Autofluorescence imaging and spectroscopy of normal and malignant mucosa in patients with head and neck cancer

An early detection of oral cancer might improve the patient's prognosis. We present preliminary results of autofluorescence photodetection of cancerous oral mucosa.

[1]  S Silverman,et al.  Early diagnosis of oral cancer , 1988, Cancer.

[2]  F. N. Ghadially,et al.  Porphyrin Fluorescence of Experimentally produced Squamous Cell Carcinoma , 1960, Nature.

[3]  F. N. Ghadially,et al.  Mechanisms involved in the production of red fluorescence of human and experimental tumours. , 1963, The Journal of pathology and bacteriology.

[4]  B Palcic,et al.  Diagnostic imaging of the larynx: autofluorescence of laryngeal tumours using the helium-cadmium laser , 1995, The Journal of Laryngology & Otology.

[5]  D. Slaughter,et al.  “Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin , 1953, Cancer.

[6]  F. N. Ghadially,et al.  Red fluoescence of experimentally induced and human tumours. , 1960, The Journal of pathology and bacteriology.

[7]  J R Leonard,et al.  Hematoporphyrin fluorescence: An aid in diagnosis of malignant neoplasms , 1971, The Laryngoscope.

[8]  L. Rasetti,et al.  Porphyrin metabolism in human neoplastic tissues. , 1966, Panminerva medica.

[9]  E. Sevick-Muraca,et al.  Quantitative optical spectroscopy for tissue diagnosis. , 1996, Annual review of physical chemistry.

[10]  M. Strong,et al.  Toluidine blue in the management of carcinoma of the oral cavity. , 1968, Archives of otolaryngology.

[11]  R. Alfano,et al.  Laser induced fluorescence spectroscopy from native cancerous and normal tissue , 1984 .

[12]  K. Benirschke,et al.  Holoacardius amorphus. Report of a case with chromosome analysis. , 1963, American Journal of Obstetrics and Gynecology.

[13]  I Itzkan,et al.  Autofluorescence characteristics of oral mucosa , 1997, Head & neck.

[14]  F. Ronchese.  The fluorescence of cancer under the Wood light. , 1954, Oral surgery, oral medicine, and oral pathology.

[15]  F. Figge,et al.  Cancer Detection and Therapy. Affinity of Neoplastic, Embryonic, and Traumatized Tissues for Porphyrins and Metalloporphyrins.∗ , 1948, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[16]  A. M. Olsen,et al.  The use of a derivative of hematoporphyrin in tumor detection. , 1961 .

[17]  D. Harris,et al.  Endogenous porphyrin fluorescence in tumors , 1987, Lasers in surgery and medicine.

[18]  C Scully,et al.  Toluidine blue and Lugol's iodine application in the assessment of oral malignant disease and lesions at risk of malignancy. , 1992, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[19]  R. van Hillegersberg,et al.  Selective accumulation of endogenously produced porphyrins in a liver metastasis model in rats. , 1992, Gastroenterology.

[20]  J. Kennedy,et al.  Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. , 1990, Journal of photochemistry and photobiology. B, Biology.

[21]  N. Navone,et al.  Heme biosynthesis in human breast cancer--mimetic "in vitro" studies and some heme enzymic activity levels. , 1990, The International journal of biochemistry.

[22]  R. Williams,et al.  B Vitamins in Cancerous Tissues. I. Riboflavin , 1942 .

[23]  K. Schomacker,et al.  Laser induced autofluorescence diagnosis of bladder cancer. , 1996, The Journal of urology.

[24]  L. Rasetti,et al.  [Ferrochelatase, ALA-dehydrase and ALA-synthetase activity in human tumor tissues]. , 1966, Minerva medica.

[25]  B Palcic,et al.  Detection of squamous cell cancer and pre-cancerous lesions by imaging of tissue autofluorescence in the hamster cheek pouch model. , 1992, Surgical oncology.

[26]  R. C. Benson,et al.  Cellular autofluorescence--is it due to flavins? , 1979, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[27]  R. Richart.  A clinical staining test for the in vivo delineation of dysplasia and carcinoma in situ. , 1963, American journal of obstetrics and gynecology.

[28]  T J Flotte,et al.  Ultraviolet laser‐induced fluorescence of colonic tissue: Basic biology and diagnostic potential , 1992, Lasers in surgery and medicine.

[29]  B. Palcic,et al.  Autofluorescence of normal and malignant bronchial tissue , 1991, Lasers in surgery and medicine.

[30]  Yang Yuanlong,et al.  Characteristic autofluorescence for cancer diagnosis and its origin , 1987, Lasers in surgery and medicine.

[31]  H E Savage,et al.  Native cellular fluorescence of neoplastic upper aerodigestive mucosa. , 1995, Archives of otolaryngology--head & neck surgery.

[32]  F. Figge,et al.  Fluorescence of human lymphatic and cancer tissues following high doses of intravenous hematoporphyrin , 1955, Surgical forum.

[33]  K. D. Devine,et al.  Tetracycline‐Induced fluorescence of laryngeal, pharyngeal, and oral cancer , 1972, The Laryngoscope.

[34]  Hitoshi Shibuya,et al.  Multiple primary cancer risk in patients with squamous cell carcinoma of the oral cavity , 1987 .

[35]  R E Singer,et al.  Effectiveness of toluidine blue as an aid to biopsy in the diagnosis of DMBA‐induced hamster pouch dysplasia and carcinoma , 1972, Cancer.

[36]  T. Tong,et al.  Cancer statistics, 1994 , 1994, CA: a cancer journal for clinicians.

[37]  A. Leunig,et al.  Photodynamische Diagnostik von Neoplasien der Mundhöhle nach lokaler Applikation von 5-Aminolävulinsäure , 1996 .

[38]  W Lohmann,et al.  Significance of autofluorescence for the optical demarcation of field cancerisation in the upper aerodigestive tract. , 1997, Acta oto-laryngologica.

[39]  H Stepp,et al.  Fluorescence imaging and spectroscopy of 5-aminolevulinic acid induced protoporphyrin IX for the detection of neoplastic lesions in the oral cavity. , 1996, American journal of surgery.