Seizure‐Promoting Effect of Blood–Brain Barrier Disruption

Summary:  Purpose: It is generally accepted that blood–brain barrier (BBB) failure occurs as a result of CNS diseases, including epilepsy. However, evidences also suggest that BBB failure may be an etiological factor contributing to the development of seizures.

[1]  G. Barnett,et al.  Serum Transthyretin Monomer as a Possible Marker of Blood-to-CSF Barrier Disruption , 2003, The Journal of Neuroscience.

[2]  R. Ichord,et al.  Electrographic Neonatal Seizures after Infant Heart Surgery , 2005, Epilepsia.

[3]  C. Betsholtz,et al.  Impaired induction of blood‐brain barrier properties in aortic endothelial cells by astrocytes from GFAB‐deficient mice , 1998, Glia.

[4]  D. Janigro,et al.  Peripheral detection of S100beta during cardiothoracic surgery: what are we really measuring? , 2004, The Annals of thoracic surgery.

[5]  W. Mutschler,et al.  Assessment of Early Brain Damage in Carotid Endarterectomy: Evaluation of S-100B Serum Levels and Somatosensory Evoked Potentials in a Pilot Study , 2002, World Journal of Surgery.

[6]  Michael M Haglund,et al.  Furosemide and mannitol suppression of epileptic activity in the human brain. , 2005, Journal of neurophysiology.

[7]  A. Naing,et al.  Methotrexate‐Induced Status Epilepticus , 2005, American journal of hematology.

[8]  P. Schwartzkroin,et al.  Osmolarity, ionic flux, and changes in brain excitability , 1998, Epilepsy Research.

[9]  M. Cavaglià,et al.  Peripheral markers of brain damage and blood-brain barrier dysfunction. , 2003, Restorative neurology and neuroscience.

[10]  S. Rapoport,et al.  Osmotic opening of the blood-brain barrier permeability to N-(2-hydroxypropyl)methacrylamide copolymers. Effect of polymer -Mw charge and hydrophobicity , 1989 .

[11]  J Perl,et al.  Serum S-100β as a possible marker of blood–brain barrier disruption , 2002, Brain Research.

[12]  Z. Járányi,et al.  Impairment of Blood-Brain Barrier Integrity during Carotid Surgery as Assessed by Serum S-100B Protein Concentrations , 2003, Clinical chemistry and laboratory medicine.

[13]  G. Jarvik,et al.  Increasing duration of deep hypothermic circulatory arrest is associated with an increased incidence of postoperative electroencephalographic seizures. , 2005, The Journal of thoracic and cardiovascular surgery.

[14]  P. Kornblith.  Outwitting the Blood-Brain Barrier for Therapeutic Purposes: Osmotic Opening and Other Means , 1998 .

[15]  D. Pham‐Dinh,et al.  Alexander disease: putative mechanisms of an astrocytic encephalopathy , 2004, Cellular and Molecular Life Sciences CMLS.

[16]  Jens P Dreier,et al.  Lasting Blood-Brain Barrier Disruption Induces Epileptic Focus in the Rat Somatosensory Cortex , 2004, The Journal of Neuroscience.

[17]  David S. Smith,et al.  A comparison of the perioperative neurologic effects of hypothermic circulatory arrest versus low-flow cardiopulmonary bypass in infant heart surgery. , 1994 .

[18]  G. Lenzi,et al.  Effects on EEG of the osmotic opening of the blood-brain barrier in rats. , 1980, Life sciences.

[19]  E. Frenkel,et al.  Neurotoxicity of chemotherapeutic agents after blood‐brain barrier modification: Neuropathological studies , 1983, Annals of neurology.

[20]  E. Frenkel,et al.  Osmotic blood-brain barrier modification: clinical documentation by enhanced CT scanning and/or radionuclide brain scanning. , 1983, AJR. American journal of roentgenology.

[21]  Lauren C. Frey,et al.  Epidemiology of Posttraumatic Epilepsy: A Critical Review , 2003, Epilepsia.

[22]  P. Mazzone,et al.  S100beta as a predictor of brain metastases: brain versus cerebrovascular damage. , 2005, Cancer.

[23]  D. Janigro.  Blood–brain barrier, ion homeostasis and epilepsy: possible implications towards the understanding of ketogenic diet mechanisms , 1999, Epilepsy Research.

[24]  P. Lewczuk,et al.  S-100 protein as marker of the blood-brain barrier disruption in children with internal hydrocephalus and epilepsy--a preliminary study. , 2004, Roczniki Akademii Medycznej w Bialymstoku.

[25]  J Perl,et al.  Serum S-100beta as a possible marker of blood-brain barrier disruption. , 2002, Brain research.

[26]  H. Davson.  Blood–brain barrier , 1977, Nature.

[27]  M. Cavaglià,et al.  Peripheral markers of blood-brain barrier damage. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[28]  W. S. Alexander.  Progressive fibrinoid degeneration of fibrillary astrocytes associated with mental retardation in a hydrocephalic infant. , 1949, Brain : a journal of neurology.

[29]  T. Shiihara,et al.  Fluctuation of Computed Tomographic Findings in White Matter in Alexander's Disease , 2002, Journal of child neurology.

[30]  M. Ball,et al.  Effects of gadopentetate dimeglumine administration after osmotic blood-brain barrier disruption: toxicity and MR imaging findings. , 1991, AJNR. American journal of neuroradiology.

[31]  Alan C. Evans,et al.  Reduced cerebral glucose metabolism and increased brain capillary permeability following high‐dose methotrexate chemotherapy: A positron emission tomographic study , 1987, Annals of neurology.

[32]  R. Braziel,et al.  Primary CNS lymphoma treated with osmotic blood-brain barrier disruption: prolonged survival and preservation of cognitive function. , 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[33]  D. Clunie,et al.  Osmotic blood-brain barrier disruption: CT and radionuclide imaging. , 1994, AJNR. American journal of neuroradiology.

[34]  G. Mathern,et al.  Epilepsia , 1991, NEURO FUNDAMENTAL.

[35]  E. Neuwelt,et al.  Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. , 1998, Neurosurgery.

[36]  B. Banwell,et al.  Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander disease , 2005, Annals of neurology.

[37]  N. Greig,et al.  Pharmacokinetics of chlorambucil-tertiary butyl ester, a lipophilic chlorambucil derivative that achieves and maintains high concentrations in brain , 2004, Cancer Chemotherapy and Pharmacology.

[38]  M. Grady,et al.  Regional patterns of blood-brain barrier breakdown following central and lateral fluid percussion injury in rodents. , 1993, Journal of neurotrauma.

[39]  R. Pascual-Marqui,et al.  Focal Cortical Dysfunction and Blood–Brain Barrier Disruption in Patients With Postconcussion Syndrome , 2005, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[40]  Effects of Gd‐DTPA after Osmotic BBB Disruption in a Rodent Model: Toxicity and MR Findings , 1994, Journal of computer assisted tomography.