Schizophrenic patients and their first-degree relatives show an excess of mixed-handedness

An excess of mixed-handedness in schizophrenia has been reported. However, it is not established whether this excess is manifest in non-schizophrenic psychoses, nor whether the underlying etiology is genetic or environmental. We investigated these issues in a group of patients with schizophrenia (n=94), affective psychosis (n=63), other psychosis (n=26); their respective first-degree relatives (total n=183) and a control group (n=85). A narrow definition of mixed-handedness was used corresponding to groups 5 and 6 as defined by the Annett Handedness Questionnaire. We found an excess of mixed-handedness in the schizophrenic group compared with controls (OR=5.2, 1.4-18.6, p<0.006). There was no difference between the other psychotic groups and controls. There was a trend for an excess of mixed-handedness in the first-degree relatives (n=99) of schizophrenic patients (p=0.055), but not in the relatives of affective or other psychotic patients. There was a striking linear trend in the proportion of mixed-handedness between controls, the relatives and the schizophrenic patients (chi2=7.0, p=0.008). There was no association between mixed-handedness and a history of pregnancy or birth complications in the schizophrenic group. There was some evidence for impaired sociability in the mixed-handed schizophrenic patients. Our results indicate that the excess of mixed-handedness in schizophrenia may have a genetic basis.

[1]  M. Annett A classification of hand preference by association analysis. , 1970, British journal of psychology.

[2]  A. Richardson Dyslexia, handedness and syndromes of psychosis-proneness. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[3]  F. Previc Nonright‐handedness, central nervous system and related pathology, and its lateralization: A reformulation and synthesis , 1996 .

[4]  H. Nelson,et al.  Dementia: The Estimation of Premorbid Intelligence Levels Using the New Adult Reading Test , 1978, Cortex.

[5]  R. C. Oldfield THE ASSESSMENT AND ANALYSIS OF HANDEDNESS , 1971 .

[6]  D. Cicchetti,et al.  Re-examining handedness in schizophrenia: now you see it--now you don't. , 1993, Journal of Clinical and Experimental Neuropsychology.

[7]  M. Annett Left, right, hand and brain : the right shift theory , 1985 .

[8]  E. Walker,et al.  Intelligence in schizophrenia: meta-analysis of the research. , 1984, Schizophrenia bulletin.

[9]  H. Nasrallah,et al.  Motoric lateralization in schizophrenic males. , 1981, The American journal of psychiatry.

[10]  E. O'callaghan,et al.  Risk of schizophrenia in adults born after obstetric complications and their association with early onset of illness: a controlled study. , 1992 .

[11]  T. J. Crow,et al.  Cerebral lateralization is delayed in children who later develop schizophrenia , 1996, Schizophrenia Research.

[12]  M. Leboyer,et al.  Is autism associated with anomalous dominance? , 1988, Journal of autism and developmental disorders.

[13]  T. Sigmundsson,et al.  Loss of cerebral asymmetry in familial schizophrenia—A volumetric MRI study using unbiased stereology , 1996, Schizophrenia Research.

[14]  D. Tudehope,et al.  The Prevalence and Origins of Left Hand Preference in High Risk Infants, and its Implications for Intellectual, Motor and Behavioural Performance at Four and Six Years , 1993, Cortex.

[15]  Y. Burns,et al.  HANDEDNESS IN CHILDREN WITH BIRTHWEIGHTS BELOW 1000 g , 1987, The Lancet.

[16]  M. Byrne,et al.  Prevalence and correlates of mixed-handedness in schizophrenia , 1995, Psychiatry Research.

[17]  M. Pike,et al.  Handedness and Developmental Disorder , 1992 .

[18]  M. Pipe Atypical laterality and retardation. , 1988, Psychological bulletin.

[19]  M Ashtari,et al.  Absence of regional hemispheric volume asymmetries in first-episode schizophrenia. , 1994, The American journal of psychiatry.

[20]  P. Sham,et al.  Psychopathological syndromes in the functional psychoses: associations with course and outcome , 1996, Psychological Medicine.

[21]  R. Murray,et al.  Psychotic illness in ethnic minorities: clarification from the 1991 census , 1996, Psychological Medicine.

[22]  W. Lishman,et al.  RETEST RELIABILITIES AND INTERRELATIONSHIP OF THE ANNETT HAND PREFERENCE QUESTIONNAIRE AND THE EDINBURGH HANDEDNESS INVENTORY , 1975 .

[23]  O. Wahl Handedness in Schizophrenia , 1976, Perceptual and motor skills.

[24]  R. Murray,et al.  Obstetric complications, neurodevelopmental deviance, and risk of schizophrenia. , 1987, Journal of psychiatric research.

[25]  N. Marlow,et al.  HANDEDNESS IN VERY‐LOW‐BIRTHWEIGHT (VLBW) CHILDREN AT 12 YEARS OF AGE: RELATION TO PERINATAL AND OUTCOME VARIABLES , 1996, Developmental medicine and child neurology.

[26]  D. Weinberger,et al.  Anomalous lateralization associated with a milder form of schizophrenia. , 1979, The American journal of psychiatry.

[27]  R. Murray,et al.  Mixed-Handedness in Patients with Functional Psychosis , 1996, British Journal of Psychiatry.

[28]  L. J. Chapman,et al.  Handedness of hypothetically psychosis-prone subjects. , 1987, Journal of abnormal psychology.

[29]  P. Satz,et al.  Is there atypical handedness in schizophrenia? , 1989, Journal of abnormal psychology.

[30]  P. Satz,et al.  Handedness patterns in autism suggest subtypes , 1986, Journal of autism and developmental disorders.

[31]  Relationship between birth order, birth stress, and lateral preferences: a critical review. , 1989 .

[32]  G. Hynd,et al.  Dyslexia and brain morphology. , 1989, Psychological bulletin.

[33]  T. Crow Is schizophrenia the price that Homo sapiens pays for language? , 1997, Schizophrenia Research.

[34]  M. Taylor,et al.  Sinister psychotics. Left-handedness in schizophrenia and affective disorder. , 1995, The Journal of nervous and mental disease.

[35]  I. Mcmanus,et al.  Hand preference and hand skill in children with autism , 1996, Journal of autism and developmental disorders.

[36]  D. Weinberger Implications of normal brain development for the pathogenesis of schizophrenia. , 1987, Archives of general psychiatry.

[37]  R. Murray,et al.  Is schizophrenia a neurodevelopmental disorder? , 1987, British medical journal.

[38]  B. Clementz,et al.  Handedness in first-episode psychotic patients and their first-degree biological relatives. , 1994, Journal of abnormal psychology.

[39]  Michael F. Green,et al.  Mixed Handedness and Features of Schizotypal Personality in a Nonclinical Sample , 1992, The Journal of nervous and mental disease.

[40]  C. Tamminga,et al.  Schizophrenia: Scientific Progress , 1989 .

[41]  R. Murray,et al.  Obstetric complications and age at onset in schizophrenia: an international collaborative meta-analysis of individual patient data. , 1997, The American journal of psychiatry.

[42]  P. Sham,et al.  Age at Onset, Sex, and Familial Psychiatric Morbidity in Schizophrenia , 1994, British Journal of Psychiatry.

[43]  Peter B. Jones,et al.  Childhood laterality and later risk of schizophrenia in the 1946 British birth cohort , 1997, Schizophrenia Research.

[44]  P. Jones,et al.  Premorbid social functioning in schizophrenia and bipolar disorder: similarities and differences. , 1997, The American journal of psychiatry.

[45]  R. Murray,et al.  Premorbid Social Underachievement in Schizophrenia , 1993, British Journal of Psychiatry.

[46]  N Marlow,et al.  Laterality and prematurity. , 1989, Archives of disease in childhood.

[47]  W. Honer,et al.  The temporal lobes, reversed asymmetry, and schizophrenia genetics , 1996, Schizophrenia Research.

[48]  T. Crow,et al.  Anomalous cerebral asymmetry and language processing in schizophrenia. , 1997, Schizophrenia bulletin.

[49]  R. C. Oldfield The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[50]  T. Crow,et al.  Schizophrenia as an anomaly of development of cerebral asymmetry. A postmortem study and a proposal concerning the genetic basis of the disease. , 1989, Archives of general psychiatry.

[51]  M. Owen,et al.  Pre-morbid Adjustment and Personality in Psychosis , 1991, British Journal of Psychiatry.

[52]  R. Priest Measurement and Classification of Psychiatric Symptoms , 1975 .

[53]  T. Crow Schizophrenia as failure of hemispheric dominance for language. , 1997, Trends in neurosciences.

[54]  J. Diamond,et al.  Correlates of left-handedness in a large sample of schizophrenic patients , 1995, Schizophrenia Research.

[55]  P. Hauser,et al.  On sinistrality and sex differences in schizophrenia. , 1985, The American journal of psychiatry.

[56]  W. Lishman,et al.  Hand Preference Patterns in Psychiatric Patients , 1976, British Journal of Psychiatry.