Magneto-Impedance Biosensor With Enhanced Sensitivity for Highly Sensitive Detection of Nanomag-D Beads

A magnetoimpedance (MI) biosensor based on Co-based amorphous ribbon was designed and tested to detect functionalized Nanomag-D magnetic beads. While previous studies were focused mainly on exploring the MI change for biosensing, we show that the sensitivity of the biosensor can be enhanced when the change in ac magnetoresistance (MR) or magnetoreactance (MX) is used. The frequency at which the sensitivity of the sensor is optimized can be tuned. This is of potential interest in developing functional biosensors with improved sensitivity and tunable frequency.

[1]  Hua-Xin Peng,et al.  Giant magnetoimpedance materials: Fundamentals and applications , 2008 .

[2]  M. McHenry,et al.  Enhanced giant magnetoimpedance effect and field sensitivity in Co-coated soft ferromagnetic amorphous ribbons , 2011 .

[3]  Shyam S. Mohapatra,et al.  Magnetoimpedance biosensor for Fe3O4 nanoparticle intracellular uptake evaluation , 2007 .

[4]  D. Drung,et al.  Highly Sensitive and Easy-to-Use SQUID Sensors , 2007, IEEE Transactions on Applied Superconductivity.

[5]  Ding Li,et al.  A prototype of giant magnetoimpedance-based biosensing system for targeted detection of gastric cancer cells. , 2011, Biosensors & bioelectronics.

[6]  R. Ivkov,et al.  Development of Tumor Targeting Bioprobes (111In-Chimeric L6 Monoclonal Antibody Nanoparticles) for Alternating Magnetic Field Cancer Therapy , 2005, Clinical Cancer Research.

[7]  J. Kosel,et al.  A half-ring GMR sensor for detection of magnetic beads immobilized on a circular micro-trap , 2011, 2011 Fifth International Conference on Sensing Technology.

[8]  L. Whitman,et al.  Magnetic labeling, detection, and system integration. , 2008, Biosensors & bioelectronics.

[9]  A P Turner,et al.  Biosensors--Sense and Sensitivity , 2000, Science.

[10]  Galina V. Kurlyandskaya Giant magnetoimpedance for biosensing : Advantages and shortcomings , 2009 .

[11]  Ding Li,et al.  Giant magnetoimpedance-based microchannel system for quick and parallel genotyping of human papilloma virus type 16/18 , 2010 .

[12]  Paolo Vavassori,et al.  Nanosized corners for trapping and detecting magnetic nanoparticles , 2009, Nanotechnology.

[13]  J. C. Rifea,et al.  Design and performance of GMR sensors for the detection of magnetic microbeads in biosensors , 2003 .

[14]  B. M. de Boer,et al.  An integrated and sensitive detection platform for magneto-resistive biosensors. , 2007, Biosensors & bioelectronics.

[15]  Horia Chiriac,et al.  Microwire array for giant magneto-impedance detection of magnetic particles for biosensor prototype , 2007 .

[16]  Gil U. Lee,et al.  A biosensor based on magnetoresistance technology. , 1998, Biosensors & bioelectronics.

[17]  Paul E. Sheehan,et al.  A DNA array sensor utilizing magnetic microbeads and magnetoelectronic detection , 2001 .

[18]  G. Hadjipanayis,et al.  Development of heparin-coated magnetic nanoparticles for targeted drug delivery applications , 2009 .

[19]  G. Kurlyandskaya,et al.  Magnetic Dynabeads detection by sensitive element based on giant magnetoimpedance. , 2005, Biosensors & bioelectronics.