Aurora kinases: novel therapy targets in cancers

Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via regulating mitosis especially the process of chromosomal segregation. Besides regulating mitosis, Aurora kinases have been implicated in regulating meiosis. The deletion of Aurora kinases could lead to failure of cell division and impair the embryonic development. Overexpression or gene amplification of Aurora kinases has been clarified in a number of cancers. And a growing number of studies have demonstrated that inhibition of Aurora kinases could potentiate the effect of chemotherapies. For the past decades, a series of Aurora kinases inhibitors (AKIs) developed effectively repress the progression and growth of many cancers both in vivo and in vitro, suggesting that Aurora kinases could be a novel therapeutic target. In this review, we'll first briefly present the structure, localization and physiological functions of Aurora kinases in mitosis, then describe the oncogenic role of Aurora kinases in tumorigenesis, we shall finally discuss the outcomes of AKIs combination with conventional therapy.

[1]  F. Peng,et al.  Aurora‐A Kinase: A Potent Oncogene and Target for Cancer Therapy , 2016, Medicinal research reviews.

[2]  M. Nakanishi,et al.  Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis , 2016, Nature Communications.

[3]  Kaori Sasai,et al.  Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex , 2016, PloS one.

[4]  E. Tongiorgi,et al.  Combined cisplatin and aurora inhibitor treatment increase neuroblastoma cell death but surviving cells overproduce BDNF , 2016, Biology Open.

[5]  R. Franco,et al.  B R I E F C O M M U N I C a T I O N Open Access , 2022 .

[6]  Weijie Cao,et al.  Aurora-B and HDAC synergistically regulate survival and proliferation of lymphoma cell via AKT, mTOR and Notch pathways. , 2016, European journal of pharmacology.

[7]  Lei Han,et al.  AURKA induces EMT by regulating histone modification through Wnt/β-catenin and PI3K/Akt signaling pathway in gastric cancer , 2016, Oncotarget.

[8]  S. Barry,et al.  Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo , 2016, Science Translational Medicine.

[9]  G. Braus,et al.  CHK2–BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly , 2016, Proceedings of the National Academy of Sciences.

[10]  S. Linardopoulos,et al.  Aurora Kinase Inhibitors: Current Status and Outlook , 2015, Front. Oncol..

[11]  E. Çubukçu,et al.  Aurora A overexpression in breast cancer patients induces taxane resistance and results in worse prognosis. , 2015, Journal of B.U.ON. : official journal of the Balkan Union of Oncology.

[12]  Jinxiang Zhang,et al.  Aurora kinase A mediates c‐Myc's oncogenic effects in hepatocellular carcinoma , 2015, Molecular carcinogenesis.

[13]  Mutsuko Ouchi,et al.  BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. , 2015, The Journal of Biological Chemistry.

[14]  H. Niu,et al.  Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer , 2015, Front. Oncol..

[15]  M. Malumbres,et al.  Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development , 2015, Molecular and Cellular Biology.

[16]  Jong-Suk Kim,et al.  Aurora kinases are essential for PKC-induced invasion and matrix metalloproteinase-9 expression in MCF-7 breast cancer cells. , 2015, Oncology reports.

[17]  M. May,et al.  High proliferation index, as determined by immunohistochemical expression of Aurora kinase B and geminin, indicates poor prognosis in neuroblastomas , 2015, Virchows Archiv.

[18]  P. Solc,et al.  Aurora kinase A is essential for correct chromosome segregation in mouse zygote , 2015, Zygote.

[19]  Sonali M. Smith,et al.  Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[20]  T. Bush,et al.  Discovery of N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), a highly selective, orally bioavailable inhibitor of aurora kinases with activity against multidrug-resistant cancer cell lines. , 2015, Journal of Medicinal Chemistry.

[21]  Kaori Sasai,et al.  Regulation of AURKC expression by CpG island methylation in human cancer cells , 2015, Tumor Biology.

[22]  W. El-Rifai,et al.  Aurora kinase A in gastrointestinal cancers: time to target , 2015, Molecular Cancer.

[23]  J. Seong,et al.  Daurinol Enhances the Efficacy of Radiotherapy in Lung Cancer via Suppression of Aurora Kinase A/B Expression , 2015, Molecular Cancer Therapeutics.

[24]  A. Laenkholm,et al.  Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer , 2015, BMC Cancer.

[25]  A. DeMichele,et al.  Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: a five-arm phase 2 study. , 2015, The Lancet. Oncology.

[26]  Qiaojun He,et al.  Sequential treatment with aurora B inhibitors enhances cisplatin-mediated apoptosis via c-Myc , 2015, Journal of Molecular Medicine.

[27]  T. Gauler,et al.  Efficacy and safety of biweekly i.v. administrations of the Aurora kinase inhibitor danusertib hydrochloride in independent cohorts of patients with advanced or metastatic breast, ovarian, colorectal, pancreatic, small-cell and non-small-cell lung cancer: a multi-tumour, multi-institutional phase II , 2015, Annals of oncology : official journal of the European Society for Medical Oncology.

[28]  M. Risio,et al.  Aurora kinase A gene copy number is associated with the malignant transformation of colorectal adenomas but not with the serrated neoplasia progression. , 2015, Human pathology.

[29]  R. Dere,et al.  β-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma. , 2015, Journal of the American Society of Nephrology : JASN.

[30]  A. Lykkesfeldt,et al.  Aurora kinase A and B as new treatment targets in aromatase inhibitor-resistant breast cancer cells , 2015, Breast Cancer Research and Treatment.

[31]  I. Pollack,et al.  Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells , 2015, Cancer biology & therapy.

[32]  Stefania Tommasi,et al.  Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy , 2015, Journal of Translational Medicine.

[33]  I. Vernos,et al.  Microtubule Nucleation in Mitosis by a RanGTP-Dependent Protein Complex , 2015, Current Biology.

[34]  C. Liang,et al.  p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma , 2014, Molecular Cancer Research.

[35]  R. Engh,et al.  Inhibition of Aurora Kinase B Is Important for Biologic Activity of the Dual Inhibitors of BCR-ABL and Aurora Kinases R763/AS703569 and PHA-739358 in BCR-ABL Transformed Cells , 2014, PloS one.

[36]  A. Faisal,et al.  Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis , 2014, Oncotarget.

[37]  J. Jónasson,et al.  Aurora A is a prognostic marker for breast cancer arising in BRCA2 mutation carriers , 2014, The journal of pathology. Clinical research.

[38]  Jie Xu,et al.  Aurora-A contributes to cisplatin resistance and lymphatic metastasis in non-small cell lung cancer and predicts poor prognosis , 2014, Journal of Translational Medicine.

[39]  Feimeng Zheng,et al.  A Novel Small Molecule Aurora Kinase Inhibitor Attenuates Breast Tumor–Initiating Cells and Overcomes Drug Resistance , 2014, Molecular Cancer Therapeutics.

[40]  H. Kantarjian,et al.  A phase I and pharmacodynamic study of AT9283, a small-molecule inhibitor of aurora kinases in patients with relapsed/refractory leukemia or myelofibrosis. , 2014, Clinical lymphoma, myeloma & leukemia.

[41]  A. Degnim,et al.  Aurora-A Mitotic Kinase Induces Endocrine Resistance through Down-Regulation of ERα Expression in Initially ERα+ Breast Cancer Cells , 2014, PloS one.

[42]  B. Davidson,et al.  BUB1 mRNA is significantly co-expressed with AURKA and AURKB mRNA in advanced-stage ovarian serous carcinoma , 2014, Virchows Archiv.

[43]  T. Ikezoe,et al.  Bcr‐Abl activates AURKA and AURKB in chronic myeloid leukemia cells via AKT signaling , 2014, International journal of cancer.

[44]  E. Oki,et al.  Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers , 2014, Surgery Today.

[45]  Jian Yu,et al.  Aurora Kinase Inhibition Induces PUMA via NF-κB to Kill Colon Cancer Cells , 2014, Molecular Cancer Therapeutics.

[46]  A. Godwin,et al.  Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion , 2014, Oncogene.

[47]  A. Degnim,et al.  The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells , 2014, Oncogene.

[48]  X. Long,et al.  Inhibition of Aurora-B suppresses osteosarcoma cell migration and invasion , 2014, Experimental and therapeutic medicine.

[49]  Yohko Nakamura,et al.  Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma , 2014, Cancer medicine.

[50]  K. Gelmon,et al.  NCIC CTG IND.181: Phase I study of AT9283 given as a weekly 24 hour infusion in advanced malignancies , 2013, Investigational New Drugs.

[51]  D. Gerlich,et al.  Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase , 2013, The Journal of cell biology.

[52]  J. G. Teodoro,et al.  BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1 , 2013, Cell Death and Differentiation.

[53]  S. Sen,et al.  RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora‐A and BRCA2 in midbody during cytokinesis , 2013, International journal of cancer.

[54]  H. Kantarjian,et al.  Stage I of a phase 2 study assessing the efficacy, safety, and tolerability of barasertib (AZD1152) versus low‐dose cytosine arabinoside in elderly patients with acute myeloid leukemia , 2013, Cancer.

[55]  P. Wei,et al.  AURKA Governs Self-Renewal Capacity in Glioma-Initiating Cells via Stabilization/Activation of β-catenin/Wnt Signaling , 2013, Molecular Cancer Research.

[56]  Y. Maehara,et al.  Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer. , 2013, Lung Cancer.

[57]  C. Bieberich,et al.  Phosphorylation of NuMA by Aurora‐A kinase in PC‐3 prostate cancer cells affects proliferation, survival, and interphase NuMA localization , 2013, Journal of cellular biochemistry.

[58]  C. Prigent,et al.  Assessment of Aurora a Kinase Expression in Breast Cancer: A Tool for Early Diagnosis? , 2013, Disease markers.

[59]  P. Halada,et al.  Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy. , 2013, Journal of proteome research.

[60]  W. Earnshaw,et al.  The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis , 2012, Nature Reviews Molecular Cell Biology.

[61]  Stephen N. Jones,et al.  Conditional Aurora A deficiency differentially affects early mouse embryo patterning. , 2012, Developmental biology.

[62]  C. Teng,et al.  FBXW7 is involved in Aurora B degradation , 2012, Cell cycle.

[63]  Huanxiang Liu,et al.  Molecular dynamics and free energy studies on Aurora kinase A and its mutant bound with MLN8054: insight into molecular mechanism of subtype selectivity. , 2012, Molecular bioSystems.

[64]  I. Ray-Coquard,et al.  Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. , 2012, Gynecologic oncology.

[65]  Jie Xu,et al.  Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells , 2012, Autophagy.

[66]  R. Pieters,et al.  Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target , 2012, Leukemia.

[67]  J. Cheong,et al.  Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells , 2012, The Korean journal of hematology.

[68]  Amanda J. Guise,et al.  Aurora B-dependent Regulation of Class IIa Histone Deacetylases by Mitotic Nuclear Localization Signal Phosphorylation* , 2012, Molecular & Cellular Proteomics.

[69]  R. Ballotti,et al.  The Epithelial-Mesenchymal Transition (EMT) Regulatory Factor SLUG (SNAI2) Is a Downstream Target of SPARC and AKT in Promoting Melanoma Cell Invasion , 2012, PloS one.

[70]  S. Sen,et al.  Aurora Kinase A deficiency during skin development impairs cell division and stratification , 2012, The Journal of investigative dermatology.

[71]  L. Yu-Lee,et al.  Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[72]  Ji-Hyun Shin,et al.  Aurora B kinase phosphorylates and instigates degradation of p53 , 2012, Proceedings of the National Academy of Sciences.

[73]  A. Zekri,et al.  Gene amplification and overexpression of Aurora-C in breast and prostate cancer cell lines. , 2012, Oncology research.

[74]  M. Tatsuka,et al.  Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer. , 2012, Oncology letters.

[75]  B. Niu,et al.  Overexpression of Aurora-A Enhances Invasion and Matrix Metalloproteinase-2 Expression in Esophageal Squamous Cell Carcinoma Cells , 2012, Molecular Cancer Research.

[76]  J. Rutka,et al.  Aurora kinase B/C inhibition impairs malignant glioma growth in vivo , 2012, Journal of Neuro-Oncology.

[77]  K. Choi,et al.  Aurora B confers cancer cell resistance to TRAIL-induced apoptosis via phosphorylation of survivin. , 2012, Carcinogenesis.

[78]  D. Zheleva,et al.  Aurora kinase inhibitors: Progress towards the clinic , 2012, Investigational New Drugs.

[79]  M. Roth,et al.  Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model. , 2012, Carcinogenesis.

[80]  R. Vibhakar,et al.  Targeting Aurora Kinase A enhances radiation sensitivity of atypical teratoid rhabdoid tumor cells , 2012, Journal of Neuro-Oncology.

[81]  Takako Sasaki,et al.  Microenvironmental Regulation by Fibrillin-1 , 2012, PLoS genetics.

[82]  P. Sonneveld,et al.  Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia. , 2011, Blood.

[83]  T. Ikezoe,et al.  CD34+/CD38− acute myelogenous leukemia cells aberrantly express Aurora kinase A , 2011, International journal of cancer.

[84]  Chi-Ying F. Huang,et al.  Aurora‐A phosphorylates hnRNPK and disrupts its interaction with p53 , 2011, FEBS letters.

[85]  G. Piontek,et al.  Aurora Kinase Inhibition Overcomes Cetuximab Resistance in Squamous Cell Cancer of the Head and Neck , 2011, Oncotarget.

[86]  G. Mor,et al.  Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFĸB pathway , 2011, Cell cycle.

[87]  G. Scagliotti,et al.  Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation , 2011, Journal of Translational Medicine.

[88]  C. Prigent,et al.  Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein. , 2011, Biochemical and biophysical research communications.

[89]  L. Moretti,et al.  Enhanced Radiosensitivity of Androgen-Resistant Prostate Cancer: AZD1152-Mediated Aurora Kinase B Inhibition , 2011, Radiation research.

[90]  R. Cincione,et al.  Aurora B Expression as a Prognostic Indicator and Possibile Therapeutic Target in Oral Squamous Cell Carcinoma , 2011, International journal of immunopathology and pharmacology.

[91]  J. Palazzo,et al.  Survivin-induced Aurora-B kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development. , 2010, The American journal of pathology.

[92]  Mark A. Hall,et al.  Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state. , 2010, Blood.

[93]  K. Pollok,et al.  Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD‐2076, against multiple myeloma , 2010, British journal of haematology.

[94]  Hong Liu,et al.  Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase , 2010, Proceedings of the National Academy of Sciences.

[95]  Sheng‐Chung Lee,et al.  Aurora-C Kinase Deficiency Causes Cytokinesis Failure in Meiosis I and Production of Large Polyploid Oocytes in Mice , 2010, Molecular biology of the cell.

[96]  G. Mills,et al.  Aurora Kinase A Promotes Ovarian Tumorigenesis through Dysregulation of the Cell Cycle and Suppression of BRCA2 , 2010, Clinical Cancer Research.

[97]  I. Petersen,et al.  The CHK2–BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells , 2010, Nature Cell Biology.

[98]  Nam‐Gyun Kim,et al.  Regulation of protein stability by GSK3 mediated phosphorylation , 2009, Cell cycle.

[99]  A. Letai,et al.  Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression. , 2009, Blood.

[100]  T. Magnuson,et al.  Aurora-A Kinase Is Essential for Bipolar Spindle Formation and Early Development , 2008, Molecular and Cellular Biology.

[101]  Junjie Chen,et al.  Aurora A Is Essential for Early Embryonic Development and Tumor Suppression* , 2008, Journal of Biological Chemistry.

[102]  A. Dar,et al.  The Aurora kinase A Regulates GSK-3β in Gastric Cancer Cells , 2008, Oncogene.

[103]  Jie Xu,et al.  Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells. , 2008, Carcinogenesis.

[104]  Y. Miki,et al.  Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy , 2008, The British journal of surgery.

[105]  K. Washington,et al.  Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions , 2008, Cancer.

[106]  Feimeng Zheng,et al.  Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia. , 2008, Blood.

[107]  R. Medema,et al.  Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment , 2008, Cell.

[108]  M. Sheikh,et al.  Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation , 2007, Oncogene.

[109]  J. Bourhis,et al.  Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells , 2007, British Journal of Cancer.

[110]  M. Schwab,et al.  Suppression of polyploidy by the BRCA2 protein. , 2007, Cancer letters.

[111]  H. Koeffler,et al.  AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. , 2007, Blood.

[112]  Rajesh Odedra,et al.  AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis , 2007, Clinical Cancer Research.

[113]  Takashi Ito,et al.  Concerted action of Aurora B, Polo and NHK-1 kinases in centromere-specific histone 2A phosphorylation , 2007, Experimental cell research.

[114]  Jennifer B. Old,et al.  Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis , 2007, The EMBO journal.

[115]  Jie He,et al.  Amplification and overexpression of Aurora-A in esophageal squamous cell carcinoma. , 2007, Oncology reports.

[116]  U. Eichenlaub-Ritter,et al.  Gender effects on the incidence of aneuploidy in mammalian germ cells. , 2007, Environmental research.

[117]  J. Jónasson,et al.  Aurora-A amplification associated with BRCA2 mutation in breast tumours. , 2007, Cancer letters.

[118]  O. Clausen,et al.  Subcellular Localization of the Spindle Proteins Aurora A, Mad2, and BUBR1 Assessed by Immunohistochemistry , 2007, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[119]  Qing Jiang,et al.  Roles of Aurora Kinases in Mitosis and Tumorigenesis , 2007, Molecular Cancer Research.

[120]  P. Stukenberg,et al.  Aurora B Is Enriched at Merotelic Attachment Sites, Where It Regulates MCAK , 2006, Current Biology.

[121]  D. Ballinari,et al.  PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity , 2006, Clinical Cancer Research.

[122]  C. Prigent,et al.  The Absence of p53 Aggravates Polyploidy and Centrosome Number Abnormality Induced by Aurora-C Overexpression , 2005, Cell cycle.

[123]  Long Yu,et al.  Aurora C is directly associated with Survivin and required for cytokinesis , 2005, Genes to cells : devoted to molecular & cellular mechanisms.

[124]  H. Kawai,et al.  Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis , 2005, Oncogene.

[125]  S. Nicosia,et al.  Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215* , 2004, Journal of Biological Chemistry.

[126]  Kaori Sasai,et al.  Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. , 2004, Cell motility and the cytoskeleton.

[127]  K. Kimura,et al.  Direct Association with Inner Centromere Protein (INCENP) Activates the Novel Chromosomal Passenger Protein, Aurora-C* , 2004, Journal of Biological Chemistry.

[128]  Ping Chen,et al.  Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor , 2004, Science.

[129]  B. Monsarrat,et al.  Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition , 2004, Journal of Cell Science.

[130]  Louise R Howe,et al.  Wnt Signaling and Breast Cancer , 2004, Cancer biology & therapy.

[131]  Pierre Gönczy,et al.  TAC-1 and ZYG-9 Form a Complex that Promotes Microtubule Assembly in C. elegans Embryos , 2003, Current Biology.

[132]  E. Nigg,et al.  Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. , 2003, Molecular biology of the cell.

[133]  S. Narumiya,et al.  Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. , 2003, Developmental cell.

[134]  C. Prigent,et al.  A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly , 2003, Nature Cell Biology.

[135]  K. Sugimoto,et al.  Molecular dynamics of Aurora-A kinase in living mitotic cells simultaneously visualized with histone H3 and nuclear membrane protein importinalpha. , 2002, Cell structure and function.

[136]  Jian Kuang,et al.  Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. , 2002, Molecular biology of the cell.

[137]  Roman Körner,et al.  Human TPX2 is required for targeting Aurora-A kinase to the spindle , 2002, The Journal of cell biology.

[138]  T. Urano,et al.  Degradation of human Aurora‐A protein kinase is mediated by hCdh1 , 2002, FEBS letters.

[139]  Michael J. Lee,et al.  Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules , 2002, The Journal of cell biology.

[140]  Erich A Nigg,et al.  Aurora‐B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation , 2002, Genes to cells : devoted to molecular & cellular mechanisms.

[141]  Samantha G. Zeitlin,et al.  CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis , 2001, The Journal of cell biology.

[142]  P. Sanseau,et al.  Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter. , 1998, Genomics.

[143]  T. Tang,et al.  Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. , 1998, DNA and cell biology.

[144]  Brian Schryver,et al.  A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers , 1998, The EMBO journal.

[145]  B. Amati,et al.  Growth arrest by the cyclin‐dependent kinase inhibitor p27Kip1 is abrogated by c‐Myc. , 1996, The EMBO journal.

[146]  洪明奇.  Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype , 2016 .

[147]  S. Robinson,et al.  Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma. , 2016, Cancer cell.

[148]  Sara Sheikholeslami,et al.  Expression Analysis of Aurora-C and Survivin, Two Testis-Specific Genes, in Patients with Colorectal Cancer. , 2015, Clinical laboratory.

[149]  Bo Xu,et al.  Elevated Aurora B expression contributes to chemoresistance and poor prognosis in breast cancer. , 2015, International journal of clinical and experimental pathology.

[150]  D. Chung,et al.  Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma. , 2014, Journal of pediatric surgery.

[151]  K. Chao,et al.  Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer. , 2009, European journal of obstetrics, gynecology, and reproductive biology.

[152]  R. Nusse,et al.  Wnt signaling in disease and in development , 2005, Cell Research.

[153]  Kaori Sasai,et al.  Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53 , 2004, Nature Genetics.

[154]  Erich A. Nigg,et al.  Cell division: Mitotic kinases as regulators of cell division and its checkpoints , 2001, Nature Reviews Molecular Cell Biology.