Phosphorylated S6 kinase and S6 ribosomal protein are diagnostic markers of antibody-mediated rejection in heart allografts.

[1]  Mary E. Ziegler,et al.  Everolimus Inhibits Anti‐HLA I Antibody‐Mediated Endothelial Cell Signaling, Migration and Proliferation More Potently Than Sirolimus , 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[2]  A. Angelini,et al.  The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation. , 2013, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[3]  X. Jouven,et al.  Pathologic classification of antibody-mediated rejection correlates with donor-specific antibodies and endothelial cell activation. , 2013, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[4]  E. Reed,et al.  HLA Class I Antibodies Trigger Increased Adherence of Monocytes to Endothelial Cells by Eliciting an Increase in Endothelial P-Selectin and, Depending on Subclass, by Engaging FcγRs , 2013, The Journal of Immunology.

[5]  E. Reed,et al.  HLA class I: an unexpected role in integrin β4 signaling in endothelial cells. , 2012, Human immunology.

[6]  M. Fishbein,et al.  Morphologic and immunohistochemical findings in antibody-mediated rejection of the cardiac allograft. , 2012, Human immunology.

[7]  Mary E. Ziegler,et al.  HLA class I-mediated stress fiber formation requires ERK1/2 activation in the absence of an increase in intracellular Ca2+ in human aortic endothelial cells. , 2012, American journal of physiology. Cell physiology.

[8]  E. Reed,et al.  HLA class I antibody-mediated endothelial and smooth muscle cell activation , 2012, Current opinion in organ transplantation.

[9]  M. Haas Pathologic features of antibody-mediated rejection in renal allografts: an expanding spectrum , 2012, Current opinion in nephrology and hypertension.

[10]  Mary E. Ziegler,et al.  Characterization of the Endothelial Cell Cytoskeleton following HLA Class I Ligation , 2012, PloS one.

[11]  E. Reed,et al.  Antibody ligation of human leukocyte antigen class I molecules stimulates migration and proliferation of smooth muscle cells in a focal adhesion kinase-dependent manner. , 2011, Human immunology.

[12]  J. Kobashigawa,et al.  Cardiac allograft rejection. , 2011, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.

[13]  A. Angelini,et al.  The ISHLT working formulation for pathologic diagnosis of antibody-mediated rejection in heart transplantation: evolution and current status (2005-2011). , 2011, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[14]  M. Haas,et al.  C4d-negative antibody-mediated rejection in renal allografts: evidence for its existence and effect on graft survival. , 2011, Clinical nephrology.

[15]  A. Angelini,et al.  Report from a consensus conference on antibody-mediated rejection in heart transplantation. , 2011, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[16]  J. Empana,et al.  Significance of C4d Banff Scores in Early Protocol Biopsies of Kidney Transplant Recipients with Preformed Donor‐Specific Antibodies (DSA) , 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[17]  E. Reed,et al.  HLA Class I Molecules Partner with Integrin β4 to Stimulate Endothelial Cell Proliferation and Migration , 2010, Science Signaling.

[18]  R. Starling,et al.  International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy-2010. , 2010, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[19]  E. Reed,et al.  Effect of Antibodies on Endothelium , 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[20]  Paul Aurora,et al.  Registry of the International Society for Heart and Lung Transplantation: Twenty-sixth Official Adult Heart Transplant Report-2009. , 2009, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[21]  E. Reed,et al.  Human leukocyte antigen antibodies in chronic transplant vasculopathy-mechanisms and pathways. , 2009, Current opinion in immunology.

[22]  R. Sodian,et al.  Donor-specific HLA alloantibodies: long-term impact on cardiac allograft vasculopathy and mortality after heart transplant. , 2008, Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.

[23]  E. Reed,et al.  MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway. , 2008, Biochemical and biophysical research communications.

[24]  W. Baldwin,et al.  In Vivo Platelet–Endothelial Cell Interactions in Response to Major Histocompatibility Complex Alloantibody , 2008, Circulation research.

[25]  E. Reed,et al.  HLA Class I Antibody-Mediated Endothelial Cell Proliferation via the mTOR Pathway1 , 2008, The Journal of Immunology.

[26]  F. Gao,et al.  Anti-MHC Class I Antibody Activation of Proliferation and Survival Signaling in Murine Cardiac Allografts1 , 2008, The Journal of Immunology.

[27]  Y. Korin,et al.  RNA Interference Elucidates the Role of Focal Adhesion Kinase in HLA Class I-Mediated Focal Adhesion Complex Formation and Proliferation in Human Endothelial Cells1 , 2007, The Journal of Immunology.

[28]  E. Trulock,et al.  Registry of the International Society for Heart and Lung Transplantation: tenth official pediatric lung and heart/lung transplantation report--2007. , 2006, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[29]  M. Fishbein,et al.  Phosphorylated S6 Ribosomal Protein: A Novel Biomarker of Antibody‐Mediated Rejection in Heart Allografts , 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[30]  O. Meyuhas,et al.  Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. , 2006, Trends in biochemical sciences.

[31]  H. Valantine,et al.  Everolimus (certican) in heart transplantation: optimizing renal function through minimizing cyclosporine exposure. , 2005, Transplantation proceedings.

[32]  S. Dunlap,et al.  The Presence of HLA-Directed Antibodies after Heart Transplantation Is Associated with Poor Allograft Outcome , 2005, Transplantation.

[33]  R. Starling,et al.  Analysis of immune markers in human cardiac allograft recipients and association with coronary artery vasculopathy. , 2005, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[34]  S. Saidman,et al.  C4d deposition in cardiac allografts correlates with alloantibody. , 2005, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[35]  D. Mancini,et al.  Anti-Human Leukocyte Antigen Antibodies are Associated with Restenosis after Percutaneous Coronary Intervention for Cardiac Allograft Vasculopathy , 2005, Transplantation.

[36]  P. Nickerson,et al.  National Conference to Assess Antibody‐Mediated Rejection in Solid Organ Transplantation , 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[37]  M. Fishbein,et al.  Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells. , 2004, Human immunology.

[38]  W. Baldwin,et al.  Beyond C4d: Other Complement‐Related Diagnostic Approaches to Antibody‐Mediated Rejection , 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[39]  M. Mihatsch,et al.  Kidney transplants, antibodies and rejection: is C4d a magic marker? , 2003, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[40]  E. Tuzcu,et al.  Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients. , 2003, The New England journal of medicine.

[41]  M. Mehra,et al.  C-Reactive protein and cardiac allograft vasculopathy. is inflammation the critical link? , 2003, Journal of the American College of Cardiology.

[42]  Paul S Mischel,et al.  Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. , 2003, Cancer research.

[43]  L. Aicher,et al.  Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. , 2002, Cancer research.

[44]  E. Reed,et al.  Ligation of HLA Class I Molecules on Endothelial Cells Induces Phosphorylation of Src, Paxillin, and Focal Adhesion Kinase in an Actin-Dependent Manner1 , 2002, The Journal of Immunology.

[45]  R. Colvin,et al.  Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification. , 2002, Journal of the American Society of Nephrology : JASN.

[46]  M. Yacoub,et al.  ANTIVIMENTIN ANTIBODIES ARE AN INDEPENDENT PREDICTOR OF TRANSPLANT-ASSOCIATED CORONARY ARTERY DISEASE AFTER CARDIAC TRANSPLANTATION1 , 2001, Transplantation.

[47]  D. Renlund,et al.  Allograft coronary artery disease: clinical correlations with circulating anti-HLA antibodies and the immunohistopathologic pattern of vascular rejection. , 2000, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[48]  G. Couper,et al.  Role of panel-reactive antibody cross-reactivity in predicting survival after orthotopic heart transplantation. , 1994, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[49]  D. Renlund,et al.  Vascular (humoral) rejection in heart transplantation: pathologic observations and clinical implications. , 1989, The Journal of heart transplantation.

[50]  T. Fenton,et al.  Functions and regulation of the 70kDa ribosomal S6 kinases. , 2011, The international journal of biochemistry & cell biology.

[51]  D. Mancini,et al.  Pre- and posttransplantation allosensitization in heart allograft recipients: major impact of de novo alloantibody production on allograft survival. , 2011, Human immunology.

[52]  A. Rahmel,et al.  Registry of the International Society for Heart and Lung Transplantation: Twelfth Official Pediatric Heart Transplantation Report-2009. , 2009, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[53]  Silviu Itescu,et al.  Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. , 2005, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[54]  M. Fishbein,et al.  Humoral rejection in cardiac transplantation: risk factors, hemodynamic consequences and relationship to transplant coronary artery disease. , 2003, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[55]  M. Rose Role of antibodies in transplant-associated cardiac allograft vasculopathy , 2000, Zeitschrift für Kardiologie.

[56]  M. Fishbein,et al.  Clinical-pathologic features of humoral rejection in cardiac allografts: a study in 81 consecutive patients. , 1995, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.