Material matters: exploring the interplay between natural biomaterials and host immune system

Biomaterials are widely used for various medical purposes, for instance, implants, tissue engineering, medical devices, and drug delivery systems. Natural biomaterials can be obtained from proteins, carbohydrates, and cell-specific sources. However, when these biomaterials are introduced into the body, they trigger an immune response which may lead to rejection and failure of the implanted device or tissue. The immune system recognizes natural biomaterials as foreign substances and triggers the activation of several immune cells, for instance, macrophages, dendritic cells, and T cells. These cells release pro-inflammatory cytokines and chemokines, which recruit other immune cells to the implantation site. The activation of the immune system can lead to an inflammatory response, which can be beneficial or detrimental, depending on the type of natural biomaterial and the extent of the immune response. These biomaterials can also influence the immune response by modulating the behavior of immune cells. For example, biomaterials with specific surface properties, such as charge and hydrophobicity, can affect the activation and differentiation of immune cells. Additionally, biomaterials can be engineered to release immunomodulatory factors, such as anti-inflammatory cytokines, to promote a tolerogenic immune response. In conclusion, the interaction between biomaterials and the body’s immune system is an intricate procedure with potential consequences for the effectiveness of therapeutics and medical devices. A better understanding of this interplay can help to design biomaterials that promote favorable immune responses and minimize adverse reactions.

[1]  Huitang Xia,et al.  Synergistic chondrogenesis promotion and arthroscopic articular cartilage restoration via injectable dual-drug-loaded sulfated hyaluronic acid hydrogel for stem cell therapy , 2023, Composites Part B: Engineering.

[2]  A. Hadjizadeh,et al.  Scaffold degradation in bone tissue engineering: An overview , 2023, International Biodeterioration & Biodegradation.

[3]  C. Mota,et al.  Development of a biomimetic arch-like 3D bioprinted construct for cartilage regeneration using gelatin methacryloyl and silk fibroin-gelatin bioinks , 2023, Biofabrication.

[4]  H. Trębacz,et al.  Mechanical Properties and Functions of Elastin: An Overview , 2023, Biomolecules.

[5]  K. Lim,et al.  Cellulose nanocrystals vs. cellulose nanospheres: A comparative study of cytotoxicity and macrophage polarization potential. , 2023, Carbohydrate polymers.

[6]  Rajesh Raju,et al.  A network map of discoidin domain receptor 1(DDR1)-mediated signaling in pathological conditions , 2022, Journal of Cell Communication and Signaling.

[7]  M. Konop,et al.  Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing , 2022, Biomolecules.

[8]  Yujiang Fan,et al.  Advanced application of collagen-based biomaterials in tissue repair and restoration , 2022, Journal of Leather Science and Engineering.

[9]  K. Novakovic,et al.  Interplay between biomaterials and the immune system: challenges and opportunities in regenerative medicine. , 2022, Acta biomaterialia.

[10]  J. Yang,et al.  Synergy of Polydopamine Nanovaccine and Endostar Alginate Hydrogel for Improving Antitumor Immune Responses Against Colon Tumor , 2022, International journal of nanomedicine.

[11]  A. Pozzi,et al.  Genetic and pharmacological tools to study the role of discoidin domain receptors in kidney disease , 2022, Frontiers in Pharmacology.

[12]  K. Fujita,et al.  Potential issues specific to cytotoxicity tests of cellulose nanofibrils , 2022, Journal of applied toxicology : JAT.

[13]  A. Cayla,et al.  Alginate-Based Bio-Composites and Their Potential Applications , 2022, Journal of functional biomaterials.

[14]  I. Botiz,et al.  Insight and Recent Advances into the Role of Topography on the Cell Differentiation and Proliferation on Biopolymeric Surfaces , 2022, International journal of molecular sciences.

[15]  M. McConnell,et al.  3D living dressing improves healing and modulates immune response in a thermal injury model. , 2022, Tissue engineering. Part C, Methods.

[16]  Y. Mizukami,et al.  Anti-inflammatory effects of differential molecular weight Hyaluronic acids on UVB-induced calprotectin-mediated keratinocyte inflammation. , 2022, Journal of dermatological science.

[17]  A. Dolatshahi-Pirouz,et al.  Progress in Gelatin as Biomaterial for Tissue Engineering , 2022, Pharmaceutics.

[18]  S. Shaarani,et al.  Bovidae-based gelatin: Extractions method, physicochemical and functional properties, applications, and future trends. , 2022, Comprehensive reviews in food science and food safety.

[19]  P. Michaud,et al.  Structures, Properties and Applications of Alginates , 2022, Marine drugs.

[20]  Jiake Xu,et al.  Osteoimmunomodulatory injectable Lithium-Heparin hydrogel with Microspheres/TGF-β1 delivery promotes M2 macrophage polarization and osteogenesis for guided bone regeneration , 2022, Chemical Engineering Journal.

[21]  Z. Qamar,et al.  Collagen Structure, Synthesis, and Its Applications: A Systematic Review , 2022, Cureus.

[22]  A. Kajbafzadeh,et al.  Decellularization in Tissue Engineering and Regenerative Medicine: Evaluation, Modification, and Application Methods , 2022, Frontiers in Bioengineering and Biotechnology.

[23]  Shan Sun,et al.  Silk Fibroin-Based Biomaterials for Tissue Engineering Applications , 2022, Molecules.

[24]  Gyeong Min Kim,et al.  Roles of osteoclast-associated receptor in rheumatoid arthritis and osteoarthritis. , 2022, Joint Bone Spine.

[25]  F. Saltel,et al.  Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation , 2022, Oncogene.

[26]  H. Norppa,et al.  Surface functionalization and size modulate the formation of reactive oxygen species and genotoxic effects of cellulose nanofibrils , 2022, Particle and Fibre Toxicology.

[27]  Bin Bao,et al.  The Molecular Interaction of Collagen with Cell Receptors for Biological Function , 2022, Polymers.

[28]  C. Ge,et al.  The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development , 2022, Bone Research.

[29]  Aarushi Sharma,et al.  Macrophage Polarization Profiling on Native and Regenerated Silk Biomaterials. , 2022, ACS biomaterials science & engineering.

[30]  Hend Al-Atif Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics , 2022, Dermatology practical & conceptual.

[31]  K. Draget,et al.  Long-term storage stability of type A and type B gelatin gels: The effect of Bloom strength and co-solutes , 2022, Food Hydrocolloids.

[32]  R. Pérez-Martín,et al.  Study of the immunologic response of marine-derived collagen and gelatin extracts for tissue engineering applications. , 2022, Acta biomaterialia.

[33]  A. Oliveira,et al.  An update on hydroxyapatite/collagen composites: What is there left to say about these bioinspired materials? , 2021, Journal of biomedical materials research. Part B, Applied biomaterials.

[34]  Xiangguang Meng,et al.  Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases , 2021, Frontiers in Cell and Developmental Biology.

[35]  Hsiu-Fen Wang A Review of the Effects of Collagen Treatment in Clinical Studies , 2021, Polymers.

[36]  M. Gauthier,et al.  Immune Response to Silk Sericin-Fibroin Composites: Potential Immunogenic Elements, and Alternatives for Immunomodulation. , 2021, Macromolecular bioscience.

[37]  M. Mustapha,et al.  Polysaccharide-Based Hydrogels for Microencapsulation of Stem Cells in Regenerative Medicine , 2021, Frontiers in Bioengineering and Biotechnology.

[38]  A. Khataee,et al.  The latest achievements in plant cellulose-based biomaterials for tissue engineering focusing on skin repair. , 2021, Chemosphere.

[39]  Otto X. Cordero,et al.  Polysaccharide-Bacteria Interactions From the Lens of Evolutionary Ecology , 2021, Frontiers in Microbiology.

[40]  S. Rajagopal,et al.  Silk Fibroin: A Promising Tool for Wound Healing and Skin Regeneration , 2021, International Journal of Polymer Science.

[41]  K. Lampe,et al.  Biomaterials via Peptide Assembly: Design, Characterization, and Application in Tissue Engineering , 2021, Acta biomaterialia.

[42]  A. Viola,et al.  Reactive Oxygen Species in Macrophages: Sources and Targets , 2021, Frontiers in Immunology.

[43]  I. Aranaz,et al.  Chitosan: An Overview of Its Properties and Applications , 2021, Polymers.

[44]  M. Maitz,et al.  The innate immune response of self-assembling silk fibroin hydrogels. , 2021, Biomaterials Science.

[45]  O. Alexa,et al.  Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review) , 2021, Experimental and therapeutic medicine.

[46]  F. Macrae,et al.  The Role of Fibrin(ogen) in Wound Healing and Infection Control , 2021, Seminars in Thrombosis and Hemostasis.

[47]  Xiao-dong Guo,et al.  Collagen mineralization and its applications in hard tissue repair , 2021, Materials Chemistry Frontiers.

[48]  Kongchang Wei,et al.  Carbohydrate-Based Macromolecular Biomaterials. , 2021, Chemical reviews.

[49]  M. B. Fauzi,et al.  Gelatin-Polyvinyl Alcohol Film for Tissue Engineering: A Concise Review , 2021, Biomedicines.

[50]  Bo Sun The mechanics of fibrillar collagen extracellular matrix , 2021, Cell reports. Physical science.

[51]  P. Halley,et al.  Advantages and Disadvantages of Bioplastics Production from Starch and Lignocellulosic Components , 2021, Polymers.

[52]  Song-Tao Shou,et al.  The roles of macrophage polarization in the host immune response to sepsis. , 2021, International immunopharmacology.

[53]  A. Bah,et al.  Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition , 2021, Cell communication and signaling : CCS.

[54]  G. Deng,et al.  Fc Gamma Receptors as Regulators of Bone Destruction in Inflammatory Arthritis , 2021, Frontiers in Immunology.

[55]  R. Shahbazian‐Yassar,et al.  Collagen biomineralization: pathways, mechanisms, and thermodynamics , 2021, Emergent Materials.

[56]  Md. Shipan Mia,et al.  Silk Biomaterials for Bone Tissue Engineering. , 2021, Macromolecular bioscience.

[57]  Hossam Nada,et al.  The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer , 2021, International journal of molecular sciences.

[58]  R. Reis,et al.  Carbohydrate amphiphiles for supramolecular biomaterials: Design, self-assembly, and applications , 2021 .

[59]  T. Ahmad,et al.  Identification of bovine, porcine and fish gelatin signatures using chemometrics fuzzy graph method , 2021, Scientific Reports.

[60]  Zhen Yang,et al.  Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling , 2021, Frontiers in Bioengineering and Biotechnology.

[61]  Q. Ao,et al.  Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine , 2021, Marine drugs.

[62]  K. Prasad,et al.  Seaweed Polysaccharide Based Products and Materials: An Assessment on Their Production from a Sustainability Point of View , 2021, Molecules.

[63]  R. Olivares-Navarrete,et al.  Control of innate immune response by biomaterial surface topography, energy, and stiffness. , 2021, Acta biomaterialia.

[64]  J. Bella,et al.  Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease , 2021, Frontiers in Cell and Developmental Biology.

[65]  M. Birajdar,et al.  Natural bio-based monomers for biomedical applications: a review , 2021, Biomaterials Research.

[66]  H. Kim,et al.  Materials roles for promoting angiogenesis in tissue regeneration , 2021, Progress in Materials Science.

[67]  S. Rowan,et al.  In Vitro and in Vivo Analyses of the Effects of Source, Length, and Charge on the Cytotoxicity and Immunocompatibility of Cellulose Nanocrystals. , 2021, ACS biomaterials science & engineering.

[68]  P. Dikshit,et al.  Recent development in bacterial cellulose production and synthesis of cellulose based conductive polymer nanocomposites , 2021, Nano Select.

[69]  Jialun Li,et al.  Antioxidant biocompatible composite collagen dressing for diabetic wound healing in rat model , 2021, Regenerative biomaterials.

[70]  S. Ricard-Blum,et al.  A guide to the composition and functions of the extracellular matrix , 2021, The FEBS journal.

[71]  W. Cui,et al.  Biomedical application of photo-crosslinked gelatin hydrogels , 2021, Journal of Leather Science and Engineering.

[72]  Hasan Zuhudi Abdullah,et al.  A review of gelatin: Properties, sources, process, applications, and commercialisation , 2021 .

[73]  Mhd Anas Tomeh,et al.  Silk Fibroin as a Functional Biomaterial for Tissue Engineering , 2021, International journal of molecular sciences.

[74]  R. Linhardt,et al.  Recent progress and advanced technology in carbohydrate-based drug development. , 2021, Current opinion in biotechnology.

[75]  P. S. Dhiwar,et al.  DDR1 and DDR2: a review on signaling pathway and small molecule inhibitors as an anticancer agent , 2021 .

[76]  Shicheng Wei,et al.  A Chondrogenesis Induction System Based on Functionalized Hyaluronic Acid Hydrogel Sequentially Promoting hMSC Proliferation, Condensation, and Differentiation and Matrix Deposition , 2021, Acta biomaterialia.

[77]  G. Cottrell,et al.  Impact of 3D cell culture on bone regeneration potential of mesenchymal stromal cells , 2021, Stem cell research & therapy.

[78]  F. O'Brien,et al.  A step closer to elastogenesis on demand; Inducing mature elastic fibre deposition in a natural biomaterial scaffold. , 2021, Materials science & engineering. C, Materials for biological applications.

[79]  T. Biswal,et al.  Alginate and its application to tissue engineering , 2021, SN Applied Sciences.

[80]  Dongan Wang,et al.  Polysaccharide-based Biomaterials in Tissue Engineering: A review. , 2020, Tissue engineering. Part B, Reviews.

[81]  Saravut Satitsri,et al.  Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications , 2020, Molecules.

[82]  Yiqian Luo,et al.  Implantable and Injectable Biomaterial Scaffolds for Cancer Immunotherapy , 2020, Frontiers in Bioengineering and Biotechnology.

[83]  A. Herbay,et al.  An in vitro assessment of the response of THP-1 macrophages to varying stiffness of a glycol-chitosan hydrogel for vocal fold tissue engineering applications. , 2020, Journal of biomedical materials research. Part A.

[84]  Andrés J. García,et al.  Toll-like receptor 2-modulating pectin-polymers in alginate-based microcapsules attenuate immune responses and support islet-xenograft survival. , 2020, Biomaterials.

[85]  Jie Liao,et al.  Applications of decellularized materials in tissue engineering: advantages, drawbacks and current improvements, and future perspectives. , 2020, Journal of materials chemistry. B.

[86]  J. A. Cecilia,et al.  Chitosan: A Natural Biopolymer with a Wide and Varied Range of Applications , 2020, Molecules.

[87]  L. Ambrosio,et al.  In vitro and in vivo biocompatibility and inflammation response of methacrylated and maleated hyaluronic acid for wound healing , 2020, RSC advances.

[88]  Junhao He,et al.  Cell migration regulated by RGD nanospacing and enhanced under moderate cell adhesion on biomaterials. , 2020, Biomaterials.

[89]  L. David,et al.  Dental pulp inflammatory/immune response to a chitosan-enriched fibrin hydrogel in the pulpotomised rat incisor. , 2020, European cells & materials.

[90]  Zhongtian Bai,et al.  Highly specific recognition of denatured collagen by fluorescent peptide probes with the repetitive Gly-Pro-Pro and Gly-Hyp-Hyp sequences. , 2020, Journal of materials chemistry. B.

[91]  Chengmin Chen,et al.  Microfluidic Technology for the Production of Well-Ordered Porous Polymer Scaffolds , 2020, Polymers.

[92]  W. Marut,et al.  Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation , 2020, Frontiers in Immunology.

[93]  F. Asimakopoulos,et al.  Versican and Versican-matrikines in Cancer Progression, Inflammation, and Immunity , 2020, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[94]  A. Rowley,et al.  Effects of Surface-Bound Collagen-Mimetic Peptides on Macrophage Uptake and Immunomodulation , 2020, Frontiers in Bioengineering and Biotechnology.

[95]  J. Gordon,et al.  Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation , 2020, Frontiers in Immunology.

[96]  P. Brun,et al.  Hyaluronic Acid: Redefining Its Role , 2020, Cells.

[97]  Xingzhi Liu,et al.  Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway , 2020, Bioactive materials.

[98]  J. Kuriyan,et al.  Structural Insights into the Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII). , 2019, Cold Spring Harbor perspectives in biology.

[99]  Lu Wang,et al.  Influence of the mechanical properties of biomaterials on degradability, cell behaviors and signaling pathways: current progress and challenges. , 2020, Biomaterials science.

[100]  K. Klimek,et al.  Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review , 2020, Polymers.

[101]  A. Kaflak,et al.  Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review , 2020, Materials.

[102]  J. Pober,et al.  Complement membrane attack complex: new roles, mechanisms of action, and therapeutic targets. , 2020, The American journal of pathology.

[103]  Xiao-Tao He,et al.  Pore size-mediated macrophage M1-to-M2 transition influences new vessel formation within the compartment of a scaffold , 2020 .

[104]  A. Casini,et al.  Fibrin(ogen) in human disease: both friend and foe , 2020, Haematologica.

[105]  Sourabh Ghosh,et al.  Regulation of decellularized matrix mediated immune response. , 2020, Biomaterials science.

[106]  Fengna Chu,et al.  Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis , 2020, Frontiers in Molecular Neuroscience.

[107]  Lianqing Liu,et al.  Recent advance in surface modification for regulating cell adhesion and behaviors , 2020 .

[108]  Dimple Chouhan,et al.  Silk Biomaterials in Wound Healing and Skin Regeneration Therapeutics: from Bench to Bedside. , 2019, Acta biomaterialia.

[109]  Ara Nazarian,et al.  Design of biodegradable, implantable devices towards clinical translation , 2019, Nature Reviews Materials.

[110]  S. Y. Kim,et al.  Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review , 2019, Polymers.

[111]  Lina Zhang,et al.  Elucidation of molecular pathways responsible for the accelerated wound healing induced by a novel fibrous chitin dressing. , 2019, Biomaterials science.

[112]  S. Omar,et al.  Effect of high molecular weight hyaluronic acid in treatment of osteoarthritic temporomandibular joints of rats. , 2019, Archives of oral biology.

[113]  Sara Metwally,et al.  Surface potential and charges impact on cell responses on biomaterials interfaces for medical applications. , 2019, Materials science & engineering. C, Materials for biological applications.

[114]  G. Bardi,et al.  Natural Polysaccharide Nanomaterials: An Overview of Their Immunological Properties , 2019, International journal of molecular sciences.

[115]  Mhd Anas Tomeh,et al.  Silk Fibroin as a Functional Biomaterial for Drug and Gene Delivery , 2019, Pharmaceutics.

[116]  J. Trček,et al.  Bacterial Cellulose: Production, Modification and Perspectives in Biomedical Applications , 2019, Nanomaterials.

[117]  M. Sergeeva,et al.  High and Low Molecular Weight Hyaluronic Acid Differentially Influences Oxylipins Synthesis in Course of Neuroinflammation , 2019, International journal of molecular sciences.

[118]  C. Castro,et al.  Ex Vivo and In Vivo Biocompatibility Assessment (Blood and Tissue) of Three-Dimensional Bacterial Nanocellulose Biomaterials for Soft Tissue Implants , 2019, Scientific Reports.

[119]  K. Landfester,et al.  Biomaterial Surface Hydrophobicity Mediated Serum Protein Adsorption and Immune Responses. , 2019, ACS applied materials & interfaces.

[120]  Ramesh C. Gupta,et al.  Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory , 2019, Front. Vet. Sci..

[121]  Antony Rodriguez,et al.  Selective cleavage of fibrinogen by diverse proteinases initiates innate allergic and antifungal immunity through CD11b , 2019, The Journal of Biological Chemistry.

[122]  F. O'Brien,et al.  Material stiffness influences the polarization state, function and migration mode of macrophages. , 2019, Acta biomaterialia.

[123]  O. Veiseh,et al.  Domesticating the foreign body response: Recent advances and applications. , 2019, Advanced drug delivery reviews.

[124]  Ryan J. Hickey,et al.  Cellulose Biomaterials for Tissue Engineering , 2019, Front. Bioeng. Biotechnol..

[125]  Gangliang Huang,et al.  Preparation and applications of hyaluronic acid and its derivatives. , 2019, International journal of biological macromolecules.

[126]  A. Mócsai,et al.  Importance of Fc Receptor γ-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis , 2019, Front. Immunol..

[127]  P. Zorlutuna,et al.  Editorial: Adverse Reactions to Biomaterials: State of the Art in Biomaterial Risk Assessment, Immunomodulation and in vitro Models for Biomaterial Testing , 2019, Front. Bioeng. Biotechnol..

[128]  J. Jansen,et al.  Titanium surfaces characteristics modulate macrophage polarization. , 2019, Materials science & engineering. C, Materials for biological applications.

[129]  G. Chinga-Carrasco,et al.  Ultrapure Wood Nanocellulose-Assessments of Coagulation and Initial Inflammation Potential. , 2019, ACS applied bio materials.

[130]  R. Olivares-Navarrete,et al.  Macrophage response to hydrophilic biomaterials regulates MSC recruitment and T-helper cell populations. , 2018, Biomaterials.

[131]  B. Maček,et al.  The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size , 2018, EMBO reports.

[132]  W. Horak,et al.  Collagen/chitosan/hyaluronic acid - based injectable hydrogels for tissue engineering applications - design, physicochemical and biological characterization. , 2018, Colloids and surfaces. B, Biointerfaces.

[133]  G. Du,et al.  The Soluble and Particulate Form of Alginates Positively Regulate Immune Response. , 2018, Iranian journal of immunology : IJI.

[134]  Christian G Elowsky,et al.  A totally recombinant fibrin matrix for mesenchymal stem cell culture and delivery. , 2018, Journal of biomedical materials research. Part A.

[135]  M. Nomizu,et al.  Cell Adhesion Activity of Peptides Conjugated to Polysaccharides , 2018, Current protocols in cell biology.

[136]  Y. Xie,et al.  Unveiling the Mechanism of Surface Hydrophilicity‐Modulated Macrophage Polarization , 2018, Advanced healthcare materials.

[137]  G. E. Fernandez,et al.  Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development , 2018, Scientific Reports.

[138]  C. D. Dela Cruz,et al.  Chitin and Its Effects on Inflammatory and Immune Responses , 2018, Clinical Reviews in Allergy & Immunology.

[139]  J. B. Moeller,et al.  Immunohistochemical Localization of Fibrinogen C Domain Containing 1 on Epithelial and Mucosal Surfaces in Human Tissues , 2018, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[140]  Zedong Jiang,et al.  Alginate enhances Toll-like receptor 4-mediated phagocytosis by murine RAW264.7 macrophages. , 2017, International Journal of Biological Macromolecules.

[141]  A. Salgado,et al.  αvβ3 and α5β1 integrin-specific ligands: From tumor angiogenesis inhibitors to vascularization promoters in regenerative medicine? , 2017, Biotechnology advances.

[142]  Soo Young Lee,et al.  Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation , 2017, Molecules and cells.

[143]  V. Papayannopoulos Neutrophil extracellular traps in immunity and disease , 2017, Nature Reviews Immunology.

[144]  M. Islam,et al.  Chitin and Chitosan: Structure, Properties and Applications in Biomedical Engineering , 2017, Journal of Polymers and the Environment.

[145]  Christina K. Chan,et al.  Crosstalk Between T Lymphocytes and Lung Fibroblasts: Generation of a Hyaluronan‐Enriched Extracellular Matrix Adhesive for Monocytes , 2017, Journal of cellular biochemistry.

[146]  R. Simari,et al.  Xenoantigenicity of porcine decellularized valves , 2017, Journal of Cardiothoracic Surgery.

[147]  Shao-Cong Sun,et al.  NF-κB signaling in inflammation , 2017, Signal Transduction and Targeted Therapy.

[148]  T. Webster,et al.  A review of fibrin and fibrin composites for bone tissue engineering , 2017, International journal of nanomedicine.

[149]  M. C. Echave,et al.  Gelatin as Biomaterial for Tissue Engineering. , 2017, Current pharmaceutical design.

[150]  D. Zeugolis,et al.  Battling bacterial infection with hexamethylene diisocyanate cross-linked and Cefaclor-loaded collagen scaffolds , 2017, Biomedical materials.

[151]  M. Elliott,et al.  Tracheal Replacement Therapy with a Stem Cell‐Seeded Graft: Lessons from Compassionate Use Application of a GMP‐Compliant Tissue‐Engineered Medicine , 2017, Stem cells translational medicine.

[152]  S. Komarova,et al.  Collagen Type I as a Ligand for Receptor-Mediated Signaling , 2017, Front. Phys..

[153]  Ruijin Zheng,et al.  Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages , 2017, Scientific Reports.

[154]  Byong-hee Lee,et al.  Current Status and New Perspectives on Chitin and Chitosan as Functional Biopolymers , 2017, Applied Biochemistry and Biotechnology.

[155]  Yong Xu,et al.  Protein arginine methyltransferase 1 (PRMT1) represses MHC II transcription in macrophages by methylating CIITA , 2017, Scientific Reports.

[156]  Kunihiro Matsumoto,et al.  The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK–JNK Signaling Pathway in Axon Regeneration , 2016, PLoS genetics.

[157]  M. Moisenovich,et al.  Effects of fibroin microcarriers on inflammation and regeneration of deep skin wounds in mice , 2016, Biochemistry (Moscow).

[158]  A. Sbarbati,et al.  Hyaluronic Acid (HA) Scaffolds and Multipotent Stromal Cells (MSCs) in Regenerative Medicine , 2016, Stem Cell Reviews and Reports.

[159]  B. Lee,et al.  Synthesis and Characterization of Types A and B Gelatin Methacryloyl for Bioink Applications , 2016, Materials.

[160]  V. Kokol,et al.  Native cellulose nanofibrills induce immune tolerance in vitro by acting on dendritic cells , 2016, Scientific Reports.

[161]  K. Vasilev,et al.  The Role of Surface Nanotopography and Chemistry on Primary Neutrophil and Macrophage Cellular Responses , 2016, Advanced healthcare materials.

[162]  Shu Liu,et al.  Graft of the NT-3 persistent delivery gelatin sponge scaffold promotes axon regeneration, attenuates inflammation, and induces cell migration in rat and canine with spinal cord injury. , 2016, Biomaterials.

[163]  Daniel J. Modulevsky,et al.  Biocompatibility of Subcutaneously Implanted Plant-Derived Cellulose Biomaterials , 2016, bioRxiv.

[164]  D. Chirgadze,et al.  Structural basis for collagen recognition by the immune receptor OSCAR. , 2016, Blood.

[165]  G. Gao,et al.  Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors , 2016, Proceedings of the National Academy of Sciences.

[166]  Jung Ha Kim,et al.  Signaling Pathways in Osteoclast Differentiation , 2016, Chonnam medical journal.

[167]  David L Kaplan,et al.  In vivo bioresponses to silk proteins. , 2015, Biomaterials.

[168]  A. Khademhosseini,et al.  Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels. , 2015, Biomaterials.

[169]  G. Vunjak‐Novakovic,et al.  Controlled release of cytokines using silk-biomaterials for macrophage polarization. , 2015, Biomaterials.

[170]  J. Ravetch,et al.  Fcγ receptor pathways during active and passive immunization , 2015, Immunological reviews.

[171]  U. Bogdahn,et al.  Intrinsic and extrinsic determinants of central nervous system axon outgrowth into alginate-based anisotropic hydrogels. , 2015, Acta biomaterialia.

[172]  K. Su,et al.  Recent advances in the use of gelatin in biomedical research , 2015, Biotechnology Letters.

[173]  J. Zimmer,et al.  A molecular description of cellulose biosynthesis. , 2015, Annual review of biochemistry.

[174]  K. Wood,et al.  The Acquired Immune System Response to Biomaterials, Including Both Naturally Occurring and Synthetic Biomaterials , 2015 .

[175]  Yong Wang,et al.  Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates , 2015, Nature materials.

[176]  Y. Li,et al.  MAPK/JNK signalling: a potential autophagy regulation pathway , 2015, Bioscience reports.

[177]  Feng Wenpo,et al.  Preparation and characterization of collagen-hydroxyapatite/pectin composite. , 2015, International journal of biological macromolecules.

[178]  J. Enghild,et al.  ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1) , 2015, Molecular biology of the cell.

[179]  R. Pașca,et al.  On the Collagen Mineralization. A Review , 2015, Clujul medical.

[180]  Jung Kwon Oh,et al.  Recent strategies to develop polysaccharide-based nanomaterials for biomedical applications. , 2014, Macromolecular rapid communications.

[181]  R. Cameron,et al.  Quantitative architectural description of tissue engineering scaffolds , 2014 .

[182]  Joel H Collier,et al.  Engaging adaptive immunity with biomaterials. , 2014, Journal of materials chemistry. B.

[183]  Y. Saeys,et al.  The function of Fcγ receptors in dendritic cells and macrophages , 2014, Nature Reviews Immunology.

[184]  Ivan Martin,et al.  The role of 3D structure and protein conformation on the innate and adaptive immune responses to silk-based biomaterials. , 2013, Biomaterials.

[185]  A. Gardner,et al.  Biomaterials-Based Modulation of the Immune System , 2013, BioMed research international.

[186]  J. Leach,et al.  β1-Integrin cytoskeletal signaling regulates sensory neuron response to matrix dimensionality , 2013, Neuroscience.

[187]  Zhenhua Li,et al.  Adhesion, proliferation, and differentiation of mesenchymal stem cells on RGD nanopatterns of varied nanospacings , 2013, Organogenesis.

[188]  Sam W. Lee,et al.  Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor , 2013, ACS chemical biology.

[189]  L. Bačáková,et al.  Cellulose-based materials as scaffolds for tissue engineering , 2013, Cellulose.

[190]  Enas M. Ahmed,et al.  Hydrogel: Preparation, characterization, and applications: A review , 2013, Journal of advanced research.

[191]  Shengmin Zhang,et al.  Evaluation of bacterial nanocellulose-based uniform wound dressing for large area skin transplantation. , 2013, Materials science & engineering. C, Materials for biological applications.

[192]  L. Bian,et al.  Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis , 2013, Proceedings of the National Academy of Sciences.

[193]  Shaker A. Mousa,et al.  Fibrin and Collagen Differentially but Synergistically Regulate Sprout Angiogenesis of Human Dermal Microvascular Endothelial Cells in 3-Dimensional Matrix , 2013, International journal of cell biology.

[194]  Rangam Rajkhowa,et al.  Silk fibroin biomaterials for tissue regenerations. , 2013, Advanced drug delivery reviews.

[195]  Benjamin M. Wu,et al.  The effect of fibrinogen, collagen type I, and fibronectin on mesenchymal stem cell growth and differentiation into osteoblasts. , 2013, Tissue engineering. Part A.

[196]  M. Collins,et al.  Hyaluronic acid based scaffolds for tissue engineering--a review. , 2013, Carbohydrate polymers.

[197]  C. Specht,et al.  Innate Sensing of Chitin and Chitosan , 2013, PLoS pathogens.

[198]  S. Chiou,et al.  Corneal repair by human corneal keratocyte-reprogrammed iPSCs and amphiphatic carboxymethyl-hexanoyl chitosan hydrogel. , 2012, Biomaterials.

[199]  J. Simon,et al.  Artificial extracellular matrices composed of collagen I and high sulfated hyaluronan modulate monocyte to macrophage differentiation under conditions of sterile inflammation , 2012, Biomatter.

[200]  Huilin Yang,et al.  The osteogenesis of bacterial cellulose scaffold loaded with bone morphogenetic protein-2. , 2012, Biomaterials.

[201]  G. Karakiulakis,et al.  Hyaluronic acid: A key molecule in skin aging , 2012, Dermato-endocrinology.

[202]  G. Pongiglione,et al.  Early and late failure of tissue-engineered pulmonary valve conduits used for right ventricular outflow tract reconstruction in patients with congenital heart disease. , 2012, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[203]  M. B. Humphrey,et al.  Osteoimmunology: the expanding role of immunoreceptors in osteoclasts and bone remodeling. , 2012, BoneKEy reports.

[204]  S. Kundu,et al.  Potential of 2D crosslinked sericin membranes with improved biostability for skin tissue engineering , 2012, Cell and Tissue Research.

[205]  F. Lecanda,et al.  Inhibition of Collagen Receptor Discoidin Domain Receptor-1 (DDR1) Reduces Cell Survival, Homing, and Colonization in Lung Cancer Bone Metastasis , 2012, Clinical Cancer Research.

[206]  M. S. Howard,et al.  Collagen IV in Normal Skin and in Pathological Processes , 2012, North American journal of medical sciences.

[207]  L. Santambrogio,et al.  Mediators of the inflammatory response to joint replacement devices , 2011, Nature Reviews Rheumatology.

[208]  A. Balbarini,et al.  Fibrin as a scaffold for cardiac tissue engineering , 2011, Biotechnology and applied biochemistry.

[209]  S. Özbek,et al.  Evolution of glycosaminoglycans , 2011, Communicative & integrative biology.

[210]  K. Draget,et al.  Chemical, physical and biological properties of alginates and their biomedical implications , 2011 .

[211]  P. Lenting,et al.  Co-expression of the collagen receptors leukocyte-associated immunoglobulin-like receptor-1 and glycoprotein VI on a subset of megakaryoblasts , 2010, Haematologica.

[212]  Kyung-Soon Park,et al.  SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells , 2010, FEBS letters.

[213]  Kristi L Kiick,et al.  Elastomeric polypeptide-based biomaterials. , 2010, Journal of polymer science. Part A, Polymer chemistry.

[214]  Jung Ha Kim,et al.  MHC class II transactivator negatively regulates RANKL-mediated osteoclast differentiation by downregulating NFATc1 and OSCAR. , 2010, Cellular signalling.

[215]  Kyongbum Lee,et al.  Relationships between degradability of silk scaffolds and osteogenesis. , 2010, Biomaterials.

[216]  Xiaodong Sun,et al.  Combinated Transplantation of Neural Stem Cells and Collagen Type I Promote Functional Recovery After Cerebral Ischemia in Rats , 2010, Anatomical record.

[217]  R. Boelens,et al.  Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI. , 2010, Blood.

[218]  Shu-guang Wang,et al.  The Role of MAPK-ERK Pathway in 67-kDa Laminin Receptor-Induced FasL Expression in Human Cholangiocarcinoma Cells , 2010, Digestive Diseases and Sciences.

[219]  Jay X. Tang,et al.  Neutrophil morphology and migration are affected by substrate elasticity. , 2009, Blood.

[220]  W. Vogel,et al.  The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA , 2009, Journal of Cell Science.

[221]  Bochu Wang,et al.  Biodegradation of Silk Biomaterials , 2009, International journal of molecular sciences.

[222]  R. Gorodetsky The use of fibrin based matrices and fibrin microbeads (FMB) for cell based tissue regeneration , 2008 .

[223]  Mark P. Lewis,et al.  αvβ3 and αvβ5 integrins and their role in muscle precursor cell adhesion , 2008, Biology of the cell.

[224]  Wenjing Hu,et al.  Surface chemistry influences implant biocompatibility. , 2008, Current topics in medicinal chemistry.

[225]  Abdel Kareem Azab,et al.  Biocompatibility evaluation of crosslinked chitosan hydrogels after subcutaneous and intraperitoneal implantation in the rat. , 2007, Journal of biomedical materials research. Part A.

[226]  Sabine Werner,et al.  Keratinocyte-fibroblast interactions in wound healing. , 2007, The Journal of investigative dermatology.

[227]  J. Schlom,et al.  Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination. , 2007, Vaccine.

[228]  Jöns Hilborn,et al.  A new and evolving paradigm for biocompatibility , 2007, Journal of Tissue Engineering and Regenerative Medicine.

[229]  Robert Stern,et al.  Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications , 2006, Biotechnology Letters.

[230]  D. Schlaepfer,et al.  Integrin-regulated FAK-Src signaling in normal and cancer cells. , 2006, Current opinion in cell biology.

[231]  Pedro Madureira,et al.  The influence of functional groups of self-assembled monolayers on fibrous capsule formation and cell recruitment. , 2006, Journal of biomedical materials research. Part A.

[232]  R. Farndale Collagen-induced platelet activation. , 2006, Blood cells, molecules & diseases.

[233]  Seoung-Hoon Lee,et al.  Nuclear Factor of Activated T Cells c1 Induces Osteoclast-associated Receptor Gene Expression during Tumor Necrosis Factor-related Activation-induced Cytokine-mediated Osteoclastogenesis* , 2005, Journal of Biological Chemistry.

[234]  N. Kieffer,et al.  A New Functional Role of the Fibrinogen RGD Motif as the Molecular Switch That Selectively Triggers Integrin αIIbβ3-dependent RhoA Activation during Cell Spreading* , 2005, Journal of Biological Chemistry.

[235]  I. Yannas,et al.  Antigenicity and immunogenicity of collagen. , 2004, Journal of biomedical materials research. Part B, Applied biomaterials.

[236]  Satya Prakash Yadav,et al.  Multiple Binding Sites in Fibrinogen for Integrin αMβ2 (Mac-1)* , 2004, Journal of Biological Chemistry.

[237]  D. Schlaepfer,et al.  Control of motile and invasive cell phenotypes by focal adhesion kinase. , 2004, Biochimica et biophysica acta.

[238]  David L Kaplan,et al.  Macrophage responses to silk. , 2003, Biomaterials.

[239]  David A. Brenner,et al.  The Role of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Signaling in Hepatic Stellate Cell Proliferation and Type I Collagen Expression* , 2003, The Journal of Biological Chemistry.

[240]  David J Mooney,et al.  Comparison of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in SCID mice. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[241]  S. Mochizuki,et al.  Signaling Pathways Transduced through the Elastin Receptor Facilitate Proliferation of Arterial Smooth Muscle Cells* , 2002, The Journal of Biological Chemistry.

[242]  N. Tonks,et al.  Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[243]  W. Vogel,et al.  Collagen-receptor signaling in health and disease. , 2001, European journal of dermatology : EJD.

[244]  K W Anderson,et al.  Cell-interactive Alginate Hydrogels for Bone Tissue Engineering , 2001, Journal of dental research.

[245]  P. Koolwijk,et al.  Role of Fibrin Matrix in Angiogenesis , 2001, Annals of the New York Academy of Sciences.

[246]  Y. Ikada,et al.  Bone regeneration by transforming growth factor beta1 released from a biodegradable hydrogel. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[247]  R. Medzhitov,et al.  Innate immune recognition: mechanisms and pathways , 2000, Immunological reviews.

[248]  M. Heinzelmann,et al.  Differences between bacterial species shown by simultaneous assessment of neutrophil phagocytosis and generation of reactive oxygen intermediates in trauma patients. , 1999, Archives of surgery.

[249]  G. Freddi,et al.  In vitro evaluation of the inflammatory potential of the silk fibroin. , 1999, Journal of biomedical materials research.

[250]  Melendez,et al.  FcγRI activation of phospholipase Cγ1 and protein kinase C in dibutyryl cAMP‐differentiated U937 cells is dependent solely on the tyrosine‐kinase activated form of phosphatidylinositol‐3‐kinase , 1999 .

[251]  S. Watson,et al.  Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets. , 1999, European journal of biochemistry.

[252]  R. Pawankar,et al.  Fibroin allergy. IgE mediated hypersensitivity to silk suture materials. , 1999, Nihon Ika Daigaku zasshi.

[253]  J. Unkeless,et al.  Inhibitory receptors, ITIM sequences and phosphatases. , 1997, Current opinion in immunology.

[254]  Kozo Kaibuchi,et al.  Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase) , 1996, Science.

[255]  D. Plas,et al.  Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling , 1996, Science.

[256]  J. Feijen,et al.  Crosslinking of dermal sheep collagen using hexamethylene diisocyanate , 1995 .

[257]  G. Skjåk‐Braek,et al.  The involvement of CD14 in stimulation of cytokine production by uronic acid polymers , 1993, European journal of immunology.

[258]  J. Hoxie,et al.  Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII. , 1992, The Journal of biological chemistry.

[259]  F. Silver,et al.  Effects of fibroblasts and basic fibroblast growth factor on facilitation of dermal wound healing by type I collagen matrices. , 1991, Journal of biomedical materials research.

[260]  D. Altieri,et al.  A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin Mac-1 (CD11b/CD18). , 1990, The Journal of biological chemistry.

[261]  S. Barondes,et al.  The elastin receptor: a galactoside-binding protein. , 1988, Science.

[262]  C. Steffen,et al.  Immunogenicity and specificity of collagen. 13. Preparation and definition of soluble collagen-anticollagen complexes by gel filtration. , 1974, Immunology.

[263]  S. Soneji,et al.  3176 – MAC-1 MARKS A QUIESCENT AND FUNCTIONALLY SUPERIOR HSC SUBSET DURING REGENERATION , 2022, Experimental Hematology.

[264]  T. Giri,et al.  Natural polysaccharides: Types, basic structure and suitability for forming hydrogels , 2021, Plant and Algal Hydrogels for Drug Delivery and Regenerative Medicine.

[265]  Chengchen Guo Insect and animal-originated fibres: silk and wool , 2021 .

[266]  Shengjie Ling,et al.  Structure of Collagen. , 2021, Methods in molecular biology.

[267]  Matthew Dovedytis,et al.  Hyaluronic acid and its biomedical applications: A review , 2020 .

[268]  B. Kolesińska,et al.  Chitosan and Its Derivatives - Biomaterials with Diverse Biological Activity for Manifold Applications. , 2019, Mini reviews in medicinal chemistry.

[269]  A. Grumezescu,et al.  Hyaluronic acid-based scaffolds for tissue engineering. , 2018, Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie.

[270]  Soon Hee Kim,et al.  Silk Fibroin in Wound Healing Process. , 2018, Advances in experimental medicine and biology.

[271]  Pedro M. Baptista,et al.  Naturally-Derived Biomaterials for Tissue Engineering Applications. , 2018, Advances in experimental medicine and biology.

[272]  K. Woo,et al.  Fibrin-Based Biomaterial Applications in Tissue Engineering and Regenerative Medicine. , 2018, Advances in experimental medicine and biology.

[273]  Ashley C. Brown,et al.  Controlling Fibrin Network Morphology, Polymerization, and Degradation Dynamics in Fibrin Gels for Promoting Tissue Repair. , 2018, Methods in molecular biology.

[274]  Tim D Smith,et al.  Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen. , 2017, Acta biomaterialia.

[275]  A. Pozzi,et al.  The nature and biology of basement membranes. , 2017, Matrix biology : journal of the International Society for Matrix Biology.

[276]  L. Bačáková,et al.  Polysaccharides as cell carriers for tissue engineering: the use of cellulose in vascular wall reconstruction. , 2014, Physiological research.

[277]  J. Brown,et al.  Lysophospholipid receptor activation of RhoA and lipid signaling pathways. , 2013, Biochimica et biophysica acta.

[278]  D. Mooney,et al.  Alginate: properties and biomedical applications. , 2012, Progress in polymer science.

[279]  S. Ricard-Blum The collagen family. , 2011, Cold Spring Harbor perspectives in biology.

[280]  J. Ravetch,et al.  Fcγ receptors as regulators of immune responses , 2008, Nature Reviews Immunology.

[281]  P. Siljander,et al.  Function of Glycoprotein VI and Integrin α2β1 in the Procoagulant Response of Single, Collagen-Adherent Platelets , 1999, Thrombosis and Haemostasis.

[282]  E Ruoslahti,et al.  RGD and other recognition sequences for integrins. , 1996, Annual review of cell and developmental biology.

[283]  J. Aubert,et al.  The biological degradation of cellulose. , 1994, FEMS microbiology reviews.

[284]  M. Ginsberg,et al.  Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif. , 1991, Trends in biochemical sciences.

[285]  R. Cameron,et al.  Optimisation of UV irradiation as a binding site conserving method for crosslinking collagen-based scaffolds , 2015, Journal of Materials Science: Materials in Medicine.