Genetic regulation of bacterial virulence.

In this review, we concentrate on genetic control of bacterial virulence. We limit this review to several systems that illustrate common molecular themes in control of virulence properties rather than presenting a comprehensive review of this extensive literature

[1]  A. Maurelli,et al.  Identification of an Escherichia coli gene homologous to virR, a regulator of Shigella virulence , 1989, Journal of bacteriology.

[2]  R. Sherburne,et al.  Bordetella parapertussis invasion of HeLa 229 cells and human respiratory epithelial cells in primary culture , 1989, Infection and immunity.

[3]  J. Mekalanos,et al.  Broad-host-range vectors for delivery of TnphoA: use in genetic analysis of secreted virulence determinants of Vibrio cholerae , 1989, Journal of bacteriology.

[4]  W. Aaronson,et al.  Phase variation in Bordetella pertussis by frameshift mutation in a gene for a novel two-component system , 1989, Nature.

[5]  A. Chakrabarty,et al.  The algR gene, which regulates mucoidy in Pseudomonas aeruginosa, belongs to a class of environmentally responsive genes , 1989, Journal of bacteriology.

[6]  E. Groisman,et al.  A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells. , 1989, Science.

[7]  R. Rappuoli,et al.  Genetics of pertussis toxin , 1989, Molecular microbiology.

[8]  G. Cornelis,et al.  Homology between virF, the transcriptional activator of the Yersinia virulence regulon, and AraC, the Escherichia coli arabinose operon regulator , 1989, Journal of bacteriology.

[9]  H. Seifert,et al.  Pilin expression in Neisseria gonorrhoeae is under both positive and negative transcriptional control. , 1988, The EMBO journal.

[10]  G. Cornelis,et al.  Nucleotide sequence and transcription analysis of yop51 from Yersinia enterocolitica W22703. , 1988, Microbial pathogenesis.

[11]  V. Fischetti,et al.  Spontaneous M6 protein size mutants of group A streptococci display variation in antigenic and opsonogenic epitopes. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[12]  S. Knapp,et al.  Two trans-acting regulatory genes (vir and mod) control antigenic modulation in Bordetella pertussis , 1988, Journal of bacteriology.

[13]  D. Nelson,et al.  Acceleration of starvation- and glycerol-induced myxospore formation by prior heat shock in Myxococcus xanthus , 1988, Journal of bacteriology.

[14]  J. Mekalanos,et al.  Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization , 1988 .

[15]  B. Iglewski,et al.  Kinetics of toxA and regA mRNA accumulation in Pseudomonas aeruginosa , 1988, Journal of bacteriology.

[16]  R. Holmes,et al.  Iron regulation of the cloned diphtheria toxin promoter in Escherichia coli , 1988, Infection and immunity.

[17]  M. F. Edwards,et al.  Construction of delta aroA his delta pur strains of Salmonella typhi , 1988, Journal of bacteriology.

[18]  A. Ninfa,et al.  Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[19]  S. Kustu,et al.  Protein kinase and phosphoprotein phosphatase activities of nitrogen regulatory proteins NTRB and NTRC of enteric bacteria: roles of the conserved amino-terminal domain of NTRC. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[20]  S. Normark,et al.  Identification of carbohydrate structures that are possible receptors for Neisseria gonorrhoeae. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[21]  H. Shuman,et al.  Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes , 1988, Infection and immunity.

[22]  G. Murphy,et al.  Recombination among Protein II genes of Neisseria gonorrhoeae generates new coding sequences and increases structural variability in the Protein II family , 1988, Molecular microbiology.

[23]  Ian R. Booth,et al.  A physiological role for DNA supercoiling in the osmotic regulation of gene expression in S. typhimurium and E. coli , 1988, Cell.

[24]  S. Bergström,et al.  Effects of recA mutations on pilus antigenic variation and phase transitions in Neisseria gonorrhoeae. , 1987, Genetics.

[25]  D. Friedman,et al.  Integration host factor is required for the DNA inversion that controls phase variation in Escherichia coli. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[26]  S. Falkow,et al.  Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells , 1987, Cell.

[27]  C. Higgins,et al.  Fimbrial phase variation in Escherichia coli: dependence on integration host factor and homologies with other site-specific recombinases , 1987, Journal of bacteriology.

[28]  Frederick M. Ausubel,et al.  Conserved domains in bacterial regulatory proteins that respond to environmental stimuli , 1987, Cell.

[29]  V. L. Miller,et al.  Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Y. Oron,et al.  Growth advantage and enhanced toxicity of Escherichia coli adherent to tissue culture cells due to restricted diffusion of products secreted by the cells. , 1987, The Journal of clinical investigation.

[31]  C. Daniels,et al.  Nucleotide sequence and characterization of toxR: a gene involved in exotoxin A regulation in Pseudomonas aeruginosa. , 1987, Nucleic acids research.

[32]  P. Reeves,et al.  Mediation of serum resistance in Salmonella typhimurium by an 11-kilodalton polypeptide encoded by the cryptic plasmid. , 1987, The Journal of infectious diseases.

[33]  D. Corwin,et al.  Gene conversion involving the pilin structural gene correlates with pilus+ ⇄ pilus− changes in Neisseria gonorrhoeae , 1986, Cell.

[34]  T. Meyer,et al.  Opacity genes in Neisseria gonorrhoeae: Control of phase and antigenic variation , 1986, Cell.

[35]  V. Fischetti,et al.  Streptococcal M protein size mutants occur at high frequency within a single strain , 1986, The Journal of experimental medicine.

[36]  P. Spears,et al.  Metastable regulation of type 1 piliation in Escherichia coli and isolation and characterization of a phenotypically stable mutant , 1986, Journal of bacteriology.

[37]  H. Bujard,et al.  lac Repressor blocks transcribing RNA polymerase and terminates transcription. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[38]  V. Mathan,et al.  The colonization of Peyer's patches by a strain of Salmonella typhimurium cured of the cryptic plasmid. , 1986, The Journal of infectious diseases.

[39]  P. Sansonetti,et al.  Transposon mutagenesis as a tool to study the role of hemolysin in the virulence of Listeria monocytogenes , 1986, Infection and immunity.

[40]  H. Seifert,et al.  Antigenic variation of gonococcal pilus involves assembly of separated silent gene segments. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[41]  E. Moxon,et al.  Genes involved in Haemophilus influenzae type b capsule expression are part of an 18-kilobase tandem duplication. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[42]  S. Normark,et al.  Transcriptional activation of a pap pilus virulence operon from uropathogenic Escherichia coli. , 1985, The EMBO journal.

[43]  T. L. Hale,et al.  Identification and antigenic characterization of virulence-associated, plasmid-coded proteins of Shigella spp. and enteroinvasive Escherichia coli , 1985, Infection and immunity.

[44]  S. Falkow,et al.  Two modes of control of pilA, the gene encoding type 1 pilin in Escherichia coli , 1985, Journal of bacteriology.

[45]  D. Corwin,et al.  Pilus- gonococcal variants. Evidence for multiple forms of piliation control , 1985, The Journal of experimental medicine.

[46]  V. Fischetti,et al.  Size variation of the M protein in group A streptococci , 1985, The Journal of experimental medicine.

[47]  P. Klemm.  Fimbrial Adhesins of Escherichia coli , 1985 .

[48]  J. Abraham,et al.  Genetic analysis of the phase variation control of expression of type 1 fimbriae in Escherichia coli , 1985, Journal of bacteriology.

[49]  T. Meyer,et al.  Role of chromosomal rearrangement in N. gonorrhoeae pilus phase variation , 1985, Cell.

[50]  J. Goguen,et al.  Genetic analysis of the low calcium response in Yersinia pestis mu d1(Ap lac) insertion mutants , 1984, Journal of bacteriology.

[51]  V. L. Miller,et al.  Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[52]  F. Grundy,et al.  Involvement of the invertible G segment in bacteriophage mu tail fiber biosynthesis. , 1984, Virology.

[53]  S. Falkow,et al.  Characterization of common virulence plasmids in Yersinia species and their role in the expression of outer membrane proteins , 1984, Infection and immunity.

[54]  S. Falkow,et al.  Genetic analysis of phase change in Bordetella pertussis , 1984, Infection and immunity.

[55]  B. Eisenstein,et al.  Genetic mapping and transcriptional orientation of the fimD gene , 1983, Journal of bacteriology.

[56]  H. Echols,et al.  Control of phage λ development by stability and synthesis of cll protein: Role of the viral clll and host hflA, himA and himD genes , 1982, Cell.

[57]  T. Meyer,et al.  Pilus expression in neisseria gonorrhoeae involves chromosomal rearrangement , 1982, Cell.

[58]  J. Diaz,et al.  Antigenic variation of outer membrane protein II in colonial variants of Neisseria gonorrhoeae P9. , 1982, Journal of general microbiology.

[59]  B. Eisenstein.  Phase variation of type 1 fimbriae in Escherichia coli is under transcriptional control. , 1981, Science.

[60]  R. Losick,et al.  Cascades of sigma factors , 1981, Cell.

[61]  B. Stocker,et al.  Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines , 1981, Nature.

[62]  R. Goldman,et al.  Mannose-binding activity of Escherichia coli: a determinant of attachment and ingestion of the bacteria by macrophages. , 1980, Infection and immunity.

[63]  J. Swanson,et al.  125I-labeled peptide mapping of some heat-modifiable proteins of the gonococcal outer membrane , 1980, Infection and immunity.

[64]  R. Sweet,et al.  Comparison of virulence markers of peritoneal and fallopian tube isolates with endocervical Neisseria gonorrhoeae isolates from women with acute salpingitis. , 1980, Infection and immunity.

[65]  L. M. Swaney,et al.  Genetic complementation analysis of Escherichia coli type 1 somatic pilus mutants , 1977, Journal of bacteriology.

[66]  T. Buchanan.  ANTIGENIC HETEROGENEITY OF GONOCOCCAL PILI * , 2022 .

[67]  R. Germanier,et al.  Isolation and characterization of Gal E mutant Ty 21a of Salmonella typhi: a candidate strain for a live, oral typhoid vaccine. , 1975, The Journal of infectious diseases.

[68]  J. Swanson,et al.  STUDIES ON GONOCOCCUS INFECTION , 1973, The Journal of experimental medicine.

[69]  C. Brinton.  Non-Flagellar Appendages of Bacteria , 1959, Nature.

[70]  J. Mekalanos,et al.  Regulation of Cholera Toxin Synthesis , 1990 .

[71]  Ronald K. Taylor,et al.  Chapter 15 – Genetic Studies of Enterotoxin and Other Potential Virulence Factors of Vibrio cholerae , 1989 .

[72]  H. Seifert,et al.  DNA transformation leads to pilin antigenic variation in Neisseria gonorrhoeae , 1988, Nature.

[73]  N. Mackman,et al.  Secretion of haemolysin by Escherichia coli. , 1986, Current topics in microbiology and immunology.

[74]  M. Ptashne.  A Genetic Switch , 1986 .