Blunted type-5 metabotropic glutamate receptor-mediated polyphosphoinositide hydrolysis in two mouse models of monogenic autism
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A. Arena | G. Battaglia | V. Bruno | M. V. Catania | C. Bonaccorso | R. Orlando | L. Di Menna | F. Nicoletti | M. Spatuzza | A. Zuena | M. Alborghetti | R. Celli | M. Scioli | Agata Machaczka | R. P. Ginerete | Giovanna D'Errico | Eleonora Ciocca | Rosamaria Orlando | Luisa Di Menna
[1] R. Kooy,et al. Towards Kinase Inhibitor Therapies for Fragile X Syndrome: Tweaking Twists in the Autism Spectrum Kinase Signaling Network , 2022, Cells.
[2] James Robert Brašić,et al. Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study , 2022, Brain sciences.
[3] A. Brownell,et al. Longitudinal PET studies of mGluR5 in FXS using an FMR1 knockout mouse model , 2022, Translational neuroscience.
[4] M. Bear,et al. mGluR5 Negative Modulators for Fragile X: Treatment Resistance and Persistence , 2021, Frontiers in Psychiatry.
[5] G. Fakhri,et al. In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker , 2021, Scientific Reports.
[6] James Robert Brašić,et al. Reduced Expression of Cerebral Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome , 2020, Brain sciences.
[7] D. Alkon,et al. Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice , 2020, Scientific Reports.
[8] Qi Ding,et al. Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model , 2020, Communications Biology.
[9] S. Jacquemont,et al. Mavoglurant in Fragile X Syndrome: Results of two open-label, extension trials in adults and adolescents , 2018, Scientific Reports.
[10] Alcino J. Silva,et al. The mouse as a model for neuropsychiatric drug development , 2018, Current Biology.
[11] F. Nicoletti,et al. In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator , 2018, Front. Pharmacol..
[12] E. Klann,et al. Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model , 2018, Neuropsychopharmacology.
[13] Mark F. Bear,et al. Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome , 2017, Nature Reviews Drug Discovery.
[14] A. Frick,et al. Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice , 2017, Nature Communications.
[15] Michael Rabbia,et al. Effect of the mGluR5-NAM Basimglurant on Behavior in Adolescents and Adults with Fragile X Syndrome in a Randomized, Double-Blind, Placebo-Controlled Trial: FragXis Phase 2 Results , 2017, Neuropsychopharmacology.
[16] K. Gregory,et al. Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery , 2017, Neuropharmacology.
[17] M. Bear,et al. β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X. , 2017, Cell reports.
[18] M. Bear,et al. Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome , 2016, The Journal of Neuroscience.
[19] M. Bennett,et al. Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice , 2016, Proceedings of the National Academy of Sciences.
[20] L. Ceolin,et al. Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model. , 2015, Cell reports.
[21] Seth M. Kelly,et al. Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome. , 2015, Cell reports.
[22] Andrew S. Felts,et al. Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles , 2015, Neuropsychopharmacology.
[23] F. Nicoletti,et al. Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740 , 2014, Neuropharmacology.
[24] S. Musumeci,et al. Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism , 2014, Neuroscience & Biobehavioral Reviews.
[25] P. Hickmott,et al. Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model , 2014, The Journal of Neuroscience.
[26] F. Nicoletti,et al. Changes in mGlu5 Receptor-Dependent Synaptic Plasticity and Coupling to Homer Proteins in the Hippocampus of Ube3A Hemizygous Mice Modeling Angelman Syndrome , 2014, The Journal of Neuroscience.
[27] E. Klann,et al. Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice , 2012, Neuron.
[28] M. Bear,et al. Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice , 2012, Neuron.
[29] C. B. Smith,et al. Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome , 2012, Neurobiology of Disease.
[30] P. Worley,et al. Disrupted mGluR5-Homer scaffolds mediate abnormal mGluR5 signaling, circuit function and behavior in a mouse model of Fragile X Syndrome , 2012, Nature Neuroscience.
[31] F. Nicoletti,et al. Metabotropic glutamate receptors: From the workbench to the bedside , 2011, Neuropharmacology.
[32] P Jeffrey Conn,et al. Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity , 2010, Molecular Pharmacology.
[33] M. Bear,et al. Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome , 2010, The Journal of Neuroscience.
[34] Mika Nakamoto,et al. Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome , 2010, The Journal of Neuroscience.
[35] E. Klann,et al. Dysregulation of mTOR Signaling in Fragile X Syndrome , 2010, The Journal of Neuroscience.
[36] J. Zhu,et al. Ras Signaling Mechanisms Underlying Impaired GluR1-Dependent Plasticity Associated with Fragile X Syndrome , 2008, The Journal of Neuroscience.
[37] I. Weiler,et al. Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome , 2008, Proceedings of the National Academy of Sciences.
[38] W. Lee,et al. Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55α Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt* , 2008, Journal of Biological Chemistry.
[39] K. M. Huber,et al. Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation , 2008, The Journal of Neuroscience.
[40] Mark F. Bear,et al. Correction of Fragile X Syndrome in Mice , 2007, Neuron.
[41] Richard Paylor,et al. Dynamic Translational and Proteasomal Regulation of Fragile X Mental Retardation Protein Controls mGluR-Dependent Long-Term Depression , 2006, Neuron.
[42] B. Oostra,et al. A Reduced Number of Metabotropic Glutamate Subtype 5 Receptors Are Associated with Constitutive Homer Proteins in a Mouse Model of Fragile X Syndrome , 2005, The Journal of Neuroscience.
[43] J. Mandel,et al. FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts. , 2005, Human molecular genetics.
[44] Q. Tang,et al. The Scaffold Protein Homer1b/c Links Metabotropic Glutamate Receptor 5 to Extracellular Signal-Regulated Protein Kinase Cascades in Neurons , 2005, The Journal of Neuroscience.
[45] Mark F Bear,et al. The mGluR theory of fragile X mental retardation , 2004, Trends in Neurosciences.
[46] E. Nagata,et al. PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis , 2003, Nature Neuroscience.
[47] Mark F. Bear,et al. Altered synaptic plasticity in a mouse model of fragile X mental retardation , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[48] M. Berridge,et al. The versatility and universality of calcium signalling , 2000, Nature Reviews Molecular Cell Biology.
[49] C. Barnes,et al. Homer: a protein that selectively binds metabotropic glutamate receptors , 1997, Nature.
[50] T. Knöpfel,et al. Expression and Coupling to Polyphosphoinositide Hydrolysis of Group I Metabotropic Glutamate Receptors in Early Postnatal and Adult Rat Brain , 1997, The European journal of neuroscience.
[51] R. Belmaker,et al. Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex , 1988, Nature.
[52] E. Costa,et al. Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors. , 1986, Proceedings of the National Academy of Sciences of the United States of America.