Effects of Application of Hyaluronan on Titanium Screw Mini-implants in the Cortical Bone of Dog Femurs

163 INTRODUCTION Bone is formed as an inorganic/organic complex via the uptake of calcium and phosphoric acid ions by osteoblasts in vivo and the aggregation/crystallization of nanoparticles combined with organic substances. In this process, osteoblasts are differentiated/induced in the extracellular matrix. In this study, on the basis of our understanding of this calcification mechanism, we planed to place the components of this matrix around the implants in order to accelerate the differentiation/induction of osteoblasts in the early stage of insertion and subsequent rapid implant stabilization. Hyaluronic acid, the linear chains of which consist of repeating disaccharide units of glucuronic acid and glucosamine, and which was chosen as a base of a biomimetic matrix, is known to be a Effects of Application of Hyaluronan on Titanium Screw Mini-implants in the Cortical Bone of Dog Femurs

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