Single-Void Urine Samples Can Be Used To Estimate Quantitative Microalbuminuria

The excretion of small quantities of urinary albumin (microalbuminuria) may predict renal failure in diabetes. The measurement of microalbuminuria with radioimmunoassays has been based on 24-h, overnight, and 3- to 4-h collections. To determine whether single-void urine samples can be used to estimate 24-h excretion, we compared the results of 24-h outpatient urine collections with single-void samples corrected for creatinine from diabetic and nondiabetic subjects. The overall correlation of single-void sample results expressed as microgram albumin per milligram creatinine with 24-h excretion (mg/24 h) was excellent (r = .82, P < .001). More important, in the diabetic patients the sensitivity and specificity of detecting 24-h microalbuminuria in the abnormal range were at least 94 and 96%, respectively. Single-void urine specimens adjusted for creatinine discriminate between normal and abnormal levels of microalbuminuria, as determined in 24-h urine collection, with high specificity and sensitivity.

[1]  R. Brodows,et al.  Evaluation of a New Radioimmunoassay for Urinary Albumin , 1986, Diabetes Care.

[2]  B. Feldt-Rasmussen,et al.  Enzyme immunoassay: an improved determination of urinary albumin in diabetics with incipient nephropathy. , 1985, Scandinavian journal of clinical and laboratory investigation.

[3]  P. Blackshear,et al.  Metabolic response to three years of continuous, basal rate intravenous insulin infusion in type II diabetic patients. , 1985, The Journal of clinical endocrinology and metabolism.

[4]  I. Jefferson,et al.  Urine albumin to creatinine ratio-response to exercise in diabetes. , 1985, Archives of disease in childhood.

[5]  H. Keen,et al.  Effect of blood glucose control on increased glomerular filtration rate and kidney size in insulin-dependent diabetes. , 1985, The New England journal of medicine.

[6]  I. Jefferson,et al.  Urinary albumin excretion in school children. , 1984, Archives of disease in childhood.

[7]  C. Mogensen,et al.  Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. , 1984, The New England journal of medicine.

[8]  S. Garella,et al.  Use of single voided urine samples to estimate quantitative proteinuria. , 1983, The New England journal of medicine.

[9]  J. Avruch,et al.  Intensive conventional and insulin pump therapies in adult type I diabetes. A crossover study. , 1982, Annals of internal medicine.

[10]  H. Keen,et al.  MICROALBUMINURIA AS A PREDICTOR OF CLINICAL NEPHROPATHY IN INSULIN-DEPENDENT DIABETES MELLITUS , 1982, The Lancet.

[11]  Steno Study Group.  EFFECT OF 6 MONTHS OF STRICT METABOLIC CONTROL ON EYE AND KIDNEY FUNCTION IN INSULIN-DEPENDENT DIABETICS WITH BACKGROUND RETINOPATHY , 1982, The Lancet.

[12]  D. Nathan,et al.  A Rapid Chemical Means for Removing Labile Glycohemoglobin , 1981, Diabetes.

[13]  Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose Intolerance , 1979, Diabetes.

[14]  J. Pickup,et al.  Effect of control of blood glucose on urinary excretion of albumin and beta2 microglobulin in insulin-dependent diabetes. , 1979, The New England journal of medicine.

[15]  C. Mogensen,et al.  Radioimmunoassay for urinary albumin using a single antibody. , 1970, Scandinavian journal of clinical and laboratory investigation.

[16]  H. Keen,et al.  AN IMMUNOASSAY METHOD FOR URINARY ALBUMIN AT LOW CONCENTRATIONS. , 1963, Lancet.