Highly Focused Supersonic Microjets

This paper describes the production of thin, focused microjets with velocities of up to 850??m/s by the rapid vaporization of a small mass of liquid in an open liquid-filled capillary. The vaporization is caused by the absorption of a low-energy laser pulse. A likely explanation of the observed phenomenon is based on the impingement of the shock wave caused by the nearly instantaneous vaporization on the free surface of the liquid. We conduct an experimental study of the dependence of the jet velocity on several parameters and develop a semiempirical relation for its prediction. The coherence of the jets and their high velocity, good reproducibility, and controllability are unique features of the system. A possible application is to development of needle-free drug-injection systems that would be of great importance for health care worldwide.

[1]  G. Mirshekari,et al.  One-dimensional model for microscale shock tube flow , 2009 .

[2]  M. S. Longuet-Higgins,et al.  Bubbles, breaking waves and hyperbolic jets at a free surface , 1983, Journal of Fluid Mechanics.

[3]  D. Lohse,et al.  High-speed jet formation after solid object impact. , 2008, Physical review letters.

[4]  M. Longuet-Higgins,et al.  Vertical jets from standing waves. II , 2001, Proceedings of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[5]  Alfred Vogel,et al.  Material ejection in nanosecond Er:YAG laser ablation of water, liver, and skin , 2005 .

[6]  Cavitation bubble dynamics inside liquid drops in microgravity. , 2006, Physical review letters.

[7]  H. Hentschel,et al.  Breaking Faraday Waves: Critical Slowing of Droplet Ejection Rates , 1999 .

[8]  R. Penner,et al.  The nature of water on surfaces of laboratory systems and implications for heterogeneous chemistry in the troposphere , 2004 .

[9]  M. Longuet-Higgins,et al.  Critical microjets in collapsing cavities , 1995, Journal of Fluid Mechanics.

[10]  Kohsei Takehara,et al.  Experiments on bubble pinch-off , 2007 .

[11]  Garrett Birkhoff,et al.  Explosives with Lined Cavities , 1948 .

[12]  F. Avellan,et al.  Cavitation bubble behavior inside a liquid jet , 2007 .

[13]  Claus-Dieter Ohl,et al.  Experimental and Theoretical Bubble Dynamics , 2007 .

[14]  R. Stephenson.  A and V , 1962, The British journal of ophthalmology.

[15]  Kazuyoshi Takayama,et al.  Shock wave driven liquid microjets for drug delivery , 2009 .

[16]  Samir Mitragotri,et al.  Current status and future prospects of needle-free liquid jet injectors , 2006, Nature Reviews Drug Discovery.

[17]  Abdellah Hadjadj,et al.  Numerical study of shock propagation and attenuation in narrow tubes including friction and heat losses , 2010 .

[18]  D. Lohse,et al.  Controlled impact of a disk on a water surface: cavity dynamics , 2008, Journal of Fluid Mechanics.

[19]  D. Lohse,et al.  Giant bubble pinch-off. , 2006, Physical review letters.

[20]  Jack J. Yoh,et al.  A laser based reusable microjet injector for transdermal drug delivery , 2010 .

[21]  A. Vogel,et al.  Mechanisms of pulsed laser ablation of biological tissues. , 2003, Chemical reviews.

[22]  Stephan Gekle,et al.  Generation and breakup of Worthington jets after cavity collapse. Part 1. Jet formation , 2009, Journal of Fluid Mechanics.

[23]  D. Lathrop,et al.  Singularity dynamics in curvature collapse and jet eruption on a fluid surface , 2000, Nature.

[24]  E. Villermaux,et al.  Short-term dynamics of a density interface following an impact , 2007, Journal of Fluid Mechanics.

[25]  M. Longuet-Higgins,et al.  On the breaking of standing waves by falling jets , 2001 .

[26]  E. Villermaux,et al.  Physics of liquid jets , 2008 .

[27]  Michel Versluis,et al.  iLIF: illumination by Laser-Induced Fluorescence for single flash imaging on a nanoseconds timescale , 2011 .

[28]  D. Lohse,et al.  Growth and collapse of a vapour bubble in a microtube: the role of thermal effects , 2009, Journal of Fluid Mechanics.

[29]  M. Longuet-Higgins.  Vertical jets from standing waves , 2001, Proceedings of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[30]  R. Kelly,et al.  Circular streamline model of shaped‐charge jet and slug formation with asymmetry , 1994 .

[31]  Andrea Prosperetti,et al.  Growth and collapse of a vapor bubble in a narrow tube , 2000 .

[32]  T. Etoh,et al.  Spray and microjets produced by focusing a laser pulse into a hemispherical drop , 2009 .

[33]  C. Fressengeas,et al.  Breakup of Copper shaped-charge jets: Experiment, numerical simulations, and analytical modeling , 2005 .