Adult‐to‐adult right hepatic lobe living donor liver transplantation

Spurred on by the critical shortage of cadaveric livers, adult‐to‐adult right hepatic lobe living donor liver transplantation has grown rapidly as a therapeutic option for selected patients. In the USA alone, the number of living donor liver transplantations has increased six‐fold in the last 4 years. The therapy can be complex, bringing together a variety of disciplines, including transplantation medicine and surgery, hepatology, psychiatry and medical ethics. Moreover, living donor liver transplantation is still defining itself in the adult‐to‐adult application. Uniform standards, guidelines and long‐term outcomes are yet to be determined. Nevertheless, initial success has been remarkable, and a basic understanding of this field is essential to any physician contemplating options for their liver failure patients. This review covers a range of topics, including recipient and donor selection and outcomes, donor risk, controversies and future issues.

[1]  J. P. Davis,et al.  Consensus statement on the live organ donor. , 2000, JAMA.

[2]  A. Marcos.  Right lobe living donor liver transplantation: A review , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[3]  G. Everson,et al.  Comprehensive cost comparison of adult-adult right hepatic lobe living-donor liver transplantation with cadaveric transplantion , 2003, Transplantation.

[4]  G. Testa,et al.  Right‐liver living donor transplantation for decompensated end‐stage liver disease , 2002, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[5]  R. Fisher,et al.  Selection and outcome of living donors for adult to adult right lobe transplantation. , 2000, Transplantation.

[6]  M. Malago',et al.  Living donor liver transplantation in adults: Outcome in Europe , 2000 .

[7]  R. C. Macridis.  A review , 1963 .

[8]  C A Bodian,et al.  Critical graft size in adult‐to‐adult living donor liver transplantation: Impact of the recipient's disease , 2001, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[9]  R. Fisher,et al.  Single‐center analysis of the first 40 adult‐to‐adult living donor liver transplants using the right lobe , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[10]  Kan-Hoe Lee,et al.  Whither living donor liver transplantation? , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[11]  G. Everson,et al.  Adult-to-adult transplantation of the right hepatic lobe from a living donor. , 2002, The New England journal of medicine.

[12]  M. Malago',et al.  Biliary anastomosis in living related liver transplantation using the right liver lobe: Techniques and complications , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[13]  R. Busuttil,et al.  Adult-to-adult living-donor liver transplantation: a critical analysis. , 2000, Seminars in liver disease.

[14]  Nancy M. Stolpman,et al.  Living donor liver transplant recipients achieve relatively higher immunosuppressant blood levels than cadaveric recipients , 2002, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[15]  T. Kiuchi,et al.  Current status of living donor liver transplantation in adults , 2000 .

[16]  G. Everson,et al.  Evaluation of 100 patients for living donor liver transplantation , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[17]  S. Kawasaki,et al.  Living‐related liver transplantation for patients with fulminant and subfulminant hepatic failure , 1999, Hepatology.

[18]  R. Mcnutt,et al.  Adult living donor liver transplantation: Preferences about donation outside the medical community , 2001, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[19]  J F Trotter,et al.  Right hepatic lobe donation for living donor liver transplantation: Impact on donor quality of life , 2001, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[20]  J. Millis,et al.  Transplantation of liver grafts from living donors into adults--too much, too soon. , 2001, The New England journal of medicine.

[21]  G. Klintmalm,et al.  Liver transplantation for hepatitis C: Recurrence and disease progression in 300 patients , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[22]  Y. Liaw.  Treatment of chronic hepatitis B: A need for consensus , 1999, Journal of gastroenterology and hepatology.

[23]  S. Todo,et al.  Living donor liver transplantation in adults: Outcome in Japan , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[24]  G. Everson,et al.  Adult living donor liver transplantation using a right hepatic lobe. , 1998, Transplantation.

[25]  J. Pomposelli,et al.  Live donor liver transplantation. , 2001, Journal of hepatology.

[26]  B. Shaw,et al.  Editorial: Where monsters hide , 2001 .

[27]  R. Fisher,et al.  Liver regeneration and function in donor and recipient after right lobe adult to adult living donor liver transplantation. , 2000, Transplantation.

[28]  R. Fisher,et al.  Segmental orthotopic hepatic transplantation as a means to improve patient survival and diminish waiting-list mortality. , 1991, Journal of pediatric surgery.

[29]  N. Tygstrup,et al.  Expression of messenger RNA for liver functions following 70% and 90% hepatectomy. , 1996, Journal of hepatology.

[30]  S. Fan,et al.  Safety of donors in live donor liver transplantation using right lobe grafts. , 2000, Archives of surgery.

[31]  S. Fan,et al.  Adult-to-adult living donor liver transplantation using extended right lobe grafts. , 1997, Annals of surgery.

[32]  J. Fung,et al.  Ethical considerations and rationale of adult‐to‐adult living donor liver transplantation , 2001, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[33]  N. Levinsky.  Organ donation by unrelated donors. , 2000, The New England journal of medicine.

[34]  A. Tanaka,et al.  Liver transplantation using a right lobe graft from a living related donor. , 1994, Transplantation.

[35]  M. Abecassis,et al.  Body mass index as a predictor of hepatic steatosis in living liver donors , 2001, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[36]  Y Koido,et al.  Successful liver transplantation from a living donor to her son. , 1990, The New England journal of medicine.

[37]  I. Kam.  Adult‐adult right hepatic lobe living donor liver transplantation for status 2a patients: Too little, too late , 2002, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[38]  Martina Sterneck,et al.  Living donor liver transplantation. , 2006, HPB : the official journal of the International Hepato Pancreato Biliary Association.

[39]  J C Imperial,et al.  Natural history of chronic hepatitis B and C , 1999, Journal of gastroenterology and hepatology.

[40]  I. Hirano,et al.  Deaths after living related liver transplantation , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[41]  A. Harper,et al.  The UNOS OPTN waiting list and donor registry. , 1998, Clinical transplants.

[42]  A J Matas,et al.  Nondirected donation of kidneys from living donors. , 2000, The New England journal of medicine.

[43]  R. Fisher,et al.  Emergency adult to adult living donor liver transplantation for fulminant hepatic failure. , 2000, Transplantation.

[44]  S. Kawasaki,et al.  Living related liver transplantation in adults. , 1998, Annals of surgery.

[45]  J. Emond,et al.  Improved results of living-related liver transplantation with routine application in a pediatric program. , 1993, Transplantation.

[46]  G. Everson,et al.  Adult‐to‐adult living donor liver transplantation using right‐lobe grafts: Results and lessons learned from a single‐center experience , 2001, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[47]  Harper Am,et al.  The UNOS OPTN waiting list and donor registry. , 1996 .