Conversion of diploidy to haploidy

Individuals susceptible to multigene disorders may now be spotted more easily.

[1]  W. Foulkes,et al.  A missense mutation in both hMSH2 andAPC in an Ashkenazi Jewish HNPCC kindred: implications for clinical screening , 1999, Journal of medical genetics.

[2]  A. de la Chapelle,et al.  Genetic susceptibility to non-polyposis colorectal cancer , 1999, Journal of medical genetics.

[3]  T. Glover,et al.  Microcell-mediated transfer of a single human chromosome complements xeroderma pigmentosum group A fibroblasts. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[4]  A. S. Warthin.  HEREDITY WITH REFERENCE TO CARCINOMA: AS SHOWN BY THE STUDY OF THE CASES EXAMINED IN THE PATHOLOGICAL LABORATORY OF THE UNIVERSITY OF MICHIGAN, 1895-1913 , 1913 .

[5]  Margaret Robertson,et al.  Identification and characterization of the familial adenomatous polyposis coli gene , 1991, Cell.

[6]  P. Møller,et al.  MSH2 genomic deletions are a frequent cause of HNPCC , 1998, Nature Genetics.

[7]  K. Kinzler,et al.  Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients , 1996, Nature Medicine.

[8]  E. Zabarovsky,et al.  Nonrandom loss of human chromosome 3 fragments from mouse‐human microcell hybrids following progressive growth in SCID mice , 1994, Genes, chromosomes & cancer.

[9]  H. Griesser,et al.  MSH2 deficient mice are viable and susceptible to lymphoid tumours , 1995, Nature Genetics.

[10]  D. Patterson,et al.  Somatic Cell Genetic Approaches to Down's Syndrome * , 1982, Annals of the New York Academy of Sciences.

[11]  K. Kinzler,et al.  Genetic instability in colorectal cancers , 1997, Nature.

[12]  Peter Beighton,et al.  de la Chapelle, A. , 1997 .

[13]  H. Harris.  Suppression of malignancy in hybrid cells: the mechanism. , 1985, Journal of cell science.

[14]  E. Friedberg,et al.  Confirmation of homozygosity for a single nucleotide substitution mutation in a Cockayne syndrome patient using monoallelic mutation analysis in somatic cell hybrids , 1997, Human mutation.

[15]  E. Stanbridge,et al.  Tumor suppressor genes studied by cell hybridization and chromosome transfer , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.