Tobacco smoking, body mass index, hypertension, and kidney cancer risk in central and eastern Europe

In a case–control study of kidney cancer in four central European countries, with 1097 incident cases and 1476 controls, we found an increased risk for self-reported hypertension and for obesity. Additional unknown risk factors are likely to be responsible for the high rates of kidney cancer in this region.

[1]  H. Orskov,et al.  Free insulin-like growth factors in human obesity. , 1995, Metabolism: clinical and experimental.

[2]  W. L. Beeson,et al.  Hypertension, antihypertensive medication and risk of renal carcinoma in California Seventh-Day Adventists. , 1990, International journal of epidemiology.

[3]  S. Coughlin,et al.  Predictors of mortality from kidney cancer in 332,547 men screened for the Multiple Risk Factor Intervention Trial , 1997, Cancer.

[4]  T. Rohan,et al.  Role of the insulin-like growth factor family in cancer development and progression. , 2000, Journal of the National Cancer Institute.

[5]  J. Stewart,et al.  Risk factors for kidney cancer in New South Wales, Australia. II. Urologic disease, hypertension, obesity, and hormonal factors , 1992, Cancer Causes & Control.

[6]  The role of the kidney in hypertension. , 1996, JAMA.

[7]  A. LaCroix,et al.  Hypertension, antihypertensive medication use, and risk of renal cell carcinoma. , 1999, American journal of epidemiology.

[8]  P. Brennan,et al.  Renal cell carcinoma in relation to cigarette smoking: Meta‐analysis of 24 studies , 2005, International journal of cancer.

[9]  R. Goldbohm,et al.  Relation of height, body mass, energy intake, and physical activity to risk of renal cell carcinoma: results from the Netherlands Cohort Study. , 2004, American journal of epidemiology.

[10]  T. Bjørge,et al.  Relation of height and body mass index to renal cell carcinoma in two million Norwegian men and women. , 2004, American journal of epidemiology.

[11]  N. Cook,et al.  Obesity and renal cell cancer – a quantitative review , 2001, British Journal of Cancer.

[12]  B Järvholm,et al.  Obesity, hypertension, and the risk of kidney cancer in men. , 2000, The New England journal of medicine.

[13]  M. Oya,et al.  Renal cell carcinoma: etiology, incidence and epidemiology , 2004, Current opinion in urology.