Carbon source availability drives nutrient utilization in CD8+ T cells

[1]  R. Deberardinis,et al.  Clinically relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function , 2022, Molecular therapy. Methods & clinical development.

[2]  J. Rabinowitz,et al.  Circulating metabolite homeostasis achieved through mass action , 2022, Nature Metabolism.

[3]  Nicole M. Chapman,et al.  Metabolic adaptation of lymphocytes in immunity and disease. , 2022, Immunity.

[4]  E. Ma,et al.  Interrogating in vivo T-cell metabolism in mice using stable isotope labeling metabolomics and rapid cell sorting , 2021, Nature Protocols.

[5]  M. Spitzer,et al.  Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response. , 2021, Immunity.

[6]  D. Sabatini,et al.  CRISPR screens in physiologic medium reveal conditionally essential genes in human cells. , 2021, Cell metabolism.

[7]  Greg M. Delgoffe,et al.  Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion , 2021, Nature immunology.

[8]  J. Rothstein,et al.  Metabolic support of tumor-infiltrating regulatory T cells by lactic acid , 2020, Nature.

[9]  A. Rudensky,et al.  Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity , 2020, Science.

[10]  D. Wallace,et al.  Lactate Limits T Cell Proliferation via the NAD(H) Redox State , 2020, Cell reports.

[11]  D. Figarella-Branger,et al.  SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution. , 2020, Cell metabolism.

[12]  Russell G. Jones,et al.  Immunometabolic Interplay in the Tumor Microenvironment. , 2020, Cancer cell.

[13]  Sean C. Bendall,et al.  Single-cell metabolic profiling of human cytotoxic T cells , 2020, Nature biotechnology.

[14]  C. Brander,et al.  TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells , 2020, Science Immunology.

[15]  S. Zheng,et al.  Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction , 2020, Nature Metabolism.

[16]  M. V. Vander Heiden,et al.  Increased demand for NAD+ relative to ATP drives aerobic glycolysis , 2020, bioRxiv.

[17]  E. Wherry,et al.  Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms. , 2020, Immunity.

[18]  J. Rabinowitz,et al.  Quantitative fluxomics of circulating metabolites , 2020, bioRxiv.

[19]  W. Leonard,et al.  Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity , 2020, Proceedings of the National Academy of Sciences.

[20]  Maxim N. Artyomov,et al.  Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming. , 2020, Cell metabolism.

[21]  R. Deberardinis,et al.  We need to talk about the Warburg effect , 2020, Nature Metabolism.

[22]  Keiryn L. Bennett,et al.  Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function , 2019, Immunity.

[23]  Takla Griss,et al.  Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells. , 2019, Immunity.

[24]  D. Schadendorf,et al.  Metabolic heterogeneity confers differences in melanoma metastatic potential , 2019, Nature.

[25]  J. Cantor.  The Rise of Physiologic Media. , 2019, Trends in cell biology.

[26]  J. Rabinowitz,et al.  T Cell Activation Depends on Extracellular Alanine. , 2019, Cell reports.

[27]  M. Lenardo,et al.  Human Plasma-like Medium Improves T Lymphocyte Activation , 2019, bioRxiv.

[28]  Elisabeth F. Heuston,et al.  Single-Cell RNA-Seq Reveals TOX as a Key Regulator of CD8+ T cell Persistence in Chronic Infection , 2019, Nature Immunology.

[29]  Gabriela Kalna,et al.  Improving the metabolic fidelity of cancer models with a physiological cell culture medium , 2019, Science Advances.

[30]  M. V. Vander Heiden,et al.  Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability , 2018, bioRxiv.

[31]  Kendra Walton,et al.  Clonal expansion of vaccine-elicited T cells is independent of aerobic glycolysis , 2018, Science Immunology.

[32]  Alexander Muir,et al.  Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies , 2018, Disease Models & Mechanisms.

[33]  J. Rabinowitz,et al.  Metabolomics and Isotope Tracing , 2018, Cell.

[34]  Joshua D. Rabinowitz,et al.  Glucose feeds the TCA cycle via circulating lactate , 2017, Nature.

[35]  Jamey D. Young,et al.  Lactate Metabolism in Human Lung Tumors , 2017, Cell.

[36]  M. Mehta,et al.  Mitochondrial control of immunity: beyond ATP , 2017, Nature Reviews Immunology.

[37]  D. Wallace,et al.  Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. , 2017, Cell metabolism.

[38]  Michael D. Buck,et al.  Metabolic Instruction of Immunity , 2017, Cell.

[39]  M. V. Vander Heiden,et al.  Biochemical Underpinnings of Immune Cell Metabolic Phenotypes , 2017, Immunity.

[40]  Xin Gao,et al.  Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase , 2017, Cell.

[41]  M. Brand,et al.  Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements , 2017, The Journal of Biological Chemistry.

[42]  Takla Griss,et al.  Serine Is an Essential Metabolite for Effector T Cell Expansion. , 2017, Cell metabolism.

[43]  Peter Ashwell,et al.  FluxFix: automatic isotopologue normalization for metabolic tracer analysis , 2016, BMC Bioinformatics.

[44]  S. Haferkamp,et al.  LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. , 2016, Cell metabolism.

[45]  John D. Storey,et al.  Systems-level analysis of mechanisms regulating yeast metabolic flux , 2016, Science.

[46]  J. Rathmell,et al.  A guide to immunometabolism for immunologists , 2016, Nature Reviews Immunology.

[47]  E. Ma,et al.  Memory CD8(+) T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function. , 2016, Immunity.

[48]  B. Faubert,et al.  Metabolic Heterogeneity in Human Lung Tumors , 2016, Cell.

[49]  Abhishek K. Jha,et al.  Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. , 2016, Cell metabolism.

[50]  Takla Griss,et al.  Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis , 2015, PLoS biology.

[51]  D. Tscharke,et al.  Sizing up the key determinants of the CD8+ T cell response , 2015, Nature Reviews Immunology.

[52]  E. E. Vincent,et al.  The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. , 2015, Immunity.

[53]  Bjoern Peters,et al.  In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation. , 2014, Immunity.

[54]  J. Rathmell,et al.  The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. , 2014, Cell metabolism.

[55]  Jamey D. Young,et al.  INCA: a computational platform for isotopically non-stationary metabolic flux analysis , 2014, Bioinform..

[56]  D. Sabatini,et al.  Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides , 2014, Nature.

[57]  Maxim N. Artyomov,et al.  TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation , 2014, Nature Immunology.

[58]  B. Faubert,et al.  Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis , 2013, Cell.

[59]  Susan M. Kaech,et al.  Transcriptional control of effector and memory CD8+ T cell differentiation , 2012, Nature Reviews Immunology.

[60]  Masaru Tomita,et al.  MMMDB: Mouse Multiple Tissue Metabolome Database , 2011, Nucleic Acids Res..

[61]  D. Green,et al.  The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. , 2011, Immunity.

[62]  Quynh-Mai Pham,et al.  Pathogen-Induced Inflammatory Environment Controls Effector and Memory CD8+ T Cell Differentiation , 2011, The Journal of Immunology.

[63]  T. Holowka,et al.  Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. , 2010, Blood.

[64]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[65]  S. Jameson,et al.  Different T Cell Receptor Signals Determine CD8+ Memory Versus Effector Development , 2009, Science.

[66]  Peter J. Woolf,et al.  GAGE: generally applicable gene set enrichment for pathway analysis , 2009, BMC Bioinformatics.

[67]  Gregor Rothe,et al.  Inhibitory effect of tumor cell-derived lactic acid on human T cells. , 2007, Blood.

[68]  M. Bevan,et al.  Effector and memory CTL differentiation. , 2007, Annual review of immunology.

[69]  T. Gajewski,et al.  Glucose Availability Regulates IFN-γ Production and p70S6 Kinase Activation in CD8+ Effector T Cells1 , 2005, The Journal of Immunology.

[70]  J. Harty,et al.  CD8+ T cell contraction is controlled by early inflammation , 2004, Nature Immunology.

[71]  C. Thompson,et al.  The CD28 signaling pathway regulates glucose metabolism. , 2002, Immunity.

[72]  H. Brunengraber,et al.  Correction of 13C mass isotopomer distributions for natural stable isotope abundance. , 1996, Journal of mass spectrometry : JMS.

[73]  S. Davis,et al.  Lactic dehydrogenase in normal and leukemia lymphocyte subpopulations: evidence for the presence of abnormal T cells and B cells in chronic lymphocytic leukemia. , 1981, Blood.

[74]  J. Plum,et al.  LDH isozymes of human T and B lymphocytes. , 1975, Clinica chimica acta; international journal of clinical chemistry.

[75]  W. J. Dyer,et al.  A rapid method of total lipid extraction and purification. , 1959, Canadian journal of biochemistry and physiology.