论文信息 - Adaptive Control of Time-Delayed Systems with Application for Control of Glucose Concentration in Type 1 Diabetic Patients

Adaptive Control of Time-Delayed Systems with Application for Control of Glucose Concentration in Type 1 Diabetic Patients

Abstract An adaptive controller for glucose control in Type 1 Diabetes Mellitus (T1DM) subject is presented in this paper. The proposed control model of T1DM subject involves a known input time-delay, due to the modeling of a subcutaneous tissues, and a disturbance submodel, where a meal ingestion acts as a measured disturbance. A main MRAC based part of controller for time-delayed systems is supplemented with a heuristic based adaptive disturbance rejection. The controller is verified by means of numerical simulations using an own implementation of T1DM simulator reported in literature.

Marian Tarnik | Jan Murgas | Eva Miklovicova | Ludovit Farkas

[1] R. Ortega,et al. Globally stable adaptive controller for systems with delay , 1988 .

[2] Anuradha M. Annaswamy,et al. Adaptive posicast controller for time-delay systems with relative degree n*<=2 , 2010, Autom..

[3] Per Olof Gutman,et al. Adaptive following of perturbed plants with input and state delays , 2011, 2011 9th IEEE International Conference on Control and Automation (ICCA).

[4] Claudio Cobelli,et al. GIM, Simulation Software of Meal Glucose—Insulin Model , 2007, Journal of diabetes science and technology.

[5] Giuseppe De Nicolao,et al. Modeling and Control of Diabetes: Towards the Artificial Pancreas , 2011 .

[6] Per-Olof Gutman,et al. State‐feedback adaptive tracking of linear systems with input and state delays , 2008 .

[7] R. Hovorka,et al. Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT. , 2002, American journal of physiology. Endocrinology and metabolism.

[8] Anuradha M. Annaswamy,et al. An adaptive Smith-controller for time-delay systems with relative degree n*≤2 , 2003, Syst. Control. Lett..

[9] Giuseppe De Nicolao,et al. Model predictive control of glucose concentration in type I diabetic patients: An in silico trial , 2009, Biomed. Signal Process. Control..