论文信息 - ACase Report : Successful Treatment of Meningeal Metastasis with Concurrent Whole Brain Radiotherapy and Erlotinib in a Patient with Non-small Cell Lung Cancer

ACase Report : Successful Treatment of Meningeal Metastasis with Concurrent Whole Brain Radiotherapy and Erlotinib in a Patient with Non-small Cell Lung Cancer

We report a case of successful treatment with erlotinib of a patient with non-small cell lung cancer (stage IV) and meningeal metastasis. Combined treatment with whole brain radiotherapy (WBRT) and erlotinib mitigated neurologic symptoms of the patient. Magnetic resonance imaging showed reduction of the brain metastasis. Partial remission was observed by chest computed tomography (CT) scan after six months of erlotinib therapy.

L. Liu | J. Huang | H. Lu | X-R Dong

[1] Andrew Shaw,et al. Neoplastic meningitis. , 2011, Journal of neurosurgery.

[2] E. Smit,et al. Phase I study of concurrent whole brain radiotherapy and erlotinib for multiple brain metastases from non-small-cell lung cancer. , 2009, International Journal of Radiation Oncology, Biology, Physics.

[3] C. Boshoff,et al. Health outcomes following treatment for 6 months with once daily tiotropium compared with twice daily salmeterol in patients with COPD , 2003, Thorax.

[4] P. Levendag,et al. Identification of prognostic factors in patients with brain metastases: a review of 1292 patients. , 1999, International journal of radiation oncology, biology, physics.

[5] L. Deangelis. Current diagnosis and treatment of leptomeningeal metastasis , 1998, Journal of Neuro-Oncology.

[6] J. Posner,et al. Diagnosis and treatment of leptomeningeal metastases from solid tumors: Experience with 90 patients , 1982, Cancer.

[7] F. Vaylet,et al. [Erlotinib and nonsmall cell lung cancer with brain metastases: a case study with a complete and prolonged response over 17 months]. , 2009, Revue de pneumologie clinique.

[8] L. Coia. The role of radiation therapy in the treatment of brain metastases. , 1992, International journal of radiation oncology, biology, physics.