Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
暂无分享,去创建一个
[1] M. Sporn,et al. Transforming growth factor I81 (TGF-f81) controls expression of major histocompatibility genes in the postnatal mouse: Aberrant histocompatibility antigen expression in the pathogenesis of the TGF-f81 null mouse phenotype , 2005 .
[2] Y. Muto,et al. Analyses of microsatellite instability and the transforming growth factor‐β receptor type II gene mutation in sporadic breast cancer and their correlation with clinicopathological features , 2004, Breast Cancer Research and Treatment.
[3] E. Stanley,et al. Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1 , 2003, The Journal of cell biology.
[4] J. Massagué,et al. Mad Upregulation and Id2 Repression Accompany Transforming Growth Factor (TGF)-β-mediated Epithelial Cell Growth Suppression* , 2003, Journal of Biological Chemistry.
[5] R. Cardiff,et al. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[6] J. Massagué,et al. Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus , 2003, Cell.
[7] M. Quintanilla,et al. Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. , 2003, The Journal of biological chemistry.
[8] Carlos L. Arteaga,et al. Targeting the TGFβ signaling network in human neoplasia , 2003 .
[9] C. Cordon-Cardo,et al. A multigenic program mediating breast cancer metastasis to bone. , 2003, Cancer cell.
[10] Jeffrey L. Wrana,et al. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover , 2003, Nature Cell Biology.
[11] K. Miyazono,et al. Chromosomal Region Maintenance 1 (CRM1)-dependent Nuclear Export of Smad Ubiquitin Regulatory Factor 1 (Smurf1) Is Essential for Negative Regulation of Transforming Growth Factor-β Signaling by Smad7* , 2003, The Journal of Biological Chemistry.
[12] P. Devilee,et al. Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene , 2003, Genes, chromosomes & cancer.
[13] C. Heldin,et al. Elucidation of Smad Requirement in Transforming Growth Factor-β Type I Receptor-induced Responses* , 2003, The Journal of Biological Chemistry.
[14] R. Xavier,et al. Transforming Growth Factor- (cid:1) Mediates Intestinal Healing and Susceptibility to Injury in Vitro and in Vivo Through Epithelial Cells , 2022 .
[15] A. Levinson,et al. Immunoregulatory Role of Transforming Growth Factor 0 ( TGF-0 ) in Development of Killer Cells : Comparison of Active and Latent TGF-01 By , 2003 .
[16] Yibin Kang,et al. A Self-Enabling TGFβ Response Coupled to Stress Signaling: Smad Engages Stress Response Factor ATF3 for Id1 Repression in Epithelial Cells.: Smad Engages Stress Response Factor ATF3 for Id1 Repression in Epithelial Cells. , 2003 .
[17] C. Hill,et al. Stoichiometry of Active Smad-Transcription Factor Complexes on DNA* , 2002, The Journal of Biological Chemistry.
[18] F. Itoh,et al. Smad‐dependent GADD45β expression mediates delayed activation of p38 MAP kinase by TGF‐β , 2002 .
[19] G. Krystal,et al. Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP , 2002, Nature Cell Biology.
[20] J. Tuxhorn,et al. Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model. , 2002, Cancer research.
[21] J. Massagué,et al. Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage , 2002, Nature.
[22] K. Miyazono,et al. Compound disruption of smad2 accelerates malignant progression of intestinal tumors in apc knockout mice. , 2002, Cancer research.
[23] A. Galloway,et al. Transforming growth factor-beta1 induces apoptosis in vascular endothelial cells by activation of mitogen-activated protein kinase. , 2002, Surgery.
[24] J. Massagué,et al. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. , 2002, Molecular cell.
[25] C. Hill,et al. Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity. , 2002, Molecular cell.
[26] Ying E. Zhang,et al. TGF‐β receptor‐activated p38 MAP kinase mediates Smad‐independent TGF‐β responses , 2002 .
[27] S. Karlsson,et al. Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. , 2002, Blood.
[28] J. Massagué,et al. E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression , 2002, Cell.
[29] A. Balmain,et al. Metastasis is driven by sequential elevation of H-ras and Smad2 levels , 2002, Nature Cell Biology.
[30] B. Olson,et al. Inhibition of Transforming Growth Factor (TGF)- 1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF- Type I Receptor Kinase Activity: SB-431542 , 2002 .
[31] A. Reith,et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. , 2002, Molecular pharmacology.
[32] C. Arteaga,et al. Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases , 2002 .
[33] L. Wakefield,et al. Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects. , 2002, The Journal of clinical investigation.
[34] J. Thiery. Epithelial–mesenchymal transitions in tumour progression , 2002, Nature Reviews Cancer.
[35] Jian Luo,et al. Extracellular domain of TGFβ type III receptor inhibits angiogenesis and tumor growth in human cancer cells , 2002, Oncogene.
[36] M. Goumans,et al. Regulation of cell proliferation by Smad proteins , 2002, Journal of cellular physiology.
[37] M. Goumans,et al. Balancing the activation state of the endothelium via two distinct TGF‐β type I receptors , 2002, The EMBO journal.
[38] E. Fearon,et al. The SLUG zinc-finger protein represses E-cadherin in breast cancer. , 2002, Cancer research.
[39] L. Wakefield,et al. TGF-β signaling: positive and negative effects on tumorigenesis , 2002 .
[40] J. Downward,et al. Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis , 2002, The Journal of Cell Biology.
[41] J. Downward,et al. Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. , 2002, The Journal of cell biology.
[42] L. Wakefield,et al. TGF-beta signaling: positive and negative effects on tumorigenesis. , 2002, Current opinion in genetics & development.
[43] R. Flavell,et al. Transforming growth factor-β in T-cell biology , 2002, Nature Reviews Immunology.
[44] Jia-Yun Chen,et al. TGF-β induces apoptosis through Smad-mediated expression of DAP-kinase , 2002, Nature Cell Biology.
[45] T. Muir,et al. Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling. , 2001, Molecular cell.
[46] Naoto Hirano,et al. Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells , 2001, Nature Immunology.
[47] T. Matsumura,et al. Involvement of CTGF, a Hypertrophic Chondrocyte-Specific Gene Product, in Tumor Angiogenesis , 2001, Oncology.
[48] A. Brunet,et al. Transforming Growth Factor (cid:1) Enhances Epithelial Cell Survival via Akt-dependent Regulation of FKHRL1 , 2022 .
[49] R. Flavell,et al. Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells , 2001, Nature Medicine.
[50] Allan Balmain,et al. TGF-β signaling in tumor suppression and cancer progression , 2001, Nature Genetics.
[51] R. Beauchamp,et al. Oncogenic Ras Represses Transforming Growth Factor-β/Smad Signaling by Degrading Tumor Suppressor Smad4* , 2001, The Journal of Biological Chemistry.
[52] Robert A. Weinberg,et al. TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation , 2001, Nature Cell Biology.
[53] A. Glick,et al. Conditional epidermal expression of TGFβ1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[54] J. Letterio,et al. The Smad3 Protein Is Involved in TGF-β Inhibition of Class II Transactivator and Class II MHC Expression1 , 2001, The Journal of Immunology.
[55] R. Fairman,et al. Formation of a Stable Heterodimer between Smad2 and Smad4* , 2001, The Journal of Biological Chemistry.
[56] J. Zavadil,et al. Genetic programs of epithelial cell plasticity directed by transforming growth factor-β , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[57] G. Berx,et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. , 2001, Molecular cell.
[58] Tomoki Chiba,et al. Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation* , 2001, The Journal of Biological Chemistry.
[59] M. Goumans,et al. Abnormal angiogenesis but intact hematopoietic potential in TGF‐β type I receptor‐deficient mice , 2001, The EMBO journal.
[60] J. Massagué,et al. TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b , 2001, Nature Cell Biology.
[61] J. Massagué,et al. Repression of p15INK4b expression by Myc through association with Miz-1 , 2001, Nature Cell Biology.
[62] T. Tsushima,et al. Transforming growth factor‐β1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma , 2001 .
[63] J. Southgate,et al. Transforming growth factor‐β promotes ‘death by neglect’ in post‐activated human T cells , 2001, Immunology.
[64] Xiao-Jing Wang. Role of TGFβ signaling in skin carcinogenesis , 2001 .
[65] J. Massagué,et al. Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[66] Kerstin Krieglstein,et al. Mechanisms of TGF-β-mediated apoptosis , 2001, Cell and Tissue Research.
[67] H. Moses,et al. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. , 2001, Molecular biology of the cell.
[68] A. Balmain,et al. TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest , 2000 .
[69] Stephanie Birkey Reffey,et al. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif , 2000, Nature Cell Biology.
[70] J D Norton,et al. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. , 2000, Journal of cell science.
[71] A. Schulze,et al. Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. , 2000, Genes & development.
[72] J. Massagué,et al. TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders , 2000, Cell.
[73] A. Iavarone,et al. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins , 2000, Nature.
[74] R. Derynck,et al. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF‐β , 2000 .
[75] N. Wake,et al. Analysis of specific gene mutations in the transforming growth factor-beta signal transduction pathway in human ovarian cancer. , 2000, Cancer research.
[76] M. Hatano,et al. Blockade of Transforming Growth Factor β/Smad Signaling in T Cells by Overexpression of Smad7 Enhances Antigen-Induced Airway Inflammation and Airway Reactivity , 2000, The Journal of experimental medicine.
[77] Andrew V. Nguyen,et al. Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution. , 2000, Development.
[78] H. Lodish,et al. A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[79] Raymond B. Runyan,et al. Slug is an essential target of TGFbeta2 signaling in the developing chicken heart. , 2000, Developmental biology.
[80] N. Holbrook,et al. Transforming Growth Factor-β1 Suppresses Serum Deprivation-induced Death of A549 Cells through Differential Effects on c-Jun and JNK Activities* , 2000, The Journal of Biological Chemistry.
[81] Jay H. Chang,et al. Absence of proximal duct apoptosis in the ventral prostate of transgenic mice carrying the C3(1)‐TGF‐β type II dominant negative receptor , 2000, The Prostate.
[82] R. Houlston,et al. Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium. , 2000, Cancer research.
[83] J. Massagué,et al. Transcriptional control by the TGF‐β/Smad signaling system , 2000 .
[84] Lin Chen,et al. Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice , 2000, Oncogene.
[85] Seong-Jin Kim,et al. Disruption of T Cell Homeostasis in Mice Expressing a T Cell–Specific Dominant Negative Transforming Growth Factor β II Receptor , 2000, The Journal of experimental medicine.
[86] P. Donahoe,et al. Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[87] R. Flavell,et al. Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease , 2000 .
[88] J. Massagué,et al. OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways , 2000, Cell.
[89] H. Moses,et al. Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription* , 1999, The Journal of Biological Chemistry.
[90] M Oshima,et al. Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice. , 1999, Cancer research.
[91] D. Bigner,et al. Transforming Growth Factor-β-mediated p15INK4BInduction and Growth Inhibition in Astrocytes Is SMAD3-dependent and a Pathway Prominently Altered in Human Glioma Cell Lines* , 1999, The Journal of Biological Chemistry.
[92] J. Massagué,et al. Ubiquitin-dependent degradation of TGF-β-activated Smad2 , 1999, Nature Cell Biology.
[93] H. Ostrer,et al. TβR-I(6A) Is a Candidate Tumor Susceptibility Allele , 1999 .
[94] H. Lodish,et al. A deletion in the gene for transforming growth factor beta type I receptor abolishes growth regulation by transforming growth factor beta in a cutaneous T-cell lymphoma. , 1999, Blood.
[95] A. Roberts,et al. β2-Microglobulin-Deficient Background Ameliorates Lethal Phenotype of the TGF-β1 Null Mouse , 1999, The Journal of Immunology.
[96] A. Kulkarni,et al. Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse. , 1999, Journal of immunology.
[97] Anita B. Roberts,et al. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response , 1999, Nature Cell Biology.
[98] Jeffrey L. Wrana,et al. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation , 1999, Nature.
[99] B. O’Malley,et al. Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[100] K. Yoshioka,et al. Gene mutation of transforming growth factor β1 type II receptor in hepatocellular carcinoma , 1999, International journal of cancer.
[101] Takeo Iwama,et al. Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis , 1999, Oncogene.
[102] A. Régnault,et al. TGF-β1 Prevents the Noncognate Maturation of Human Dendritic Langerhans Cells , 1999, The Journal of Immunology.
[103] D. L. Weeks,et al. TGFbeta2 and TGFbeta3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart. , 1999, Developmental biology.
[104] A. Régnault,et al. TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells. , 1999, Journal of immunology.
[105] J. Massagué,et al. A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. , 1999, Genes & development.
[106] H. Moses,et al. Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching. , 1999, Molecular biology of the cell.
[107] X. F. Wang,et al. Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction , 1999, Molecular and Cellular Biology.
[108] J. Rhim,et al. Role of interleukin 10 and transforming growth factor beta1 in the angiogenesis and metastasis of human prostate primary tumor lines from orthotopic implants in severe combined immunodeficiency mice. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[109] A. Roberts,et al. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF‐β , 1999, The EMBO journal.
[110] P. Howe,et al. TGF‐β induces fibronectin synthesis through a c‐Jun N‐terminal kinase‐dependent, Smad4‐independent pathway , 1999, The EMBO journal.
[111] K. Kinzler,et al. Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. , 1999, Cancer research.
[112] R Wieser,et al. TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. , 1999, The Journal of clinical investigation.
[113] Liliana Attisano,et al. SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor , 1998, Cell.
[114] R. Hruban,et al. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. , 1998, Cancer research.
[115] G. Nabel,et al. Regulation of the proinflammatory effects of Fas ligand (CD95L). , 1998, Science.
[116] H. Beug,et al. TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis , 1998, Current Biology.
[117] M. Reiss,et al. Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer. , 1998, Cancer research.
[118] J. Graff,et al. Smad3 Mutant Mice Develop Metastatic Colorectal Cancer , 1998, Cell.
[119] H. Sheng,et al. TGF-β1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression , 1998, Oncogene.
[120] L. Aaltonen,et al. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. , 1998, Science.
[121] A. Balmain,et al. Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[122] Hiroyuki Miyoshi,et al. Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes , 1998, Cell.
[123] R. Derynck,et al. Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[124] P. V. van Diest,et al. Expression of growth factors, growth‐inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis , 1998, The Journal of pathology.
[125] L. Wakefield,et al. Transgenic Mice Overexpressing a Dominant-negative Mutant Type II Transforming Growth Factor β Receptor Show Enhanced Tumorigenesis in the Mammary Gland and Lung in Response to the Carcinogen 7,12-Dimethylbenz-[a]-anthracene , 1997 .
[126] J. Massagué,et al. Differential Interaction of the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 with Cyclin A-Cdk2 and Cyclin D2-Cdk4* , 1997, The Journal of Biological Chemistry.
[127] M. Kretzschmar,et al. Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1 , 1997, Nature.
[128] Kenneth M. Yamada,et al. The Zinc-Finger Protein Slug Causes Desmosome Dissociation, an Initial and Necessary Step for Growth Factor–induced Epithelial–Mesenchymal Transition , 1997, The Journal of cell biology.
[129] S. Thorgeirsson,et al. Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice. , 1997, Cancer research.
[130] K. Alitalo,et al. Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia , 1997, Oncogene.
[131] G. Gores,et al. Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. , 1997, The Journal of clinical investigation.
[132] L. Wakefield,et al. Expression of a dominant‐negative mutant TGF‐β type II receptor in transgenic mice reveals essential roles for TGF‐β in regulation of growth and differentiation in the exocrine pancreas , 1997 .
[133] R. Derynck,et al. Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition , 1997 .
[134] J. Massagué,et al. The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. , 1997, Genes & development.
[135] M. Ohue,et al. Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas. , 1997, Cancer letters.
[136] A. Kulkarni,et al. Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression. , 1996, The Journal of clinical investigation.
[137] Xin Chen,et al. A transcriptional partner for MAD proteins in TGF-β signalling , 1996, Nature.
[138] Y. Yuasa,et al. Genomic structure of the transforming growth factor beta type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers. , 1996, Cancer research.
[139] M. Taketo,et al. TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. , 1996, Developmental biology.
[140] H. Beug,et al. TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. , 1996, Genes & development.
[141] Allan Balmain,et al. TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice , 1996, Cell.
[142] Irene L Andrulis,et al. MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma , 1996, Cell.
[143] M. Sporn,et al. The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[144] Kathleen R. Cho,et al. DPC4 gene in various tumor types. , 1996, Cancer research.
[145] Scott E. Kern,et al. DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1 , 1996, Science.
[146] T. Mitsudomi,et al. Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers. , 1996, Cancer research.
[147] K. Irie,et al. Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction , 1995, Science.
[148] M. Yin,et al. Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[149] Kathleen R. Cho,et al. A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. , 1995, Cancer research.
[150] M. Ferguson,et al. Transforming growth factor–β3 is required for secondary palate fusion , 1995, Nature Genetics.
[151] V. Kaartinen,et al. Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction , 1995, Nature Genetics.
[152] B. Ballermann,et al. Inhibition of Capillary Morphogenesis and Associated Apoptosis by Dominant Negative Mutant Transforming Growth Factor-β Receptors (*) , 1995, The Journal of Biological Chemistry.
[153] A. Iavarone,et al. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. , 1995, Genes & development.
[154] L. Feng,et al. Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-beta 1. , 1995, The American journal of pathology.
[155] Xiao-Fan Wang,et al. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[156] K. Kinzler,et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. , 1995, Science.
[157] A. Kulkarni,et al. Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. , 1995, Development.
[158] R. Coffey,et al. Mammary tumor suppression by transforming growth factor beta 1 transgene expression. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[159] A. Balmain,et al. Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice. , 1995, Genes & development.
[160] H. Moses,et al. Transforming Growth Factor β and Cell Cycle Regulation , 1995 .
[161] M. Sporn,et al. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[162] R. Derynck,et al. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors , 1994, The Journal of cell biology.
[163] Gregory J. Hannon,et al. pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest , 1994, Nature.
[164] James M. Roberts,et al. Cloning of p27 Kip1 , a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals , 1994, Cell.
[165] K. Alitalo,et al. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. , 1994, The Journal of biological chemistry.
[166] G. Hannon,et al. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. , 1994, Nature.
[167] B. Hogan,et al. Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1. , 1993, Genes & development.
[168] Mahlon D. Johnson,et al. Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression. , 1993, The Journal of clinical investigation.
[169] M. Sporn,et al. Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[170] A. Geiser,et al. Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. , 1993, The EMBO journal.
[171] T. Wirth,et al. Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site , 1993, Molecular and cellular biology.
[172] M. Sporn,et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[173] G. Proetzel,et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease , 1992, Nature.
[174] N. Kyprianou,et al. Effect of Transforming Growth Factor-β1 on Proliferation and Death of Rat Prostatic Cells* , 1990 .
[175] A. Levinson,et al. Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: comparison of active and latent TGF-beta 1 , 1990, The Journal of experimental medicine.
[176] H. Moses,et al. Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane , 1990, The Journal of cell biology.
[177] J. Massagué,et al. Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation , 1990, Cell.
[178] H. Koeppen,et al. A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[179] M. Sporn,et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. , 1986, Proceedings of the National Academy of Sciences of the United States of America.