A Liquid Crystal Polymer‐Based Neuromodulation System: An Application on Animal Model of Neuropathic Pain

We developed a custom‐made miniaturized neural stimulation system with a liquid crystal polymer (LCP)‐based electrode array for animal experiments. In order to verify the feasibility of the system, motor cortex stimulation (MCS) was applied on the rat pain model induced by sciatic nerve injury.

[1]  T. Yaksh,et al.  Quantitative assessment of tactile allodynia in the rat paw , 1994, Journal of Neuroscience Methods.

[2]  Philippe Decq,et al.  Chronic motor cortex stimulation in the treatment of central and neuropathic pain. Correlations between clinical, electrophysiological and anatomical data , 1999, PAIN.

[3]  R. Masri,et al.  Motor cortex stimulation reduces hyperalgesia in an animal model of central pain , 2011, PAIN.

[4]  R. L. Pagano,et al.  Antinociception induced by epidural motor cortex stimulation in naive conscious rats is mediated by the opioid system , 2009, Behavioural Brain Research.

[5]  M. Tentzeris,et al.  Packaging of MMICs in multilayer LCP substrates , 2006, IEEE Microwave and Wireless Components Letters.

[6]  M. D. Rooij,et al.  Electrochemical Methods: Fundamentals and Applications , 2003 .

[7]  Arun K. Senapati,et al.  Spinal dorsal horn neuron response to mechanical stimuli is decreased by electrical stimulation of the primary motor cortex , 2005, Brain Research.

[8]  Seung Jae Oh,et al.  Neural signal recording using microelectrode arrays fabricated on liquid crystal polymer material , 2004 .

[9]  Sung June Kim,et al.  Design for a Simplified Cochlear Implant System , 2007, IEEE Transactions on Biomedical Engineering.

[10]  Timothy J. Johnson,et al.  Polymer-Based Microelectrode Arrays , 2006 .

[11]  E. J. Tehovnik Electrical stimulation of neural tissue to evoke behavioral responses , 1996, Journal of Neuroscience Methods.

[12]  Seung Woo Lee,et al.  Development of microelectrode arrays for artificial retinal implants using liquid crystal polymers. , 2009, Investigative ophthalmology & visual science.

[13]  Z. Cho,et al.  Magnetic Resonance Imaging Compatibility of the Polymer-based Cochlear Implant , 2012, Clinical and experimental otorhinolaryngology.

[14]  T Hirayama,et al.  Chronic motor cortex stimulation for the treatment of central pain. , 1991, Acta neurochirurgica. Supplementum.

[15]  George Paxinos,et al.  AChE-stained horizontal sections of the rat brain in stereotaxic coordinates , 1980, Journal of Neuroscience Methods.

[16]  P. E. K. Donaldson,et al.  When are actively balanced biphasic (‘Lilly’) stimulating pulses necessary in a neurological prosthesis? I Historical background; Pt resting potential;Q studies , 2006, Medical and Biological Engineering and Computing.

[17]  Joonsoo Jeong,et al.  Monolithic Encapsulation of Implantable Neuroprosthetic Devices Using Liquid Crystal Polymers , 2011, IEEE Transactions on Biomedical Engineering.

[18]  Y. Katayama,et al.  Treatment of Thalamic Pain by Chronic Motor Cortex Stimulation , 1991, Pacing and clinical electrophysiology : PACE.

[19]  T. Yamamoto,et al.  Poststroke pain control by chronic motor cortex stimulation: neurological characteristics predicting a favorable response. , 1998, Journal of neurosurgery.

[20]  K. Molina-Luna,et al.  Cortical stimulation mapping using epidurally implanted thin-film microelectrode arrays , 2007, Journal of Neuroscience Methods.

[21]  E. C. Culbertson A new laminate material for high performance PCBs: liquid crystal polymer copper clad films , 1995, 1995 Proceedings. 45th Electronic Components and Technology Conference.

[22]  R. L. Pagano,et al.  Motor cortex stimulation inhibits thalamic sensory neurons and enhances activity of PAG neurons: Possible pathways for antinociception , 2012, PAIN®.

[23]  Hirokazu Takahashi,et al.  Microelectrode array on folding polyimide ribbon for epidural mapping of functional evoked potentials , 2003, IEEE Transactions on Biomedical Engineering.

[24]  C. Woolf,et al.  Spared nerve injury: an animal model of persistent peripheral neuropathic pain , 2000, Pain.

[25]  M. Zimmermann,et al.  Ethical guidelines for investigations of experimental pain in conscious animals , 1983, Pain.

[26]  Alexandra J. Golby,et al.  PTFOS: Flexible and Absorbable Intracranial Electrodes for Magnetic Resonance Imaging , 2012, PloS one.

[27]  H. Graf,et al.  RF tissue-heating near metallic implants during magnetic resonance examinations: an approach in the ac limit. , 2011, Medical physics.

[28]  J. Hetke,et al.  Realization of Ultra Fine Pitch Traces on LCP Substrates , 2008, IEEE Transactions on Components and Packaging Technologies.

[29]  T. Stieglitz,et al.  Polymers for neural implants , 2011 .

[30]  Roberto Fabian Rodríguez,et al.  Bilateral Motor Cortex Stimulation for the Relief of Central Dysesthetic Pain and Intentional Tremor Secondary to Spinal Cord Surgery: A Case Report , 2002, Neuromodulation : journal of the International Neuromodulation Society.

[31]  Elliot S. Krames,et al.  What Is Neuromodulation , 2009 .

[32]  V. Tronnier,et al.  Chronic precentral stimulation in trigeminal neuropathic pain , 2005, Acta Neurochirurgica.