A twist in the tail: synergism between mitochondria and NADPH oxidase in the hypoxia-induced elevation of reactive oxygen species in pulmonary artery.

[1]  Y. Ho,et al.  Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells. , 2008, Free radical biology & medicine.

[2]  K. Garlid,et al.  S3/7 Intramitochondrial signaling — Interactions among mitoKATP, PKCε, ROS, and MPT , 2008 .

[3]  P. Schumacker,et al.  Oxygen sensing in hypoxic pulmonary vasoconstriction: using new tools to answer an age‐old question , 2008, Experimental physiology.

[4]  J. Sham,et al.  Hydrogen peroxide-induced Ca2+ mobilization in pulmonary arterial smooth muscle cells. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[5]  Y. Ho,et al.  Role of mitochondrial reactive oxygen species in hypoxia-dependent increase in intracellular calcium in pulmonary artery myocytes. , 2007, Free radical biology & medicine.

[6]  Y. Ho,et al.  Mitochondrial ROS-PKCε signaling axis is uniquely involved in hypoxic increase in [Ca2+]i in pulmonary artery smooth muscle cells , 2006 .

[7]  J. Marks,et al.  Increases in Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Induced Calcium Responses in Pulmonary Artery Smooth Muscle Cells , 2006, Circulation research.

[8]  S. Archer,et al.  Counterpoint: Hypoxic pulmonary vasoconstriction is not mediated by increased production of reactive oxygen species. , 2006, Journal of applied physiology.

[9]  S. Gupte,et al.  Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction. , 2006, Pulmonary pharmacology & therapeutics.

[10]  K. Griendling,et al.  Modulation of vascular smooth muscle signaling by reactive oxygen species. , 2006, Physiology.

[11]  W. Seeger,et al.  Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction. , 2006, American journal of respiratory cell and molecular biology.

[12]  P. Aaronson,et al.  Hypoxic pulmonary vasoconstriction: mechanisms and controversies , 2006, The Journal of physiology.

[13]  C. Wyatt,et al.  Does AMP-activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Calcium Signaling in O2-sensing Cells?* , 2005, Journal of Biological Chemistry.

[14]  S. Gupte,et al.  Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[15]  P. Aaronson,et al.  Protein kinases in vascular smooth muscle tone--role in the pulmonary vasculature and hypoxic pulmonary vasoconstriction. , 2004, Pharmacology & therapeutics.

[16]  G. Feldman,et al.  Protein Kinase Cδ Is Required for p47phox Phosphorylation and Translocation in Activated Human Monocytes1 , 2004, The Journal of Immunology.

[17]  N. Chandel,et al.  Model for Hypoxic Pulmonary Vasoconstriction Involving Mitochondrial Oxygen Sensing , 2001, Circulation research.

[18]  W. Seeger,et al.  Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)? , 2000, American journal of physiology. Lung cellular and molecular physiology.

[19]  S. Archer,et al.  O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[20]  B. Marshall,et al.  Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction. , 1996, American journal of respiratory cell and molecular biology.

[21]  S. Archer,et al.  The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[22]  J. Ward,et al.  Oxygen sensors in context. , 2008, Biochimica et biophysica acta.

[23]  K. Krause,et al.  The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. , 2007, Physiological reviews.

[24]  J. Sham,et al.  Hydrogen peroxide-induced Ca 2 mobilization in pulmonary arterial smooth muscle cells , 2007 .

[25]  S. Archer,et al.  Hypoxic pulmonary vasoconstriction , 1990, Acta anaesthesiologica Scandinavica. Supplementum.

[26]  K. Morris,et al.  Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction. , 2003, American journal of physiology. Heart and circulatory physiology.

[27]  Y. Akita.  Protein kinase C-epsilon (PKC-epsilon): its unique structure and function. , 2002, Journal of biochemistry.

[28]  P. Aaronson,et al.  Hypoxic vasoconstriction and intracellular Ca2+ in pulmonary arteries: evidence for PKC-independent Ca2+ sensitization. , 1995, The American journal of physiology.