The versatile β-barrel membrane protein

Abstract The β-barrel membrane protein is found in the outer membranes of bacteria, mitochondria and chloroplasts. Approximately 2–3% of the genes in Gram-negative bacterial genomes encode β-barrels. Whereas there are fewer than 20 known three-dimensional β-barrel structures, genomic databases currently contain thousands of β-barrels belonging to dozens of families. New research is revealing the variety of β-barrel structures and the variety of functions performed by these versatile proteins.

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