Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2

[1]  Huiwen Liu,et al.  Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice , 2015, Respirology.

[2]  Maha Almanan,et al.  Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation. , 2013, The Journal of allergy and clinical immunology.

[3]  Satoru Takahashi,et al.  Transcription Factors GATA-3 and RORγt Are Important for Determining the Phenotype of Allergic Airway Inflammation in a Murine Model of Asthma , 2013, The Journal of Immunology.

[4]  Z. Qiu,et al.  Protein tyrosine phosphatase SHP2 regulates TGF‐β1 production in airway epithelia and asthmatic airway remodeling in mice , 2012, Allergy.

[5]  Yong-liang Jia,et al.  Shp2 Plays an Important Role in Acute Cigarette Smoke-Mediated Lung Inflammation , 2012, The Journal of Immunology.

[6]  Li Teng,et al.  Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  Byung Soo Kim,et al.  Eosinophil Development, Regulation of Eosinophil-Specific Genes, and Role of Eosinophils in the Pathogenesis of Asthma , 2011, Allergy, asthma & immunology research.

[8]  A. Friedman,et al.  SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis. , 2011, Blood.

[9]  J. Yee,et al.  A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells. , 2011, Blood.

[10]  Linheng Li,et al.  Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. , 2011, Blood.

[11]  T. Han,et al.  Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. , 2011, Cancer cell.

[12]  J. Kutok,et al.  Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. , 2011, Blood.

[13]  A. Friedman,et al.  M-CSF elevates c-Fos and phospho-C/EBPalpha(S21) via ERK whereas G-CSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to myeloid lineage specification. , 2009, Blood.

[14]  K. Akashi,et al.  Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor , 2009, The Journal of experimental medicine.

[15]  Jörg Rademann,et al.  Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking , 2008, Proceedings of the National Academy of Sciences.

[16]  A. Kurosky,et al.  Cross-talk between ICAM-1 and granulocyte-macrophage colony-stimulating factor receptor signaling modulates eosinophil survival and activation. , 2008, Journal of immunology.

[17]  T. Curran,et al.  Deletion of Shp2 in the Brain Leads to Defective Proliferation and Differentiation in Neural Stem Cells and Early Postnatal Lethality , 2007, Molecular and Cellular Biology.

[18]  S. Phipps,et al.  Eosinophil trafficking in allergy and asthma. , 2007, The Journal of allergy and clinical immunology.

[19]  D. Alexander,et al.  The src Homology 2 Domain-Containing Tyrosine Phosphatase 2 Regulates Primary T-Dependent Immune Responses and Th Cell Differentiation1 , 2005, The Journal of Immunology.

[20]  K. Akashi,et al.  Identification of eosinophil lineage–committed progenitors in the murine bone marrow , 2005, The Journal of experimental medicine.

[21]  E. Lenkiewicz,et al.  Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils , 2004, Science.

[22]  P. O'Byrne,et al.  Kinetics of bone marrow eosinophilopoiesis and associated cytokines after allergen inhalation. , 2004, American journal of respiratory and critical care medicine.

[23]  G. Feng,et al.  A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. , 2003, Blood.

[24]  L. Gibson,et al.  Regulation of Eosinophilopoiesis in a Murine Model of Asthma 1 , 2003, The Journal of Immunology.

[25]  P. O'Byrne,et al.  Allergen‐induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation , 2003, Immunology.

[26]  B. Neel,et al.  The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. , 2003, Trends in biochemical sciences.

[27]  S. Orkin,et al.  Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo , 2002, The Journal of experimental medicine.

[28]  A. Iwama,et al.  Essential and Instructive Roles of GATA Factors in Eosinophil Development , 2002, The Journal of experimental medicine.

[29]  E. Gelfand,et al.  IL‐5‐induced airway eosinophilia – the key to asthma? , 2001, Immunological reviews.

[30]  S. Stafford,et al.  The Differential Role of Extracellular Signal-Regulated Kinases and p38 Mitogen-Activated Protein Kinase in Eosinophil Functions1 , 2000, The Journal of Immunology.

[31]  G. Feng Shp-2 tyrosine phosphatase: signaling one cell or many. , 1999, Experimental cell research.

[32]  P. O'Byrne,et al.  Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in mice. , 1999, American journal of respiratory cell and molecular biology.

[33]  S. Rankin,et al.  Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow. , 1998, Blood.

[34]  T. Adachi,et al.  Src Homology 2 Protein Tyrosine Phosphatase (SHPTP2)/Src Homology 2 Phosphatase 2 (SHP2) Tyrosine Phosphatase Is a Positive Regulator of the Interleukin 5 Receptor Signal Transduction Pathways Leading to the Prolongation of Eosinophil Survival , 1997, The Journal of experimental medicine.

[35]  P. Foster,et al.  Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice. , 1997, The Journal of clinical investigation.

[36]  T. Graf,et al.  GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts. , 1995, Genes & development.

[37]  R. Alam,et al.  The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1- MEK-microtubule-associated protein kinase pathway , 1995, The Journal of experimental medicine.

[38]  T. Pawson,et al.  SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. , 1993, Science.

[39]  T. Dexter,et al.  The mouse M-lysozyme gene domain: identification of myeloid and differentiation specific DNasel hypersensitive sites and of a 3'-cis acting regulatory element. , 1992, Nucleic acids research.

[40]  D. Longo,et al.  Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. , 1991, Journal of immunology.

[41]  G. Gleich The eosinophil and bronchial asthma: current understanding. , 1990, The Journal of allergy and clinical immunology.

[42]  C. Sanderson,et al.  Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF. , 1989, Blood.

[43]  R. Renkawitz,et al.  Mouse lysozyme M gene: isolation, characterization, and expression studies. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[44]  K. Takatsu,et al.  Interleukin 5 in the link between the innate and acquired immune response. , 2009, Advances in immunology.

[45]  R. Sehmi,et al.  Increased eosinophil-lineage committed progenitors in the lung of allergen-challenged mice. , 2005, The Journal of allergy and clinical immunology.

[46]  C. Sanderson,et al.  Interleukin-5, eosinophils, and disease. , 1992, Blood.