Unlocking the Energy Dynamics of Executive Functioning: Linking Executive Functioning to Brain Glycogen

Past work suggests that executive functioning relies on glucose as a depletable energy, such that executive functioning uses a relatively large amount of glucose and is impaired when glucose is low. Glucose from the bloodstream is one energy source for the brain, and glucose stored in the brain as glycogen is another. A review of the literature on glycogen suggests that executive functioning uses it in much the same way as glucose, such that executive functioning uses glycogen and is impaired when glycogen is low. Findings on stress, physical persistence, glucose tolerance, diabetes, sleep, heat, and other topics provide general support for this view.

[1]  M. Virkkunen Reactive hypoglycemic tendency among habitually violent offenders. , 2009, Nutrition reviews.

[2]  W. Pardridge Blood-brain barrier transport of nutrients. , 2009, Nutrition reviews.

[3]  T. Noakes,et al.  The Brain and Fatigue , 2009 .

[4]  D. Flanagan Hypoglycaemia in clinical diabetes , 2008 .

[5]  R. Baumeister,et al.  The Physiology of Willpower: Linking Blood Glucose to Self-Control , 2007, Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc.

[6]  K. Cheng,et al.  Improvements in self-control from financial monitoring , 2007 .

[7]  Mark Muraven,et al.  Restoring the self: Positive affect helps improve self-regulation following ego depletion , 2007 .

[8]  R. Baumeister,et al.  Self-control relies on glucose as a limited energy source: willpower is more than a metaphor. , 2007, Journal of personality and social psychology.

[9]  David A. Butz,et al.  Increasing Self-Regulatory Strength Can Reduce the Depleting Effect of Suppressing Stereotypes , 2007, Personality & social psychology bulletin.

[10]  R. Baumeister,et al.  Self-regulation and personality: how interventions increase regulatory success, and how depletion moderates the effects of traits on behavior. , 2006, Journal of personality.

[11]  K. Cheng,et al.  Longitudinal gains in self-regulation from regular physical exercise. , 2006, British journal of health psychology.

[12]  M. Vornanen,et al.  Seasonal changes in glycogen content and Na+-K+-ATPase activity in the brain of crucian carp. , 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

[13]  H. Heller,et al.  Glycogen content in the cerebral cortex increases with sleep loss in C57BL/6J mice , 2006, Neuroscience Letters.

[14]  R. Baumeister,et al.  Self-regulatory processes defend against the threat of death: Effects of self-control depletion and trait self-control on thoughts and fears of dying. , 2006, Journal of personality and social psychology.

[15]  R. Meeusen,et al.  The brain and fatigue: New opportunities for nutritional interventions? , 2006, Journal of sports sciences.

[16]  Mads K Dalsgaard,et al.  Fuelling Cerebral Activity in Exercising Man , 2006, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[17]  Z. Bloomgarden Insulin treatment and type 1 diabetes topics. , 2006, Diabetes care.

[18]  K. Cheng,et al.  Improved Self-Control: The Benefits of a Regular Program of Academic Study , 2006 .

[19]  Barry E. Levin,et al.  Neurobiology of Exercise , 2006 .

[20]  Cheryl L. Dickter,et al.  Stereotype activation and control of race bias: cognitive control of inhibition and its impairment by alcohol. , 2006, Journal of personality and social psychology.

[21]  J. N. Shelton,et al.  African Americans' Implicit Racial Attitudes and the Depletion of Executive Function after Interracial Interactions. , 2005 .

[22]  J. Richeson,et al.  Why do interracial interactions impair executive function? A resource depletion account. , 2005, Journal of personality and social psychology.

[23]  Mark Muraven,et al.  Daily fluctuations in self-control demands and alcohol intake. , 2005, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[24]  K. Vohs,et al.  Self-regulation and self-presentation: regulatory resource depletion impairs impression management and effortful self-presentation depletes regulatory resources. , 2005, Journal of personality and social psychology.

[25]  Philip J. Niro,et al.  Severe decrements in cognition function and mood induced by sleep loss, heat, dehydration, and undernutrition during simulated combat , 2005, Biological Psychiatry.

[26]  S. Maier,et al.  The consequences of uncontrollable stress are sensitive to duration of prior wheel running , 2005, Brain Research.

[27]  Zhe Ying,et al.  Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition , 2004, The European journal of neuroscience.

[28]  N. Secher,et al.  Cerebral carbohydrate cost of physical exertion in humans. , 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

[29]  Takuya Osada,et al.  Brain and central haemodynamics and oxygenation during maximal exercise in humans , 2004, The Journal of physiology.

[30]  Angus M. Brown Brain glycogen re‐awakened , 2004, Journal of neurochemistry.

[31]  R. Baumeister,et al.  High self-control predicts good adjustment, less pathology, better grades, and interpersonal success. , 2004, Journal of personality.

[32]  S. Fairclough,et al.  A metabolic measure of mental effort , 2004, Biological Psychology.

[33]  N. Secher,et al.  Cerebral perturbations provoked by prolonged exercise , 2004, Progress in Neurobiology.

[34]  R. Sapolsky,et al.  Glucocorticoids influence brain glycogen levels during sleep deprivation. , 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

[35]  A. van Knippenberg,et al.  Consequences of Stereotype Suppression and Internal Suppression Motivation: A Self-Regulation Approach , 2004, Personality & social psychology bulletin.

[36]  N. Secher,et al.  A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain , 2004, The Journal of physiology.

[37]  P. Magistretti,et al.  Glucocorticoids modulate neurotransmitter‐induced glycogen metabolism in cultured cortical astrocytes , 2003, Journal of neurochemistry.

[38]  A. Pack,et al.  Glycogen in the brain of Drosophila melanogaster: diurnal rhythm and the effect of rest deprivation , 2003, Journal of neurochemistry.

[39]  S. Crowe,et al.  Effect on plasma insulin and plasma glucose of consuming white wine alone after a meal. , 2003, Alcoholism, clinical and experimental research.

[40]  Rolf Gruetter,et al.  Localized in vivo 13C NMR spectroscopy of the brain , 2003, NMR in biomedicine.

[41]  N. Secher,et al.  Neurohumoral responses during prolonged exercise in humans. , 2003, Journal of applied physiology.

[42]  R. Gruetter,et al.  In vivo 13C NMR assessment of brain glycogen concentration and turnover in the awake rat , 2003, Neurochemistry International.

[43]  R. Gruetter,et al.  Direct, noninvasive measurement of brain glycogen metabolism in humans , 2003, Neurochemistry International.

[44]  N. Secher,et al.  Association between fatigue and failure to preserve cerebral energy turnover during prolonged exercise. , 2003, Acta physiologica Scandinavica.

[45]  C. Sempos,et al.  The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease: an overview. , 2003, Addiction.

[46]  Maria L. Thomas,et al.  Neural basis of alertness and cognitive performance impairments during sleepiness: II. Effects of 48 and 72 h of sleep deprivation on waking human regional brain activity , 2003 .

[47]  Bengt Kayser,et al.  Exercise starts and ends in the brain , 2003, European Journal of Applied Physiology.

[48]  Angus M. Brown,et al.  Glycogen Regulation and Functional Role in Mouse White Matter , 2003, The Journal of physiology.

[49]  P. Marsden,et al.  Lactate: A Preferred Fuel for Human Brain Metabolism in Vivo , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[50]  H. Heller,et al.  Changes in brain glycogen after sleep deprivation vary with genotype. , 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

[51]  S. Maier,et al.  Freewheel Running Prevents Learned Helplessness/Behavioral Depression: Role of Dorsal Raphe Serotonergic Neurons , 2003, The Journal of Neuroscience.

[52]  R. Gruetter,et al.  Effect of hypoglycemia on brain glycogen metabolism in vivo , 2003, Journal of neuroscience research.

[53]  J. Polivy,et al.  Conformity and dietary disinhibition: a test of the ego-strength model of self-regulation. , 2003, The International journal of eating disorders.

[54]  R. Vannucci,et al.  Hypoxic Preconditioning Increases Brain Glycogen and Delays Energy Depletion from Hypoxia-Ischemia in the Immature Rat , 2003, Developmental Neuroscience.

[55]  G. Dienel,et al.  Generalized Sensory Stimulation of Conscious Rats Increases Labeling of Oxidative Pathways of Glucose Metabolism When the Brain Glucose–Oxygen Uptake Ratio Rises , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[56]  G. Dienel,et al.  High Glycogen Levels in Brains of Rats with Minimal Environmental Stimuli: Implications for Metabolic Contributions of Working Astrocytes , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[57]  R. Gruetter,et al.  Effect of Deep Pentobarbital Anesthesia on Neurotransmitter Metabolism in Vivo: On the Correlation of Total Glucose Consumption with Glutamatergic Action , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[58]  R. Gruetter,et al.  Brain glycogen: an insulin-sensitive carbohydrate store. , 2002, Diabetes, nutrition & metabolism.

[59]  G. Bonvento,et al.  Role of neuron-glia interaction in the regulation of brain glucose utilization. , 2002, Diabetes, nutrition & metabolism.

[60]  R. Gruetter In vivo 13 C NMR studies of compartmentalized cerebral carbohydrate metabolism , 2002, Neurochemistry International.

[61]  A. A. Levin,et al.  The restorative effect of naps on perceptual deterioration , 2002, Nature Neuroscience.

[62]  P. Maquet,et al.  Be caught napping: you're doing more than resting your eyes , 2002, Nature Neuroscience.

[63]  A. Pack,et al.  Brain Glycogen Decreases with Increased Periods of Wakefulness: Implications for Homeostatic Drive to Sleep , 2002, The Journal of Neuroscience.

[64]  N. Secher,et al.  The intent to exercise influences the cerebral O2/carbohydrate uptake ratio in humans , 2002, The Journal of physiology.

[65]  Angus M. Brown,et al.  Functional insulin receptors are selectively expressed on cns astrocytes , 2002 .

[66]  R. Baumeister,et al.  Ostracism and Ego Depletion: The Strains of Silence , 2001 .

[67]  R G Shulman,et al.  Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[68]  R. Silberstein,et al.  Evaluation of cognitive performance in the heat by functional brain imaging and psychometric testing. , 2001, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[69]  S. Gandevia Spinal and supraspinal factors in human muscle fatigue. , 2001, Physiological reviews.

[70]  Maria L. Thomas,et al.  Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity , 2000, Journal of sleep research.

[71]  Adelbert Ames,et al.  CNS energy metabolism as related to function , 2000, Brain Research Reviews.

[72]  R A Swanson,et al.  Astrocytic Glycogen Influences Axon Function and Survival during Glucose Deprivation in Central White Matter , 2000, The Journal of Neuroscience.

[73]  H. Arito,et al.  Maintenance of alertness and performance by a brief nap after lunch under prior sleep deficit. , 2000, Sleep.

[74]  T. Pratt,et al.  THE EMPIRICAL STATUS OF GOTTFREDSON AND HIRSCHI'S GENERAL THEORY OF CRIME: A META‐ANALYSIS , 2000 .

[75]  K. Vohs,et al.  Self-Regulatory Failure: A Resource-Depletion Approach , 2000, Psychological science.

[76]  A. B. Scholey,et al.  Glucose administration, heart rate and cognitive performance: effects of increasing mental effort , 2000, Psychopharmacology.

[77]  R. Baumeister,et al.  Self-regulation and depletion of limited resources: does self-control resemble a muscle? , 2000, Psychological bulletin.

[78]  N. Secher,et al.  Lactate, glucose and O2 uptake in human brain during recovery from maximal exercise , 2000, The Journal of physiology.

[79]  K Ide,et al.  Cerebral metabolic response to submaximal exercise. , 1999, Journal of applied physiology.

[80]  E. Meléndez-Hevia,et al.  The fractal structure of glycogen: A clever solution to optimize cell metabolism. , 1999, Biophysical journal.

[81]  J. Mitchell,et al.  Activation of the insular cortex is affected by the intensity of exercise. , 1999, Journal of applied physiology.

[82]  Rolf Gruetter,et al.  Noninvasive Measurements of [1‐13C] Glycogen Concentrations and Metabolism in Rat Brain In Vivo , 1999, Journal of neurochemistry.

[83]  D. Benton,et al.  Cognitive functioning is susceptible to the level of blood glucose , 1999, Psychopharmacology.

[84]  P. Greenhaff,et al.  Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle. , 1999, Journal of applied physiology.

[85]  R. Baumeister,et al.  Longitudinal improvement of self-regulation through practice: building self-control strength through repeated exercise. , 1999, The Journal of social psychology.

[86]  P. Magistretti,et al.  Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging. , 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[87]  Y. Minokoshi,et al.  L‐Glutamate and Insulin Enhance Glycogen Synthesis in Cultured Astrocytes from the Rat Brain Through Different Intracellular Mechanisms , 1999, Journal of neurochemistry.

[88]  Jane A. Kent-Braun,et al.  Central and peripheral contributions to muscle fatigue in humans during sustained maximal effort , 1999, European Journal of Applied Physiology and Occupational Physiology.

[89]  D. Benton,et al.  Blood glucose control and aggressiveness in females , 1999 .

[90]  L. Sokoloff,et al.  Cerebral Oxygen/Glucose Ratio is Low during Sensory Stimulation and Rises above Normal during Recovery: Excess Glucose Consumption during Stimulation is Not Accounted for by Lactate Efflux from or Accumulation in Brain Tissue , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[91]  M. Febbraio,et al.  Effect of ambient temperature on human skeletal muscle metabolism during fatiguing submaximal exercise. , 1999, Journal of applied physiology.

[92]  R G Shulman,et al.  Energy on Demand , 1999, Science.

[93]  P. Magistretti,et al.  Evidence Supporting the Existence of an Activity-Dependent Astrocyte-Neuron Lactate Shuttle , 1998, Developmental Neuroscience.

[94]  Nigel A. S. Taylor,et al.  Physical WorK and Cognitive Function During Acute Heat Exposure before and after Heat Acclimation. , 1998 .

[95]  R. Baumeister,et al.  Self-control as limited resource: regulatory depletion patterns. , 1998, Journal of personality and social psychology.

[96]  R. Dishman,et al.  Activity Wheel Running Reduces Escape Latency and Alters Brain Monoamine Levels After Footshock , 1997, Brain Research Bulletin.

[97]  Anand Rangarajan,et al.  Oxidative Glucose Metabolism in Rat Brain during Single Forepaw Stimulation: A Spatially Localized 1H[13C] Nuclear Magnetic Resonance Study , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[98]  A J Scheen,et al.  Roles of circadian rhythmicity and sleep in human glucose regulation. , 1997, Endocrine reviews.

[99]  R. Dringen,et al.  Metabolic pathways for glucose in astrocytes , 1997, Glia.

[100]  R. Maughan,et al.  Effects of ambient temperature on the capacity to perform prolonged cycle exercise in man. , 1997, Medicine and science in sports and exercise.

[101]  L. L. Grange,et al.  Adjudicated adolescent males: measures of urinary 5-hydroxyindoleacetic acid and reactive hypoglycemia , 1997 .

[102]  S. Woods,et al.  The evaluation of insulin as a metabolic signal influencing behavior via the brain , 1996, Neuroscience & Biobehavioral Reviews.

[103]  B. O'dowd,et al.  Astrocyte-Neuron Interaction During One-trial Aversive Learning in the Neonate Chick * * These results were originally presented at the Second Annual International Behavioral Neuroscience Society Conference, Clearwater Beach, Florida, USA, 22–25 April 1993. , 1996, Neuroscience & Biobehavioral Reviews.

[104]  J. Medina,et al.  Lactate spares glucose as a metabolic fuel in neurons and astrocytes from primary culture , 1996, Neuroscience Research.

[105]  I. K. Wood,et al.  Neuroscience: Exploring the brain , 1996 .

[106]  F. Hyder,et al.  Increased tricarboxylic acid cycle flux in rat brain during forepaw stimulation detected with 1H[13C]NMR. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[107]  J. Horne,et al.  Counteracting driver sleepiness: effects of napping, caffeine, and placebo. , 1996, Psychophysiology.

[108]  P. Magistretti,et al.  Metabolic coupling between glia and neurons , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[109]  R. Meeusen,et al.  Exercise and Brain Neurotransmission , 1995, Sports medicine.

[110]  David C. Hodgins,et al.  Prospective and retrospective reports of mood states before relapse to substance use. , 1995, Journal of consulting and clinical psychology.

[111]  N. Lassen,et al.  Persistent Resetting of the Cerebral Oxygen/Glucose Uptake Ratio by Brain Activation: Evidence Obtained with the Kety—Schmidt Technique , 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[112]  M. Larrabee Lactate Metabolism and Its Effects on Glucose Metabolism in an Excised Neural Tissue , 1995, Journal of neurochemistry.

[113]  H. Craig Heller,et al.  Restoration of brain energy metabolism as the function of sleep , 1995, Progress in Neurobiology.

[114]  R. Baumeister,et al.  Losing Control: How and Why People Fail at Self-Regulation , 1994 .

[115]  M. Bonnet,et al.  Impact of naps and caffeine on extended nocturnal performance , 1994, Physiology & Behavior.

[116]  D. Benton,et al.  Blood glucose influences memory and attention in young adults , 1994, Neuropsychologia.

[117]  B. O'dowd,et al.  Astrocytic glycogenolysis energizes memory processes in neonate chicks. , 1994, Brain research. Developmental brain research.

[118]  R. Gebhardt,et al.  Glycogen in astrocytes: possible function as lactate supply for neighboring cells , 1993, Brain Research.

[119]  D. Benton,et al.  Is raised blood glucose associated with the relief of tension? , 1993, Journal of psychosomatic research.

[120]  T. W. Moon,et al.  Carbohydrate metabolism in the brain of the adult Lamprey , 1993 .

[121]  R. Dringen,et al.  Differences in glycogen metabolism in astroglia‐rich primary cultures and sorbitol‐selected astroglial cultures derived from mouse brain , 1993, Glia.

[122]  David S. Smith,et al.  Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy. , 1993 .

[123]  David S. Smith,et al.  Glial glycogen stores affect neuronal survival during glucose deprivation in vitro. , 1993 .

[124]  P. Magistretti,et al.  Vasoactive intestinal peptide and noradrenaline exert long-term control on glycogen levels in astrocytes: blockade by protein synthesis inhibition , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[125]  Roy J. Shephard,et al.  Endurance in sport , 1992 .

[126]  F. Sharp,et al.  Sensory stimulation induces local cerebral glycogenolysis: Demonstration by autoradiography , 1992, Neuroscience.

[127]  S. Woods,et al.  Insulin in the brain: a hormonal regulator of energy balance. , 1992, Endocrine reviews.

[128]  G. Fein,et al.  Effect of Photic Stimulation on Human Visual Cortex Lactate and Phosphates Using 1H and 31P Magnetic Resonance Spectroscopy , 1992, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[129]  R. Dringen,et al.  Glucose, Insulin, and Insulin‐Like Growth Factor I Regulate the Glycogen Content of Astroglia‐Rich Primary Cultures , 1992, Journal of neurochemistry.

[130]  L. Fisher,et al.  Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport. , 1991, The Journal of clinical investigation.

[131]  Richard P. Larrick,et al.  Temper and Temperature on the Diamond: The Heat-Aggression Relationship in Major League Baseball , 1991 .

[132]  Bonnet Mh,et al.  The effect of varying prophylactic naps on performance, alertness and mood throughout a 52-hour continuous operation. , 1991 .

[133]  J. McGill,et al.  Relationship of personality characteristics to glucose regulation in adults with diabetes. , 1991, Psychosomatic medicine.

[134]  Walter Mischel,et al.  Predicting adolescent cognitive and self-regulatory competencies from preschool delay of gratification: Identifying diagnostic conditions. , 1990 .

[135]  S. K. Bhattacharya,et al.  Acute effects of heat on neuropsychological changes and physiological responses under noise condition. , 1990, Indian journal of experimental biology.

[136]  J. Bachorowski,et al.  Sucrose and delinquency: oral sucrose tolerance test and nutritional assessment. , 1990, Pediatrics.

[137]  N. Volkow,et al.  Acute effects of ethanol on regional brain glucose metabolism and transport , 1990, Psychiatry Research: Neuroimaging.

[138]  F. Sharp,et al.  Methionine sulfoximine reduces cortical infarct size in rats after middle cerebral artery occlusion. , 1990, Stroke.

[139]  D. Benton The impact of increasing blood glucose on psychological functioning , 1990, Biological Psychology.

[140]  Michaela Johnson Sleep and Alertness: Chronobiological, Behavioral, and Medical Aspects of Napping , 1990 .

[141]  A. Abdul-Ghani,et al.  Species-directed variation and non-uniform distribution of glycogen in mammalian brains during starvation, diabetes and anesthesia , 1989, Neurochemistry International.

[142]  Sidney R. Cohen,et al.  Vasoactive intestinal peptide , 1989, Digestive Diseases and Sciences.

[143]  K. Wells,et al.  Affective, substance use, and anxiety disorders in persons with arthritis, diabetes, heart disease, high blood pressure, or chronic lung conditions. , 1989, General hospital psychiatry.

[144]  J. Bartko,et al.  Relationship of psychobiological variables to recidivism in violent offenders and impulsive fire setters. A follow-up study. , 1989, Archives of general psychiatry.

[145]  C. Anderson Temperature and aggression: ubiquitous effects of heat on occurrence of human violence. , 1989, Psychological bulletin.

[146]  F. Sharp,et al.  Regulation of Glycogen Content in Primary Astrocyte Culture: Effects of Glucose Analogues, Phenobarbital, and Methionine Sulfoximine , 1989, Journal of neurochemistry.

[147]  F. Sharp,et al.  Regional brain glycogen stores and metabolism during complete global ischaemia. , 1989, Neurological research.

[148]  R. Surwit,et al.  Psychological Predictors of Glucose Control in Patients With IDDM , 1988, Diabetes Care.

[149]  M. Tsacopoulos,et al.  Honeybee retinal glial cells transform glucose and supply the neurons with metabolic substrate. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[150]  A. Schurr,et al.  Lactate-supported synaptic function in the rat hippocampal slice preparation. , 1988, Science.

[151]  J. Gutiérrez,et al.  The effect of temperature on immunoreactive glucagon plasma level in carp Cyprinus carpio. , 1988, Revista espanola de fisiologia.

[152]  W. Mischel,et al.  The nature of adolescent competencies predicted by preschool delay of gratification. , 1988, Journal of personality and social psychology.

[153]  T. Nowak Effects of Amphetamine on Protein Synthesis and Energy Metabolism in Mouse Brain: Role of Drug‐Induced Hyperthermia , 1988, Journal of neurochemistry.

[154]  R. Ehrlich,et al.  Effect of Temperament on Metabolic Control in Children With Diabetes Mellitus , 1988, Diabetes Care.

[155]  J. Weiss,et al.  Glycolysis preferentially inhibits ATP-sensitive K+ channels in isolated guinea pig cardiac myocytes. , 1987, Science.

[156]  M. Kjaer,et al.  Cardiovascular, ventilatory and catecholamine responses to maximal dynamic exercise in partially curarized man. , 1987, The Journal of physiology.

[157]  R. Ehrlich,et al.  Intellectual Deficits Associated With Early Onset of Insulin-Dependent Diabetes Mellitus in Children , 1987, Diabetes Care.

[158]  F. Goodwin,et al.  Cerebrospinal fluid monoamine metabolite levels in male arsonists. , 1987, Archives of general psychiatry.

[159]  P. Cryer,et al.  Psychiatric Illness in Diabetes Mellitus: Relationship to Symptoms and Glucose Control , 1986, The Journal of nervous and mental disease.

[160]  M. Linnoila,et al.  Indices of Serotonin and Glucose Metabolism in Violent Offenders, Arsonists, and Alcoholics , 1986, Annals of the New York Academy of Sciences.

[161]  R. Auer Progress review: hypoglycemic brain damage. , 1986, Stroke.

[162]  P. Barglow,et al.  Psychosocial Childbearing Stress and Metabolic Control in Pregnant Diabetics , 1985, The Journal of nervous and mental disease.

[163]  C. Ryan,et al.  The effects of diabetes mellitus on the school attendance and school achievement of adolescents. , 1985, Child: care, health and development.

[164]  A. Drash,et al.  Cognitive deficits in adolescents who developed diabetes early in life. , 1985, Pediatrics.

[165]  J. Mitchell,et al.  Partial neuromuscular blockade and cardiovascular responses to static exercise in man. , 1985, The Journal of physiology.

[166]  M. Raizada,et al.  Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain. , 1984, The Journal of biological chemistry.

[167]  C. Ryan,et al.  Neuropsychological changes in adolescents with insulin-dependent diabetes. , 1984, Journal of consulting and clinical psychology.

[168]  M. Virkkunen,et al.  Reactive hypoglycemic tendency among arsonists , 1984, Acta psychiatrica Scandinavica.

[169]  P. Barglow,et al.  Stress and Metabolic Control in Diabetes: Psychosomatic Evidence and Evaluation of Methods , 1984, Psychosomatic medicine.

[170]  M D Curley,et al.  Cognitive performance during a heat acclimatization regimen. , 1983, Aviation, space, and environmental medicine.

[171]  M. Karnovsky,et al.  Changes in Brain Glycogen During Slow‐Wave Sleep in the Rat , 1983, Journal of neurochemistry.

[172]  J. Passonneau,et al.  Regulation of Glycogen Metabolism in Primary and Transformed Astrocytes In Vitro , 1983, Journal of neurochemistry.

[173]  P. Hancock Task categorization and the limits of human performance in extreme heat. , 1982, Aviation, space, and environmental medicine.

[174]  P. Brain,et al.  Mild hypoglycaemia and questionnaire measures of aggression , 1982, Biological Psychology.

[175]  V. Pentreath,et al.  Significance of the potassium signal from neurones to glial cells , 1982, Nature.

[176]  J. Hull A self-awareness model of the causes and effects of alcohol consumption. , 1981, Journal of abnormal psychology.

[177]  M. Alexander,et al.  Principles of Neural Science , 1981 .

[178]  M. Brownstein,et al.  Radiohistochemical localization of insulin receptors in the adult and developing rat brain , 1980, Neuropeptides.

[179]  B Bigland-Ritchie,et al.  Central and peripheral fatigue in sustained maximum voluntary contractions of human quadriceps muscle. , 1978, Clinical science and molecular medicine.

[180]  G. Viberti,et al.  Does "afternoon diabetes" predict diabetes? , 1978, British medical journal.

[181]  Daniel Pm,et al.  The Influence of Insulin upon the Metabolism of Glucose by the Brain , 1977 .

[182]  G. Varela,et al.  [Diet effect on fatty acids composition in trout (salmo gairdnerii). rev. esp. fisiol., (author's transl)]. , 1976, Revista espanola de fisiologia.

[183]  A. Dyer,et al.  Epidemiologic Findings on the Relationship of Time of Day and Time Since Last Meal to Glucose Tolerance , 1976, Diabetes.

[184]  J. Gagliardino,et al.  Insulin-induced hypoglycemia: 24-H variation , 1976, Acta diabetologia latina.

[185]  J. Passonneau,et al.  Regulation of glycogen metabolism in astrocytoma and neuroblastoma cells in culture. , 1976, The Journal of biological chemistry.

[186]  A. Pronaszko-Kurczyńska Diurnal and seasonal variations of glycogen content in the rat brain. , 1976, Acta physiologica Polonica.

[187]  Dr. M. Z. M. Ibrahim,et al.  Glycogen and its Related Enzymes of Metabolism in the Central Nervous System , 1975, Advances in Anatomy, Embryology and Cell Biology / Ergebnisse der Anatomie und Entwicklungsgeschichte / Revues d’anatomie et de morphologie expérimentale.

[188]  P. M. Daniel,et al.  INSULIN AND THE WAY THE BRAIN HANDLES GLUCOSE 1 , 1975, Journal of neurochemistry.

[189]  L A Bullara,et al.  Electrical stimulation of the brain. III. The neural damage model. , 1975, Surgical neurology.

[190]  I. Campbell,et al.  The plasma insulin and growth hormone response to oral glucose: Diurnal and seasonal observations in the antarctic , 1975, Diabetologia.

[191]  J. Ater,et al.  Effects of alloxan diabetes, anti-insulin serum diabetes, and non-diabetic dehydration on brain carbohydrate and energy metabolism in young mice. , 1975, The Journal of biological chemistry.

[192]  H. Rahmann,et al.  Temperature effect on brain glycogen of fish. , 1974, Brain research.

[193]  G C Simpson,et al.  The effects of noise stress on blood glucose level and skilled performance. , 1974, Ergonomics.

[194]  D. Sherrod,et al.  Crowding, Perceived Control, and Behavioral Aftereffects1 , 1974 .

[195]  R J Jarrett,et al.  Diurnal Variation in Glucose Tolerance: Associated Changes in Plasma Insulin, Growth Hormone, and Non-esterified , 1974, British medical journal.

[196]  H. Keen,et al.  Diurnal Variation in Response to Intravenous Glucose* , 1974, British medical journal.

[197]  H. Keen,et al.  Cardiorespiratory disease and diabetes among middle-aged male Civil Servants. A study of screening and intervention. , 1974, Lancet.

[198]  J. Gagliardino,et al.  Circadian Variation of the Blood Glucose, Plasma Insulin and Human Growth Hormone Levels in Response to an Oral Glucose Load in Normal Subjects , 1974, Diabetes.

[199]  R. Orkand,et al.  Glial metabolism: alteration by potassium levels comparable to those during neural activity. , 1973, Brain research.

[200]  V. Wynn,et al.  Diurnal variation in oral glucose tolerance: Insulin and growth hormone changes with special reference to women taking oral contraceptives , 1973, Diabetologia.

[201]  P. Nestel,et al.  Diurnal Variation in Glucose Tolerance and in Insulin Secretion in Man , 1973, Diabetes.

[202]  R. Jarrett,et al.  Diurnal variation in insulin sensitivity. , 1972, Lancet.

[203]  C. Phelps,et al.  Barbiturate-induced glycogen accumulation in brain. An electron microscopic study. , 1972, Brain research.

[204]  O. H. Lowry,et al.  CEREBRAL CARBOHYDRATE METABOLISM DURING ACUTE HYPOXIA AND RECOVERY 1 , 1972, Journal of neurochemistry.

[205]  R J Jarrett,et al.  Diurnal Variation in Oral Glucose Tolerance: Blood Sugar and Plasma Insulin Levels Morning, Afternoon, and Evening , 1972, British medical journal.

[206]  J. Passonneau,et al.  THE EFFECT OF VOLATILE ANAESTHETICS ON LEVELS OF METABOLITES AND ON METABOLIC RATE IN BRAIN 1 , 1971, Journal of neurochemistry.

[207]  R. Ben-Dyke Diurnal variation of oral glucose tolerance in volunteers and laboratory animals , 1971, Diabetologia.

[208]  J. Koizumi,et al.  Glycogen accumulation in dendrites of the rabbit pallidum following trifluoperazine administration , 1970, Experimental Brain Research.

[209]  H. Keen,et al.  Further Observations on the Diurnal Variation in Oral Glucose Tolerance , 1970, British medical journal.

[210]  D. A. Hutchins,et al.  Physiological and drug‐induced changes in the glycogen content of mouse brain , 1970, British journal of pharmacology.

[211]  Sandy L. Jones,et al.  Human Anatomy and Physiology. 6th ed , 1970 .

[212]  M. Gasparo,et al.  Circadian variations of blood sugar and plasma insulin levels in man , 1969, Diabetologia.

[213]  J. Singer,et al.  Psychic cost of adaptation to an environmental stressor. , 1969, Journal of personality and social psychology.

[214]  H. Keen,et al.  Diurnal Variation of Oral Glucose Tolerance: a Possible Pointer to the Evolution of Diabetes Mellitus , 1969, British medical journal.

[215]  O. Rafaelsen,et al.  BRAIN GLYCOGEN AFTER INTRACISTERNAL INSULIN INJECTION , 1969, Journal of neurochemistry.

[216]  V. Karadžić,et al.  DEPRIVATION OF PARADOXICAL SLEEP AND BRAIN GLYCOGEN , 1969, Journal of neurochemistry.

[217]  L. Guth,et al.  A correlated histochemical and quantitative study on cerebral glycogen after brain injury in the rat. , 1968, Experimental neurology.

[218]  O. H. Lowry,et al.  CONTROL OF GLYCOGEN LEVELS IN BRAIN 1 , 1968, Journal of neurochemistry.

[219]  H. J. Roberts,et al.  The value of afternoon glucose tolerance testing in the diagnosis, prognosis and rational treatment of «early chemical diabetes». A five-year experience , 1968, Acta diabetologia latina.

[220]  A. J. Bowen,et al.  Diurnal variation in glucose tolerance. , 1967, Archives of internal medicine.

[221]  C. Faiman,et al.  Diurnal variation in the levels of glucose and related substances in healthy and diabetic subjects during starvation. , 1967, Clinical science.

[222]  E. Hultman,et al.  Muscle Glycogen Synthesis after Exercise : an Enhancing Factor localized to the Muscle Cells in Man , 1966, Nature.

[223]  E. Asmussen,et al.  ON THE NERVOUS FACTORS CONTROLLING RESPIRATION AND CIRCULATION DURING EXERCISE. EXPERIMENTS WITH CURARIZATION. , 1965, Acta physiologica Scandinavica.

[224]  C. R. Swift,et al.  Adjustment Problems in Juvenile Diabetes , 1964, Psychosomatic medicine.

[225]  N. Shimizu,et al.  Deposition of Glycogen and Changes in some Enzymes in Brain Wounds , 1958, Nature.

[226]  Wilson Dr Electroencephalographic studies in diabetes mellitus. , 1951 .

[227]  B. Pacella,et al.  Labile diabetes; electroencephalographic status and effect of anticonvulsive therapy. , 1948, Annals of internal medicine.

[228]  Berrien Fk,et al.  The effects of noise. , 1946 .

[229]  H. Himwich,et al.  EFFECT OF INSULIN HYPOGLYCEMIA ON GLYCOGEN CONTENT OF PARTS OF THE CENTRAL NERVOUS SYSTEM OF THE DOG , 1944 .

[230]  C. Reid The Mechanism of Voluntary Muscular Fatigue , 1927, British medical journal.

[231]  Andriezen Wl,et al.  The Neuroglia Elements in the Human Brain , 1893 .

[232]  N. Abumrad,et al.  Differential responses of brain, liver, and muscle glycogen to opiates and surgical stress , 2010, Surgery Today.

[233]  Edward H. Miller,et al.  Comparative Biochemistry and Physiology, Part A , 2009 .

[234]  Angus M. Brown,et al.  Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter , 2005, Journal of neuroscience research.

[235]  N. Volkow,et al.  Relationship between ethanol-induced changes in brain regional metabolism and its motor, behavioural and cognitive effects. , 2004, Alcohol and alcoholism.

[236]  P. Rutland,et al.  Diurnal variation in the effects of insulin on blood glucose, plasma non-esterified fatty acids and growth hormone , 2004, Diabetologia.

[237]  J. Koizumi,et al.  Ultrastructural appearance of glycogen in the hypothalamus of the rabbit following chlorpromazine administration , 2004, Experimental Brain Research.

[238]  C. Hoven,et al.  Diabetes and eating disorders in primary care. , 2003, The International journal of eating disorders.

[239]  I. Eren,et al.  [Relationship between blood glucose control and psychiatric disorders in type II diabetic patients]. , 2003, Turk psikiyatri dergisi = Turkish journal of psychiatry.

[240]  Lars Nybo,et al.  Cerebral Changes During Exercise in the Heat , 2003, Sports medicine.

[241]  R. L. Collins,et al.  Self-control and alcohol restraint: an initial application of the self-control strength model. , 2002, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[242]  E. Finkel,et al.  Self-control and accommodation in close relationships: an interdependence analysis. , 2001, Journal of personality and social psychology.

[243]  S. Nagornev,et al.  [Informational assets of glucose tolerance test in evaluation of endurance to psychoemotional stress]. , 1999, Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine.

[244]  M. Larimer,et al.  Relapse Prevention , 1999, Alcohol Research & Health.

[245]  J. Davis,et al.  Possible mechanisms of central nervous system fatigue during exercise. , 1997, Medicine and science in sports and exercise.

[246]  P. Magistretti,et al.  Cellular bases of brain energy metabolism and their relevance to functional brain imaging: evidence for a prominent role of astrocytes. , 1996, Cerebral cortex.

[247]  H. Begleiter,et al.  The pharmacology of alcohol and alcohol dependence , 1996 .

[248]  D. Benton,et al.  The impact of raising blood glucose on reaction times. , 1994, Neuropsychobiology.

[249]  Pierre J. Magistretti,et al.  Regulation of glycogen metabolism in astrocytes: physiological, pharmacological and pathological aspects , 1993 .

[250]  R. Swanson,et al.  Physiologic coupling of glial glycogen metabolism to neuronal activity in brain. , 1992, Canadian journal of physiology and pharmacology.

[251]  T. Wadden,et al.  Predictors of attrition and weight loss in patients treated by moderate and severe caloric restriction. , 1992 .

[252]  T. Wadden,et al.  Treatment of the seriously obese patient , 1992 .

[253]  T. Hévor,et al.  Biochemical and ultrastructural study of glycogen in cultured astrocytes submitted to the convulsant methionine sulfoximine , 1991, Glia.

[254]  M H Bonnet,et al.  The effect of varying prophylactic naps on performance, alertness and mood throughout a 52-hour continuous operation. , 1991, Sleep.

[255]  Sheldon Cohen,et al.  Perceived stress, quitting smoking, and smoking relapse. , 1990, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[256]  D. Sutherland,et al.  Prevalence of major depression, simple phobia, and other psychiatric disorders in patients with long-standing type I diabetes mellitus. , 1988, Archives of general psychiatry.

[257]  M. E. Wewers,et al.  The role of postcessation factors in tobacco abstinence: stressful events and coping responses. , 1988, Addictive behaviors.

[258]  R. Friis,et al.  Diabetes, depression and employment status. , 1986, Social science & medicine.

[259]  M. Virkkunen Insulin secretion during the glucose tolerance test among habitually violent and impulsive offenders , 1986 .

[260]  J. Gagliardino,et al.  Chronobiological aspects of blood glucose regulation: a new scope for the study of diabetes mellitus. , 1984, Chronobiologia.

[261]  M. Huttunen,et al.  Evidence for abnormal glucose tolerance test among violent offenders. , 1982, Neuropsychobiology.

[262]  M. Virkkunen Reactive hypoglycemic tendency among habitually violent offenders. A further study by means of the glucose tolerance test. , 1982, Neuropsychobiology.

[263]  J. Coleman,et al.  The nature of adolescence , 1980 .

[264]  P. M. Daniel,et al.  The influence of insulin upon the metabolism of glucose by the brain , 1977, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[265]  R. Bolton Hostility in fantasy: A further test of the hypoglycemia‐aggression hypothesis , 1976 .

[266]  J. Koizumi,et al.  Glycogen in the central nervous system. , 1974, Progress in histochemistry and cytochemistry.

[267]  J. Singer,et al.  Urban stress: experiments on noise and social stressors , 1972 .

[268]  D. Alcalay,et al.  [Influence of the time of the test on the results of the glucose tolerance test]. , 1971, Le Diabete.

[269]  E. Joslin,et al.  Joslin's Diabetes Mellitus , 1971 .

[270]  M. Mager,et al.  Cyclicity in the interrelationships between plasma insulin and glucose during starvation in normal young men. , 1968, The Journal of laboratory and clinical medicine.

[271]  O. H. Lowry,et al.  EFFECT OF ISCHEMIA ON KNOWN SUBSTRATES AND COFACTORS OF THE GLYCOLYTIC PATHWAY IN BRAIN. , 1964, The Journal of biological chemistry.

[272]  A. Brun,et al.  HEMORRHAGES INTO PERIPHERAL NERVES IN ASSOCIATION WITH LEUKEMIA. , 1964, Journal of neuropathology and experimental neurology.

[273]  S. Kety,et al.  The circulation and energy metabolism of the brain. , 1963, Clinical neurosurgery.

[274]  Eletskiĭ IuK CHANGES IN THE BRAIN GLYCOGEN CONTENT OF RATS IN ACUTE ALCOHOLIC INTOXICATION , 1963 .

[275]  L. C. Reid The metabolic pathways of glucose. , 1953, New York state journal of medicine.

[276]  D. Wilson Electroencephalographic studies in diabetes mellitus. , 1951, Canadian Medical Association journal.

[277]  D. Richter Biochemistry of the nervous system. , 1950, Recent progress in psychiatry.

[278]  F. K. Berrien,et al.  The effects of noise. , 1946, Psychological bulletin.