Integrative and Translational Physiology : Inflammation and Immunity in Organ System Physiology Short-term bed rest increases TLR 4 and IL-6 expression in skeletal muscle of older adults

Micah J. Drummond, Kyle L. Timmerman, Melissa M. Markofski, Dillon K. Walker, Jared M. Dickinson, Mohammad Jamaluddin, Allan R. Brasier, Blake B. Rasmussen, and Elena Volpi Departments of Nutrition and Metabolism and Internal Medicine; Division of Rehabilitation Science; Sealy Center on Aging; Institute for Translational Sciences University of Texas Medical Branch, Galveston, Texas; and The University of Utah, Salt Lake City, Utah

[1]  L. Deldicque,et al.  TLR2 and TLR4 activate p38 MAPK and JNK during endurance exercise in skeletal muscle. , 2012, Medicine and science in sports and exercise.

[2]  E. Volpi,et al.  Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. , 2012, American journal of physiology. Endocrinology and metabolism.

[3]  J. Schertzer,et al.  Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury , 2011, Journal of Inflammation.

[4]  James E. Graham,et al.  Pilot study examining the association between ambulatory activity and falls among hospitalized older adults. , 2011, Archives of physical medicine and rehabilitation.

[5]  P. Greenhaff,et al.  Novel events in the molecular regulation of muscle mass in critically ill patients , 2011, The Journal of physiology.

[6]  Yan Li,et al.  Myocardial Ischemia Activates an Injurious Innate Immune Signaling via Cardiac Heat Shock Protein 60 and Toll-like Receptor 4* , 2011, The Journal of Biological Chemistry.

[7]  M. Kjaer,et al.  Activated Protein Synthesis and Suppressed Protein Breakdown Signaling in Skeletal Muscle of Critically Ill Patients , 2011, PloS one.

[8]  E. Ropelle,et al.  Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats , 2011, Diabetes.

[9]  B. Pedersen.  Muscles and their myokines , 2011, Journal of Experimental Biology.

[10]  James E. Graham,et al.  Ambulatory Activity of Older Adults Hospitalized with Acute Medical Illness , 2011, Journal of the American Geriatrics Society.

[11]  L. Heilbronn,et al.  Toll-like receptor 4 modulates skeletal muscle substrate metabolism. , 2010, American journal of physiology. Endocrinology and metabolism.

[12]  J. Rosa,et al.  Chronic low frequency/low volume resistance training reduces pro-inflammatory cytokine protein levels and TLR4 mRNA in rat skeletal muscle , 2010, European Journal of Applied Physiology.

[13]  R. Tyrrell,et al.  Time course of changes in inflammatory markers during a 6-mo exercise intervention in sedentary middle-aged men: a randomized-controlled trial. , 2010, Journal of applied physiology.

[14]  M. Tarnopolsky,et al.  Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy. , 2010, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[15]  E. Volpi,et al.  An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle. , 2010, American journal of physiology. Endocrinology and metabolism.

[16]  S. Devaraj,et al.  Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects , 2010, Diabetes Care.

[17]  Richard H Fortinsky,et al.  Recovery of Activities of Daily Living in Older Adults After Hospitalization for Acute Medical Illness , 2008, Journal of the American Geriatrics Society.

[18]  R. Wolfe,et al.  Functional impact of 10 days of bed rest in healthy older adults. , 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

[19]  Ohad Parnes,et al.  Inflammation , 2008, The Lancet.

[20]  K. Kelley,et al.  Exaggerated expression of skeletal muscle-derived interleukin-6, but not TNFα, in mice lacking interleukin-10 , 2008, Journal of Neuroimmunology.

[21]  M. Mack,et al.  CC family chemokines directly regulate myoblast responses to skeletal muscle injury , 2008, The Journal of physiology.

[22]  C. Lambert,et al.  Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. , 2008, Journal of applied physiology.

[23]  Martina Heer,et al.  Calorie restriction modulates inactivity-induced changes in the inflammatory markers C-reactive protein and pentraxin-3. , 2008, The Journal of clinical endocrinology and metabolism.

[24]  R. DeFronzo,et al.  Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects , 2008, Diabetes.

[25]  Ashok Kumar,et al.  Nuclear factor-kappa B signaling in skeletal muscle atrophy , 2008, Journal of Molecular Medicine.

[26]  R. Nitsch,et al.  A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS , 2008, The Journal of Neuroscience.

[27]  Krista Vandenborne,et al.  Transcriptional pathways associated with skeletal muscle disuse atrophy in humans. , 2007, Physiological genomics.

[28]  B. Pedersen,et al.  Expression of interleukin‐15 in human skeletal muscle – effect of exercise and muscle fibre type composition , 2007, The Journal of physiology.

[29]  R. Wolfe,et al.  Effect of 10 days of bed rest on skeletal muscle in healthy older adults. , 2007, JAMA.

[30]  E. Pistilli,et al.  Interleukin-15 responses to aging and unloading-induced skeletal muscle atrophy. , 2007, American journal of physiology. Cell physiology.

[31]  B. Pedersen,et al.  Plasma levels of interleukin‐6 and C‐reactive protein are associated with physical inactivity independent of obesity , 2006, Scandinavian journal of medicine & science in sports.

[32]  S. Anderssen,et al.  Markers of inflammation are inversely related to physical activity and fitness in sedentary men with treated hypertension. , 2006, American journal of hypertension.

[33]  F. López‐Soriano,et al.  The pivotal role of cytokines in muscle wasting during cancer. , 2005, The international journal of biochemistry & cell biology.

[34]  P. Murray.  The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[35]  C. Lang,et al.  Skeletal muscle cytokines: regulation by pathogen-associated molecules and catabolic hormones , 2005, Current opinion in clinical nutrition and metabolic care.

[36]  D. Cooper,et al.  IL-6-induced skeletal muscle atrophy. , 2005, Journal of applied physiology.

[37]  A. Mebazaa,et al.  Human Septic Myopathy: Induction of Cyclooxygenase, Heme Oxygenase and Activation of the Ubiquitin Proteolytic Pathway , 2004, Anesthesiology.

[38]  Simon W. Jones,et al.  Disuse atrophy and exercise rehabilitation in humans profoundly affects the expression of genes associated with the regulation of skeletal muscle mass , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[39]  A. Steensberg,et al.  IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. , 2003, American journal of physiology. Endocrinology and metabolism.

[40]  C. Lang,et al.  Endotoxin Stimulates In Vivo Expression of Inflammatory Cytokines Tumor Necrosis Factor Alpha, Interleukin-1&bgr;, -6, and High-Mobility-Group Protein-1 in Skeletal Muscle , 2003, Shock.

[41]  J. Argilés,et al.  Overexpression of interleukin-15 induces skeletal muscle hypertrophy in vitro: implications for treatment of muscle wasting disorders. , 2002, Experimental cell research.

[42]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[43]  L. DiPietro,et al.  Age-related alterations in the inflammatory response to dermal injury. , 2001, The Journal of investigative dermatology.

[44]  A. Steensberg,et al.  Muscle‐derived interleukin‐6: possible biological effects , 2001, The Journal of physiology.

[45]  H. Kolb,et al.  Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex1 , 2000, The Journal of Immunology.

[46]  R. Wolfe,et al.  Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. , 1996, The American journal of physiology.

[47]  R. Henry,et al.  The expression of TNF alpha by human muscle. Relationship to insulin resistance. , 1996, The Journal of clinical investigation.

[48]  M. Goodman.  Interleukin-6 Induces Skeletal Muscle Protein Breakdown in Rats , 1994, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[49]  M. Goodman.  Tumor necrosis factor induces skeletal muscle protein breakdown in rats. , 1991, The American journal of physiology.

[50]  T. Libermann,et al.  Activation of interleukin-6 gene expression through the NF-kappa B transcription factor , 1990, Molecular and cellular biology.

[51]  M. Mayo,et al.  Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding. , 1999, The Journal of biological chemistry.