bazan,et al.  Synthesis of molybdenum imido alkylidene complexes and some reactions involving acyclic olefins , 1990 .

[846]  K. Nicolaou,et al.  Chemie und Biologie der Saragossasuren/Squalestatine , 1996 .

[847]  E. Corey,et al.  TOTAL SYNTHESIS OF APLASMOMYCIN , 1982 .

[848]  K. Memmert,et al.  Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. I. Taxonomy, fermentation, isolation and biological activity. , 1999, The Journal of antibiotics.

[849]  R. Sakai,et al.  Bioactive compounds from aquatic and terrestrial sources. , 1990, Journal of natural products.

[850]  E. Corey,et al.  A total synthesis of ( )-fumagillin. , 1972, Journal of the American Chemical Society.

[851]  Otto Diels,et al.  Synthesen in der hydroaromatischen Reihe , 1928 .

[852]  G. Just,et al.  A prostaglandin synthesis. , 1967, Tetrahedron letters.

[853]  E. Corey,et al.  Total synthesis of erythromycins. 3. Stereoselective routes to intermediates corresponding to C(1) to C(9) and C(10) to C(13) fragments of erythronolide B , 1978 .

[854]  K. Nicolaou,et al.  Total synthesis of calicheamicin .gamma.1I. 1. Synthesis of the oligosaccharide fragment , 1993 .

[855]  K. Nakatani,et al.  Synthetic studies on duocarmycin. 2. Synthesis and cytotoxicity of natural (+)-duocarmycin A and its three possible stereoisomers. , 1994 .

[856]  N. Langlois,et al.  A new efficient total synthesis of vindorosine and vindoline , 1985 .

[857]  H. Müller,et al.  Eine weitere Synthese von (±)‐Lycopodin , 1982 .

[858]  W. Hartwig.  Modern methods for the radical deoxygenation of alcohols , 1983 .

[859]  Peter I. Dalko,et al.  TOTALSYNTHESE VON ALTOHYRTIN A (SPONGISTATIN 1) : TEIL 2 , 1998 .

[860]  E. Corey,et al.  A biomimetic chemical synthesis of humulene from farnesol , 1993 .

[861]  R. Woodward,et al.  The penems, a new class of .beta.-lactam antibiotics. 3. Synthesis of optically active 2-methyl-(5R)-penem-3-carboxylic acid , 1979 .

[862]  R. Russell,et al.  Biogenetic-type total synthesis of (.+-.)-aphidicolin , 1983 .

[863]  M. Ohashi,et al.  Isoxazole annelation reaction. Method for the construction of cyclohexenone rings in polycyclic systems , 1967 .

[864]  R. Hughes,et al.  Total Synthesis of Vancomycin—Part 4: Attachment of the Sugar Moieties and Completion of the Synthesis , 1999 .

[865]  David A. Evans,et al.  Unkonventionelle stereochemische Fragestellungen bei der Planung der Synthese von Vancomycin‐Antibiotika: Herausforderungen durch axial‐ und nicht‐planar‐chirale Elemente der Heptapeptid‐Aglyconbausteine , 1998 .

[866]  G. Fallon,et al.  Constituents of Endiandra species. III. 4-[(E,E)-5'-Phenylpenta-2',4'-dien-1'-yl]tetra-cyclo[5,4,0,02,5,03,9]undec-10-ene-8-carboxylic acid from Endiandra introrsa (Lauraceae) , 1982 .

[867]  G. Stork,et al.  Stereoselective total syntheses of (plus minus)-yohimbine, (plus minus)-psi-yohimbine, and (plus minus)- -yohimbine. , 1972, Journal of the American Chemical Society.

[868]  N. Wendler,et al.  The total synthesis of (±) compactin and its natural (+) enantiomer , 1982 .

[869]  S. Danishefsky,et al.  A formal synthesis of FK-506. Exploration of some alternatives to macrolactamization , 1990 .

[870]  J. Clardy,et al.  Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria , 1981 .

[871]  M. Siegel,et al.  Calicheamicins, a novel family of antitumor antibiotics. 4. Structure elucidation of calicheamicins .beta.1Br, .gamma.1Br, .alpha.2I, .alpha.3I, .beta.1I, .gamma.1I, and .delta.1I , 1992 .

[872]  S. Martin,et al.  Vinylogous Mannich Reactions. The Asymmetric Total Synthesis of (+)-Croomine , 1996 .

[873]  K. Nicolaou,et al.  Total Synthesis of Vancomycin—Part 1: Design and Development of Methodology , 1999 .

[874]  K. Nicolaou,et al.  Radiofrequency Encoded Combinatorial Chemistry , 1995 .

[875]  Paul A. Keifer,et al.  Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata , 1990 .

[876]  Dirk Trauner,et al.  Formale Totalsynthese von (−)‐Morphin über konjugierte Cuprataddition , 1996 .

[877]  I. Ugi.  From Isocyanides via Four-Component Condensations to Antibiotic Syntheses†‡ , 1982 .

[878]  W. Bachmann,et al.  THE TOTAL SYNTHESIS OF THE SEX HORMONE EQUILENIN , 1939 .

[879]  A. Baeyer.  Synthese des Indigblaus , 1878 .

[880]  G. Quinkert,et al.  Ein photochemischer Weg zu (±)‐östron , 1980 .

[881]  Kwunmin Chen,et al.  Formal total synthesis of FK506. Concise construction of the C(10)-C(34) segment via an effective coupling tactic , 1994 .

[882]  P. Jadhav,et al.  Chiral synthesis via organoboranes. 6. Asymmetric allylboration via chiral allyldialkylboranes. Synthesis of homoallylic alcohols with exceptionally high enantiomeric excess , 1986 .

[883]  W. C. Still,et al.  Synthesis of the polyether antibiotic monensin. 1. Strategy and degradations , 1980 .

[884]  B. McCarry,et al.  Acetylenic bond participation in biomimetic polyene cyclizations. Model studies directed toward the synthesis of 20-keto steroids. Synthesis of dl-progesterone and dl-.DELTA.4-androstene-3,17-dione , 1978 .

[885]  D. Hodgkin,et al.  The x-ray analysis of the structure of cephalosporin C. , 1961, The Biochemical journal.

[886]  T. Imanishi,et al.  A FORMAL TOTAL SYNTHESIS OF (±)-QUADRONE , 1985 .

[887]  Roessner Ca,et al.  GENETICALLY ENGINEERED SYNTHESIS OF NATURAL PRODUCTS: From Alkaloids to Corrins , 1996 .

[888]  D. N. Deaton,et al.  Synthesis of (+)-dihydrocompactin and (+)-compactin via vinylsilane terminated cationic cyclization , 1991 .

[889]  P. Botschwina,et al.  Cyanoisocyanoacetylene, NC—CC—NC. , 1999 .

[890]  K. Nicolaou,et al.  Total synthesis of amphoteronolide B and amphotericin B. 2. Total synthesis of amphoteronolide B , 1988 .

[891]  R. Woodward,et al.  THE SYNTHESIS OF LANOSTENOL , 1954 .

[892]  R. S. Coleman,et al.  Total synthesis of (+)-CC-1065 and ent-(-)-CC-1065 , 1988 .

[893]  J. G. Cumming,et al.  The total synthesis of swinholide A. Part 1: A stereocontrolled synthesis of a C19-C32 segment , 1995 .

[894]  S. Bräse,et al.  Chemie, Biologie und medizinische Anwendungen der Glycopeptid-Antibiotika , 1999 .

[895]  E. Corey,et al.  Total synthesis of prostaglandins F2-alpha and E2 as the naturally occurring forms. , 1970, Journal of the American Chemical Society.

[896]  E. Corey,et al.  Total synthesis of leukotrienes. An effective procedure for the synthesis of conjugated dienals by four-carbon homologation , 1983 .

[897]  Andreas Fath,et al.  Doppelhelicale zweikernige Kupfer(I)‐Komplexe mit makrocyclischen Bis(dithiadiimin)‐Liganden , 1995 .

[898]  E. Corey,et al.  Generation and synthetic applications of 2-lithio-1,3-dithianes , 1975 .

[899]  S. Rychnovsky,et al.  Iterative butenolide construction of polypropionate chains , 1987 .

[900]  J. D. Willett,et al.  Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol. , 1966, Journal of the American Chemical Society.

[901]  W. Wierenga,et al.  Biogenetic-type total synthesis. .delta.-Amyrin, .beta.-amyrin, and germanicol , 1972 .

[902]  A. Takai,et al.  Inhibitory effect of okadaic acid on the p-nitrophenyl phosphate phosphatase activity of protein phosphatases. , 1991, The Biochemical journal.

[903]  E. Corey,et al.  A simplified synthesis of (+)-brefeldin A , 1990 .

[904]  C. Walsh,et al.  Harnessing the biosynthetic code: combinations, permutations, and mutations. , 1998, Science.

[905]  K. Nicolaou,et al.  Chemie und Biologie von Taxol , 1994 .

[906]  Friedrich Wöhler,et al.  Ueber künstliche Bildung des Harnstoffs , 1828 .

[907]  R. Sakai,et al.  Manzamine A, a novel antitumor alkaloid from a sponge , 1986 .

[908]  A. Eschenmoser.  Vitamin B12: Experiments Concerning the Origin of Its Molecular Structure , 1988 .

[909]  W. S. Johnson.  Nonenzymic biogenetic-like olefinic cyclizations , 1968 .

[910]  Guncheol Kim,et al.  Stereocontrolled synthesis of disaccharides via the temporary silicon connection , 1992 .

[911]  K. Nicolaou,et al.  Total Synthesis of Swinholide A , 1996 .

[912]  E. J. Corey,et al.  Eine effiziente und kurze enantioselektive Totalsynthese von Lactacystin , 1998 .

[913]  G. Sauer,et al.  Synthese von D‐Norgestrel , 1975 .

[914]  K. Rice.  Synthetic opium alkaloids and derivatives. A short total synthesis of (.+-.)-dihydrothebainone, (.+-.)-dihydrocodeinone, and (.+-.)-nordihydrocodeinone as an approach to a practical synthesis of morphine, codeine, and congeners , 1980 .

[915]  K. Nicolaou,et al.  SYNTHESIS OF THE TRICYCLIC CORE OF ELEUTHEROBIN AND SARCODICTYINS AND TOTAL SYNTHESIS OF SARCODICTYIN A , 1997 .

[916]  J. Winkler,et al.  Stereochemical control of intramolecular conjugate addition. A short, highly stereoselective synthesis of adrenosterone , 1982 .