The anti‐interleukin‐6 antibody siltuximab down‐regulates genes implicated in tumorigenesis in prostate cancer patients from a phase I study
暂无分享,去创建一个
K. Pantel | S. Riethdorf | U. Prabhakar | M. Qi | Z. Culig | J. Karkera | H. Steiner | T. Puchalski | V. Skradski | P. Moser | M. Reddy | Weimin Li | Patrizia L. Moser | K. Safer | Viktor Skradski
[1] J. Pinski,et al. Clinical and Correlative Results of SWOG S0354: A Phase II Trial of CNTO328 (Siltuximab), a Monoclonal Antibody against Interleukin-6, in Chemotherapy-Pretreated Patients with Castration-Resistant Prostate Cancer , 2010, Clinical Cancer Research.
[2] Hugh M. Davis,et al. Pharmacokinetic and Pharmacodynamic Modeling of an Anti–Interleukin-6 Chimeric Monoclonal Antibody (Siltuximab) in Patients with Metastatic Renal Cell Carcinoma , 2010, Clinical Cancer Research.
[3] G. Jenster,et al. Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer. , 2010, Cancer research.
[4] H. Kung,et al. Interleukin-6 Regulates Androgen Synthesis in Prostate Cancer Cells , 2009, Clinical Cancer Research.
[5] Sandra A. Moore,et al. Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. , 2009, Blood.
[6] Dietmar Fuchs,et al. Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor. , 2008, Endocrine-related cancer.
[7] M. Rajendran,et al. A novel role of Shc adaptor proteins in steroid hormone-regulated cancers. , 2008, Endocrine-related cancer.
[8] R. Dhir. Stat3 Promotes Metastatic Progression of Prostate Cancer , 2009 .
[9] W. Grant. Vitamin D may reduce prostate cancer metastasis by several mechanisms including blocking Stat3. , 2008, The American journal of pathology.
[10] T. Burke,et al. Grb2 signaling in cell motility and cancer , 2008, Expert opinion on therapeutic targets.
[11] P. Nelson,et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. , 2008, Cancer research.
[12] B. Potter,et al. 17β‐hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone‐dependent breast cancer , 2008 .
[13] Robyn L Prueitt,et al. Tumor immunobiological differences in prostate cancer between African-American and European-American men. , 2008, Cancer research.
[14] D. Fuchs,et al. The antiapoptotic effect of IL-6 autocrine loop in a cellular model of advanced prostate cancer is mediated by Mcl-1 , 2007, Oncogene.
[15] Brigitte Rack,et al. Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Metastatic Breast Cancer: A Validation Study of the CellSearch System , 2007, Clinical Cancer Research.
[16] J. Bektic,et al. Regulation of growth of prostate cancer cells selected in the presence of interleukin‐6 by the anti‐interleukin‐6 antibody CNTO 328 , 2006, The Prostate.
[17] Daniel W Lin,et al. Influence of surgical manipulation on prostate gene expression: implications for molecular correlates of treatment effects and disease prognosis. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[18] Yi Lu,et al. Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice. , 2006, Cancer research.
[19] Georg Bartsch,et al. Interleukin‐6 regulation of prostate cancer cell growth , 2005, Journal of cellular biochemistry.
[20] J. Pinski,et al. Interleukin‐6 inhibits the growth of prostate cancer xenografts in mice by the process of neuroendocrine differentiation , 2004, International journal of cancer.
[21] M. Trikha,et al. CNTO 328, a monoclonal antibody to IL‐6, inhibits human tumor‐induced cachexia in nude mice , 2004, International journal of cancer.
[22] Alison Stopeck,et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. , 2004, The New England journal of medicine.
[23] G. Bartsch,et al. An autocrine loop for vascular endothelial growth factor is established in prostate cancer cells generated after prolonged treatment with interleukin 6. , 2004, European journal of cancer.
[24] R. Tibshirani,et al. Gene expression profiling identifies clinically relevant subtypes of prostate cancer. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[25] J. Cheville,et al. Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression. , 2003, Cancer research.
[26] D. Fuchs,et al. Accelerated in vivo growth of prostate tumors that up-regulate interleukin-6 is associated with reduced retinoblastoma protein expression and activation of the mitogen-activated protein kinase pathway. , 2003, The American journal of pathology.
[27] Rajiv Dhir,et al. Gene expression analysis of prostate cancers , 2002, Molecular carcinogenesis.
[28] H. Klocker,et al. Prostate cancer cells (LNCaP) generated after long-term interleukin 6 (IL-6) treatment express IL-6 and acquire an IL-6 partially resistant phenotype. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[29] J. Welsh,et al. Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. , 2001, Cancer research.
[30] E. Keller,et al. Anti‐interleukin‐6 monoclonal antibody induces regression of human prostate cancer xenografts in nude mice , 2001, The Prostate.
[31] E. Keller,et al. Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[32] H. Klocker,et al. Immunohistochemical localization of interleukin‐6 and its receptor in benign, premalignant and malignant prostate tissue , 2000, The Journal of pathology.
[33] T. Chung,et al. STAT3 mediates IL‐6‐induced growth inhibition in the human prostate cancer cell line LNCaP , 2000, The Prostate.
[34] J. M. Lin,et al. Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines. , 2000, The Prostate.
[35] Bernhard O. Palsson,et al. Cancer cell lines , 1999 .
[36] H. Klocker,et al. Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor. , 1998, Cancer research.
[37] F. Fauvel-Lafève,et al. Stromal cells from human benign prostate hyperplasia produce a growth‐inhibitory factor for LNCaP prostate cancer cells, identified as interleukin‐6 , 1996, International journal of cancer.
[38] J. Simons,et al. Interleukin-6: a candidate mediator of human prostate cancer morbidity. , 1995, Urology.
[39] Jean D. Wilson,et al. Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells , 1991, Molecular and Cellular Endocrinology.
[40] A. J. Garrett,et al. CANCER XENOGRAFTS IN NUDE MICE , 1976, The Lancet.