The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis

[1]  Liqi Zhu,et al.  The Deletion of IL-17A Enhances Helicobacter hepaticus Colonization and Triggers Colitis , 2022, Journal of inflammation research.

[2]  S. Snapper,et al.  CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor , 2022, Scientific reports.

[3]  Nadezhda T. Doncheva,et al.  The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets , 2020, Nucleic Acids Res..

[4]  J. Mar,et al.  Investigating transcriptome-wide sex dimorphism by multi-level analysis of single-cell RNA sequencing data in ten mouse cell types , 2020, Biology of sex differences.

[5]  D. Foell,et al.  Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease , 2020, World journal of gastroenterology.

[6]  S. Vermeire,et al.  JAK–STAT pathway targeting for the treatment of inflammatory bowel disease , 2020, Nature Reviews Gastroenterology & Hepatology.

[7]  G. Núñez,et al.  Host–microbiota interactions in inflammatory bowel disease , 2020, Nature Reviews Immunology.

[8]  G. Rogler.  Efficacy of JAK inhibitors in Crohn’s Disease , 2019, Journal of Crohn's & colitis.

[9]  A. Larochelle,et al.  Commensal microbiota drive the functional diversification of colon macrophages , 2019, Mucosal Immunology.

[10]  G. Matteoli,et al.  Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD , 2019, Nature Reviews Gastroenterology & Hepatology.

[11]  Eyal David,et al.  IL-23–producing IL-10Rα–deficient gut macrophages elicit an IL-22–driven proinflammatory epithelial cell response , 2019, Science Immunology.

[12]  S. Clare,et al.  Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis , 2018, Nature Communications.

[13]  T. Ohteki,et al.  IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo , 2018, Mucosal Immunology.

[14]  C. Thomson,et al.  Proinflammatory Role of Monocyte-Derived CX3CR1int Macrophages in Helicobacter hepaticus-Induced Colitis , 2017, Infection and Immunity.

[15]  Rajsavi S. Anand,et al.  Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD , 2017, Inflammatory bowel diseases.

[16]  Eugenia G. Giannopoulou,et al.  Interferon‐&ggr; Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF , 2017, Immunity.

[17]  G. Gerber,et al.  Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor , 2017, eLife.

[18]  S. Snapper,et al.  Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages , 2017, Science.

[19]  S. Snapper,et al.  Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation , 2017, The Journal of Immunology.

[20]  Johannes U. Mayer,et al.  Tissue-Specific Differentiation of Colonic Macrophages Requires TGFβ Receptor Mediated Signalling , 2017, Mucosal Immunology.

[21]  C. Klein,et al.  Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. , 2016, Gastroenterology.

[22]  J. Samsom,et al.  IL-10 control of CD11c+ myeloid cells is essential to maintain immune homeostasis in the small and large intestine , 2016, Oncotarget.

[23]  S. Macdonald,et al.  Differential Requirements for IL-17A and IL-22 in Cecal versus Colonic Inflammation Induced by Helicobacter hepaticus. , 2015, The American journal of pathology.

[24]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[25]  P. Vogel,et al.  IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T cell-mediated colitis , 2014, Nature Communications.

[26]  Timothy L. Tickle,et al.  Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. , 2014, The Journal of clinical investigation.

[27]  C. Bain,et al.  Macrophages in intestinal homeostasis and inflammation , 2014, Immunological reviews.

[28]  C. Klein,et al.  Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. , 2014, Immunity.

[29]  T. Decker,et al.  The regulation of inflammation by interferons and their STATs , 2013, JAK-STAT.

[30]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[31]  Ansuman T. Satpathy,et al.  Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. , 2012, Immunity.

[32]  J. Casanova,et al.  Immunity to infection in IL‐17‐deficient mice and humans , 2012, European journal of immunology.

[33]  G. Cheng,et al.  Systematic identification of type I and type II interferon-induced antiviral factors , 2012, Proceedings of the National Academy of Sciences.

[34]  C. Klein,et al.  IL‐10 and IL‐10 receptor defects in humans , 2011, Annals of the New York Academy of Sciences.

[35]  A. Fischer,et al.  Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis , 2011, The Journal of experimental medicine.

[36]  F. Rieux-Laucat,et al.  Defective IL10 Signaling Defining a Subgroup of Patients With Inflammatory Bowel Disease , 2011, The American Journal of Gastroenterology.

[37]  N. Sebire,et al.  Infant colitis—it's in the genes , 2010, The Lancet.

[38]  J. Affourtit,et al.  Cdcs1 a major colitis susceptibility locus in mice; Subcongenic analysis reveals genetic complexity , 2010, Inflammatory bowel diseases.

[39]  M. Robinson,et al.  A scaling normalization method for differential expression analysis of RNA-seq data , 2010, Genome Biology.

[40]  A. Schäffer,et al.  Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. , 2009, The New England journal of medicine.

[41]  Lionel B Ivashkiv,et al.  Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. , 2009, Immunity.

[42]  G. Parmigiani,et al.  Genome‐wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: Insights into distinctive pathogenesis , 2007, Inflammatory bowel diseases.

[43]  L. Ivashkiv,et al.  Role of STAT3 in Type I Interferon Responses , 2006, Journal of Biological Chemistry.

[44]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[45]  L. Ivashkiv,et al.  IFN-γ-Primed Macrophages Exhibit Increased CCR2-Dependent Migration and Altered IFN-γ Responses Mediated by Stat11 , 2005, The Journal of Immunology.

[46]  R. Kiesslich,et al.  Activation Pattern of Signal Transducers and Activators of Transcription (STAT) Factors in Inflammatory Bowel Diseases , 2005, The American Journal of Gastroenterology.

[47]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[48]  J. Hampe,et al.  Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease , 2002, Gut.

[49]  Peter J. Murray,et al.  Shaping Gene Expression in Activated and Resting Primary Macrophages by IL-101 , 2002, The Journal of Immunology.

[50]  G. Stark,et al.  Complex roles of Stat1 in regulating gene expression , 2000, Oncogene.

[51]  H. Dickensheets,et al.  Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1 , 1999 .

[52]  J M Ward,et al.  Helicobacter hepaticus Triggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism , 1998, Infection and Immunity.

[53]  R. Sartor,et al.  Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice , 1998, Infection and Immunity.

[54]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[55]  K. Rajewsky,et al.  Interleukin-10-deficient mice develop chronic enterocolitis , 1993, Cell.