Optimising diagnostic accuracy with the exercise ECG: opportunities for women and men with stable ischaemic heart disease

The exercise ECG is an integral part within the evaluation algorithm for diagnosis and risk stratification of patients with stable ischaemic heart disease (SIHD). There is evidence, both older and new, that the exercise ECG can be an effective and cost-efficient option for patients capable of performing at maximal levels of exercise with suitable resting ECG findings. In this review, we will highlight the major dilemmas in interpreting suspected coronary artery disease symptoms in women and identify optimal strategies for employing exercise ECG as a first-line diagnostic test in the SIHD evaluation algorithm. We will highlight current evidence as well as recent guideline statements on this subject. Trial registration number NCT01471522; Pre-results.

[1]  R. Fogel,et al.  Evaluating patients with ventricular arrhythmia. Role of the signal-averaged electrocardiogram, exercise test, ambulatory electrocardiogram, and electrophysiologic studies. , 1992, Cardiology clinics.

[2]  R. Brant,et al.  Health-related quality of life outcomes of patients with coronary artery disease treated with cardiac surgery, percutaneous coronary intervention or medical management. , 2004, The Canadian journal of cardiology.

[3]  W. Weintraub,et al.  The Seattle angina questionnaire: reliability and validity in women with chronic stable angina. , 2002, Heart disease.

[4]  D. Berman,et al.  Optimal medical therapy with or without PCI for stable coronary disease. , 2007, The New England journal of medicine.

[5]  Sankey V. Williams,et al.  2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Ass , 2012, Journal of the American College of Cardiology.

[6]  R. Pedrosa,et al.  Prognostic Value of Exercise‐Induced Ventricular Arrhythmia in Chagas’ Heart Disease , 2011, Pacing and clinical electrophysiology : PACE.

[7]  E. DeLong,et al.  Value of exercise treadmill testing in women. , 1998, Journal of the American College of Cardiology.

[8]  Manish Prakash,et al.  Exercise capacity and mortality among men referred for exercise testing. , 2002, The New England journal of medicine.

[9]  T. Graboys Import of exercise-induced ventricular arrhythmia in malignant ventricular arrhythmia. , 1983, American Journal of Cardiology.

[10]  D. Berman,et al.  Influence of sex on risk stratification with stress myocardial perfusion Rb-82 positron emission tomography: Results from the PET (Positron Emission Tomography) Prognosis Multicenter Registry. , 2013, Journal of the American College of Cardiology.

[11]  P M Okin,et al.  Impaired heart rate response to graded exercise. Prognostic implications of chronotropic incompetence in the Framingham Heart Study. , 1996, Circulation.

[12]  D. Berman,et al.  Role of Noninvasive Testing in the Clinical Evaluation of Women With Suspected Ischemic Heart Disease: A Consensus Statement From the American Heart Association , 2014, Circulation.

[13]  Daniel Berman,et al.  Effect of PCI on Long-Term Survival in Patients with Stable Ischemic Heart Disease. , 2015, The New England journal of medicine.

[14]  Ronald A. Thisted,et al.  Exercise Capacity and the Risk of Death in Women: The St James Women Take Heart Project , 2003, Circulation.

[15]  M. Lauer,et al.  Heart rate recovery following maximal exercise testing as a predictor of cardiovascular disease and all-cause mortality in men with diabetes. , 2003, Diabetes care.

[16]  R. Gibbons Abnormal heart-rate recovery after exercise , 2002, The Lancet.

[17]  S. Kusachi,et al.  Prediction of acute left main coronary artery obstruction by 12-lead electrocardiography. ST segment elevation in lead aVR with less ST segment elevation in lead V(1). , 2001, Journal of the American College of Cardiology.

[18]  M. Lauer Chronotropic incompetence: ready for prime time. , 2004, Journal of the American College of Cardiology.

[19]  Jagmeet P. Singh,et al.  Blood pressure response during treadmill testing as a risk factor for new-onset hypertension. The Framingham heart study. , 1999, Circulation.

[20]  L. Shaw,et al.  Ethnic differences in the prognostic value of stress technetium-99m tetrofosmin gated single-photon emission computed tomography myocardial perfusion imaging. , 2005, Journal of the American College of Cardiology.

[21]  L. Shaw,et al.  Heart Rate Response to Exercise Stress Testing in Asymptomatic Women: The St. James Women Take Heart Project , 2010, Circulation.

[22]  D. Berman,et al.  Impact of body mass index on cardiac mortality in patients with known or suspected coronary artery disease undergoing myocardial perfusion single-photon emission computed tomography. , 2006, Journal of the American College of Cardiology.

[23]  Eugene H Blackstone,et al.  Heart rate recovery after exercise is a predictor of mortality, independent of the angiographic severity of coronary disease. , 2003, Journal of the American College of Cardiology.

[24]  M. Lauer,et al.  Development and validation of a simple exercise test score for use in women with symptoms of suspected coronary artery disease. , 2002, American heart journal.

[25]  D. Moser,et al.  Women’s Early Warning Symptoms of Acute Myocardial Infarction , 2003, Circulation.

[26]  V. Froelicher,et al.  Nomogram based on metabolic equivalents and age for assessing aerobic exercise capacity in men. , 1993, Journal of the American College of Cardiology.

[27]  L. Shaw,et al.  Comparative Effectiveness of Exercise Electrocardiography With or Without Myocardial Perfusion Single Photon Emission Computed Tomography in Women With Suspected Coronary Artery Disease: Results From the What Is the Optimal Method for Ischemia Evaluation in Women (WOMEN) Trial , 2011, Circulation.

[28]  H. Wellens,et al.  Lead aVR, a mostly ignored but very valuable lead in clinical electrocardiography. , 2001, Journal of the American College of Cardiology.

[29]  R. Dreyer,et al.  Gender Differences in the Trajectory of Recovery in Health Status Among Young Patients With Acute Myocardial Infarction: Results From the Variation in Recovery Role of Gender on Outcomes of Young AMI Patients (VIRGO) Study , 2015, Circulation.

[30]  G. Stone,et al.  Medical Therapy With Versus Without Revascularization in Stable Patients With Moderate and Severe Ischemia: The Case for Community Equipoise. , 2016, Journal of the American College of Cardiology.

[31]  M. Kattan,et al.  An Externally Validated Model for Predicting Long-Term Survival after Exercise Treadmill Testing in Patients with Suspected Coronary Artery Disease and a Normal Electrocardiogram , 2007, Annals of Internal Medicine.

[32]  Scott D Flamm,et al.  Role of noninvasive testing in the clinical evaluation of women with suspected coronary artery disease: Consensus statement from the Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee, Council on Cardiovascular Radiology and Intervent , 2005, Circulation.

[33]  Morton F Arnsdorf,et al.  The prognostic value of a nomogram for exercise capacity in women. , 2005, The New England journal of medicine.

[34]  D. Berman,et al.  Impact of optimal medical therapy with or without percutaneous coronary intervention on long-term cardiovascular end points in patients with stable coronary artery disease (from the COURAGE Trial). , 2009, The American journal of cardiology.

[35]  D. Berman,et al.  Prognostic significance of dyspnea in patients referred for cardiac stress testing. , 2005, The New England journal of medicine.

[36]  M. Lauer Resuscitating the exercise stress test. , 1999, Cleveland Clinic journal of medicine.