GAP JUNCTIONS OCCUR IN VERTEBRATE RENAL PROXIMAL TUBULE CELLS

Renal proximal tubular cells are known to be electrically coupled (1) . In other tissues, three types of specialized junctions have been implicated in intercellular ionic communication : septate desmosomes (2), gap junctions (3, 4), and tight junctions (5, 6) . Of these, only the tight junction has been previously identified in kidney tubular epithelium (7) and, therefore, has been thought to be the site of electrical coupling in this tissue . In this report, we describe the occurrence of gap junctions in the proximal tubule cells of rabbit, fish, and monkey.

[1]  B W Payton,et al.  Permeability and Structure of Junctional Membranes at an Electrotonic Synapse , 1969, Science.

[2]  T. Reese,et al.  JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN , 1969, The Journal of cell biology.

[3]  B. Roots,et al.  Fixation of the central nervous system by perfusion with aldehydes and its effect on the extracellular space as seen by electron microscopy. , 1967, Journal of cell science.

[4]  J. Revel,et al.  HEXAGONAL ARRAY OF SUBUNITS IN INTERCELLULAR JUNCTIONS OF THE MOUSE HEART AND LIVER , 1967, The Journal of cell biology.

[5]  A. Lasansky.  CELL JUNCTIONS IN OMMATIDIA OF LIMULUS , 1967, The Journal of cell biology.

[6]  Trump Bf,et al.  Human renal ultrastructure. I. Proximal tubule of healthy individuals. , 1966 .

[7]  A. B. Maunsbach,et al.  The influence of different fixatives and fixation methods on the ultrastructure of rat kidney proximal tubule cells. I. Comparison of different perfusion fixation methods and of glutaraldehyde, formaldehyde and osmium tetroxide fixatives. , 1966, Journal of ultrastructure research.

[8]  A. B. Maunsbach.  The influence of different fixatives and fixation methods on the ultrastructure of rat kidney proximal tubule cells. II. Effects of varying osmolality, ionic strength, buffer system and fixative concentration of glutaraldehyde solutions. , 1966, Journal of ultrastructure research.

[9]  B. Trump,et al.  Human renal ultrastructure. I. Proximal tubule of healthy individuals. , 1966, Laboratory investigation; a journal of technical methods and pathology.

[10]  M. Fuortes,et al.  Electrical Connections between Visual Cells in the Ommatidium of Limulus , 1965, Science.

[11]  M. Karnovsky,et al.  A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron-microscopy , 1965 .

[12]  Werner R. Loewenstein,et al.  STUDIES ON AN EPITHELIAL (GLAND) CELL JUNCTION I. Modifications of Surface Membrane Permeability , 1964 .

[13]  W. Loewenstein,et al.  STUDIES ON AN EPITHELIAL (GLAND) CELL JUNCTION , 1964, The Journal of cell biology.

[14]  G. Palade,et al.  JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA , 1963, The Journal of cell biology.