An image interpolation approach for acquisition time reduction in navigator‐based 4D MRI

&NA; Navigated 2D multi‐slice dynamic Magnetic Resonance (MR) imaging enables high contrast 4D MR imaging during free breathing and provides in‐vivo observations for treatment planning and guidance. Navigator slices are vital for retrospective stacking of 2D data slices in this method. However, they also prolong the acquisition sessions. Temporal interpolation of navigator slices can be used to reduce the number of navigator acquisitions without degrading specificity in stacking. In this work, we propose a convolutional neural network (CNN) based method for temporal interpolation, with motion field prediction as an intermediate step. The proposed formulation incorporates the prior knowledge that a motion field underlies changes in the image intensities over time. Previous approaches that interpolate directly in the intensity space are prone to produce blurry images or even remove structures in the images. Our method avoids such problems and faithfully preserves the information in the image. Further, an important advantage of our formulation is that it provides an unsupervised estimation of bi‐directional motion fields. These motion fields can potentially be used to halve the number of registrations required during 4D reconstruction, thus substantially reducing the reconstruction time. These advantages are achieved while preserving 4D reconstruction quality as compared to that with the true navigators.