DNA damage checkpoints in stem cells, ageing and cancer

[1]  Z. Ju,et al.  Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function , 2012, Aging cell.

[2]  H. Kestler,et al.  Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation. , 2012, Gastroenterology.

[3]  F. D. D. Fagagna,et al.  Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation , 2012, Nature Cell Biology.

[4]  Jing Huang,et al.  Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells. , 2012, Molecular cell.

[5]  Steffen Jung,et al.  The ATM–BID pathway regulates quiescence and survival of haematopoietic stem cells , 2012, Nature Cell Biology.

[6]  F. D. D. Fagagna,et al.  Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation , 2012, Nature Cell Biology.

[7]  H A Kestler,et al.  Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease , 2012, Neurology.

[8]  T. Hoang,et al.  Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis. , 2012, Blood.

[9]  Pat Monaghan,et al.  Telomere length in early life predicts lifespan , 2012, Proceedings of the National Academy of Sciences.

[10]  Clara Correia-Melo,et al.  Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence , 2012, Nature Communications.

[11]  S. Olthof,et al.  Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells , 2011, The Journal of experimental medicine.

[12]  M. Speicher,et al.  Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction , 2011, Nature Cell Biology.

[13]  Debashis Sahoo,et al.  Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age , 2011, Proceedings of the National Academy of Sciences.

[14]  T. Luedde,et al.  Senescence surveillance of pre-malignant hepatocytes limits liver cancer development , 2011, Nature.

[15]  N. LeBrasseur,et al.  Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders , 2011, Nature.

[16]  T. Kirkwood,et al.  On the Programmed/Non-Programmed Nature of Ageing within the Life History , 2011, Current Biology.

[17]  Christoph Lepper,et al.  An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration , 2011, Development.

[18]  K. Rudolph,et al.  Immunoaging induced by hematopoietic stem cell aging. , 2011, Current opinion in immunology.

[19]  C. Rübe,et al.  Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging , 2011, PloS one.

[20]  Derrick J. Rossi,et al.  DNA damage response in adult stem cells: pathways and consequences , 2011, Nature Reviews Molecular Cell Biology.

[21]  J. DeGregori,et al.  Relative fitness of hematopoietic progenitors influences leukemia progression , 2011, Leukemia.

[22]  E. Passegué,et al.  DNA-damage response in tissue-specific and cancer stem cells. , 2011, Cell stem cell.

[23]  R. Lehmann,et al.  Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila , 2010, PLoS genetics.

[24]  F. Gage,et al.  Puma is required for p53-induced depletion of adult stem cells , 2010, Nature Cell Biology.

[25]  Hans Clevers,et al.  Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells , 2010, Cell.

[26]  S. Ménendez,et al.  p53: Guardian of reprogramming , 2010, Cell cycle.

[27]  M. Warr,et al.  Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. , 2010, Cell stem cell.

[28]  E. Domany,et al.  A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. , 2010, Cell stem cell.

[29]  G. Krumschnabel,et al.  Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation. , 2010, Genes & development.

[30]  A. Strasser,et al.  Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death. , 2010, Genes & development.

[31]  S. Lowe,et al.  p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. , 2010, Genes & development.

[32]  Michael R. Elliott,et al.  Clearance of apoptotic cells: implications in health and disease , 2010, The Journal of cell biology.

[33]  H. Nakauchi,et al.  Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment , 2010, The Journal of experimental medicine.

[34]  J. Marine,et al.  Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death , 2010, Nature Cell Biology.

[35]  E. Taparowsky,et al.  Batf coordinates multiple aspects of B and T cell function required for normal antibody responses , 2010, The Journal of experimental medicine.

[36]  R. Medzhitov,et al.  p53-mediated hematopoietic stem and progenitor cell competition. , 2010, Cell stem cell.

[37]  Michèle T. Martin,et al.  Response of normal stem cells to ionizing radiation: a balance between homeostasis and genomic stability. , 2010, Mutation research.

[38]  I. Weissman,et al.  Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion , 2010, Proceedings of the National Academy of Sciences.

[39]  Nathan C Boles,et al.  Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. , 2010, Cell stem cell.

[40]  A. Marusyk,et al.  Irradiation Selects for p53-Deficient Hematopoietic Progenitors , 2010, PLoS biology.

[41]  R. O'Sullivan,et al.  Telomeres: protecting chromosomes against genome instability , 2010, Nature Reviews Molecular Cell Biology.

[42]  J. Hoeijmakers DNA damage, aging, and cancer. , 2009, The New England journal of medicine.

[43]  J. Bartek,et al.  The DNA-damage response in human biology and disease , 2009, Nature.

[44]  H. Kestler,et al.  p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice , 2009, Nature Genetics.

[45]  Pier Paolo Di Fiore,et al.  The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells , 2009, Cell.

[46]  S. Verhulst,et al.  Telomere shortening and survival in free-living corvids , 2009, Proceedings of the Royal Society B: Biological Sciences.

[47]  N. Sharpless,et al.  Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging , 2009, Aging cell.

[48]  I. Weissman,et al.  CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis , 2009, Cell.

[49]  C. Schildkraut,et al.  Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication , 2009, Cell.

[50]  D. Allman Faculty Opinions recommendation of Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. , 2009 .

[51]  N. Binh,et al.  Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation , 2009, Cell.

[52]  C. Pronk,et al.  Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence , 2009, Oncogene.

[53]  J. Campisi,et al.  Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion , 2009, Nature Cell Biology.

[54]  Y. Liu,et al.  p53 regulates hematopoietic stem cell quiescence. , 2009, Cell stem cell.

[55]  A. Clarke,et al.  Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation , 2008, Oncogene.

[56]  Andreas Trumpp,et al.  Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair , 2008, Cell.

[57]  P. Klatt,et al.  Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice , 2008, Cell.

[58]  Sean J. Morrison,et al.  Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression , 2008, Cell.

[59]  Jichun Chen,et al.  Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice. , 2008, Experimental hematology.

[60]  M. Manns,et al.  Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease , 2008, Proceedings of the National Academy of Sciences.

[61]  M. Karin,et al.  p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling , 2008, Cell.

[62]  D. Cortez,et al.  ATR: an essential regulator of genome integrity , 2008, Nature Reviews Molecular Cell Biology.

[63]  A. Terzic,et al.  Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency , 2008, Nature Cell Biology.

[64]  H. Sieburg,et al.  A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. , 2008, Blood.

[65]  M. Capecchi,et al.  Bmi1 is expressed in vivo in intestinal stem cells , 2008, Nature Genetics.

[66]  Fred H. Gage,et al.  A role for adult TLX-positive neural stem cells in learning and behaviour , 2008, Nature.

[67]  A. Levine,et al.  Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations , 2007, Proceedings of the National Academy of Sciences.

[68]  K. Rudolph,et al.  Telomere shortening and ageing , 2007, Zeitschrift für Gerontologie und Geriatrie.

[69]  T. Kunkel,et al.  Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice , 2007, Cell.

[70]  P. Klatt,et al.  Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeres. , 2007, Genes & development.

[71]  T. Lange,et al.  Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1 , 2007, Nature.

[72]  Manuel Serrano,et al.  The common biology of cancer and ageing , 2007, Nature.

[73]  Chad A Shaw,et al.  Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation , 2007, PLoS biology.

[74]  P. Klatt,et al.  Delayed ageing through damage protection by the Arf/p53 pathway , 2007, Nature.

[75]  Anastasia Nijnik,et al.  DNA repair is limiting for haematopoietic stem cells during ageing , 2007, Nature.

[76]  Irving L. Weissman,et al.  Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age , 2007, Nature.

[77]  A. Bhandoola,et al.  Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. , 2007, Cell stem cell.

[78]  A. Trumpp,et al.  Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment , 2007, Nature Medicine.

[79]  T. Partridge,et al.  A Population of Myogenic Stem Cells That Survives Skeletal Muscle Aging , 2007, Stem cells.

[80]  L. Bystrykh,et al.  A Limited Role for p21Cip1/Waf1 in Maintaining Normal Hematopoietic Stem Cell Functioning , 2007, Stem cells.

[81]  J. Roder,et al.  Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice , 2007, Proceedings of the National Academy of Sciences.

[82]  L. Donehower,et al.  The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. , 2007, Blood.

[83]  Carlos Cordon-Cardo,et al.  Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas , 2007, Nature.

[84]  P. Jeggo,et al.  ATR‐dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling , 2006, The EMBO journal.

[85]  Hong Jiang,et al.  Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation , 2006, Nature Genetics.

[86]  S. Pitzalis,et al.  Aging is associated with increased clonogenic potential in rat liver in vivo , 2006, Aging cell.

[87]  K. Ligon,et al.  p16INK4a induces an age-dependent decline in islet regenerative potential , 2006, Nature.

[88]  R. DePinho,et al.  Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a , 2006, Nature.

[89]  S. Morrison,et al.  Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing , 2006, Nature.

[90]  T. Rando Stem cells, ageing and the quest for immortality , 2006, Nature.

[91]  P. Klatt,et al.  Increased p53 activity does not accelerate telomere‐driven ageing , 2006, EMBO reports.

[92]  J. Sedivy,et al.  Cellular Senescence in Aging Primates , 2006, Science.

[93]  R. Cardiff,et al.  Impaired DNA Replication within Progenitor Cell Pools Promotes Leukemogenesis , 2005, PLoS biology.

[94]  Eric J. Brown,et al.  The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor , 2005, Nature.

[95]  K. Meletis,et al.  p53 suppresses the self-renewal of adult neural stem cells , 2005, Development.

[96]  B. Sorrentino,et al.  A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress. , 2005, Blood.

[97]  I. Weissman,et al.  Cell intrinsic alterations underlie hematopoietic stem cell aging. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[98]  J. Tilly,et al.  A central role for ceramide in the age‐related acceleration of apoptosis in the female germline , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[99]  D. van der Kooy,et al.  p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. , 2005, Genes & development.

[100]  Frederick W. Alt,et al.  DNA Repair, Genome Stability, and Aging , 2005, Cell.

[101]  J. Hoeijmakers,et al.  Reduced hematopoietic reserves in DNA interstrand crosslink repair‐deficient Ercc1−/− mice , 2005, The EMBO journal.

[102]  P. Klatt,et al.  Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. , 2004, Genes & development.

[103]  N. Sharpless,et al.  Ink4a/Arf expression is a biomarker of aging. , 2004, The Journal of clinical investigation.

[104]  Tak W. Mak,et al.  Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells , 2004, Nature.

[105]  R. Kumar,et al.  BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice , 2004, Nature Genetics.

[106]  R. DePinho,et al.  The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis , 2004, Oncogene.

[107]  N. Carter,et al.  A DNA damage checkpoint response in telomere-initiated senescence , 2003, Nature.

[108]  T. Lange,et al.  DNA Damage Foci at Dysfunctional Telomeres , 2003, Current Biology.

[109]  Lili Liu,et al.  Repopulating defect of mismatch repair-deficient hematopoietic stem cells. , 2003, Blood.

[110]  Jichun Chen,et al.  Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. , 2003, Experimental hematology.

[111]  Irving L. Weissman,et al.  Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells , 2003, Nature.

[112]  T. Kunkel,et al.  Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility. , 2003, Genes & development.

[113]  J. Hoeijmakers,et al.  Aging and Genome Maintenance: Lessons from the Mouse? , 2003, Science.

[114]  Robert M. Bachoo,et al.  Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing , 2003, Nature.

[115]  R. Cawthon,et al.  Association between telomere length in blood and mortality in people aged 60 years or older , 2003, The Lancet.

[116]  P. Klatt,et al.  'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally , 2002, The EMBO journal.

[117]  J. Potter,et al.  Chromosomal instability in ulcerative colitis is related to telomere shortening , 2002, Nature Genetics.

[118]  D. Lydall,et al.  EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. , 2002, Genes & development.

[119]  C. Leeuwenburgh,et al.  The Role of Apoptosis in the Normal Aging Brain, Skeletal Muscle, and Heart , 2002, Annals of the New York Academy of Sciences.

[120]  M. Manns,et al.  Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[121]  T. Volkert,et al.  E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. , 2002, Genes & development.

[122]  Stephen N. Jones,et al.  p53 mutant mice that display early ageing-associated phenotypes , 2002, Nature.

[123]  D. Carrasco,et al.  Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis , 2001, Nature.

[124]  E. Laconi,et al.  A growth-constrained environment drives tumor progression in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[125]  R. DePinho,et al.  Telomere dysfunction and evolution of intestinal carcinoma in mice and humans , 2001, Nature Genetics.

[126]  H. Nakauchi,et al.  Age-Associated Characteristics of Murine Hematopoietic Stem Cells , 2000, The Journal of experimental medicine.

[127]  Lynda Chin,et al.  Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice , 2000, Nature.

[128]  D. Scadden,et al.  Hematopoietic stem cell quiescence maintained by p21cip1/waf1. , 2000, Science.

[129]  R. Swerdloff,et al.  Reproductive aging in the Brown Norway rat is characterized by accelerated germ cell apoptosis and is not altered by luteinizing hormone replacement. , 1999, Journal of andrology.

[130]  Lynda Chin,et al.  p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis , 1999, Cell.

[131]  Sandy Chang,et al.  Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice , 1999, Cell.

[132]  R. DePinho,et al.  Essential role of mouse telomerase in highly proliferative organs , 1998, Nature.

[133]  C. Harley,et al.  Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.

[134]  T. Pandita,et al.  Influence of ATM function on telomere metabolism , 1997, Oncogene.

[135]  María A Blasco,et al.  Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA , 1997, Cell.

[136]  Wenyi Wei,et al.  Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. , 1997, Science.

[137]  I. Weissman,et al.  The aging of hematopoietic stem cells , 1996, Nature Medicine.

[138]  C Roskelley,et al.  A biomarker that identifies senescent human cells in culture and in aging skin in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[139]  K. Ohyashiki,et al.  Telomere shortening associated with disease evolution patterns in myelodysplastic syndromes. , 1994, Cancer research.

[140]  C. Purdie,et al.  Thymocyte apoptosis induced by p53-dependent and independent pathways , 1993, Nature.

[141]  U. Paulus,et al.  A model of the control of cellular regeneration in the intestinal crypt after perturbation based solely on local stem cell regulation , 1992, Cell proliferation.

[142]  J. Shay,et al.  The two-stage mechanism controlling cellular senescence and immortalization , 1992, Experimental Gerontology.

[143]  J. Shay,et al.  A role for both RB and p53 in the regulation of human cellular senescence. , 1991, Experimental cell research.

[144]  George C. Williams,et al.  PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE , 1957, Science of Aging Knowledge Environment.

[145]  E. Shelton,et al.  Modification of irradiation injury in mice and guinea pigs by bone marrow injections. , 1951, Journal of the National Cancer Institute.

[146]  A. Schambach,et al.  A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage , 2014 .

[147]  Carolien M Woolthuis The biology of human hematopoietic stem and progenitor cells in acute myeloid leukemia, aging and autologous transplantation , 2013 .

[148]  S. Ménendez,et al.  Guardian of reprogramming , 2010 .

[149]  Myriam Alcalay,et al.  Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells , 2009, Nature.

[150]  R. Eisenman,et al.  Tumor suppression and normal aging in mice with constitutively high p53 activity. , 2006, Genes & development.

[151]  V. Meineke The role of damage to the cutaneous system in radiation-induced multi-organ failure , 2005 .