Graft-versus-host disease.

measuring quality in medical articles) described a study of publications on schistosomiasis.'7 The articles were ranked in importance by a team of experts, and Warren found that, though the BMJ (which has always used peer review) and the Lancet (which for this period did not) had published roughly an equal and large number of articles on the subject, the two journals were ranked near the bottom of the league table for quality (quite the reverse for their overall rating as measured by citation indexes and impact factors). Thus merely having a peer-review system is not enough: editors must ensure that it works. Was a previous editor of the Lancet, Sir Theodore Fox,18 really joking when he said in his Heath Clark lectures "When I divide the week's contributions into two piles-one that we are going to publish and the other that we are going to return-I wonder whether it would make any real difference to the journal or its readers if I exchanged one pile for the other"? Editors and referees should start a rigorous audit of their practices so that Sir Theodore's question can be answered. STEPHEN LOCK Editor, BMJ

[1]  R. Nuscher,et al.  Bone marrow transplantation. , 1977, The American journal of nursing.

[2]  G. Striker,et al.  Donor origin of the in vitro haematopoietic microenvironment after marrow transplantation in man , 1982, Nature.

[3]  R. Bast,et al.  AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN CALLA-POSITIVE ACUTE LYMPHOBLASTIC LEUKAEMIA AFTER IN-VITRO TREATMENT WITH J5 MONOCLONAL ANTIBODY AND COMPLEMENT , 1982, The Lancet.

[4]  J. Kersey,et al.  PRETREATMENT OF DONOR BONE MARROW WITH MONOCLONAL ANTIBODY OKT3 FOR PREVENTION OF ACUTE GRAFT-VERSUS-HOST DISEASE IN ALLOGENEIC HISTOCOMPATIBLE BONE-MARROW TRANSPLANTATION , 1982, The Lancet.

[5]  R. Yolken,et al.  Infectious gastroenteritis in bone-marrow-transplant recipients. , 1982, The New England journal of medicine.

[6]  R. Yolken,et al.  OUTBREAK OF COXSACKIE A1 GASTROENTERITIS: A COMPLICATION OF BONE-MARROW TRANSPLANTATION , 1982, The Lancet.

[7]  W. Friedrich,et al.  Abnormal humoral immune responses in peripheral blood lymphocyte cultures of bone marrow transplant recipients. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[8]  G. Janossy,et al.  USE OF ANTI-T-CELL MONOCLONAL ANTIBODY OKT3 TO PREVENT ACUTE GRAFT-VERSUS-HOST DISEASE IN ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR ACUTE LEUKAEMIA , 1982, The Lancet.

[9]  N. Flournoy,et al.  Intravenous acyclovir to treat mucocutaneous herpes simplex virus infection after marrow transplantation: a double-blind trial. , 1982, Annals of internal medicine.

[10]  D. Neville,et al.  Bone marrow transplantation across major histocompatibility barriers. V. Protection of mice from lethal graft-vs.-host disease by pretreatment of donor cells with monoclonal anti-Thy-1.2 coupled to the toxin ricin , 1982, Journal of Experimental Medicine.

[11]  L. Robison,et al.  A randomized study of the prevention of acute graft-versus-host disease. , 1982, The New England journal of medicine.

[12]  J. Meyers,et al.  The effect of granulocyte transfusions on the incidence of cytomegalovirus infection after allogeneic marrow transplantation. , 1982, Annals of internal medicine.

[13]  W. Friedrich,et al.  T-Lymphocyte Reconstitution in Recipients of Bone Marrow Transplants With and Without GVHD : Imbalances of T-Cell Subpopulations Having Unique Regulatory and Cognitive Functions , 2005 .

[14]  K. Sullivan,et al.  Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation. , 1981, The New England journal of medicine.

[15]  J. Sloane,et al.  CYCLOSPORIN A TO PREVENT GRAFT-VERSUS-HOST DISEASE IN MAN AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION , 1980, The Lancet.

[16]  R. Storb Decrease in the graft rejection rate and improvement in survival after marrow transplantation for severe aplastic anemia. , 1979, Transplantation proceedings.