Comparison of Threshold-Based Segmentation Methods on Pre- and Post-Therapy PET Scans

The aim of this study was to compare several threshold-based segmentation methods in delineating tumours on preand posttherapy PET scans both in terms of the volumes segmented and the effect on predicting survival. On a dataset of 14 patients with mesothelioma, different segmentation methods were found to correlate well with each other for preand posttherapy tumour volume (TV) and total lesion glycolysis (TLG) but did not correlated as well for absolute change and % change of TV and TLG between preand posttherapy images. This was also found for the effect of the TV and TLG on receiver operator characteristics (ROC) analysis on 6month progression free survival (PFS) in where the segmentation method had little effect when assessing preor posttherapy TV and TLG but showed significant differences when using change of % change as a predictor of PFS.

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