Psychosocial factors in medication adherence and diabetes self-management: Implications for research and practice.

Diabetes is a chronic illness that places a significant self-management burden on affected individuals and families. Given the importance of health behaviors-such as medication adherence, diet, physical activity, blood glucose self-monitoring-in achieving optimal glycemic control in diabetes, interventions designed and delivered by psychologists hold promise in assisting children, adolescents, and adults with diabetes in improving their health status and lowering their risk of serious complications. This article first provides an overview of diabetes self-management and associated challenges and burdens. Socioeconomic status factors that may influence diabetes management and outcomes are briefly highlighted. We then review the evidence base for select psychosocial factors that may be implicated in diabetes self-management. Modifiable targets of psychological intervention are presented across 3 overarching domains: (a) knowledge, beliefs, and related cognitive constructs; (b) emotional distress and well-being; and (c) behavioral skills and coping. Important methodological issues facing future research are discussed, along with opportunities for psychologists in improving the care and treatment outcomes of individuals and families living with diabetes. In conclusion, we advocate for continued research emphasis on improving psychosocial aspects of living with diabetes, with greater attention to the situational context in which the self-regulatory processes underlying self-management occur. Psychologists have important roles to play in reducing emotional distress, improving patient knowledge, and providing training in behavioral skills to promote successful self-management and to support patient-centered diabetes care. (PsycINFO Database Record

[1]  Perri Klass,et al.  Literacy and child health: a systematic review. , 2009, Archives of pediatrics & adolescent medicine.

[2]  Jorie M. Butler,et al.  Perceived Diabetes Task Competence Mediates the Relationship of both Negative and Positive Affect with Blood Glucose in Adolescents with Type 1 Diabetes , 2009, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[3]  Felicia Hill-Briggs,et al.  Problem solving interventions for diabetes self-management and control: a systematic review of the literature. , 2013, Diabetes research and clinical practice.

[4]  Ross T Tsuyuki,et al.  A meta-analysis of the association between adherence to drug therapy and mortality , 2006, BMJ : British Medical Journal.

[5]  S. Braniecki,et al.  Childhood illness-related parenting stress: the pediatric inventory for parents. , 2001, Journal of pediatric psychology.

[6]  Dianne Davis,et al.  Association of Numeracy and Diabetes Control , 2008, Annals of Internal Medicine.

[7]  Arleen F. Brown,et al.  Out-of-pocket costs and diabetes preventive services: the Translating Research Into Action for Diabetes (TRIAD) study. , 2003, Diabetes care.

[8]  F. Pouwer,et al.  If it does not significantly change HbA1c levels why should we waste time on it? A plea for the prioritization of psychological well‐being in people with diabetes , 2015, Diabetic medicine : a journal of the British Diabetic Association.

[9]  K. Lorig,et al.  Spanish Diabetes Self-Management With and Without Automated Telephone Reinforcement , 2008, Diabetes Care.

[10]  C. Berg,et al.  Self-Control as a Mediator of the Link Between Intelligence and HbA1c During Adolescence , 2014 .

[11]  R. Beck,et al.  Race, socioeconomic status, and treatment center are associated with insulin pump therapy in youth in the first year following diagnosis of type 1 diabetes. , 2013, Diabetes technology & therapeutics.

[12]  Paul Karoly,et al.  Self‐Regulation Assessment and Intervention in Physical Health and Illness: A Review , 2005 .

[13]  D. Torgerson,et al.  Clinical effectiveness of a brief educational intervention in Type 1 diabetes: results from the BITES (Brief Intervention in Type 1 diabetes, Education for Self-efficacy) trial , 2008, Diabetic medicine : a journal of the British Diabetic Association.

[14]  A. Farmer,et al.  Self‐monitoring of blood glucose changed non‐insulin‐treated Type 2 diabetes patients’ beliefs about diabetes and self‐monitoring in a randomized trial , 2008, Diabetic medicine : a journal of the British Diabetic Association.

[15]  R. Vigersky,et al.  An Overview of Management Issues in Adult Patients with Type 2 Diabetes Mellitus , 2011, Journal of diabetes science and technology.

[16]  Yinghui Xu,et al.  An Assessment of Attitudes, Behaviors, and Outcomes of Patients with Type 2 Diabetes , 2009, The Journal of the American Board of Family Medicine.

[17]  Stephanie R. Johnson,et al.  Long-term outcome of insulin pump therapy in children with type 1 diabetes assessed in a large population-based case–control study , 2013, Diabetologia.

[18]  Melinda D. Maryniuk,et al.  AADE7 Self-Care Behaviors. , 2008, The Diabetes educator.

[19]  P. Sheeran,et al.  The impact of positive affect on health cognitions and behaviours: a meta-analysis of the experimental evidence , 2015, Health psychology review.

[20]  L. Gonder-Frederick,et al.  A critical review of the literature on fear of hypoglycemia in diabetes: Implications for diabetes management and patient education. , 2007, Patient education and counseling.

[21]  Sumit R. Majumdar,et al.  Health Literacy and Health Outcomes in Diabetes: A Systematic Review , 2013, Journal of General Internal Medicine.

[22]  V L Lawson,et al.  The importance of health belief models in determining self‐care behaviour in diabetes , 2009, Diabetic medicine : a journal of the British Diabetic Association.

[23]  N. Hermanns,et al.  Negative association between depression and diabetes control only when accompanied by diabetes-specific distress , 2015, Journal of Behavioral Medicine.

[24]  Jeffrey S. Gonzalez,et al.  Methodological Issues in the Assessment of Diabetes Treatment Adherence , 2011, Current diabetes reports.

[25]  S. Norris,et al.  Effectiveness of self-management training in type 2 diabetes: a systematic review of randomized controlled trials. , 2001, Diabetes care.

[26]  B. Ingersoll-Dayton,et al.  Effect of adults' self-regulation of diabetes on quality-of-life outcomes. , 2000, Diabetes care.

[27]  M. de Groot,et al.  Psychological conditions in adults with diabetes. , 2016, The American psychologist.

[28]  Jessica Y. Breland,et al.  Successful self‐management among non‐insulin‐treated adults with Type 2 diabetes: a self‐regulation perspective , 2015, Diabetic medicine : a journal of the British Diabetic Association.

[29]  L. Geiss,et al.  Diabetes Knowledge and Its Relationship With Achieving Treatment Recommendations in a National Sample of People With Type 2 Diabetes , 2012, Diabetes Care.

[30]  Jeffrey S. Gonzalez,et al.  A review of treating depression in diabetes: emerging findings. , 2011, Psychosomatics.

[31]  N. Schneiderman,et al.  Prevalence of Diabetes Among Hispanics/Latinos From Diverse Backgrounds: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) , 2014, Diabetes Care.

[32]  C. Chesla,et al.  Health and Psychosocial Outcomes in U.S. Adult Patients with Diabetes from Diverse Ethnicities , 2012, Current Diabetes Reports.

[33]  Deborah F Tate,et al.  A self-regulation program for maintenance of weight loss. , 2006, The New England journal of medicine.

[34]  R. Rothman,et al.  Glycemic control in young children with diabetes: the role of parental health literacy. , 2014, Patient education and counseling.

[35]  John D. Voss,et al.  The association between diabetes metabolic control and drug adherence in an indigent population. , 2002, Diabetes care.

[36]  Shakir Hussain,et al.  Comparison of the role of self-efficacy and illness representations in relation to dietary self-care and diabetes distress in adolescents with type 1 diabetes , 2009, Psychology & health.

[37]  W. Polonsky,et al.  Depression in Diabetes: Have We Been Missing Something Important? , 2011, Diabetes Care.

[38]  W. Polonsky,et al.  Assessing psychosocial distress in diabetes: development of the diabetes distress scale. , 2005, Diabetes care.

[39]  V. Helgeson,et al.  The social context of managing diabetes across the life span. , 2016, The American psychologist.

[40]  M. Peyrot,et al.  A biopsychosocial model of glycemic control in diabetes: stress, coping and regimen adherence. , 1999, Journal of health and social behavior.

[41]  A. Bandura,et al.  Effect of perceived controllability and performance standards on self-regulation of complex decision making. , 1989, Journal of personality and social psychology.

[42]  M. Hernandez-Tejada,et al.  Effect of diabetes fatalism on medication adherence and self-care behaviors in adults with diabetes. , 2012, General hospital psychiatry.

[43]  K. Hood,et al.  From caregiver psychological distress to adolescent glycemic control: the mediating role of perceived burden around diabetes management. , 2011, Journal of pediatric psychology.

[44]  Jeffrey S. Gonzalez,et al.  Distress and type 2 diabetes-treatment adherence: A mediating role for perceived control. , 2015, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[45]  S. Weller,et al.  Explanatory models of diabetes in the U.S. and Mexico: the patient-provider gap and cultural competence. , 2012, Social science & medicine.

[46]  Aesha Drozdowski,et al.  Standards of medical care in diabetes. , 2004, Diabetes care.

[47]  F. Pouwer,et al.  Diabetes Attitudes, Wishes and Needs second study (DAWN2™): Cross‐national benchmarking of diabetes‐related psychosocial outcomes for people with diabetes , 2013, Diabetic medicine : a journal of the British Diabetic Association.

[48]  Jennifer Y. Liu,et al.  Low Socioeconomic Status is Associated with Increased Risk for Hypoglycemia in Diabetes Patients: The Diabetes Study of Northern California (DISTANCE) , 2014, Journal of health care for the poor and underserved.

[49]  C. Berg,et al.  Adolescent self-regulation as a foundation for chronic illness self-management. , 2014, Journal of pediatric psychology.

[50]  C. Celano,et al.  Positive Psychological Characteristics in Diabetes: A Review , 2013, Current Diabetes Reports.

[51]  Arleen F. Brown,et al.  Socioeconomic position and health among persons with diabetes mellitus: a conceptual framework and review of the literature. , 2004, Epidemiologic reviews.

[52]  S. McGilloway,et al.  Psychological family intervention for poorly controlled type 2 diabetes. , 2011, The American journal of managed care.

[53]  R. Platt,et al.  Effect of Increased Cost-Sharing on Oral Hypoglycemic Use in Five Managed Care Organizations: How Much Is Too Much? , 2005, Medical care.

[54]  M. Craig,et al.  Microvascular complications assessment in adolescents with 2‐ to 5‐yr duration of type 1 diabetes from 1990 to 2006 , 2011, Pediatric diabetes.

[55]  R. Rubin,et al.  Barriers to Insulin Injection Therapy , 2009, The Diabetes educator.

[56]  Jean Coope,et al.  The Impact of Treatment , 1996 .

[57]  E. Halm,et al.  Predictors of adherence to diabetes medications: the role of disease and medication beliefs , 2009, Journal of Behavioral Medicine.

[58]  W. Polonsky,et al.  The confusing tale of depression and distress in patients with diabetes: a call for greater clarity and precision , 2014, Diabetic medicine : a journal of the British Diabetic Association.

[59]  J. Yudkin,et al.  Intensified glucose lowering in type 2 diabetes: time for a reappraisal , 2010, Diabetologia.

[60]  Arleen F. Brown,et al.  Investing time in health: do socioeconomically disadvantaged patients spend more or less extra time on diabetes self-care? , 2009, Health economics.

[61]  R. Rubin,et al.  The Impact of Treatment Noncompliance on Mortality in People With Type 2 Diabetes , 2012, Diabetes Care.

[62]  David V. Power,et al.  Standards of Medical Care in Diabetes: Response to position statement of the American Diabetes Association , 2006 .

[63]  J. Fuller,et al.  Depression and Diabetes , 1988, Diabetic medicine : a journal of the British Diabetic Association.

[64]  David G. Armstrong,et al.  Mind the Gap: Disparity Between Research Funding and Costs of Care for Diabetic Foot Ulcers , 2013, Diabetes Care.

[65]  Louise B Russell,et al.  Time requirements for diabetes self-management: too much for many? , 2005, The Journal of family practice.

[66]  R. Rodríguez‐Gutiérrez,et al.  Myths and Misconceptions about Insulin Therapy among Latinos/ Hispanics with Diabetes: A Fresh Look at an Old Problem , 2015 .

[67]  R. Beck,et al.  Most Youth With Type 1 Diabetes in the T1D Exchange Clinic Registry Do Not Meet American Diabetes Association or International Society for Pediatric and Adolescent Diabetes Clinical Guidelines , 2013, Diabetes Care.

[68]  K. Khunti,et al.  Effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: cluster randomised controlled trial , 2008, BMJ : British Medical Journal.

[69]  C. Aguilar-Salinas,et al.  Diabetes Knowledge and Its Determinants in a Mexican Population , 1999, The Diabetes educator.

[70]  James S Goodwin,et al.  Inconsistent use of diabetes medications, diabetes complications, and mortality in older mexican americans over a 7-year period: data from the Hispanic established population for the epidemiologic study of the elderly. , 2003, Diabetes care.

[71]  J. Piette,et al.  Racial differences in long-term adherence to oral antidiabetic drug therapy: a longitudinal cohort study , 2009, BMC health services research.

[72]  Glycemic control in type 2 diabetes: time for an evidence-based about-face? , 2009 .

[73]  B. Anderson,et al.  Evidence-based behavioral interventions to promote diabetes management in children, adolescents, and families. , 2016, The American psychologist.

[74]  R. Rubin,et al.  The Effect of a Diabetes Education Program Incorporating Coping Skills Training on Emotional Well-Being and Diabetes Self-Efficacy , 1993 .

[75]  B. Compas,et al.  Coping with chronic illness in childhood and adolescence. , 2012, Annual review of clinical psychology.

[76]  R. Ostini,et al.  Investigating the association between health literacy and non-adherence , 2014, International Journal of Clinical Pharmacy.

[77]  Suzanne Bennett Johnson,et al.  Psychosocial factors in juvenile diabetes: A review , 1980, Journal of Behavioral Medicine.

[78]  Howard Leventhal,et al.  Illness cognition: Using common sense to understand treatment adherence and affect cognition interactions , 1992, Cognitive Therapy and Research.

[79]  J. Fortenberry,et al.  Impulse control, diabetes-specific self-efficacy, and diabetes management among emerging adults with type 1 diabetes. , 2013, Journal of pediatric psychology.

[80]  Russell E. Glasgow,et al.  Self-Efficacy, Problem Solving, and Social-Environmental Support Are Associated With Diabetes Self-Management Behaviors , 2010, Diabetes Care.

[81]  D. Meltzer,et al.  Racial/Ethnic Differences in Concerns About Current and Future Medications Among Patients With Type 2 Diabetes , 2009, Diabetes Care.

[82]  S. M. Hudson,et al.  Metabolic control and psychological sense of control in women with diabetes mellitus. Alternative considerations of the relationship. , 2000, Journal of psychosomatic research.

[83]  W. Polonsky,et al.  Identifying the worries and concerns about hypoglycemia in adults with type 2 diabetes. , 2015, Journal of diabetes and its complications.

[84]  A. Karter,et al.  Self-monitoring of blood glucose: language and financial barriers in a managed care population with diabetes. , 2000, Diabetes care.

[85]  E. Skinner A guide to constructs of control. , 1996, Journal of personality and social psychology.

[86]  E. Loveman,et al.  The clinical effectiveness of diabetes education models for Type 2 diabetes: a systematic review. , 2008, Health technology assessment.

[87]  H. Murphy,et al.  Psycho‐educational interventions for children and young people with Type 1 diabetes , 2006, Diabetic medicine : a journal of the British Diabetic Association.

[88]  S. Roesch,et al.  Coping with diabetes in adulthood: a meta-analysis , 2008, Journal of Behavioral Medicine.

[89]  Ian J. Deary,et al.  Intelligence Predicts Health and Longevity, but Why? , 2004 .

[90]  R. Moss‐Morris,et al.  Illness perceptions and glycaemic control in diabetes: a systematic review with meta‐analysis , 2011, Diabetic medicine : a journal of the British Diabetic Association.

[91]  C. Hunter Understanding diabetes and the role of psychology in its prevention and treatment. , 2016, The American psychologist.

[92]  Korey K Hood,et al.  Association Between Adherence and Glycemic Control in Pediatric Type 1 Diabetes: A Meta-analysis , 2009, Pediatrics.

[93]  Russell E. Glasgow,et al.  Personal Models of Diabetes Among Older Adults: Relationship to Self-Management and Other Variables , 1995, The Diabetes educator.

[94]  K. Driscoll,et al.  Use of Technology When Assessing Adherence to Diabetes Self-Management Behaviors , 2014, Current Diabetes Reports.

[95]  D. Ellis,et al.  Brief report: Parent's health literacy among high-risk adolescents with insulin dependent diabetes. , 2010, Journal of pediatric psychology.

[96]  Dianne Davis,et al.  Addressing Literacy and Numeracy to Improve Diabetes Care , 2009, Diabetes Care.

[97]  Issued December,et al.  AADE7™ Self-Care Behaviors American Association of Diabetes Educators (AADE) Position Statement , 2014 .

[98]  I. Deary,et al.  Psychosocial factors and diabetes‐related outcomes following diagnosis of Type 1 diabetes in adults: The Edinburgh Prospective Diabetes Study , 2003, Diabetic medicine : a journal of the British Diabetic Association.

[99]  H. Bitterman,et al.  Defining the Role of Medication Adherence in Poor Glycemic Control among a General Adult Population with Diabetes , 2014, PloS one.

[100]  M. Dimatteo Variations in Patients’ Adherence to Medical Recommendations: A Quantitative Review of 50 Years of Research , 2004, Medical care.

[101]  Shelagh A. Mulvaney,et al.  Development and validation of the diabetes adolescent problem solving questionnaire. , 2014, Patient Education and Counseling.

[102]  Urmimala Sarkar,et al.  Is self-efficacy associated with diabetes self-management across race/ethnicity and health literacy? , 2006, Diabetes care.

[103]  R. Wing,et al.  A preliminary investigation of the role of self-control in behavioral weight loss treatment. , 2014, Obesity research & clinical practice.

[104]  N. Endler,et al.  Coping, control, and adjustment in Type 2 diabetes. , 2001, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[105]  E. Jacobs,et al.  Concepts of diabetes self-management in Mexican American and African American low-income patients with diabetes. , 2012, Health education research.

[106]  L. Bherer,et al.  Glycaemic control and self‐management behaviours in Type 2 diabetes: results from a 1‐year longitudinal cohort study , 2015, Diabetic medicine : a journal of the British Diabetic Association.

[107]  P. Johnson,et al.  Differences in Diabetes Self-care Activities by Race/Ethnicity and Insulin Use , 2013, The Diabetes educator.

[108]  Steven Shea,et al.  Improvement in diabetes self-efficacy and glycaemic control using telemedicine in a sample of older, ethnically diverse individuals who have diabetes: the IDEATel project. , 2008, Age and ageing.

[109]  R. Glasgow,et al.  Diabetes Distress but Not Clinical Depression or Depressive Symptoms Is Associated With Glycemic Control in Both Cross-Sectional and Longitudinal Analyses , 2009, Diabetes Care.

[110]  C. Berg,et al.  Emotional processing and self-control in adolescents with type 1 diabetes. , 2012, Journal of pediatric psychology.

[111]  Molly L. Tanenbaum,et al.  Diabetes Burden and Diabetes Distress: the Buffering Effect of Social Support , 2014, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[112]  M. Feinglos,et al.  Diabetes and behavior. A paradigm for health psychology. , 1983, The American psychologist.

[113]  N. Freemantle,et al.  Understanding Patients’ Adherence-Related Beliefs about Medicines Prescribed for Long-Term Conditions: A Meta-Analytic Review of the Necessity-Concerns Framework , 2013, PloS one.

[114]  Jeffrey S. Gonzalez,et al.  Recognition and management of psychosocial issues in diabetic neuropathy. , 2014, Handbook of clinical neurology.

[115]  R. Glasgow,et al.  The summary of diabetes self-care activities measure: results from 7 studies and a revised scale. , 2000, Diabetes care.

[116]  R. Jenkins,et al.  Self monitoring of blood glucose. , 1993, BMJ.

[117]  T. Skinner,et al.  Personal models of diabetes in relation to self-care, well-being, and glycemic control. A prospective study in adolescence. , 2001, Diabetes care.

[118]  PREVALENCE OF DIABETES. , 1929, Science.

[119]  Lao Juan,et al.  Development and Validation of a Scale for Measuring Instructors' Attitudes toward Concept-Based or Reform-Oriented Teaching of Introductory Statistics in the Health and Behavioral Sciences , 2010, 1007.3219.

[120]  J. Steiner,et al.  A Systematic Review of the Literature , 2019, HIV/AIDS and Adolescents.

[121]  P. Gollwitzer,et al.  Intervention effects of information and self-regulation on eating fruits and vegetables over two years. , 2010, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[122]  S. Saydah,et al.  The Prevalence of Meeting A1C, Blood Pressure, and LDL Goals Among People With Diabetes, 1988–2010 , 2013, Diabetes Care.

[123]  Yael Benn,et al.  Does monitoring goal progress promote goal attainment? A meta-analysis of the experimental evidence. , 2016, Psychological bulletin.

[124]  Stanton Newman,et al.  Illness perceptions and self efficacy beliefs in adolescents and young adults with insulin dependent diabetes mellitus , 2000 .

[125]  M. Mimiaga,et al.  Depression and Diabetes Treatment Nonadherence: A Meta-Analysis , 2008, Diabetes Care.

[126]  C. Rosano,et al.  Neurocognitive consequences of diabetes. , 2016, The American psychologist.