Nitro-Pyrazinotriazapentalene scaffolds– nitroreductase quantification and in vitro fluorescence imaging of hypoxia

[1]  Hai‐Liang Zhu,et al.  Recent progress in the design principles, sensing mechanisms, and applications of small-molecule probes for nitroreductases , 2020 .

[2]  Yanli Tang,et al.  A ratiometric fluorescent biosensor based on conjugated polymers for sensitive detection of nitroreductase and hypoxia diagnosis in tumor cells , 2020 .

[3]  E. Graves,et al.  An Activatable NIR Fluorescent Rosol for Selectively Imaging Nitroreductase Activity. , 2020, Sensors and actuators. B, Chemical.

[4]  G. Guillaumet,et al.  Intramolecular Metal Free N-N Bond Formation with Heteroaromatic Amines: Mild Access to Fused-Triazapentalene Derivatives. , 2019, Chemistry.

[5]  M. Xie,et al.  Role of hypoxia in cancer therapy by regulating the tumor microenvironment , 2019, Molecular Cancer.

[6]  Y. Nakajima,et al.  4,4'-Bipyridyl-Catalyzed Reduction of Nitroarenes by Bis(neopentylglycolato)diboron. , 2019, Organic letters.

[7]  N. Chopin,et al.  An original class of small sized molecules as versatile fluorescent probes for cellular imaging. , 2019, Chemical communications.

[8]  Stephen M. Douglass,et al.  Bad company: Microenvironmentally mediated resistance to targeted therapy in melanoma , 2018, Pigment cell & melanoma research.

[9]  B. Liu,et al.  A novel fluorescent turn-on probe for highly selective detection of nitroreductase in tumor cells , 2018, Sensors and Actuators B: Chemical.

[10]  Lin Li,et al.  Recent progress in small molecule fluorescent probes for nitroreductase , 2018, Chinese Chemical Letters.

[11]  Yueqing Gu,et al.  A fluorescent turn-on probe for nitroreductase imaging in living cells and tissues under hypoxia conditions , 2018, Sensors and Actuators B: Chemical.

[12]  J. Smaill,et al.  Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy. , 2017, Cell chemical biology.

[13]  G. Dobretsov,et al.  On mechanisms of fluorescence quenching by water , 2014, Biofizika.

[14]  Sua Myong,et al.  Protein induced fluorescence enhancement (PIFE) for probing protein-nucleic acid interactions. , 2014, Chemical Society reviews.

[15]  Lin Li,et al.  On the Dielectric “Constant” of Proteins: Smooth Dielectric Function for Macromolecular Modeling and Its Implementation in DelPhi , 2013, Journal of chemical theory and computation.

[16]  B. Polyak,et al.  Interaction of a fluorescent probe, CAPIDAN, with human serum albumin , 2013 .

[17]  W. Wilson,et al.  Targeting hypoxia in cancer therapy , 2011, Nature Reviews Cancer.

[18]  A. H. Wang,et al.  Flavin-containing reductase: new perspective on the detoxification of nitrobenzodiazepine , 2010, Expert opinion on drug metabolism & toxicology.

[19]  S. Kizaka-Kondoh,et al.  Significance of nitroimidazole compounds and hypoxia‐inducible factor‐1 for imaging tumor hypoxia , 2009, Cancer science.

[20]  Longqin Hu,et al.  Design of anticancer prodrugs for reductive activation , 2009, Medicinal research reviews.

[21]  Taeg Kyu Kwon,et al.  Desferrioxamine, an iron chelator, enhances HIF-1alpha accumulation via cyclooxygenase-2 signaling pathway. , 2006, Biochemical and biophysical research communications.

[22]  G. Semenza.  Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.

[23]  W. Denny,et al.  Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. , 2003, Journal of medicinal chemistry.

[24]  M. Grever,et al.  Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9. , 1996, Journal of the National Cancer Institute.

[25]  W. Denny,et al.  Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide. , 1995, Journal of medicinal chemistry.

[26]  C. Bryant,et al.  Purification and characterization of an oxygen-insensitive NAD(P)H nitroreductase from Enterobacter cloacae. , 1991, The Journal of biological chemistry.

[27]  H. Yoshimura,et al.  Mode of reactions between xanthine oxidase and aromatic nitro compounds. , 1981, Journal of pharmacobio-dynamics.

[28]  R. Mason,et al.  Oxygen-sensitive and -insensitive nitroreduction by Escherichia coli and rat hepatic microsomes. , 1979, The Journal of biological chemistry.

[29]  R. Mason,et al.  The mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates. , 1975, Biochemistry.