Clinical and Microcomputed Topography Evaluation of the Concentrated Growth Factors as a Sole Material in a Cystic Bony Defect in Alveolar Bone Followed by Dental Implantation: A Case Report

Concentrated growth factors (CGFs) can be used to enhance wound healing. This case report describes a short-term effect of CGF grafting followed by implant placement in a cystic bony defect within the mandible. Healing conditions were monitored by 2 implant-related surgeries, radiographs, and a microcomputed topography examination. Continuous increase of radiopacity in radiographs was noticed till 6 months after grafting. Bone core specimen was taken at 3.5 months after grafting, and percent bone volume reached 32.7% analyzed by microcomputed topography. In conclusion, the present case showed bone regeneration in the cystic bony defect grafted by CGFs alone.

[1]  Takashi Inoue,et al.  The Effect of Concentrated Growth Factor on Rat Bone Marrow Cells In Vitro and on Calvarial Bone Healing In Vivo. , 2015, The International journal of oral & maxillofacial implants.

[2]  Yoon Jeong Kim,et al.  Micro-computed tomography assessment of human alveolar bone: bone density and three-dimensional micro-architecture. , 2015, Clinical implant dentistry and related research.

[3]  J. Yang,et al.  Antimicrobial activity of platelet-rich plasma and other plasma preparations against periodontal pathogens. , 2015, Journal of periodontology.

[4]  Yu-Chao Chang,et al.  Management of radicular cysts using platelet-rich fibrin and bioactive glass: a report of two cases. , 2014, Journal of the Formosan Medical Association = Taiwan yi zhi.

[5]  G. Sàndor,et al.  Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing. , 2014, Archives of oral biology.

[6]  H. Greenwell,et al.  Platelet-rich plasma-assisted guided bone regeneration for ridge augmentation: a randomized, controlled clinical trial. , 2014, Journal of periodontology.

[7]  Ju-hyoung Lee,et al.  Flapless Transcrestal Sinus Augmentation Using Hydrodynamic Piezoelectric Internal Sinus Elevation With Autologous Concentrated Growth Factors Alone , 2014, Implant dentistry.

[8]  R. Sader,et al.  Jaw cysts - filling or no filling after enucleation? A review. , 2012, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[9]  C. Chung,et al.  The evaluation of the correlation between histomorphometric analysis and micro-computed tomography analysis in AdBMP-2 induced bone regeneration in rat calvarial defects , 2011, Journal of periodontal & implant science.

[10]  Ju-hyoung Lee,et al.  Bone Regeneration in the Maxillary Sinus Using an Autologous Fibrin-Rich Block With Concentrated Growth Factors Alone , 2011, Implant dentistry.

[11]  Ki-Hyun Kim,et al.  Removal of Displaced Foreign Body From the Maxillary Sinus Using Replaceable Bony Windows and Saline Irrigation, Followed by Suctioning of the Foreign Body , 2011, Implant dentistry.

[12]  E. Hunziker,et al.  The influence of PRP on early bone formation in membrane protected defects. A histological and histomorphometric study in the rabbit calvaria. , 2011, Clinical implant dentistry and related research.

[13]  I. Springer,et al.  Platelet-rich plasma and platelet-rich fibrin in human cell culture. , 2009, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[14]  D. M. Dohan Ehrenfest,et al.  Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies , 2009, Growth factors.

[15]  G. Ambrosano,et al.  Platelet-rich plasma may not provide any additional effect when associated with guided bone regeneration around dental implants in dogs. , 2007, Clinical oral implants research.

[16]  R. Müller,et al.  Diagnostic value of micro-CT in comparison with histology in the qualitative assessment of historical human skull bone pathologies. , 2007, American journal of physical anthropology.

[17]  A. Kantarcı,et al.  Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties. , 2007, Journal of periodontology.

[18]  A. Dohan,et al.  Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. , 2006, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[19]  A. Dohan,et al.  Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. , 2006, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[20]  A. Dohan,et al.  Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. , 2006, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[21]  A. Dohan,et al.  Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. , 2006, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[22]  A. Dohan,et al.  Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? , 2006, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[23]  D. Buser,et al.  Bone regeneration in standardized bone defects with autografts or bone substitutes in combination with platelet concentrate: a histologic and histomorphometric study in the mandibles of minipigs. , 2005, The International journal of oral & maxillofacial implants.

[24]  I. Martineau,et al.  Platelet-rich Plasmas: Growth Factor Content and Roles in Wound Healing , 2005, Journal of dental research.

[25]  J. Choukroun,et al.  Une opportunite´ en paro-implantologie: Le PRF , 2001 .

[26]  M. Reynolds,et al.  Alveolar ridge and sinus augmentation utilizing platelet-rich plasma in combination with freeze-dried bone allograft: case series. , 2000, Journal of periodontology.

[27]  M. Chiapasco,et al.  Spontaneous bone regeneration after enucleation of large mandibular cysts: a radiographic computed analysis of 27 consecutive cases. , 2000, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[28]  M. Karpatkin,et al.  Risks of using platelet rich plasma gel. , 1998, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[29]  R. Marx,et al.  Platelet-rich plasma: Growth factor enhancement for bone grafts. , 1998, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[30]  L. Bodner.  Osseous regeneration in the jaws using demineralized allogenic bone implants. , 1998, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[31]  L. Bodner.  Effect of decalcified freeze-dried bone allograft on the healing of jaw defects after cyst enucleation. , 1996, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[32]  P. Sheridan,et al.  Is platelet-rich plasma the perfect enhancement factor? A current review. , 2003, The International journal of oral & maxillofacial implants.