Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance
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R. de Cabo | G. Shulman | M. Bernier | Dongyan Zhang | A. Birkenfeld | B. Hamilton | E. Simon | Rachel J. Perry | D. Vatner | C. Henke | J. König | C. von Loeffelholz | D. Willmes | J. Chami | D. Pesta | N. El-Agroudy | A. Kurzbach | T. Schumann | R. Perry | John F O Sullivan
[1] Gina M. Butrico,et al. Glucagon stimulates gluconeogenesis by InsP3R-I mediated hepatic lipolysis , 2020, Nature.
[2] E. Lander,et al. Gain-of-Function Claims for Type-2-Diabetes-Associated Coding Variants in SLC16A11 Are Not Supported by the Experimental Data. , 2019, Cell reports.
[3] Tan Zhang,et al. Adeno-Associated Virus-Mediated Knockdown of SLC16A11 Improves Glucose Tolerance and Hepatic Insulin Signaling in High Fat Diet-Fed Mice. , 2019, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
[4] J. Florez,et al. The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-size adipocytes. , 2019, European journal of endocrinology.
[5] N. Schneiderman,et al. Associations between SLC16A11 variants and diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) , 2019, Scientific Reports.
[6] G. Shulman,et al. Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes. , 2019, Annual review of pharmacology and toxicology.
[7] G. Shulman,et al. Mechanisms of Insulin Action and Insulin Resistance. , 2018, Physiological reviews.
[8] J. Lykkesfeldt,et al. Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease , 2018, Cellular and Molecular Life Sciences.
[9] David S. Wishart,et al. MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis , 2018, Nucleic Acids Res..
[10] Mark S. Schmidt,et al. Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. , 2018, Cell metabolism.
[11] A. Morris,et al. Progress in defining the genetic contribution to type 2 diabetes susceptibility. , 2018, Current opinion in genetics & development.
[12] K. Petersen,et al. Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice , 2017, Proceedings of the National Academy of Sciences.
[13] M. Cruz,et al. Associations of common variants in the SLC16A11, TCF7L2, and ABCA1 genes with pediatric‐onset type 2 diabetes and related glycemic traits in families: A case‐control and case‐parent trio study , 2017, Pediatric diabetes.
[14] Q. Qian,et al. Lactic Acid: No Longer an Inert and End-Product of Glycolysis. , 2017, Physiology.
[15] C. Sempoux,et al. AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice , 2017, Molecular metabolism.
[16] M. Bauer,et al. Retinol saturase coordinates liver metabolism by regulating ChREBP activity , 2017, Nature Communications.
[17] G. Shulman,et al. The human longevity gene homolog INDY and interleukin‐6 interact in hepatic lipid metabolism , 2017, Hepatology.
[18] Nicholette D. Palmer,et al. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms , 2017, Cell.
[19] Michael J. Marcel,et al. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. , 2016, The Journal of clinical investigation.
[20] Pierre Sonveaux,et al. Monocarboxylate transporters in the brain and in cancer☆ , 2016, Biochimica et biophysica acta.
[21] Jianguo Xia,et al. Using MetaboAnalyst 3.0 for Comprehensive Metabolomics Data Analysis , 2016, Current protocols in bioinformatics.
[22] L. Ferrucci,et al. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. , 2016, Cell metabolism.
[23] M. Hanefeld,et al. Determinants of mortality in patients with type 2 diabetes: a review , 2016, Reviews in Endocrine and Metabolic Disorders.
[24] C. Bogardus,et al. Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression , 2015, Diabetes.
[25] M. G. Ortiz-López,et al. Diabetes susceptibility in Mayas: Evidence for the involvement of polymorphisms in HHEX, HNF4α, KCNJ11, PPARγ, CDKN2A/2B, SLC30A8, CDC123/CAMK1D, TCF7L2, ABCA1 and SLC16A11 genes. , 2015, Gene.
[26] C. Aguilar-Salinas,et al. Genetic Determinants for Gestational Diabetes Mellitus and Related Metabolic Traits in Mexican Women , 2015, PloS one.
[27] G. Shulman,et al. Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats , 2015, Science.
[28] Matthew E. Ritchie,et al. limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.
[29] G. Shulman,et al. Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids , 2015, Proceedings of the National Academy of Sciences.
[30] Matthias Blüher,et al. Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. , 2014, Cell metabolism.
[31] G. Shulman. Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. , 2014, The New England journal of medicine.
[32] Gerald M. Saidel,et al. Relating tissue/organ energy expenditure to metabolic fluxes in mouse and human: experimental data integrated with mathematical modeling , 2014, Physiological reports.
[33] G. Shulman,et al. The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes , 2014, Diabetes.
[34] G. Shulman,et al. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 Diabetes , 2014, Hepatology.
[35] Tanya M. Teslovich,et al. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico , 2013, Nature.
[36] P. Magistretti,et al. Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice , 2013, PloS one.
[37] G. Shulman,et al. Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. , 2013, Cell metabolism.
[38] A. Halestrap. The SLC16 gene family - structure, role and regulation in health and disease. , 2013, Molecular aspects of medicine.
[39] G. Rutter,et al. Overexpression of Monocarboxylate Transporter-1 (Slc16a1) in Mouse Pancreatic β-Cells Leads to Relative Hyperinsulinism During Exercise , 2012, Diabetes.
[40] K. Petersen,et al. Apolipoprotein CIII Overexpressing Mice Are Predisposed to Diet-Induced Hepatic Steatosis and Hepatic Insulin Resistance , 2011, Hepatology.
[41] R. de Cabo,et al. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. , 2011, Cell metabolism.
[42] B. McManus,et al. The Human Serum Metabolome , 2011, PloS one.
[43] B. Astor,et al. Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study , 2010, International journal of epidemiology.
[44] K. Petersen,et al. Lipid-induced insulin resistance: unravelling the mechanism , 2010, The Lancet.
[45] Peter J. Woolf,et al. GAGE: generally applicable gene set enrichment for pathway analysis , 2009, BMC Bioinformatics.
[46] Oliver Fiehn,et al. Quality control for plant metabolomics: reporting MSI-compliant studies. , 2008, The Plant journal : for cell and molecular biology.
[47] K. Motojima,et al. PPARα Agonists Positively and Negatively Regulate the Expression of Several Nutrient/Drug Transporters in Mouse Small Intestine , 2007 .
[48] J. Kere,et al. Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. , 2007, American journal of human genetics.
[49] Martin F. Fromm,et al. The Influence of Macrolide Antibiotics on the Uptake of Organic Anions and Drugs Mediated by OATP1B1 and OATP1B3 , 2007, Drug Metabolism and Disposition.
[50] M. Matsuda,et al. Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation , 2007, Diabetes.
[51] G. Shulman,et al. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. , 2006, The Journal of clinical investigation.
[52] O. Cummings,et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease , 2005, Hepatology.
[53] N. Price,et al. Structure and regulation of acetyl-CoA carboxylase genes of metazoa. , 2005, Biochimica et biophysica acta.
[54] K. Petersen,et al. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. , 2004, The New England journal of medicine.
[55] D. Meredith,et al. The SLC16 gene family—from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond , 2004, Pflügers Archiv.
[56] K. Nair,et al. Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[57] G. Shulman,et al. Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle* , 2002, The Journal of Biological Chemistry.
[58] G. Shulman,et al. Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. , 2001, American journal of physiology. Endocrinology and metabolism.
[59] N. Price,et al. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. , 1999, The Biochemical journal.
[60] A. Bröer,et al. Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. , 1998, The Biochemical journal.
[61] C. Cobelli,et al. Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals. , 1996, The Journal of clinical investigation.
[62] R. Turner,et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.
[63] Todd A. Johnson,et al. Genome-wide association study identifies three novel loci for type 2 diabetes. , 2014, Human molecular genetics.
[64] J. Kere,et al. Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release. , 2003, Diabetes.
[65] S. Wakil,et al. Fatty acid synthesis and its regulation. , 1983, Annual review of biochemistry.