Next steps in cardiovascular disease genomic research--sequencing, epigenetics, and transcriptomics.
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[1] A. Banerjee,et al. Relative Familial Clustering of Cerebral Versus Coronary Ischemic Events , 2011, Circulation. Cardiovascular genetics.
[2] Olli Saarela,et al. A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease , 2011, Circulation. Cardiovascular genetics.
[3] Huidong Shi,et al. Loss of Methyl-CpG–Binding Domain Protein 2 Enhances Endothelial Angiogenesis and Protects Mice Against Hind-Limb Ischemic Injury , 2011, Circulation.
[4] N. Mehta. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. , 2011, Circulation. Cardiovascular genetics.
[5] C. Stoeckert,et al. Coronary Artery Endothelial Transcriptome In Vivo: Identification of Endoplasmic Reticulum Stress and Enhanced Reactive Oxygen Species by Gene Connectivity Network Analysis , 2011, Circulation. Cardiovascular genetics.
[6] J. Ioannidis,et al. Strengthening the reporting of genetic risk prediction studies: the GRIPS statement , 2011, Genetics in Medicine.
[7] Deborah A Nickerson,et al. Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy. , 2011, American journal of human genetics.
[8] P. Elliott,et al. Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels , 2011, Circulation.
[9] N. Schork,et al. Effect of direct-to-consumer genomewide profiling to assess disease risk. , 2011, The New England journal of medicine.
[10] D. Mozaffarian,et al. Heart disease and stroke statistics--2011 update: a report from the American Heart Association. , 2011, Circulation.
[11] Nathaniel D. Heintzman,et al. 9p21 DNA variants associated with Coronary Artery Disease impair IFNγ signaling response , 2011, Nature.
[12] Wendy A. Wolf,et al. The eMERGE Network: A consortium of biorepositories linked to electronic medical records data for conducting genomic studies , 2011, BMC Medical Genomics.
[13] Donna K Arnett,et al. Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study , 2011, BMC Medical Genomics.
[14] S. Leal,et al. Rare copy number variants disrupt genes regulating vascular smooth muscle cell adhesion and contractility in sporadic thoracic aortic aneurysms and dissections. , 2010, American journal of human genetics.
[15] Jan A Staessen,et al. Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease , 2010, Circulation. Cardiovascular genetics.
[16] George Church,et al. Ethical and Practical Guidelines for Reporting Genetic Research Results to Study Participants: Updated Guidelines from a National Heart, Lung, and Blood Institute Working Group , 2010, Circulation. Cardiovascular genetics.
[17] A. Baccarelli,et al. Cardiovascular Epigenetics: Basic Concepts and Results From Animal and Human Studies , 2010, Circulation. Cardiovascular genetics.
[18] David D. Smith,et al. Dual DNA Methylation Patterns in the CNS Reveal Developmentally Poised Chromatin and Monoallelic Expression of Critical Genes , 2010, PloS one.
[19] Natalie Jäger,et al. Genome-wide mapping of DNA methylation: a quantitative technology comparison , 2010, Nature Biotechnology.
[20] Stefanie Dimmeler,et al. Circulating MicroRNAs in Patients With Coronary Artery Disease , 2010, Circulation research.
[21] Michael Q. Zhang,et al. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications , 2010, Nature Biotechnology.
[22] Ayellet V. Segrè,et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height , 2010, Nature.
[23] Olle Melander,et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus , 2010, Nature.
[24] F. Crea,et al. MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients. , 2010, Physiological genomics.
[25] Tanya M. Teslovich,et al. Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids , 2010, Nature.
[26] M. Civelek,et al. MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro , 2010, Proceedings of the National Academy of Sciences.
[27] R. Natarajan,et al. The role of epigenetics in the pathology of diabetic complications. , 2010, American journal of physiology. Renal physiology.
[28] Arturas Petronis,et al. Epigenetics as a unifying principle in the aetiology of complex traits and diseases , 2010, Nature.
[29] Silke Szymczak,et al. Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility , 2010, PloS one.
[30] Yue Li,et al. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. , 2010, European heart journal.
[31] Marcel H. Schulz,et al. Prediction of alternative isoforms from exon expression levels in RNA-Seq experiments , 2010, Nucleic acids research.
[32] G. Wang,et al. Histone Deacetylase 3 Is Critical in Endothelial Survival and Atherosclerosis Development in Response to Disturbed Flow , 2010, Circulation.
[33] J. Mattick,et al. A global view of genomic information--moving beyond the gene and the master regulator. , 2010, Trends in genetics : TIG.
[34] S. Turner,et al. Real-time DNA sequencing from single polymerase molecules. , 2010, Methods in enzymology.
[35] Maris Laan,et al. Hypervariable intronic region in NCX1 is enriched in short insertion-deletion polymorphisms and showed association with cardiovascular traits , 2010, BMC Medical Genetics.
[36] Daniel F. Gudbjartsson,et al. Parental origin of sequence variants associated with complex diseases , 2009, Nature.
[37] Lee E. Edsall,et al. Human DNA methylomes at base resolution show widespread epigenomic differences , 2009, Nature.
[38] A. Gabrielsen,et al. Relationship between CAD Risk Genotype in the Chromosome 9p21 Locus and Gene Expression. Identification of Eight New ANRIL Splice Variants , 2009, PloS one.
[39] D. Srivastava,et al. Hypoxic Repression of Endothelial Nitric-oxide Synthase Transcription Is Coupled with Eviction of Promoter Histones*♦ , 2009, The Journal of Biological Chemistry.
[40] R. Feil,et al. Chromatin mechanisms in genomic imprinting , 2009, Mammalian Genome.
[41] T. Rauch,et al. Insulin Gene Expression Is Regulated by DNA Methylation , 2009, PloS one.
[42] R. Jaenisch,et al. Loss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure , 2009, Circulation research.
[43] Jianqin Jiao,et al. miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy , 2009, Proceedings of the National Academy of Sciences.
[44] F. Collins,et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits , 2009, Proceedings of the National Academy of Sciences.
[45] J. Lieberman,et al. miR-24–mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells , 2009, Nature Structural &Molecular Biology.
[46] Stephen C. J. Parker,et al. Local DNA Topography Correlates with Functional Noncoding Regions of the Human Genome , 2009, Science.
[47] Karen L. Mohlke,et al. INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis , 2009, PloS one.
[48] E. Antman,et al. Cytochrome p-450 polymorphisms and response to clopidogrel. , 2009, The New England journal of medicine.
[49] K. Frazer,et al. Human genetic variation and its contribution to complex traits , 2009, Nature Reviews Genetics.
[50] Derek J Van Booven,et al. Reciprocal Regulation of Myocardial microRNAs and Messenger RNA in Human Cardiomyopathy and Reversal of the microRNA Signature by Biomechanical Support , 2009, Circulation.
[51] Robert L Moritz,et al. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing , 2009, Nature Structural &Molecular Biology.
[52] E. Sontheimer,et al. Origins and Mechanisms of miRNAs and siRNAs , 2009, Cell.
[53] Alberto Piazza,et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants , 2009, Nature Genetics.
[54] A. Feinberg,et al. Genome-wide methylation analysis of human colon cancer reveals similar hypo- and hypermethylation at conserved tissue-specific CpG island shores , 2008, Nature Genetics.
[55] John J. Rossi,et al. The promises and pitfalls of RNA-interference-based therapeutics , 2009, Nature.
[56] M. Ychou,et al. Reverse transcription-quantitative polymerase chain reaction: description of a RIN-based algorithm for accurate data normalization , 2009, BMC Molecular Biology.
[57] W. Rottbauer,et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts , 2008, Nature.
[58] Cornelia M van Duijn,et al. Genome-based prediction of common diseases: advances and prospects. , 2008, Human molecular genetics.
[59] Marcel H. Schulz,et al. A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome , 2008, Science.
[60] Joshua M. Hare,et al. Transcriptomic Biomarkers for Individual Risk Assessment in New-Onset Heart Failure , 2008, Circulation.
[61] Joshua M. Korn,et al. Mapping and sequencing of structural variation from eight human genomes , 2008, Nature.
[62] Nicholas Denko,et al. Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. , 2008, Mutation research.
[63] Olle Melander,et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. , 2008, The New England journal of medicine.
[64] Dolores Corella,et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans , 2008, Nature Genetics.
[65] B. Horne,et al. Randomized Trial of Genotype-Guided Versus Standard Warfarin Dosing in Patients Initiating Oral Anticoagulation , 2007, Circulation.
[66] W. R. Taylor,et al. Human Heart Failure Is Associated With Abnormal C-Terminal Splicing Variants in the Cardiac Sodium Channel , 2007, Circulation research.
[67] Sanjay Shete,et al. Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathy. , 2007, Human molecular genetics.
[68] L. Liang,et al. A genome-wide association study of global gene expression , 2007, Nature Genetics.
[69] L. Almasy,et al. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes , 2007, Nature Genetics.
[70] D. Koller,et al. Population genomics of human gene expression , 2007, Nature Genetics.
[71] Kari Stefansson,et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. , 2007, Science.
[72] Praveen Sethupathy,et al. Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. , 2007, American journal of human genetics.
[73] Eric E. Smith,et al. Variants conferring risk of atrial fibrillation on chromosome 4q25 , 2007, Nature.
[74] A. Barabasi,et al. Human disease classification in the postgenomic era: A complex systems approach to human pathobiology , 2007, Molecular systems biology.
[75] A. Feinberg. Phenotypic plasticity and the epigenetics of human disease , 2007, Nature.
[76] Michael T. McManus,et al. Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2 , 2007, Cell.
[77] Nathaniel D. Heintzman,et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome , 2007, Nature Genetics.
[78] Jonathan C. Cohen,et al. A Common Allele on Chromosome 9 Associated with Coronary Heart Disease , 2007, Science.
[79] T. Kouzarides. Chromatin Modifications and Their Function , 2007, Cell.
[80] E. Olson,et al. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure , 2006, Proceedings of the National Academy of Sciences.
[81] M. Capogrossi,et al. Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. , 2006, Circulation research.
[82] P. Davies,et al. Endothelial Protein Kinase C Isoform Identity and Differential Activity of PKC&zgr; in an Athero-Susceptible Region of Porcine Aorta , 2005, Circulation research.
[83] P. M. Hwang,et al. Circulating transcriptome reveals markers of atherosclerosis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[84] J. Erdmann,et al. Distinct Heritable Patterns of Angiographic Coronary Artery Disease in Families With Myocardial Infarction , 2005, Circulation.
[85] M. West,et al. Gene Expression Phenotypes of Atherosclerosis , 2004, Arteriosclerosis, thrombosis, and vascular biology.
[86] Jan Bressler,et al. Epigenetics and human disease. , 2004, Annual review of genomics and human genetics.
[87] Esteban Ballestar,et al. DNA Methylation Polymorphisms Precede Any Histological Sign of Atherosclerosis in Mice Lacking Apolipoprotein E* , 2004, Journal of Biological Chemistry.
[88] C. Stoeckert,et al. Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[89] J. Fish,et al. The cell-specific expression of endothelial nitric oxide synthase: A role for DNA methylation , 2004 .
[90] Jun Ma,et al. Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease. , 2003, Journal of molecular and cellular cardiology.
[91] Mark Hanson,et al. Dietary Protein Restriction in Pregnancy Induces Hypertension and Vascular Defects in Rat Male Offspring , 2003, Pediatric Research.
[92] J. Haerting,et al. Gene-expression signatures in breast cancer. , 2003, The New England journal of medicine.
[93] J. Loscalzo,et al. Platelet-monocyte aggregates: bridging thrombosis and inflammation. , 2002, Circulation.
[94] D. Girelli,et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[95] D. DeMets,et al. Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework , 2001, Clinical pharmacology and therapeutics.
[96] International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome , 2001, Nature.
[97] D. Arveiler,et al. New polymorphisms of the angiotensin II type 1 receptor gene and their associations with myocardial infarction and blood pressure: the ECTIM study , 1998, Journal of hypertension.
[98] L. Berkman,et al. Genetic susceptibility to death from coronary heart disease in a study of twins. , 1994, The New England journal of medicine.