An integrated method for hemorrhage segmentation from brain CT Imaging

This paper presents an integrated segmentation method which combines the features of Fuzzy C-Mean (FCM) clustering and region-based active contour method. In the proposed method, FCM clustering is used to initialize the contour around the hemorrhagic region and then region-based active contour method propagates the initial contour towards the hemorrhage boundaries. Further, the FCM clustering is also used to estimate the contour propagation controlling parameters adaptively from the given image. The region-based active contour method uses the intensity information in the local regions as against the global regions in the traditional region-based active contour methods to guide the contour motion. The effectiveness of the proposed method is tested on the dataset of total 100 hemorrhagic brain CT images of 20 patients and the results are compared with region growing, FCM clustering and Chan & Vese methods. The proposed method yields the higher average values of the similarity indices namely sensitivity, specificity, accuracy and overlap metric as 79.93%, 99.10%, 84.83% and 88.84% respectively.

[1]  Rosli Besar,et al.  Abnormalities detection in serial computed tomography brain images using multi-level segmentation approach , 2011, Multimedia Tools and Applications.

[2]  S. Osher,et al.  Regular Article: A PDE-Based Fast Local Level Set Method , 1999 .

[3]  Tony F. Chan,et al.  Active contours without edges , 2001, IEEE Trans. Image Process..

[4]  D. Mumford,et al.  Optimal approximations by piecewise smooth functions and associated variational problems , 1989 .

[5]  Sven Loncaric,et al.  Quantitative intracerebral brain hemorrhage analysis , 1999, Medical Imaging.

[6]  Demetri Terzopoulos,et al.  Snakes: Active contour models , 2004, International Journal of Computer Vision.

[7]  Chunming Li,et al.  Level set evolution without re-initialization: a new variational formulation , 2005, 2005 IEEE Computer Society Conference on Computer Vision and Pattern Recognition (CVPR'05).

[8]  Tzong-Jer Chen,et al.  Fuzzy c-means clustering with spatial information for image segmentation , 2006, Comput. Medical Imaging Graph..

[9]  Chunming Li,et al.  Minimization of Region-Scalable Fitting Energy for Image Segmentation , 2008, IEEE Transactions on Image Processing.

[10]  Jerry L. Prince,et al.  An Adaptive Fuzzy Segmentation Algorithm for Three-Dimensional Magnetic Resonance Images , 1999, IPMI.

[11]  S. Loncaric,et al.  Fuzzy expert system for edema segmentation , 1998, MELECON '98. 9th Mediterranean Electrotechnical Conference. Proceedings (Cat. No.98CH36056).

[12]  Katsushi Ikeuchi,et al.  Geodesic Active Contour , 2014, Computer Vision, A Reference Guide.

[13]  C. Metz Basic principles of ROC analysis. , 1978, Seminars in nuclear medicine.

[14]  Tao Chan,et al.  Computer aided detection of small acute intracranial hemorrhage on computer tomography of brain , 2007, Comput. Medical Imaging Graph..

[15]  Ronald Fedkiw,et al.  Level set methods and dynamic implicit surfaces , 2002, Applied mathematical sciences.

[16]  Guillermo Sapiro,et al.  Geodesic Active Contours , 1995, International Journal of Computer Vision.

[17]  J. Sethian,et al.  Fronts propagating with curvature-dependent speed: algorithms based on Hamilton-Jacobi formulations , 1988 .

[18]  Lian-Wen Jin,et al.  A robust graph-based segmentation method for breast tumors in ultrasound images. , 2012, Ultrasonics.

[19]  Olivier Faugeras,et al.  Reconciling Distance Functions and Level Sets , 2000, J. Vis. Commun. Image Represent..

[20]  Jau-Min Wong,et al.  Computer-aided diagnosis of intracranial hematoma with brain deformation on computed tomography , 2010, Comput. Medical Imaging Graph..

[21]  Imma Boada,et al.  Semi-automated method for brain hematoma and edema quantification using computed tomography , 2009, Comput. Medical Imaging Graph..

[22]  Sankar K. Pal,et al.  Fuzzy models for pattern recognition , 1992 .

[23]  V. Caselles,et al.  A geometric model for active contours in image processing , 1993 .