MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling

[1]  Dominic J. B. Hunter,et al.  Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88 , 2018, BMC Biology.

[2]  D. Klenerman,et al.  Single-Molecule Light-Sheet Imaging of Suspended T Cells. , 2018, Biophysical journal.

[3]  Nils A. Berglund,et al.  Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub , 2018, eLife.

[4]  Conrad C. Huang,et al.  UCSF ChimeraX: Meeting modern challenges in visualization and analysis , 2018, Protein science : a publication of the Protein Society.

[5]  F. Dimaio,et al.  Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling , 2017, Nature Structural &Molecular Biology.

[6]  I. Fraser,et al.  Systematic Investigation of Multi-TLR Sensing Identifies Regulators of Sustained Gene Activation in Macrophages. , 2017, Cell systems.

[7]  Markus Stabrin,et al.  High-resolution Single Particle Analysis from Electron Cryo-microscopy Images Using SPHIRE , 2017, Journal of visualized experiments : JoVE.

[8]  D. Agard,et al.  MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy , 2017, Nature Methods.

[9]  David J. Fleet,et al.  cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination , 2017, Nature Methods.

[10]  Sjors H.W. Scheres,et al.  Helical reconstruction in RELION , 2016, bioRxiv.

[11]  L. Joosten,et al.  Toll-like receptors and chronic inflammation in rheumatic diseases: new developments , 2016, Nature Reviews Rheumatology.

[12]  J. Tavernier,et al.  Reconstructing the TIR Side of the Myddosome: a Paradigm for TIR-TIR Interactions. , 2016, Structure.

[13]  Kai Zhang,et al.  Gctf: Real-time CTF determination and correction , 2015, bioRxiv.

[14]  Charlotta P. I. Schärfe,et al.  Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization. , 2014, Blood.

[15]  Matthew L. Baker,et al.  An atomic model of brome mosaic virus using direct electron detection and real-space optimization , 2014, Nature Communications.

[16]  Martyn F. Symmons,et al.  Assembly and localization of Toll-like receptor signalling complexes , 2014, Nature Reviews Immunology.

[17]  Uri Alon,et al.  Evolution of Bow-Tie Architectures in Biology , 2014, PLoS Comput. Biol..

[18]  Sjors H.W. Scheres,et al.  RELION: Implementation of a Bayesian approach to cryo-EM structure determination , 2012, Journal of structural biology.

[19]  N. Harris,et al.  MYD88 L265P somatic mutation in Waldenström's macroglobulinemia. , 2012, The New England journal of medicine.

[20]  R. Jerala,et al.  Toll/Interleukin-1 Receptor Domain Dimers as the Platform for Activation and Enhanced Inhibition of Toll-like Receptor Signaling* , 2012, The Journal of Biological Chemistry.

[21]  Joseph M. Connors,et al.  Oncogenically active MYD88 mutations in human lymphoma , 2011, Nature.

[22]  Y. Lo,et al.  Helical assembly in the MyD88:IRAK4:IRAK2 complex in TLR/IL-1R signaling , 2010, Nature.

[23]  P. Emsley,et al.  Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.

[24]  C. Robinson,et al.  An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4* , 2009, The Journal of Biological Chemistry.

[25]  M. Fischer,et al.  Toll‐like Receptors in Autoimmunity , 2008, Annals of the New York Academy of Sciences.

[26]  G. Mor,et al.  Cancers take their Toll—the function and regulation of Toll-like receptors in cancer cells , 2008, Oncogene.

[27]  T. Nishiya,et al.  Distinct roles of TIR and non‐TIR regions in the subcellular localization and signaling properties of MyD88 , 2007, FEBS letters.

[28]  H. H. Park,et al.  Serveur Académique Lausannois SERVAL serval.unil.ch , 2022 .

[29]  R. Medzhitov,et al.  Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling , 2006, Cell.

[30]  S. Akira,et al.  Pathogen Recognition and Innate Immunity , 2006, Cell.

[31]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[32]  B. Beutler,et al.  Inferences, questions and possibilities in Toll-like receptor signalling , 2004, Nature.

[33]  Polly Matzinger,et al.  Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses , 2004, Nature Reviews Immunology.

[34]  P. Schuck On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation. , 2003, Analytical biochemistry.

[35]  K. Burns,et al.  Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4 , 2003, The Journal of experimental medicine.

[36]  T. Mak,et al.  Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4 , 2002, Nature.

[37]  A. Vagin,et al.  Spherically averaged phased translation function and its application to the search for molecules and fragments in electron-density maps. , 2001, Acta crystallographica. Section D, Biological crystallography.

[38]  C. Weber,et al.  The death domain superfamily: a tale of two interfaces? , 2001, Trends in biochemical sciences.

[39]  E. Egelman A robust algorithm for the reconstruction of helical filaments using single-particle methods. , 2000, Ultramicroscopy.

[40]  P. Schuck,et al.  Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. , 2000, Biophysical journal.

[41]  S. Fakan,et al.  Ultrastructural distribution of the death-domain-containing MyD88 protein in HeLa cells. , 1998, Experimental cell research.

[42]  C. Janeway,et al.  MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. , 1998, Molecular cell.

[43]  D. Bray,et al.  Receptor clustering as a cellular mechanism to control sensitivity , 1998, Nature.

[44]  Z. Cao,et al.  MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. , 1997, Immunity.

[45]  N. Gay,et al.  Drosophila Toll and IL-1 receptor , 1991, Nature.

[46]  J. Adler,et al.  The Range of Attractant Concentrations for Bacterial Chemotaxis and the Threshold and Size of Response over This Range , 1973, The Journal of general physiology.

[47]  Vincent B. Chen,et al.  Acta Crystallographica Section D Biological , 2001 .