Transcriptional and epigenetic networks in haematological malignancy

[1]  N. López-Bigas,et al.  Transcriptional activation of polycomb-repressed genes by ZRF1 , 2010, Nature.

[2]  N. Zeleznik-Le,et al.  Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes. , 2010, Cancer research.

[3]  Christian Steidl,et al.  Cooperative epigenetic modulation by cancer amplicon genes. , 2010, Cancer cell.

[4]  C. So,et al.  β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. , 2010, Cancer cell.

[5]  B. Ko,et al.  Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations. , 2010, Blood.

[6]  L. Aravind,et al.  Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2 , 2010, Nature.

[7]  G. Mufti,et al.  Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value. , 2010, Blood.

[8]  D. Birnbaum,et al.  ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia , 2010, British journal of haematology.

[9]  Yi Zhang,et al.  Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification , 2010, Nature.

[10]  O. Abdel-Wahab,et al.  EZH2 Mutations: Mutating the Epigenetic Machinery in Myeloid Malignancies , 2010 .

[11]  Howard Y. Chang,et al.  Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes , 2010, Science.

[12]  H. Drexler,et al.  Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders , 2010, Nature Genetics.

[13]  R. Kuiper,et al.  Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes , 2010, Nature Genetics.

[14]  Thomas A. Milne,et al.  Pro Isomerization in MLL1 PHD3-Bromo Cassette Connects H3K4me Readout to CyP33 and HDAC-Mediated Repression , 2010, Cell.

[15]  J. Martens,et al.  The molecular signature of oncofusion proteins in acute myeloid leukemia , 2010, FEBS letters.

[16]  Jiaying Tan,et al.  The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. , 2010, Cancer cell.

[17]  M. Wilm,et al.  Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB , 2010, Nature.

[18]  A. Shilatifard,et al.  The JARID2-PRC2 duality. , 2010, Genes & development.

[19]  Saraswati Sukumar,et al.  The Hox genes and their roles in oncogenesis , 2010, Nature Reviews Cancer.

[20]  Berthold Göttgens,et al.  Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1 , 2010, Nature Structural &Molecular Biology.

[21]  Kristian Helin,et al.  Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes , 2010, Nucleic acids research.

[22]  Juri Rappsilber,et al.  JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells , 2010, Nature.

[23]  A. Tichelli,et al.  Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. , 2010, Blood.

[24]  Howard Y. Chang,et al.  Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis , 2010, Nature.

[25]  M. Cleary,et al.  A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. , 2010, Cancer cell.

[26]  H. Stunnenberg,et al.  PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia. , 2010, Cancer cell.

[27]  Hui Zhang,et al.  MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. , 2010, Cancer cell.

[28]  A. Shilatifard,et al.  AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. , 2010, Molecular cell.

[29]  M. Fornerod,et al.  Nucleoporins Directly Stimulate Expression of Developmental and Cell-Cycle Genes Inside the Nucleoplasm , 2010, Cell.

[30]  Ulrich Wagner,et al.  Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes , 2010, Cell.

[31]  J. Hess,et al.  Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia. , 2010, Blood.

[32]  J. Hess,et al.  Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice. , 2010, Developmental biology.

[33]  O. Bernard,et al.  Analyses of TET2 mutations in post-myeloproliferative neoplasm acute myeloid leukemias , 2010, Leukemia.

[34]  S. Orkin,et al.  Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells , 2009, Cell.

[35]  Arend Sidow,et al.  Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells , 2009, Cell.

[36]  J. Soulier,et al.  Mutation in TET2 in myeloid cancers. , 2009, The New England journal of medicine.

[37]  D. Birnbaum,et al.  TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia , 2009, Haematologica.

[38]  Giacomo Cavalli,et al.  Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice , 2009, Development.

[39]  C. Bach,et al.  Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia , 2009, PLoS biology.

[40]  D. Reinberg,et al.  Role of the polycomb protein EED in the propagation of repressive histone marks , 2009, Nature.

[41]  D. Reinberg,et al.  The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate , 2009, The Journal of Biological Chemistry.

[42]  Robert E. Kingston,et al.  Mechanisms of Polycomb gene silencing: knowns and unknowns , 2009, Nature Reviews Molecular Cell Biology.

[43]  P. Park.  ChIP–seq: advantages and challenges of a maturing technology , 2009, Nature Reviews Genetics.

[44]  Andrew J. Bannister,et al.  JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin , 2009, Nature.

[45]  C. Bond,et al.  Paraspeckles: nuclear bodies built on long noncoding RNA , 2009, The Journal of cell biology.

[46]  Dustin E. Schones,et al.  Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes , 2009, Cell.

[47]  H. Lipshitz,et al.  A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain , 2009, Cell.

[48]  Ben S. Wittner,et al.  Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 , 2009, Nature.

[49]  D. Birnbaum,et al.  Mutations of ASXL1 gene in myeloproliferative neoplasms , 2009, Leukemia.

[50]  D. Gilliland,et al.  Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. , 2009, Blood.

[51]  A. Hagemeijer,et al.  Acquired mutations in TET2 are common in myelodysplastic syndromes , 2009, Nature Genetics.

[52]  R. Slany.  The molecular biology of mixed lineage leukemia , 2009, Haematologica.

[53]  M. Liedtke,et al.  Therapeutic targeting of MLL. , 2009, Blood.

[54]  A. Kohlmann,et al.  Gene expression profiling in acute myeloid leukaemia (AML). , 2009, Best practice & research. Clinical haematology.

[55]  Daniel Birnbaum,et al.  Mutations of polycomb‐associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia , 2009, British journal of haematology.

[56]  Michael J. Emanuele,et al.  A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene , 2009, Cell.

[57]  T. Kondo,et al.  Brpf1, a subunit of the MOZ histone acetyl transferase complex, maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons. , 2009, Developmental biology.

[58]  G. Peters,et al.  Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. , 2009, Genes & development.

[59]  K. Helin,et al.  The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. , 2009, Genes & development.

[60]  David R. Liu,et al.  Conversion of 5-Methylcytosine to 5- Hydroxymethylcytosine in Mammalian DNA by the MLL Partner TET1 , 2009 .

[61]  Sridhar Ramaswamy,et al.  Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells , 2009, Cell.

[62]  Dinshaw J. Patel,et al.  Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger , 2009, Nature.

[63]  M. Stallcup,et al.  Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation. , 2009, Molecular endocrinology.

[64]  Bin Tean Teh,et al.  Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer , 2009, Nature Genetics.

[65]  D. Gilliland,et al.  Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML , 2009, Leukemia.

[66]  Tina N. Davis,et al.  HOXA9 is required for survival in human MLL-rearranged acute leukemias. , 2009, Blood.

[67]  D. Reinberg,et al.  Processing the H3K36me3 signature , 2009, Nature Genetics.

[68]  J. Yates,et al.  Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein. , 2009, Molecular cell.

[69]  Howard Y. Chang,et al.  Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. , 2009, Cell stem cell.

[70]  S. Clarke,et al.  Protein arginine methylation in mammals: who, what, and why. , 2009, Molecular cell.

[71]  Lee T. Sam,et al.  Transcriptome Sequencing to Detect Gene Fusions in Cancer , 2009, Nature.

[72]  Dustin E. Schones,et al.  Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. , 2009, Cell stem cell.

[73]  M. Krzywinski,et al.  New insights to the MLL recombinome of acute leukemias , 2009, Leukemia.

[74]  Richard A Young,et al.  Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. , 2008, Genes & development.

[75]  B. Druker,et al.  Translation of the Philadelphia chromosome into therapy for CML. , 2008, Blood.

[76]  J. Simon,et al.  Roles of the EZH2 histone methyltransferase in cancer epigenetics. , 2008, Mutation research.

[77]  C. Allis,et al.  PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. , 2008, Mutation research.

[78]  Jerry L. Workman,et al.  Crosstalk among Histone Modifications , 2008, Cell.

[79]  C. So,et al.  Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia. , 2008, Cancer cell.

[80]  Xiaobo Xia,et al.  H3K79 methylation profiles define murine and human MLL-AF4 leukemias. , 2008, Cancer cell.

[81]  N. Zeleznik-Le,et al.  Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization. , 2008, Cancer research.

[82]  Akihiko Yokoyama,et al.  Menin critically links MLL proteins with LEDGF on cancer-associated target genes. , 2008, Cancer cell.

[83]  Michael Q. Zhang,et al.  Combinatorial patterns of histone acetylations and methylations in the human genome , 2008, Nature Genetics.

[84]  R. Roeder,et al.  Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation , 2008, Nature.

[85]  C. Kimmel,et al.  The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity , 2008, Development.

[86]  K. Helin,et al.  Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. , 2008, Genes & development.

[87]  A. Regev,et al.  An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors , 2008, Nature Genetics.

[88]  J. Hess,et al.  HOX proteins and leukemia. , 2008, International journal of clinical and experimental pathology.

[89]  Vikki M. Weake,et al.  Histone ubiquitination: triggering gene activity. , 2008, Molecular cell.

[90]  Zhen-yi Wang,et al.  Acute promyelocytic leukemia: from highly fatal to highly curable. , 2008, Blood.

[91]  Christopher R. Vakoc,et al.  DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells , 2008, Molecular and Cellular Biology.

[92]  R. Arceci,et al.  The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. , 2008, Blood.

[93]  J. Hess,et al.  The PHD fingers of MLL block MLL fusion protein-mediated transformation. , 2007, Blood.

[94]  J. Hess,et al.  Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia , 2008, International journal of hematology.

[95]  Y. Dou,et al.  PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. , 2007, Genes & development.

[96]  A. Chinnaiyan,et al.  A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. , 2007, Blood.

[97]  Dinshaw J. Patel,et al.  Multivalent engagement of chromatin modifications by linked binding modules , 2007, Nature Reviews Molecular Cell Biology.

[98]  Yi Zhang,et al.  New Nomenclature for Chromatin-Modifying Enzymes , 2007, Cell.

[99]  Sean D. Taverna,et al.  How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers , 2007, Nature Structural &Molecular Biology.

[100]  Scott A. Armstrong,et al.  MLL translocations, histone modifications and leukaemia stem-cell development , 2007, Nature Reviews Cancer.

[101]  Yingming Zhao,et al.  JMJD6 Is a Histone Arginine Demethylase , 2007, Science.

[102]  Min Gyu Lee,et al.  Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination , 2007, Science.

[103]  Jürg Bähler,et al.  Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation , 2007, Nature.

[104]  E. Guccione,et al.  Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive , 2007, Nature.

[105]  D. Reinberg,et al.  Facultative heterochromatin: is there a distinctive molecular signature? , 2007, Molecular cell.

[106]  I. Issaeva,et al.  UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development , 2007, Nature.

[107]  Howard Y. Chang,et al.  A histone H3 lysine 27 demethylase regulates animal posterior development , 2007, Nature.

[108]  M. Cleary,et al.  Protein arginine-methyltransferase-dependent oncogenesis , 2007, Nature Cell Biology.

[109]  D. Gary Gilliland,et al.  Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders , 2007, Nature Reviews Cancer.

[110]  H. Gronemeyer,et al.  Recruitment of RXR by homotetrameric RARalpha fusion proteins is essential for transformation. , 2007, Cancer cell.

[111]  R. Nasr,et al.  RXR is an essential component of the oncogenic PML/RARA complex in vivo. , 2007, Cancer cell.

[112]  Howard Y. Chang,et al.  Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs , 2007, Cell.

[113]  G. Wang,et al.  NUP98–NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis , 2007, Nature Cell Biology.

[114]  T. Jenuwein,et al.  Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. , 2007, Cancer cell.

[115]  Dustin E. Schones,et al.  High-Resolution Profiling of Histone Methylations in the Human Genome , 2007, Cell.

[116]  B. Johansson,et al.  The impact of translocations and gene fusions on cancer causation , 2007, Nature Reviews Cancer.

[117]  Kristian Helin,et al.  The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. , 2007, Genes & development.

[118]  Daniel Chourrout,et al.  Genome Regulation by Polycomb and Trithorax Proteins , 2007, Cell.

[119]  E. Lander,et al.  The Mammalian Epigenome , 2007, Cell.

[120]  T. Kouzarides.  Chromatin Modifications and Their Function , 2007, Cell.

[121]  Yang Shi,et al.  Dynamic regulation of histone lysine methylation by demethylases. , 2007, Molecular cell.

[122]  C. Allis,et al.  Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. , 2007, Molecular cell.

[123]  Vincenzo Pirrotta,et al.  Polycomb silencing mechanisms and the management of genomic programmes , 2007, Nature Reviews Genetics.

[124]  M. Caligiuri,et al.  Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. , 2006, The Journal of clinical investigation.

[125]  Yi Zhang,et al.  JmjC-domain-containing proteins and histone demethylation , 2006, Nature Reviews Genetics.

[126]  Yi Zhang,et al.  Leukaemic transformation by CALM–AF10 involves upregulation of Hoxa5 by hDOT1L , 2006, Nature Cell Biology.

[127]  C. Kimmel,et al.  Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face , 2006, Development.

[128]  J. Esteve,et al.  Gene expression profiling of acute myeloid leukemia with translocation t(8;16)(p11;p13) and MYST3-CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression. , 2006, Cancer research.

[129]  A. Iwama,et al.  MOZ is essential for maintenance of hematopoietic stem cells. , 2006, Genes & development.

[130]  A. Veronese,et al.  Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene , 2006, Genes, chromosomes & cancer.

[131]  James A. Cuff,et al.  A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells , 2006, Cell.

[132]  C. So,et al.  Forced homo-oligomerization of RARalpha leads to transformation of primary hematopoietic cells. , 2006, Cancer cell.

[133]  Song Tan,et al.  ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. , 2006, Molecular cell.

[134]  M. L. Le Beau,et al.  Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia. , 2006, Cancer cell.

[135]  C. Allis,et al.  Histone arginine methylation and its dynamic regulation. , 2006, Frontiers in bioscience : a journal and virtual library.

[136]  Matthew Meyerson,et al.  The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis , 2005, Cell.

[137]  Emily Bernstein,et al.  RNA meets chromatin. , 2005, Genes & development.

[138]  Takuro Nakamura.  NUP98 Fusion in Human Leukemia: Dysregulation of the Nuclear Pore and Homeodomain Proteins , 2005, International journal of hematology.

[139]  Thomas A. Milne,et al.  Physical Association and Coordinate Function of the H3 K4 Methyltransferase MLL1 and the H4 K16 Acetyltransferase MOF , 2005, Cell.

[140]  Mark T Bedford,et al.  Arginine methylation an emerging regulator of protein function. , 2005, Molecular cell.

[141]  Yi Zhang,et al.  hDOT1L Links Histone Methylation to Leukemogenesis , 2005, Cell.

[142]  T. Golub,et al.  Conditional MLL‐CBP targets GMP and models therapy‐related myeloproliferative disease , 2005, The EMBO journal.

[143]  M. Mann,et al.  Identifying and quantifying in vivo methylation sites by heavy methyl SILAC , 2004, Nature Methods.

[144]  J. Hess.  MLL: a histone methyltransferase disrupted in leukemia. , 2004, Trends in molecular medicine.

[145]  Paul Tempst,et al.  Histone Deimination Antagonizes Arginine Methylation , 2004, Cell.

[146]  M. Cleary,et al.  Dimerization: a versatile switch for oncogenesis. , 2004, Blood.

[147]  David Landsman,et al.  High-resolution genome-wide mapping of histone modifications , 2004, Nature Biotechnology.

[148]  W. Herr,et al.  Leukemia Proto-Oncoprotein MLL Forms a SET1-Like Histone Methyltransferase Complex with Menin To Regulate Hox Gene Expression , 2004, Molecular and Cellular Biology.

[149]  R. Roeder,et al.  Ordered Cooperative Functions of PRMT1, p300, and CARM1 in Transcriptional Activation by p53 , 2004, Cell.

[150]  T. Rabbitts,et al.  Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis. , 2004, Genes & development.

[151]  S. Korsmeyer,et al.  Definitive hematopoiesis requires the mixed-lineage leukemia gene. , 2004, Developmental cell.

[152]  K. Lukong,et al.  Sam68, the KH domain-containing superSTAR. , 2003, Biochimica et biophysica acta.

[153]  François-Michel Boisvert,et al.  A Proteomic Analysis of Arginine-methylated Protein Complexes* , 2003, Molecular & Cellular Proteomics.

[154]  Debashis Ghosh,et al.  EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[155]  J. Licht,et al.  Molecular pathogenesis of acute promyelocytic leukaemia and APL variants. , 2003, Best practice & research. Clinical haematology.

[156]  M. Greaves,et al.  Origins of chromosome translocations in childhood leukaemia , 2003, Nature Reviews Cancer.

[157]  G. Ehninger,et al.  Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia , 2003, Genes, chromosomes & cancer.

[158]  S. Armstrong,et al.  Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. , 2003, Blood.

[159]  J. Kutok,et al.  MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. , 2003, Cancer cell.

[160]  S. Mathew,et al.  TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23) , 2003, Leukemia.

[161]  黒滝 直弘.  私の論文から Haploinsufficiency of NSD1 causes Sotos syndrome , 2003 .

[162]  F. Boisvert,et al.  Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. , 2003, Molecular biology of the cell.

[163]  Tony Kouzarides,et al.  Crosstalk between CARM1 Methylation and CBP Acetylation on Histone H3 , 2002, Current Biology.

[164]  M. Cleary,et al.  Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties. , 2002, Blood.

[165]  S. Dhanasekaran,et al.  The polycomb group protein EZH2 is involved in progression of prostate cancer , 2002, Nature.

[166]  Y. Hayashi,et al.  LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). , 2002, Cancer research.

[167]  A. Veronese,et al.  NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). , 2002, Blood.

[168]  E. Lander,et al.  MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia , 2002, Nature Genetics.

[169]  M. Cleary,et al.  Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins , 2001, Oncogene.

[170]  J. Cheng,et al.  A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia. , 2001, Blood.

[171]  C. Allis,et al.  Translating the Histone Code , 2001, Science.

[172]  C. Allis,et al.  Methylation of Histone H4 at Arginine 3 Facilitating Transcriptional Activation by Nuclear Hormone Receptor , 2001, Science.

[173]  P. Chambon,et al.  NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines. , 2001, Genomics.

[174]  J. Licht,et al.  Translocations of the RARalpha gene in acute promyelocytic leukemia. , 2001, Oncogene.

[175]  N. Kakazu,et al.  Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation , 2001, Leukemia.

[176]  C. Harrison,et al.  MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study , 2000, Leukemia.

[177]  A. Hagemeijer,et al.  MLL amplification in myeloid leukemias: A study of 14 cases with multiple copies of 11q23 , 2000, Genes, chromosomes & cancer.

[178]  Changchun Du,et al.  Chromatin‐related properties of CBP fused to MLL generate a myelodysplastic‐like syndrome that evolves into myeloid leukemia , 2000, The EMBO journal.

[179]  D. Birnbaum,et al.  MOZ is fused to p300 in an acute monocytic leukemia with t(8;22) , 2000, Genes, chromosomes & cancer.

[180]  W. Hiddemann,et al.  Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML , 2000, Leukemia.

[181]  C. Allis,et al.  The language of covalent histone modifications , 2000, Nature.

[182]  J. Mesirov,et al.  Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. , 1999, Science.

[183]  D. Aswad,et al.  Regulation of transcription by a protein methyltransferase. , 1999, Science.

[184]  A. Miyajima,et al.  Definitive but not primitive hematopoiesis is impaired in jumonji mutant mice. , 1999, Blood.

[185]  K. Blanchard,et al.  Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the genes for MOZ and TIF2. , 1998, Blood.

[186]  Unnur Thorsteinsdottir,et al.  Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b , 1998, The EMBO journal.

[187]  J. Rowley,et al.  The critical role of chromosome translocations in human leukemias. , 1998, Annual review of genetics.

[188]  P. L. Bergsagel,et al.  The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. , 1998, Blood.

[189]  Y. Hayashi,et al.  Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13). , 1997, Blood.

[190]  A T Look,et al.  Oncogenic transcription factors in the human acute leukemias. , 1997, Science.

[191]  Damian Smedley,et al.  Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma , 1997, Oncogene.

[192]  D. Housman,et al.  MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3). , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[193]  F. Behm,et al.  All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders. , 1997, Blood.

[194]  C. Disteche,et al.  The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein , 1996, Nature Genetics.

[195]  R. Marschalek,et al.  A specific deletion in the breakpoint cluster region of the ALL-1 gene is associated with acute lymphoblastic T-cell leukemias. , 1996, Cancer research.

[196]  S. Korsmeyer,et al.  Altered Hox expression and segmental identity in Mll-mutant mice , 1995, Nature.

[197]  T. Rabbitts,et al.  Chromosomal translocations in human cancer , 1994, Nature.