Trends in Scientific Literature on Atypical Antipsychotics in South Korea: A Bibliometric Study

Objective We have carried out a bibliometric study on the scientific publications in relation to atypical or second-generation antipsychotic drugs (SGAs) in South Korea. Methods With the EMBASE and MEDLINE databases, we selected those publications made in South Korea whose title included the descriptors atypic* (atypical*) antipsychotic*, second-generation antipsychotic*, clozapine, risperidone, olanzapine, ziprasidone, quetiapine, sertindole, aripiprazole, paliperidone, amisulpride, zotepine, asenapine, iloperidone, lurasidone, perospirone and blonanserin. We applied some bibliometric indicators of paper production and dispersion with Price's law and Bradford's law, respectively. We also calculated the participation index (PI) of the different countries, and correlated the bibliometric data with some social and health data from Korea (such as total per capita expenditure on health and gross domestic expenditure on research and development). Results We collected 326 original papers published between 1993 and 2011. Our results state fulfilment of fulfilled Price's law, with scientific production on SGAs showing exponential growth (correlation coefficient r=0.8978, as against an r=0.8149 after linear adjustment). The most widely studied drugs were risperidone (91 papers), aripiprazole (77), olanzapine (53), and clozapine (43). Division into Bradford zones yielded a nucleus occupied by the Progress in Neuro-Psychopharmacology and Biological Psychiatry (36 articles). A total of 86 different journals were published, with 4 of the first 10 used journals having an impact factor being greater than 4. Conclusion The publications on SGAs in South Korea have undergone exponential growth over the studied period, without evidence of reaching a saturation point.

[1]  M. Pérez-Nieto,et al.  International Scientific Productivity on Second-Generation Antipsychotic Drugs in Taiwan: A Bibliometric Study , 2012 .

[2]  Jacques Cohen,et al.  The uses and abuses of bibliometrics. , 2012, Reproductive biomedicine online.

[3]  F. López-Muñoz,et al.  Evolution of the Concept of Treatment-resistant Schizophrenia: Toward a Reformulation for Lack of an Adequate Response , 2012 .

[4]  L. Dixon,et al.  Clozapine Use in Schizophrenia: Findings of the Research on Asia Psychotropic Prescription (REAP) Studies from 2001 to 2009 , 2011, The Australian and New Zealand journal of psychiatry.

[5]  F. López-Muñoz,et al.  Neurobiological Background for the Development of New Drugs in Schizophrenia , 2011, Clinical neuropharmacology.

[6]  T. Hoshuyama,et al.  P.3.c.018 The characteristics of pharmacotherapy for inpatients with schizophrenia: a multicentre comparative study in Asia , 2010, European Neuropsychopharmacology.

[7]  T. Si,et al.  Prescribing antipsychotic drugs for inpatients with schizophrenia in Asia: Comparison of REAP‐2001 and REAP‐2004 studies , 2010 .

[8]  S. Theander,et al.  Schizophrenia in Medline 1950–2006: A bibliometric investigation , 2010, Schizophrenia Research.

[9]  F. López-Muñoz,et al.  The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice , 2009, Brain Research Bulletin.

[10]  I. Caridad,et al.  Limitaciones en el uso de los indicadores bibliométricos para la evaluación científica , 2009 .

[11]  F. López-Muñoz,et al.  A bibliometric study of international scientific productivity in attention-deficit hyperactivity disorder covering the period 1980–2005 , 2008, European Child & Adolescent Psychiatry.

[12]  J. Mezzich,et al.  A Bibliometric Study of the Use of the Classification and Diagnostic Systems in Psychiatry over the Last 25 Years , 2008, Psychopathology.

[13]  Eduard Vieta,et al.  Bipolar disorder as an emerging pathology in the scientific literature: a bibliometric approach. , 2006, Journal of affective disorders.

[14]  A. Mortimer,et al.  Primary care use of antipsychotic drugs: an audit and intervention study , 2005, Annals of general psychiatry.

[15]  F. López-Muñoz,et al.  History of the discovery and clinical introduction of chlorpromazine. , 2005, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

[16]  G. Kaprinis,et al.  Off-label indications for atypical antipsychotics: A systematic review , 2004, Annals of general hospital psychiatry.

[17]  F. López-Muñoz,et al.  Half a century since the clinical introduction of chlorpromazine and the birth of modern psychopharmacology , 2004, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[18]  Gabriel Rubio,et al.  Bibliometric analysis of biomedical publications on SSRI during 1980–2000 , 2003, Depression and anxiety.

[19]  T. Burns,et al.  Status of bipolar disorder research , 2003, British Journal of Psychiatry.

[20]  H. Hippius.  A historical perspective of clozapine. , 1999, The Journal of clinical psychiatry.

[21]  W. Shen.  A history of antipsychotic drug development. , 1999, Comprehensive psychiatry.

[22]  F. López-Muñoz,et al.  [Bibliometric evaluation of the Spanish scientific output in neurosciences. Analysis of the publication with international readership between 1984 and 1993]. , 1996, Revista de neurologia.

[23]  G Honigfeld,et al.  Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. , 1988, Archives of general psychiatry.

[24]  M. A. Zulueta,et al.  [Evaluation of the scientific activity through bibliometric indices]. , 1999, Revista espanola de cardiologia.

[25]  María Bordons,et al.  Evaluación de la actividad científica a través de indicadores bibliométricos , 1999 .

[26]  A. Pritchard,et al.  Statistical bibliography or bibliometrics , 1969 .