Socially-induced brain ‘fertilization’: play promotes brain derived neurotrophic factor transcription in the amygdala and dorsolateral frontal cortex in juvenile rats

Rough and tumble (R&T) play is assumed to have beneficial effects in developing organisms. To evaluate this idea, brain derived neurotrophic factor (BDNF) gene expression was evaluated in 32-day-old juvenile rats that were allowed to play for 30 min prior to sacrifice. In situ hybridization for BDNF mRNA revealed that the amygdala and dorsolateral frontal cortex had significantly elevated BDNF mRNA expression as a result of play. These effects suggest that play may help program higher brain regions involved in emotional behaviors.

[1]  L. Olson,et al.  Deprived of habitual running, rats downregulate BDNF and TrkB messages in the brain , 1999, Neuroscience Research.

[2]  Barry J. Everitt,et al.  Rapid and selective induction of BDNF expression in the hippocampus during contextual learning , 2000, Nature Neuroscience.

[3]  A. Granholm,et al.  Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain , 2000, Experimental Neurology.

[4]  J. J. Bolhuis,et al.  The corticomedial amygdala and learning in an agonistic situation in the rat , 1984, Physiology & Behavior.

[5]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[6]  I. Black,et al.  Localization of brain‐derived neurotrophic factor and trkb receptors to postsynaptic densities of adult rat cerebral cortex , 2000, Journal of neuroscience research.

[7]  Nakia S. Gordon,et al.  Expression of c-fos gene activation during rough and tumble play in juvenile rats , 2002, Brain Research Bulletin.

[8]  Jane Stewart,et al.  A descriptive study of social development in the rat (Rattus norvegicus) , 1981, Animal Behaviour.

[9]  E. Welker,et al.  Upregulation of BDNF mRNA Expression in the Barrel Cortex of Adult Mice after Sensory Stimulation , 1996, The Journal of Neuroscience.

[10]  J. Panksepp Attention Deficit Hyperactivity Disorders, Psychostimulants, and Intolerance of Childhood Playfulness , 1998 .

[11]  Nicoletta Berardi,et al.  Critical periods during sensory development , 2000, Current Opinion in Neurobiology.

[12]  M. Verity,et al.  8 – Nervous System , 1995 .

[13]  W. Snider,et al.  Functions of the neurotrophins during nervous system development: What the knockouts are teaching us , 1994, Cell.

[14]  J. Panksepp The ontogeny of play in rats. , 1981, Developmental psychobiology.

[15]  L. Nadel,et al.  Cognitive neuroscience of emotion , 2000 .

[16]  C. Cotman,et al.  Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain , 1996, Brain Research.

[17]  Jaak Panksepp,et al.  The psychobiology of play: Theoretical and methodological perspectives , 1984, Neuroscience & Biobehavioral Reviews.

[18]  R. Barkley The Executive Functions and Self-Regulation: An Evolutionary Neuropsychological Perspective , 2001, Neuropsychology Review.

[19]  M. Bekoff,et al.  Animal play : evolutionary, comparative, and ecological perspectives , 1998 .

[20]  Joseph E LeDoux Fear and the brain: where have we been, and where are we going? , 1998, Biological Psychiatry.

[21]  David G. Amaral,et al.  The role of the amygdala in primate social cognition. , 2000 .