Recent applications of polymer-supported reagents and scavengers in combinatorial, parallel, or multistep synthesis.

There has been a wealth of recent reports concerning support-bound reagents and scavengers in the solution-phase synthesis of compound libraries and natural products. Important advances in 1999 include the continued development and use of novel reagents for heterocycle synthesis, the increased use of catch-and-release purification, and the development of increasingly sophisticated techniques to allow sequestering of many types of impurities from desired compounds. These techniques have all been combined to enable the complicated multistep synthesis of natural products and of libraries of novel drug-like molecules, without conventional purification.

[1]  M. S. South,et al.  High-throughput purification of solution-phase periodinane mediated oxidation reactions utilizing a novel thiosulfate resin , 1999 .

[2]  W. DeGrado,et al.  Resin-to-Resin Acyl- and Aminoacyl-Transfer Reactions Using Oxime Supports , 1999 .

[3]  C. Hulme,et al.  Remarkable three-step-one-pot solution phase preparation of novel imidazolines utilizing a UDC (Ugi/de-Boc/cyclize) strategy , 1999 .

[4]  Paul A. Bartlett,et al.  Combinatorial chemistry: The search continues Editorial overview , 1999 .

[5]  J. Bussolari,et al.  Parallel synthesis of 2-alkoxy and 2-acyloxyphenylpropyl amides and amines using dihydrocoumarins as versatile synthons. Application of a novel resin quench-capture method , 1999 .

[6]  G. Trainor,et al.  Functionalized porous silica microspheres as scavengers in parallel synthesis. , 2000, Combinatorial chemistry & high throughput screening.

[7]  Steven V. Ley,et al.  Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents , 1999 .

[8]  J. C. Hodges,et al.  Solid-Supported Reagent Strategies for Rapid Purification of Combinatorial Synthesis Products , 1999 .

[9]  D. Brittelli,et al.  Protocols for amide high-speed analoging. Preparation of novel, small molecule cathepsin D inhibitors , 1999 .

[10]  M. Siegel,et al.  Rapid purification of small molecule libraries by ion exchange chromatography , 1997 .

[11]  D. Flynn,et al.  POLYMER-ASSISTED SOLUTION PHASE SYNTHESIS : A GENERAL METHOD FOR SEQUESTRATION OF BYPRODUCTS FORMED FROM ACTIVATED ACYL-TRANSFER REACTANTS , 1999 .

[12]  Eric M. Smith.  A polymer-supported silyl triflate and subsequent functionalization: synthesis and solid-phase Diels-Alder reactions of silyloxydienes , 1999 .

[13]  K. Janda,et al.  Liquid-phase chemistry: recent advances in soluble polymer-supported catalysts, reagents and synthesis , 1999 .

[14]  D. Boger,et al.  Solution Phase Combinatorial Synthesis of Biaryl Libraries Employing Heterogeneous Conditions for Catalysis and Isolation with Size Exclusion Chromatography for Purification , 1999 .

[15]  J. Porco,et al.  Ester enolate Claisen rearrangement using a polymer-supported silyl triflate , 1999 .

[16]  Novel synthesis of oxindole quinazolines using solid phase multiparallel chemistry , 1999 .

[17]  M. Siegel,et al.  Rapid parallel synthesis applied to the optimization of a series of potent nonpeptide neuropeptide Y-1 receptor antagonists , 1999 .

[18]  A. Barrett,et al.  Chameleon catches in combinatorial chemistry: Tebbe olefination of polymer supported esters and the synthesis of amines, cyclohexanones, enones, methyl ketones and thiazoles , 1998 .

[19]  Harikrishnan,et al.  Preparation of Designer Resins via Living Free Radical Polymerization of Functional Monomers on Solid Support. , 2000, Journal of combinatorial chemistry.

[20]  R. Devraj,et al.  Solution-phase chemical library synthesis using polymer-assisted purification techniques. , 1999, Current opinion in chemical biology.

[21]  Yonghan Hu,et al.  Parallel Synthesis of 1,2,3-Thiadiazoles Employing a "Catch and Release" Strategy. , 1999, The Journal of organic chemistry.

[22]  Jieping Zhu,et al.  A high throughput synthesis of aryl triflate and aryl nonaflate promoted by a polymer supported base (PTBD) , 1999 .

[23]  A. Ganesan,et al.  A solid-phase equivalent of van Leusen's TosMIC, and its application in oxazole synthesis , 1999 .

[24]  Jonathan A. Ellman,et al.  Synthesis and Applications of Small Molecule Libraries. , 1996, Chemical reviews.

[25]  P. Seneci,et al.  HIGH THROUGHPUT PURIFICATION METHODS IN COMBINATORIAL SOLUTION PHASE SYNTHESIS , 1998 .

[26]  M. Allen,et al.  An easily prepared, air and moisture stable, resin-bound palladium catalyst for Suzuki cross-coupling reactions , 1999 .

[27]  Anthony W. Czarnik,et al.  A practical guide to combinatorial chemistry , 1997 .

[28]  Barry A. Bunin.  The Combinatorial Index , 1998 .

[29]  P. Wipf,et al.  Fluorous Synthesis: A Fluorous-Phase Strategy for Improving Separation Efficiency in Organic Synthesis , 1997, Science.

[30]  B. Schweitzer,et al.  Design and synthesis of beta-carboxamido phosphonates as potent inhibitors of imidazole glycerol phosphate dehydratase. , 1999, Bioorganic & medicinal chemistry letters.

[31]  A. Ganesan,et al.  Solution-phase parallel oxazole synthesis with TosMIC , 1999 .

[32]  S V Ley,et al.  Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents. , 1999, Bioorganic & medicinal chemistry letters.

[33]  Y. Hamuro,et al.  Solid-Phase Synthesis of Acyclic and Cyclic Amino Acid Derived Urea Peptidomimetics Using Phoxime Resin † , 1999 .

[34]  W. König,et al.  Parallel Synthesis of Polyethylene Glycol Supported Biaryl Benzimidazoles and Imidazopyridines , 1999 .

[35]  K. Fukase,et al.  New methodology for high throughput solution-phase synthesis: affinity purification by using crown ether and ammonium ion interaction , 1999 .

[36]  D. Curran.  Parallel synthesis with fluorous reagents and reactants , 1999, Medicinal research reviews.

[37]  Miles G. Siegel,et al.  Use of solid supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries , 1996 .

[38]  R. Mortishire-Smith,et al.  Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands. , 1999, Bioorganic & medicinal chemistry letters.

[39]  Steven V. Ley,et al.  Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents , 1999 .

[40]  Y. Hamuro,et al.  Phosgenated p-Nitrophenyl(polystyrene)ketoxime or Phoxime Resin. A New Resin for the Solid-Phase Synthesis of Ureas via Thermolytic Cleavage of Oxime-Carbamates† , 1998 .

[41]  P. Grieco,et al.  Total synthesis of (.+-.)-bruceantin , 1993 .