Single photon emission computed tomography (SPECT) brain imaging using N,N,N′‐trimethyl‐N′‐(2 hydroxy‐3‐methyl‐5–123Iiodobenzyl)‐1,3‐propanediamine 2 HCl (HIPDM)

HIPDM-SPECT brain imaging was performed in four patients with intractable complex partial seizures (CPS). Three patients had an epileptogenic focus in one temporal lobe and underwent anterior temporal lobectomy. Interictal HIPDM-SPECT demonstrated decreased regional cerebral perfusion (rCP) in the epileptogenic area in only one patient, but ictal studies showed increased rCP in the epileptic foci of all three patients. In the fourth patient, interictal HIPDM-SPECT showed increased rCP in the area of epileptogenic focus; when antiepileptic medication was taken, rCP decreased. HIPDM-SPECT brain imaging is useful for localizing epileptogenic foci in CPS.

[1]  W. J. Brown,et al.  Pathological findings underlying focal temporal lobe hypometabolism in partial epilepsy , 1982, Annals of neurology.

[2]  F Plum,et al.  Cerebral energy metabolism, pH, and blood flow during seizures in the cat. , 1974, The American journal of physiology.

[3]  J. Mazziotta,et al.  The Use and Impact of Positron Computed Tomography Scanning in Epilepsy , 1984, Epilepsia.

[4]  R. Uren,et al.  Cerebral blood flow patterns in epilepsy. , 1983, Progress in clinical and biological research.

[5]  M E Phelps,et al.  Epileptic patterns of local cerebral metabolism and perfusion in humans determined by emission computed tomography of 18FDG and 13NH3 , 1980, Annals of neurology.

[6]  D. Ingvar.  Epilepsy related to cerebral blood flow and metabolism , 1984, Acta psychiatrica Scandinavica. Supplementum.

[7]  D. Kuhl,et al.  Local cerebral metabolism during partial seizures , 1983, Neurology.

[8]  S. Goldring,et al.  A method for surgical management of focal epilepsy, especially as it relates to children. , 1978, Journal of neurosurgery.

[9]  E. Melamed,et al.  Interictal regional cerebral blood flow in patients with partial seizures , 1976, Neurology.

[10]  J C Mazziotta,et al.  Interictal cerebral glucose metabolism in partial epilepsy and its relation to EEG changes , 1982, Annals of neurology.

[11]  M E Raichle,et al.  Correlation Between Regional Cerebral Blood Flow and Oxidative Metabolism: In Vivo Studies in Man , 1976 .

[12]  W. Oldendorf,et al.  N-isopropyl-[123I] p-iodoamphetamine: single-pass brain uptake and washout; binding to brain synaptosomes; and localization in dog and monkey brain. , 1980, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[13]  D. Ingvar,et al.  Regional cerebral blood flow in focal cortical epilepsy. , 1976, Archives of neurology.

[14]  D. H. Ingvar,et al.  rCBF in Focal Cortical Epilepsy , 1975 .

[15]  Walsh Go,et al.  The selection process for surgery of intractable complex partial seizures: surface EEG and depth electrography. , 1983, Research publications - Association for Research in Nervous and Mental Disease.

[16]  M Blau,et al.  A new brain perfusion imaging agent: [I-123]HIPDM:N,N,N'-trimethyl-N'-[2-hydroxy-3-methyl-5-iodobenzyl]-1,3-propanediamine. , 1983, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[17]  J. Barrio,et al.  Quantifying local cerebral blood flow by N-isopropyl-p-[123I]iodoamphetamine (IMP) tomography. , 1982, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[18]  J. Talairach,et al.  Stereotaxic Approach to Epilepsy , 1973 .

[19]  P. Crandall,et al.  Comparative localization of epileptic foci in partial epilepsy by PCT and EEG. , 1982, Annals of neurology.

[20]  F. Fazio,et al.  Metabolic and Kinetic Considerations in the Use of [125I]HIPDM for Quantitative Measurement of Regional Cerebral Blood Flow , 1985, Journal of Cerebral Blood Flow and Metabolism.

[21]  D Front,et al.  Initial experience with SPECT (single-photon computerized tomography) of the brain using N-isopropyl I-123 p-iodoamphetamine: concise communication. , 1982, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[22]  Wilder Penfield,et al.  CEREBRAL BLOOD FLOW DURING INDUCED EPILEPTIFORM SEIZURES IN ANIMALS AND MAN , 1939 .

[23]  N. Lassen,et al.  The Mechanism of Cerebral Hyperemia in Electrically Induced Epileptic Seizures in Man , 1975 .