Data acquisition and instrument control system for ion flight time measurements in mass spectrometry

A microcomputer system is described that provides instrument control and data acquisition for ion flight time measurements in mass spectrometry. This system is designed specifically for time‐resolved ion momentum spectrometry (TRIMS), a new mass spectrometry/mass spectrometry (MS/MS) technique that utilizes time‐of‐flight measurements in a magnetic sector instrument. The flexibility of the design, however, makes it applicable to many types of instruments that employ ion flight time measurements. The heart of the system is a digital boxcar integrator with 10‐ns timing precision. The microcomputer has control of both the magnetic field and the sampled flight time. Software, written in forth, allows all standard MS/MS scans to be obtained, even those requiring complex linked scans of the magnetic field strength and the sampled flight time. Data that demonstrate the accuracy of these scans are shown for metastable decompositions of n decane.

[1]  Christie G. Enke,et al.  A Modular Twin Bus Microprocessor System for Laboratory Automation. , 1984 .

[2]  P. Roepstorff,et al.  Molecular weight determinations of proteins by californium plasma desorption mass spectrometry. , 1984, Science.

[3]  G. Glish,et al.  Tandem quadrupole/time-of-flight instrument for mass spectrometry/mass spectrometry , 1984 .

[4]  R. W. Crawford,et al.  Instrument database system and application to mass spectrometry/mass spectrometry. , 1984, Analytical chemistry.

[5]  L. M. Jones,et al.  Intelligent multichannel data‐acquisition system for pulsed laser applications , 1984 .

[6]  J. Tabet,et al.  Laser desorption mass spectrometry: Mechanisms and applications , 1983 .

[7]  B. Turko,et al.  252Cf-plasma desorption mass spectrometry multistop time digitizer , 1983 .

[8]  Bruce Hewitt Newcome,et al.  Mass Spectrometry on the Chromatographic Time Scale: Realistic Expectations , 1983 .

[9]  C. Enke,et al.  Mass spectrometry/mass spectrometry by time-resolved magnetic dispersion , 1983 .

[10]  P. A. Hoffman,et al.  Inter-processor communications software for a hierarchical system of intelligent laboratory instrumentation , 1983, Comput. Chem..

[11]  C. Lifshitz.  Time-resolved appearance energies, breakdown graphs, and mass spectra: The elusive “kinetic shift”† , 1982 .

[12]  T. D. Pearson,et al.  Autozeroing microcomputerized boxcar integrator , 1982 .

[13]  R. Grieken,et al.  Laser microprobe mass spectrometry. 1. Basic principles and performance characteristics , 1982 .

[14]  A. Hudor.  Fast electronics for time‐of‐flight measurements , 1981 .

[15]  R. Macfarlane,et al.  Observation of a fully protected oligonucleotide dimer at m/z 12637 by californium-252 plasma desorption mass spectrometry , 1981 .

[16]  F. McLafferty.  Tandem mass spectrometry. , 1981, Science.

[17]  B. Chait,et al.  High-performance digital timing system , 1980 .

[18]  P. Esquinazi,et al.  Production of ribbon quenched samples using an arc furnace , 1980 .

[19]  N. Spinelli,et al.  Electronic hardware for high resolution time-of-flight measurements , 1979 .

[20]  W. Jones,et al.  A Computer Interfaced, Time-Of-Flight Mass Spectrometer for Studies of Rapid, Gas-Phase Reactions. , 1979 .

[21]  R. Gandy,et al.  Modification of a time-of-flight mass spectrometer for studies in collisionally induced dissociations , 1977 .

[22]  P. Armentrout,et al.  Laser photodissociation of ions in a bendix time-of-flight mass spectrometer , 1977 .

[23]  I C Plumb,et al.  A fast signal averager based on a sampling oscilloscope interfaced to a minicomputer , 1977 .

[24]  D. C. Johnson,et al.  Sodium tungsten bronze as a potentiometric indicating electrode for dissolved oxygen in aqueous solution , 1973 .

[25]  F. McLafferty,et al.  Simple modification of a commercial mass spectrometer for metastable data collection , 1972 .

[26]  D. Field,et al.  Selection of ions for mass and energy by a repeated time-of-flight principle , 1971 .

[27]  J. Paulson,et al.  Study of ion—neutral reactions with a time-of-flight double mass spectrometer☆ , 1970 .