Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.
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J. Breed | V. Oza | P. Lyne | J. Janetka | S. Ashwell | S. Zabludoff | Yafeng Xue | S. Rowsell | N. Newcombe | P. Brassil | C. Horn | J. Read | M. Grondine | Stephanos Ioannidis | Vibha B. Oza | Dongfang Liu | L. Almeida | T. Gero | M. Pass | Mei Su | D. Toader | M. Vasbinder | D. Yu | Yan Yu | Shannon Ready | C. Deng