Identification of inhibitors for the transmembrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation

[1]  D. A. Gomes,et al.  Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites , 2022, mBio.

[2]  E. Chatelain,et al.  The Chagas disease study landscape: A systematic review of clinical and observational antiparasitic treatment studies to assess the potential for establishing an individual participant-level data platform , 2021, PLoS neglected tropical diseases.

[3]  B. McGwire,et al.  Cyclophilin 19 secreted in the host cell cytosol by Trypanosoma cruzi promotes ROS production required for parasite growth , 2020, Cellular microbiology.

[4]  Mark C. Field,et al.  EIF2α phosphorylation is regulated in intracellular amastigotes for the generation of infective Trypanosoma cruzi trypomastigote forms , 2020, Cellular microbiology.

[5]  Normanda Souza-Melo,et al.  GCN2-Like Kinase Modulates Stress Granule Formation During Nutritional Stress in Trypanosoma cruzi , 2020, Frontiers in Cellular and Infection Microbiology.

[6]  A. Komar,et al.  A Retrospective on eIF2A—and Not the Alpha Subunit of eIF2 , 2020, International journal of molecular sciences.

[7]  B. Garat,et al.  Upstream ORFs Influence Translation Efficiency in the Parasite Trypanosoma cruzi , 2020, Frontiers in Genetics.

[8]  S. Favaro,et al.  Quantitative , 2020, Psychology through Critical Auto-Ethnography.

[9]  Y. Hashem,et al.  Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts , 2019, bioRxiv.

[10]  Jadel Müller Kratz.  Drug discovery for chagas disease: A viewpoint. , 2019, Acta tropica.

[11]  K. Matthews,et al.  An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei , 2019, bioRxiv.

[12]  C. Clayton.  Regulation of gene expression in trypanosomatids: living with polycistronic transcription , 2019, Open Biology.

[13]  E. Chatelain,et al.  Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection , 2019, Tropical medicine and infectious disease.

[14]  Maria Paola Costi,et al.  Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform , 2019, SLAS discovery : advancing life sciences R & D.

[15]  D. Lamont,et al.  Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix , 2019, PLoS neglected tropical diseases.

[16]  G. Cerqueira,et al.  Whole genome sequencing of Trypanosoma cruzi field isolates reveals extensive genomic variability and complex aneuploidy patterns within TcII DTU , 2018, BMC Genomics.

[17]  M. Fresno,et al.  Genomic assemblies of newly sequenced Trypanosoma cruzi strains reveal new genomic expansion and greater complexity , 2018, Scientific Reports.

[18]  Qi Wu,et al.  COACH-D: improved protein–ligand binding sites prediction with refined ligand-binding poses through molecular docking , 2018, Nucleic Acids Res..

[19]  A. Ishida,et al.  Facile preparation of highly active casein kinase 1 using Escherichia coli constitutively expressing lambda phosphatase. , 2018, Analytical biochemistry.

[20]  D. Bartholomeu,et al.  Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection , 2017, PLoS pathogens.

[21]  M. Krieger,et al.  Quantitative proteome and phosphoproteome analyses highlight the adherent population during Trypanosoma cruzi metacyclogenesis , 2017, Scientific Reports.

[22]  M. Krieger,et al.  Quantitative proteome and phosphoproteome analyses highlight the adherent population during Trypanosoma cruzi metacyclogenesis , 2017, Scientific Reports.

[23]  L. Pacheco-Lugo,et al.  Effective gene delivery to Trypanosoma cruzi epimastigotes through nucleofection. , 2017, Parasitology international.

[24]  M. Cassera,et al.  Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch in Trypanosoma cruzi epimastigotes , 2017, The Journal of Biological Chemistry.

[25]  Mila Ljujic,et al.  The integrated stress response , 2016, EMBO reports.

[26]  Marco Y. Hein,et al.  The Perseus computational platform for comprehensive analysis of (prote)omics data , 2016, Nature Methods.

[27]  K. Gull,et al.  The Flagellum Attachment Zone: ‘The Cellular Ruler’ of Trypanosome Morphology , 2016, Trends in parasitology.

[28]  José A. Dianes,et al.  2016 update of the PRIDE database and its related tools , 2016, Nucleic Acids Res..

[29]  R. Docampo,et al.  CRISPR/Cas9-Induced Disruption of Paraflagellar Rod Protein 1 and 2 Genes in Trypanosoma cruzi Reveals Their Role in Flagellar Attachment , 2015, mBio.

[30]  M. Shapira,et al.  The eIF3 complex of Leishmania—subunit composition and mode of recruitment to different cap-binding complexes , 2015, Nucleic acids research.

[31]  S. Goldenberg,et al.  Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi , 2015, BMC Genomics.

[32]  Ho Jeong Kwon,et al.  Target deconvolution of bioactive small molecules: the heart of chemical biology and drug discovery , 2015, Archives of Pharmacal Research.

[33]  Min Zhang,et al.  A Membrane-bound eIF2 Alpha Kinase Located in Endosomes Is Regulated by Heme and Controls Differentiation and ROS Levels in Trypanosoma cruzi , 2015, PLoS pathogens.

[34]  S. P. Kurup,et al.  CRISPR-Cas9-Mediated Single-Gene and Gene Family Disruption in Trypanosoma cruzi , 2014, mBio.

[35]  Christian R S Reis,et al.  The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates – identification of conserved and divergent features based on orthologue analysis , 2014, BMC Genomics.

[36]  S. Pantano,et al.  Identification of novel cyclic nucleotide binding proteins in Trypanosoma cruzi. , 2014, Molecular and biochemical parasitology.

[37]  P. Roepstorff,et al.  Quantitative Proteomic and Phosphoproteomic Analysis of Trypanosoma cruzi Amastigogenesis* , 2014, Molecular & Cellular Proteomics.

[38]  Alan G Hinnebusch,et al.  The scanning mechanism of eukaryotic translation initiation. , 2014, Annual review of biochemistry.

[39]  R. Zahedi,et al.  Impact of digestion conditions on phosphoproteomics. , 2014, Journal of proteome research.

[40]  E. Chatelain,et al.  Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development , 2014, Scientific Reports.

[41]  Yang Zhang,et al.  Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment , 2013, Bioinform..

[42]  A. Chang,et al.  Molecular mechanisms of action and potential biomarkers of growth inhibition of dasatinib (BMS-354825) on hepatocellular carcinoma cells , 2013, BMC Cancer.

[43]  P. Clemons,et al.  Target identification and mechanism of action in chemical biology and drug discovery. , 2013, Nature chemical biology.

[44]  Sanjeev Gupta,et al.  The eIF2α kinases: their structures and functions , 2013, Cellular and Molecular Life Sciences.

[45]  Chih-Hao Lee,et al.  Host metabolism regulates intracellular growth of Trypanosoma cruzi. , 2013, Cell host & microbe.

[46]  S. Goldenberg,et al.  Quantitative proteomics of Trypanosoma cruzi during metacyclogenesis , 2012, Proteomics.

[47]  Shao Q Yao,et al.  Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. , 2012, Journal of the American Chemical Society.

[48]  S. Knapp,et al.  Analysis of conditions affecting auto-phosphorylation of human kinases during expression in bacteria , 2012, Protein Expression and Purification.

[49]  B. A. Castilho,et al.  Protein Synthesis Attenuation by Phosphorylation of eIF2α Is Required for the Differentiation of Trypanosoma cruzi into Infective Forms , 2011, PloS one.

[50]  D. Bartholomeu,et al.  Genomic Analyses, Gene Expression and Antigenic Profile of the Trans-Sialidase Superfamily of Trypanosoma cruzi Reveal an Undetected Level of Complexity , 2011, PloS one.

[51]  M. Mann,et al.  Profiling the Trypanosoma cruzi Phosphoproteome , 2011, PloS one.

[52]  M. Salit,et al.  Synthetic Spike-in Standards for Rna-seq Experiments Material Supplemental Open Access License Commons Creative , 2022 .

[53]  D. Ron,et al.  The structure of the PERK kinase domain suggests the mechanism for its activation. , 2011, Acta crystallographica. Section D, Biological crystallography.

[54]  J. Coura,et al.  Chagas disease: 100 years after its discovery. A systemic review. , 2010, Acta tropica.

[55]  R. Jackson,et al.  The mechanism of eukaryotic translation initiation and principles of its regulation , 2010, Nature Reviews Molecular Cell Biology.

[56]  Peter M. Rice,et al.  The Sanger FASTQ file format for sequences with quality scores, and the Solexa/Illumina FASTQ variants , 2009, Nucleic acids research.

[57]  Eileen Kraemer,et al.  TriTrypDB: a functional genomic resource for the Trypanosomatidae , 2009, Nucleic Acids Res..

[58]  D. B. Weatherly,et al.  The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi , 2009, BMC Genomics.

[59]  M. Mann,et al.  MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification , 2008, Nature Biotechnology.

[60]  P. O'Connor,et al.  Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1 , 2008, Molecular Cancer Therapeutics.

[61]  S. Schenkman,et al.  Active transcription and ultrastructural changes during Trypanosoma cruzi metacyclogenesis. , 2008, Anais da Academia Brasileira de Ciencias.

[62]  B. A. Castilho,et al.  Novel Membrane-Bound eIF2α Kinase in the Flagellar Pocket of Trypanosoma brucei , 2007, Eukaryotic Cell.

[63]  Carol V Robinson,et al.  Structural Characterization of the Human Eukaryotic Initiation Factor 3 Protein Complex by Mass Spectrometry*S , 2007, Molecular & Cellular Proteomics.

[64]  C. Ho,et al.  Trypanosoma brucei Encodes a Bifunctional Capping Enzyme Essential for Cap 4 Formation on the Spliced Leader RNA* , 2007, Journal of Biological Chemistry.

[65]  Zheng Yang,et al.  Dasatinib (BMS-354825) Pharmacokinetics and Pharmacodynamic Biomarkers in Animal Models Predict Optimal Clinical Exposure , 2006, Clinical Cancer Research.

[66]  M. Parsons,et al.  Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi , 2005, BMC Genomics.

[67]  Ping Chen,et al.  Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor , 2004, Science.

[68]  J. Bangs,et al.  A Soluble Secretory Reporter System in Trypanosoma brucei , 1996, The Journal of Biological Chemistry.

[69]  S. Schenkman,et al.  A proteolytic fragment of Trypanosoma cruzi trans-sialidase lacking the carboxyl-terminal domain is active, monomeric, and generates antibodies that inhibit enzymatic activity. , 1994, The Journal of biological chemistry.

[70]  G. Cross,et al.  Rapid isolation of DNA from trypanosomatid protozoa using a simple 'mini-prep' procedure. , 1993, Molecular and biochemical parasitology.

[71]  E. Camargo.  GROWTH AND DIFFERENTIATION IN TRYPANOSOMA CRUZI. I. ORIGIN OF METACYCLIC TRYPANOSOMES IN LIQUID MEDIA. , 1964, Revista do Instituto de Medicina Tropical de Sao Paulo.

[72]  Wei Zhang,et al.  eIF3a: A new anticancer drug target in the eIF family. , 2018, Cancer letters.

[73]  S. Goldenberg,et al.  Biological aspects of the Dm 28c clone of Trypanosoma cruzi after metacyclogenesis in chemically defined media. , 1988, Memorias do Instituto Oswaldo Cruz.