Survivin ( g ) Adult T-cell Leukemia / Lymphoma December

In this issue of ONCOLOGY, Tobinai reviews the management of human T-cell lymphotropic virus type 1 (HTLV-1)–associated adult T-cell leukemia/lymphoma (ATL). Although rare in the United States, an estimated 10 to 20 million people are infected with HTLV-1 worldwide and 2% to 5% will develop ATL.[1] The prevalence of HTLV-1 infection and the consequent poor prognosis of ATL mark the disease as a public health issue in many countries. Prevention of transmission will ultimately eliminate disease associated with HTLV-1 infection.

[1]  W. Harrington,et al.  First Line Antiviral Therapy Significantly Improves Survival of Patients with Acute, Chronic and Smoldering ATL: a Worldwide Meta-Analysis. , 2009 .

[2]  T. Waldmann,et al.  Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability. , 2009, Blood.

[3]  K. Yamaguchi,et al.  Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  T. Waldmann,et al.  Receptor-Directed Therapy of T-Cell Leukemias and Lymphomas , 2008, Journal of immunotoxicology.

[5]  R. Ueda,et al.  VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  H. Aburatani,et al.  A genomic analysis of adult T-cell leukemia , 2007, Oncogene.

[7]  T. Waldmann,et al.  Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence. , 2006, Blood.

[8]  S. Kamihira,et al.  Survivin an Important Determinant for Prognosis in Adult T-cell Leukemia: A Novel Biomarker in Practical Hemato-oncology , 2002, Leukemia & lymphoma.

[9]  S. Katamine,et al.  Primary prevention of HTLV-1 in Japan. , 1997, Leukemia.

[10]  T. Waldmann,et al.  Distribution of human leukocyte antigens in a population of black patients with human T-cell lymphotrophic virus type I-associated adult T-cell leukemia/lymphoma. , 1996, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[11]  D. Altieri Survivin, cancer networks and pathway-directed drug discovery , 2008, Nature Reviews Cancer.